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1. 发明申请

US20100151476A1 PHENYLTHIOCARBAMIDE (PTC) TASTE RECEPTOR 有权
标题翻译：苯乙烯（PTC）吸收剂
公开(公告)号：US20100151476A1
公开(公告)日：2010-06-17
申请号：US12690286
申请日：2010-01-20
申请人： Dennis Drayna , Un-Kyung Kim , Mark Leppert
发明人： Dennis Drayna , Un-Kyung Kim , Mark Leppert
IPC分类号： C12Q1/68 , C07H21/04 , C12N15/63 , C12N5/10 , C12P21/06 , C07K14/705
CPC分类号： C07K14/705
摘要： The invention provides isolated nucleic and amino acid sequences of a taste cell receptor that serves as a sensor for the bitter taste of phenylthiocarbamide (PTC), antibodies to such PTC taste receptor, methods of detecting such nucleic and amino acid sequences, and methods of screening for modulators of such PTC taste receptor.
摘要翻译：本发明提供了作为苯基硫代氨基甲酸（PTC）的苦味的传感器，这种PTC味觉受体的抗体，检测这种核酸和氨基酸序列的方法以及筛选方法的味细胞受体的分离的核酸和氨基酸序列用于这种PTC味觉受体的调节剂。

2. 发明授权

US07314725B2 Phenylthiocarbamide (PTC) taste receptor 有权
标题翻译：苯硫代氨基甲酸（PTC）味觉受体
公开(公告)号：US07314725B2
公开(公告)日：2008-01-01
申请号：US10484525
申请日：2002-07-19
申请人： Dennis Drayna , Un-Kyung Kim , Mark Leppert
发明人： Dennis Drayna , Un-Kyung Kim , Mark Leppert
IPC分类号： C07K14/705 , C12N15/12 , G01N33/566
CPC分类号： C07K14/705
摘要： The invention provides isolated nucleic and amino acid sequences of a taste cell receptor that serves as a sensor for the bitter taste of phenylthiocarbamide (PTC), antibodies to such PTC taste receptor, methods of detecting such nucleic and amino acid sequences, and methods of screening for modulators of such PTC taste receptor.
摘要翻译：本发明提供了作为苯基硫代氨基甲酸（PTC）的苦味的传感器，这种PTC味觉受体的抗体，检测这种核酸和氨基酸序列的方法以及筛选方法的味细胞受体的分离的核酸和氨基酸序列用于这种PTC味觉受体的调节剂。

3. 发明申请

US20060177854A1 Hereditary hemochromatosis gene 有权
公开(公告)号：US20060177854A1
公开(公告)日：2006-08-10
申请号：US11327689
申请日：2006-01-05
申请人： Winston Thomas , Dennis Drayna , John Feder , Andreas Gnirke , David Ruddy , Zenta Tsuchihashi , Roger Wolff
发明人： Winston Thomas , Dennis Drayna , John Feder , Andreas Gnirke , David Ruddy , Zenta Tsuchihashi , Roger Wolff
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C07K14/795
CPC分类号： C07K14/47 , A61K38/00 , A61K48/00 , C07H21/04 , C07K14/70539 , C12Q1/6883
摘要： The invention relates generally to the gene, and mutations thereto, that are responsible for the disease hereditary hemochromatosis (HH). More particularly, the invention relates to the identification, isolation, and cloning of the DNA sequence corresponding to the normal and mutant HH genes, as well as the characterization of their transcripts and gene products. The invention also related to methods and the like for screening for HH homozygotes and further relates to HH diagnosis, prenatal screening and diagnosis, and therapies of HH disease, including gene therapeutics, protein and antibody based therapeutics, and small molecule therapeutics.

4. 发明授权

US08309701B2 Variants of human taste receptor genes 有权
标题翻译：人类受体基因的变体
公开(公告)号：US08309701B2
公开(公告)日：2012-11-13
申请号：US12534505
申请日：2009-08-03
申请人： Dennis Drayna , Un-Kyung Kim
发明人： Dennis Drayna , Un-Kyung Kim
IPC分类号： C07H21/04 , C12N15/63 , C12N15/85 , C12Q1/68
CPC分类号： C07K14/705 , A61K38/00 , C12Q1/6876 , C12Q2600/156 , G01N33/566 , G01N2500/10 , Y10S435/81
摘要： Identified herein are different forms of bitter receptor genes that occur in different humans. These alleles are generated by numerous coding single nucleotide polymorphisms (cSNP's) that occur within the members of the T2R gene family. Some SNP's cause amino acid substitutions, while others introduce chain termination codons, rendering the allele non-functional. Differences in these genes are believed to have a large effect on those individuals' sense of bitter taste, such that these individuals perceive the taste of bitter substances differently than the rest of the population. The ability to assay this allelic information is useful in the development of flavorings and flavor enhancers, as it can be used to define large groups and populations who perceive bitter tastes differently. This in turn allows the taste preferences of these groups to be addressed at the molecular level for the first time.
摘要翻译：本文所确定的是发生在不同人类中的不同形式的苦味受体基因。这些等位基因是通过发生在T2R基因家族成员内的许多编码单核苷酸多态性（cSNP）产生的。一些SNP引起氨基酸取代，而其他引入链终止密码子，使得等位基因无功能。这些基因的差异被认为对这些个体的苦味感具有很大的影响，使得这些个体感觉到与其他人群不同的苦味物质的味道。测定这种等位基因信息的能力可用于调味和风味增强剂的开发，因为它可以用于定义感染苦味的大群体和群体。这反过来允许这些群体的味道偏好在分子水平上首次得到解决。

