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1. 发明授权

US08101189B2 Vaccines and immunopotentiating compositions and methods for making and using them 有权
标题翻译：疫苗和免疫增强组合物和制备和使用它们的方法
公开(公告)号：US08101189B2
公开(公告)日：2012-01-24
申请号：US11556678
申请日：2006-11-03
申请人： Denis Leclerc , Nathalie Majeau , Constantino III Roberto Lopez-Macias , Alain Lamarre
发明人： Denis Leclerc , Nathalie Majeau , Constantino III Roberto Lopez-Macias , Alain Lamarre
IPC分类号： A61K35/00 , C12N15/00
CPC分类号： A61K39/12 , A61K39/02 , A61K2039/5258 , A61K2039/55555 , A61K2039/6075 , C07K14/005 , C07K14/62 , C07K2319/00 , C07K2319/21 , C12N7/00 , C12N2760/10122 , C12N2770/24222 , C12N2770/26022 , C12N2770/26023
摘要： An immunopotentiating composition comprising a papaya mosaic virus (PapMV), or a virus-like particle (VLP) derived from PapMV coat protein, which is capable of functioning as an adjuvant and thus potentiating an immune response in an animal is provided. The immunopotentiating composition can further comprise an immunogen, which can be fused or otherwise linked to the VLP, or not linked to the VLP. The immunopotentiating composition is capable of potentiating a humoral and/or a cellular response in the animal and is suitable for use as an adjuvant or vaccine. Methods of potentiating an immune response in an animal comprising administering to the animal an immunopotentiating composition are also provided have application in both human and veterinary medicine.
摘要翻译：提供了包含番木瓜花叶病毒（PapMV）或衍生自PapMV外壳蛋白的病毒样颗粒（VLP）的免疫增强组合物，其能够起到佐剂的作用，从而增强动物的免疫应答。免疫增强组合物还可以包含免疫原，其可以融合或以其它方式连接到VLP，或不与VLP连接。免疫增强组合物能够增强动物体液和/或细胞应答，并且适合用作佐剂或疫苗。增强动物免疫应答的方法包括向动物施用免疫增强组合物也可应用于人和兽药。

2. 发明申请

US20100111996A1 Papaya Mosaic Virus-Based Vaccines for Influenza 审中-公开
标题翻译：木瓜花叶病毒型流感疫苗
公开(公告)号：US20100111996A1
公开(公告)日：2010-05-06
申请号：US12515265
申请日：2007-11-15
申请人： Denis Leclerc
发明人： Denis Leclerc
IPC分类号： A61K39/295 , C07K14/11 , C07H21/04 , A61P37/04 , A61P31/16
CPC分类号： A61K39/145 , A61K39/12 , A61K39/385 , A61K39/39 , A61K2039/5258 , A61K2039/55516 , A61K2039/6075 , A61K2039/64 , C07K14/005 , C07K2319/00 , C12N2760/16122 , C12N2760/16134 , C12N2770/00022 , C12N2770/00023 , C12N2770/00043
摘要： An antigen-presenting system (APS) comprising one or more antigens in combination with a papaya mosaic virus (PapMV) or a virus like particle (VLP) derived from papaya mosaic virus is provided. Specifically an APS comprising one or more influenza virus antigens is provided. The APS can be used, for example, as a vaccine against influenza. The one or more antigens comprised by the APS can be conjugated to a coat protein of the PapMV or PaPMV VLP, or they may be non-conjugated (i.e. separate from the PapMV or PapMV VLP). Conjugation can be, for example, by genetic fusion with the coat protein, or binding via covalent, non-covalent or affinity means.
摘要翻译：提供了包含与番木瓜花叶病毒（PapMV）或源自番木瓜花叶病毒的病毒样颗粒（VLP））组合的一种或多种抗原的抗原呈递系统（APS）。具体地提供了包含一种或多种流感病毒抗原的APS。 APS可以用作例如针对流感的疫苗。由APS包含的一种或多种抗原可以与PapMV或PaPMV VLP的外壳蛋白缀合，或者它们可以是非共轭的（即与PapMV或PapMV VLP分离）。缀合可以是例如通过与外壳蛋白的遗传融合，或通过共价，非共价或亲和手段结合。

3. 发明授权

US07641896B2 Adjuvant viral particle 失效
标题翻译：佐剂病毒颗粒
公开(公告)号：US07641896B2
公开(公告)日：2010-01-05
申请号：US10609417
申请日：2003-07-01
申请人： Denis Leclerc , Nathalie Majeau , Constantino III Roberto López-Macías
发明人： Denis Leclerc , Nathalie Majeau , Constantino III Roberto López-Macías
IPC分类号： A61K35/00
CPC分类号： A61K39/39 , A61K39/385 , A61K2039/525 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/64 , C07K14/005 , C07K2319/00 , C12N2770/24222 , C12N2770/26023 , Y02A50/484
摘要： The present invention relates to an immunogen-carrier having immunopotentiating or adjuvant properties. More particularly, the immunogen-carrier is a virus-like particle (VLP) from the family of potexvirus, and most particularly the papaya mosaic virus. The VLP produced by recombinant techniques is in fusion with one of its own proteins a protein immunogen. The above VLP and a protein or a protein extract from a viral, bacterial or parasital pathogen may be used as a vaccine.
摘要翻译：本发明涉及具有免疫增强或佐剂性质的免疫原载体。更具体地，免疫原载体是来自虫病毒病毒的病毒样颗粒（VLP），最特别是木瓜花叶病毒。通过重组技术产生的VLP与其自身蛋白质之一融合蛋白免疫原。上述VLP和来自病毒，细菌或寄生虫病原体的蛋白质或蛋白质提取物可以用作疫苗。

4. 发明授权

US07158725B2 Saturable light absorber structure and a device incorporating the structure for regenerating a wavelength division multiplexed signal 失效
标题翻译：可饱和光吸收体结构和结合有再生波分复用信号的结构的装置
公开(公告)号：US07158725B2
公开(公告)日：2007-01-02
申请号：US10207887
申请日：2002-07-31
申请人： Alexandre Shen , Denis Leclerc
发明人： Alexandre Shen , Denis Leclerc
IPC分类号： H04B10/16 , H04J14/02
CPC分类号： G02F1/3523 , B82Y20/00 , G02B2006/12126 , G02F1/01725 , G02F2203/15
摘要： The invention relates to a saturable light absorber adapted to receive different focused spectral components, wherein the structure of said saturable light absorber comprises microcavities integrated into a substrate and each associated with a respective one of said spectral components, each microcavity comprising a saturable absorber layer delimited by a top reflector and a bottom reflector and being disposed and having dimensions such that it receives only the focused spectral component associated with it.
摘要翻译：本发明涉及适于接收不同聚焦光谱分量的可饱和光吸收体，其中所述可饱和光吸收体的结构包括集成到衬底中的每一个与相应的所述光谱分量相关联的微腔，每个微腔包括限定的饱和吸收层通过顶部反射器和底部反射器设置并具有使其仅接收与其相关联的聚焦光谱分量的尺寸。

5. 发明申请

US20050048082A1 Adjuvant viral particle 失效
标题翻译：佐剂病毒颗粒
公开(公告)号：US20050048082A1
公开(公告)日：2005-03-03
申请号：US10609417
申请日：2003-07-01
申请人： Denis Leclerc , Nathalie Majeau , Philippe Tessier , Constantino Lopez-Macias
发明人： Denis Leclerc , Nathalie Majeau , Philippe Tessier , Constantino Lopez-Macias
IPC分类号： A61K39/00 , A61K39/385 , C07K14/08 , C07K14/18 , A61K39/12 , A61K38/16
CPC分类号： A61K39/39 , A61K39/385 , A61K2039/525 , A61K2039/5256 , A61K2039/5258 , A61K2039/6075 , A61K2039/64 , C07K14/005 , C07K2319/00 , C12N2770/24222 , C12N2770/26023 , Y02A50/484
摘要： The present invention relates to an immunogen-carrier having immunopotentiating or adjuvant properties. More particularly, the immunogen—carrier is a virus-like particle (VLP) from the family of potexvirus, and most particularly the papaya mosaic virus. The VLP produced by recombinant techniques is in fusion with one of its own proteins a protein immunogen. The above VLP and a protein or a protein extract from a viral, bacterial or parasital pathogen may be used as a vaccine.
摘要翻译：本发明涉及具有免疫增强或佐剂性质的免疫原载体。更具体地，免疫原载体是来自虫病毒病毒的病毒样颗粒（VLP），最特别是木瓜花叶病毒。通过重组技术产生的VLP与其自身蛋白质之一融合蛋白免疫原。上述VLP和来自病毒，细菌或寄生虫病原体的蛋白质或蛋白质提取物可以用作疫苗。