5. 发明申请

US20080227093A1 PHENYLTHIOCARBAMIDE (PTC) TASTE RECEPTOR 有权
标题翻译：苯乙烯（PTC）吸收剂
公开(公告)号：US20080227093A1
公开(公告)日：2008-09-18
申请号：US11871131
申请日：2007-10-11
申请人： Dennis Drayna , Un-Kyung Kim , Mark Leppert
发明人： Dennis Drayna , Un-Kyung Kim , Mark Leppert
IPC分类号： C12Q1/68
CPC分类号： C07K14/705
摘要： The invention provides isolated nucleic and amino acid sequences of a taste cell receptor that serves as a sensor for the bitter taste of phenylthiocarbamide (PTC), antibodies to such PTC taste receptor, methods of detecting such nucleic and amino acid sequences, and methods of screening for modulators of such PTC taste receptor.
摘要翻译：本发明提供了作为苯基硫代氨基甲酸（PTC）的苦味的传感器，这种PTC味觉受体的抗体，检测这种核酸和氨基酸序列的方法以及筛选方法的味细胞受体的分离的核酸和氨基酸序列用于这种PTC味觉受体的调节剂。

6. 发明授权

US07666601B2 Phenylthiocarbamide (PTC) taste receptor 有权
标题翻译：苯硫代氨基甲酸（PTC）味觉受体
公开(公告)号：US07666601B2
公开(公告)日：2010-02-23
申请号：US11871131
申请日：2007-10-11
申请人： Dennis Drayna , Un-Kyung Kim , Mark Leppert
发明人： Dennis Drayna , Un-Kyung Kim , Mark Leppert
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/48 , C07K14/705
CPC分类号： C07K14/705
摘要： The invention provides isolated nucleic and amino acid sequences of a taste cell receptor that serves as a sensor for the bitter taste of phenylthiocarbamide (PTC), antibodies to such PTC taste receptor, methods of detecting such nucleic and amino acid sequences, and methods of screening for modulators of such PTC taste receptor.
摘要翻译：本发明提供了作为苯基硫代氨基甲酸（PTC）的苦味的传感器，这种PTC味觉受体的抗体，检测这种核酸和氨基酸序列的方法以及筛选方法的味细胞受体的分离的核酸和氨基酸序列用于这种PTC味觉受体的调节剂。

7. 发明授权

US07579453B2 Variants of human taste receptor genes 有权
标题翻译：人类受体基因的变体
公开(公告)号：US07579453B2
公开(公告)日：2009-08-25
申请号：US10561487
申请日：2004-06-18
申请人： Dennis Drayna , Un-Kyung Kim
发明人： Dennis Drayna , Un-Kyung Kim
IPC分类号： C07H21/04 , C12N15/63 , C12N15/85 , C12Q1/68
CPC分类号： C07K14/705 , A61K38/00 , C12Q1/6876 , C12Q2600/156 , G01N33/566 , G01N2500/10 , Y10S435/81
摘要： Identified herein are different forms of bitter receptor genes that occur in different humans. These alleles are generated by numerous coding single nucleotide polymorphisms (cSNP's) that occur within the members of the T2R gene family. Some SNP's cause amino acid substitutions, while others introduce chain termination codons, rendering the allele non-functional. Differences in these genes are believed to have a large effect on those individuals' sense of bitter taste, such that these individuals perceive the taste of bitter substances differently than the rest of the population. The ability to assay this allelic information is useful in the development of flavorings and flavor enhancers, as it can be used to define large groups and populations who perceive bitter tastes differently. This in turn allows the taste preferences of these groups to be addressed at the molecular level for the first time.
摘要翻译：本文所确定的是发生在不同人类中的不同形式的苦味受体基因。这些等位基因是通过发生在T2R基因家族成员内的许多编码单核苷酸多态性（cSNP）产生的。一些SNP引起氨基酸取代，而其他引入链终止密码子，使得等位基因无功能。这些基因的差异被认为对这些个体的苦味感具有很大的影响，使得这些个体感觉到与其他人群不同的苦味物质的味道。测定这种等位基因信息的能力可用于调味和风味增强剂的开发，因为它可以用于定义感染苦味的大群体和群体。这反过来允许这些群体的味道偏好在分子水平上首次得到解决。