6. 发明授权

US6005708A Wavelength converter for binary optical signals 失效
标题翻译：用于二进制光信号的波长转换器
公开(公告)号：US6005708A
公开(公告)日：1999-12-21
申请号：US57512
申请日：1998-04-09
申请人： Denis Leclerc , Leon Goldstein , Jean-Yves Emery , Beatrice Dagens , Christopher Janz , Michael Schilling , Klaus Wunstel
发明人： Denis Leclerc , Leon Goldstein , Jean-Yves Emery , Beatrice Dagens , Christopher Janz , Michael Schilling , Klaus Wunstel
IPC分类号： G02B6/12 , G02F2/00 , G02F2/02 , H04B10/17 , G02F1/39
CPC分类号： H04B10/2914 , G02F2/004 , G02F2001/212 , G02F2001/215 , G02F2002/006
摘要： The invention relates to wavelength converters for optical signals, as used in telecommunications, in particular for routing signals. The invention relates in particular to a wavelength converter including an interferometer structure for delivering an output optical signal, in which converter first and second branches, including at least one first semiconductor optical amplifier, are coupled to input peripheral semiconductor optical amplifiers and/or to an output peripheral semiconductor optical amplifier, wherein the structure of the active waveguide of at least one peripheral amplifier is so designed that it has a ratio of active area to confinement factor greater than that of the active waveguide of said first amplifier.
摘要翻译：本发明涉及用于光通信中的光信号的波长转换器，特别是用于路由信号。本发明具体涉及包括用于传送输出光信号的干涉仪结构的波长转换器，其中包括至少一个第一半导体光放大器的转换器第一和第二分支耦合到输入外围半导体光放大器和/或输出外围半导体光放大器，其中至少一个外围放大器的有源波导的结构被设计成使得其有效面积与约束因子的比率大于所述第一放大器的有源波导的比率。

7. 发明授权

US5265111A Positive feedback device for processing an optical signal 失效
标题翻译：用于处理光信号的正反馈装置
公开(公告)号：US5265111A
公开(公告)日：1993-11-23
申请号：US841710
申请日：1992-02-26
申请人： Jose Chesnoy , Jean-Michel Gabriagues , Denis Leclerc
发明人： Jose Chesnoy , Jean-Michel Gabriagues , Denis Leclerc
IPC分类号： H04B10/04 , G02F3/02 , H01S5/06 , H01S5/062 , H01S5/068 , H04B10/06 , H04B10/14 , H01S3/10
CPC分类号： H01S5/068 , H01S5/0601 , G02F3/026 , H01S5/06223
摘要： A photodiode (26) receives an optical input signal (P1) and an internal optical signal (P2) and supplies in response thereto an internal electrical signal (I2), which in turn controls a laser (4) which effects amplification and supplies the internal optical signal and an output signal (P3). The feedback loop formed by this photodiode and laser leads to a strong non-linearity in the variation of the output signal as a function of the input signal. The invention is useful especially in optical fiber telecommunications systems.
摘要翻译：光电二极管（26）接收光输入信号（P1）和内部光信号（P2），并响应于内部电信号（I2）供应光电输入信号（I2），内部电信号（I2）进而控制实现放大的内部激光器（4）光信号和输出信号（P3）。由该光电二极管和激光器形成的反馈环路作为输入信号的函数导致输出信号变化的强非线性。本发明特别适用于光纤通信系统。

8. 发明授权

US08117253B2 Condition control system, device and process for message transmission 有权
标题翻译：条件控制系统，消息传输的设备和过程
公开(公告)号：US08117253B2
公开(公告)日：2012-02-14
申请号：US11574977
申请日：2007-03-02
申请人： Julien Robinson , Mathieu Boussard , Denis Leclerc , Fabien Bataille , Abdelkrim Hebbar , Bruno Mongazon-Cazavet
发明人： Julien Robinson , Mathieu Boussard , Denis Leclerc , Fabien Bataille , Abdelkrim Hebbar , Bruno Mongazon-Cazavet
IPC分类号： G06F15/16 , H04W4/00 , H04Q9/00 , G06Q10/00
CPC分类号： G06Q50/22 , H04L51/14 , H04W4/12
摘要： The invention concerns in particular a system comprising: a first terminal (1); a second terminal (21 or 22 or 23); at least a first messaging system (31 or 32 or 33) able to transmit, to the second terminal, at least the message body of a message (10) from the first terminal; at least one device (4) controlling at least one condition (11), at least once, the said control device allowing the first messaging system to transmit to the second terminal at least the message body of the said message if the condition control result is positive, the said control device preventing the first messaging system from transmitting to the second terminal at least the message body of the said message if the condition control is negative, at least during the time for which the condition control result remains negative; at least one data server (51 or 52 or 53 or 54) external to the control device; at least one link providing communication through the Internet between on the hand the external server, or at least one of the external servers, and on the other hand the control device, the condition control device being designed to: store a message sent by the first terminal; receive at least one item of information from at least one external server; at least partially perform the condition control relating to the said message stored by means of the information received from the external server.
摘要翻译：本发明尤其涉及一种系统，包括：第一终端（1）; 第二终端（21或22或23）; 至少第一消息系统（31或32或33）能够从所述第一终端向所述第二终端至少传送消息（10）的消息主体; 至少一个设备（4）控制至少一个条件（11）至少一次所述控制设备，允许所述第一消息系统至少将所述消息的消息体发送到所述第二终端，如果所述条件控制结果是肯定的是，至少在条件控制结果保持为负的时间内，如果条件控制是否定的，则所述控制设备防止第一消息传送系统至少向所述消息的消息体发送至第二终端; 在所述控制设备外部的至少一个数据服务器（51或52或53或54）; 至少一个链路，通过互联网提供在外部服务器或外部服务器之间的至少一个上的通信，另一方面，控制设备，条件控制设备被设计为：存储由第一终奌站; 从至少一个外部服务器接收至少一个信息项; 至少部分地通过从外部服务器接收的信息来执行与所述消息有关的条件控制。