8. 发明申请

US20070128604A1 Variants of human taste receptor genes 有权
标题翻译：人类受体基因的变体
公开(公告)号：US20070128604A1
公开(公告)日：2007-06-07
申请号：US10561487
申请日：2004-06-18
申请人： Dennis Drayna , Un-Kyung Kim
发明人： Dennis Drayna , Un-Kyung Kim
IPC分类号： C12Q1/68 , C07K14/705 , A61K38/17 , C07H21/04 , C12P21/06
CPC分类号： C07K14/705 , A61K38/00 , C12Q1/6876 , C12Q2600/156 , G01N33/566 , G01N2500/10 , Y10S435/81
摘要： Identified herein are different forms of bitter receptor genes that occur in different humans. These alleles are generated by numerous coding single nucleotide polymorphisms (cSNP's) that occur within the members of the T2R gene family. Some SNP's cause amino acid substitutions, while others introduce chain termination codons, rendering the allele non-functional. Differences in these genes are believed to have a large effect on those individuals' sense of bitter taste, such that these individuals perceive the taste of bitter substances differently than the rest of the population. The ability to assay this allelic information is useful in the development of flavorings and flavor enhancers, as it can be used to define large groups and populations who perceive bitter tastes differently. This in turn allows the taste preferences of these groups to be addressed at the molecular level for the first time.
摘要翻译：本文所确定的是发生在不同人类中的不同形式的苦味受体基因。这些等位基因是通过发生在T2R基因家族成员内的许多编码单核苷酸多态性（cSNP）产生的。一些SNP引起氨基酸取代，而其他引入链终止密码子，使得等位基因无功能。这些基因的差异被认为对这些个体的苦味感具有很大的影响，使得这些个体感觉到与其他人群不同的苦味物质的味道。测定这种等位基因信息的能力可用于调味和风味增强剂的开发，因为它可以用于定义感染苦味的大群体和群体。这反过来允许这些群体的味道偏好在分子水平上首次得到解决。

9. 发明授权

US08148082B2 Phenylthiocarbamide (PTC) taste receptor 有权
标题翻译：苯硫代氨基甲酸（PTC）味觉受体
公开(公告)号：US08148082B2
公开(公告)日：2012-04-03
申请号：US12690286
申请日：2010-01-20
申请人： Dennis Drayna , Un-Kyung Kim , Mark Leppert
发明人： Dennis Drayna , Un-Kyung Kim , Mark Leppert
IPC分类号： C12Q1/68
CPC分类号： C07K14/705
摘要： The invention provides isolated nucleic and amino acid sequences of a taste cell receptor that serves as a sensor for the bitter taste of phenylthiocarbamide (PTC), antibodies to such PTC taste receptor, methods of detecting such nucleic and amino acid sequences, and methods of screening for modulators of such PTC taste receptor.
摘要翻译：本发明提供了作为苯基硫代氨基甲酸（PTC）的苦味的传感器，这种PTC味觉受体的抗体，检测这种核酸和氨基酸序列的方法以及筛选方法的味细胞受体的分离的核酸和氨基酸序列用于这种PTC味觉受体的调节剂。

10. 发明申请

US20100035340A1 VARIANTS OF HUMAN TASTE RECEPTOR GENES 有权
标题翻译：人类受体基因变异
公开(公告)号：US20100035340A1
公开(公告)日：2010-02-11
申请号：US12534505
申请日：2009-08-03
申请人： Dennis Drayna , Un-Kyung Kim
发明人： Dennis Drayna , Un-Kyung Kim
IPC分类号： C12N5/10 , C12N15/12 , C40B40/08 , C12N15/85
CPC分类号： C07K14/705 , A61K38/00 , C12Q1/6876 , C12Q2600/156 , G01N33/566 , G01N2500/10 , Y10S435/81
摘要： Identified herein are different forms of bitter receptor genes that occur in different humans. These alleles are generated by numerous coding single nucleotide polymorphisms (cSNP's) that occur within the members of the T2R gene family. Some SNP's cause amino acid substitutions, while others introduce chain termination codons, rendering the allele non-functional. Differences in these genes are believed to have a large effect on those individuals' sense of bitter taste, such that these individuals perceive the taste of bitter substances differently than the rest of the population. The ability to assay this allelic information is useful in the development of flavorings and flavor enhancers, as it can be used to define large groups and populations who perceive bitter tastes differently. This in turn allows the taste preferences of these groups to be addressed at the molecular level for the first time.
摘要翻译：本文所确定的是发生在不同人类中的不同形式的苦味受体基因。这些等位基因是通过发生在T2R基因家族成员内的许多编码单核苷酸多态性（cSNP）产生的。一些SNP引起氨基酸取代，而其他引入链终止密码子，使得等位基因无功能。这些基因的差异被认为对这些个体的苦味感具有很大的影响，使得这些个体感觉到与其他人群不同的苦味物质的味道。测定这种等位基因信息的能力可用于调味和风味增强剂的开发，因为它可以用于定义感染苦味的大群体和群体。这反过来允许这些群体的味道偏好在分子水平上首次得到解决。

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