9. 发明申请

US20110189231A1 Compositions Comprising Salmonella Porins and Uses Thereof as Adjuvants and Vaccines 审中-公开
标题翻译：组成包括沙门氏菌和其用途作为佐剂和疫苗
公开(公告)号：US20110189231A1
公开(公告)日：2011-08-04
申请号：US12999989
申请日：2009-06-17
申请人： Denis Leclerc , Constantino Roberto Lopez-Macias, III
发明人： Denis Leclerc , Constantino Roberto Lopez-Macias, III
IPC分类号： A61K39/145 , A61K39/39 , A61P37/04 , A61P31/16
CPC分类号： A61K39/39 , A61K39/0275 , A61K39/04 , A61K39/12 , A61K39/145 , A61K2039/5252 , A61K2039/55516 , A61K2039/58 , A61K2039/70 , C12N2760/16134 , C12N2760/16234 , Y02A50/482 , Y02A50/484
摘要： Adjuvants comprising OmpC porin, OmpF porin, or a combination thereof, are provided. The adjuvants can be administered to a subject in combination with antigenic material in order to potentiate the immunogenic effect of the antigenic material. Also provided are products comprising antigenic material in combination with OmpC and/or OmpF, including products comprising a pre-formulated vaccine in combination with OmpC and/or OmpF. Further provided is the use of OmpC and/or OmpF to improve the effect of a pre-formulated vaccine.
摘要翻译：提供了包含OmpC孔蛋白，OmpF孔蛋白或其组合的佐剂。佐剂可以与抗原物质组合施用于受试者，以增强抗原物质的免疫原性作用。还提供了包含与OmpC和/或OmpF组合的抗原物质的产品，包括与OmpC和/或OmpF组合的预配制疫苗的产品。还提供了使用OmpC和/或OmpF来改善预配制疫苗的效果。

10. 发明授权

US6040246A Method of manufacturing an integrated optical component comprising a thick waveguide coupled to a thin waveguide 有权
标题翻译：制造集成光学部件的方法，其包括耦合到薄波导的厚波导
公开(公告)号：US6040246A
公开(公告)日：2000-03-21
申请号：US148480
申请日：1998-09-08
申请人： Leon Goldstein , Denis Leclerc , Beatrice Dagens
发明人： Leon Goldstein , Denis Leclerc , Beatrice Dagens
IPC分类号： G02B6/12 , G02B6/122 , G02B6/26 , H01S5/026 , H01L21/02 , G02B6/13 , G02B6/136 , H01L21/20 , H01L21/3065
CPC分类号： G02B6/26 , G02B6/12004 , G02B6/1228 , H01S5/026
摘要： To form an integrated optical component comprising a thick waveguide coupled to a thin waveguide, the method consists in:depositing a first guiding layer of said thick waveguide on a substrate;locally etching said first guiding layer over a portion allocated both to a coupling interface and to the thin waveguide;depositing a second guiding layer on the first guiding layer and on the locally etched portion so as to form said thick waveguide in a manner such that it has a maximum thickness in a first zone, a graded-thickness section in a second zone, and a reduced-thickness section in a third zone;locally etching the second guiding layer over a portion of the third zone, said portion being allocated to the thin waveguide; anddepositing a third guiding layer in said portion of said third zone so as to form said thin waveguide.
摘要翻译：为了形成包括耦合到薄波导的厚波导的集成光学部件，该方法包括：在衬底上沉积所述厚波导的第一引导层; 在分配给耦合接口和薄波导的部分上局部蚀刻所述第一引导层; 在第一引导层和局部蚀刻部分上沉积第二引导层，以便形成所述厚波导，使得其在第一区域具有最大厚度，在第二区域中具有最大厚度，在第二区域中具有渐变厚度部分，第三区的厚度减薄部分; 在第三区域的一部分上局部蚀刻第二引导层，所述部分被分配给薄波导; 以及在所述第三区的所述部分中沉积第三引导层以形成所述薄波导。

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