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1. 发明申请

US20050209168A1 Isolation of tigogenin pentaglycoside from chlorophytum nimonii 失效
标题翻译：从枸杞子中分离出tigogenin五糖苷
公开(公告)号：US20050209168A1
公开(公告)日：2005-09-22
申请号：US10806065
申请日：2004-03-22
申请人： Lakshmi Vijay , Kartikay Pandey , Raja Roy , Bhawani Joshi , Padmanabhan Kunnath , Ramesh Chandra , Arvind Srivastava , Deepak Raina , Anil Rastogi
发明人： Lakshmi Vijay , Kartikay Pandey , Raja Roy , Bhawani Joshi , Padmanabhan Kunnath , Ramesh Chandra , Arvind Srivastava , Deepak Raina , Anil Rastogi
IPC分类号： A61K31/704 , C07J17/00
CPC分类号： C07J17/00
摘要： The present invention provides a novel saponin tigogenin penta glycoside isolated from the aerial parts of Chlorophytum nimonii and a process for the isolation thereof as well as its use in anti-hyperglycemic and hypolipidemic activities.
摘要翻译：本发明提供了一种从Chlorophytum nimonii的地上部分分离的新型皂苷tigogenin penta糖苷及其分离方法及其在抗高血糖和降血脂活性中的应用。

2. 发明授权

US07959954B2 Pharmaceutical composition for treatment of diabetes and dyslipidemia 有权
标题翻译：用于治疗糖尿病和血脂异常的药物组合物
公开(公告)号：US07959954B2
公开(公告)日：2011-06-14
申请号：US11519327
申请日：2006-09-11
申请人： Vijai Lakshmi , Ajet Saxena , Rajesh Kumar , Raghwendra Pal , Satyawan Singh , Arvind Kumar Srivastava , Preeti Tiwari , Deepak Raina , Anil Kumar Rastogi , Mahendra Nath Srivastava , Ramesh Chandra , Anju Puri , Ram Raghubir , Poonam Gupta , Narender Tadigoppula , Brijendra Kumar Tripathi , Sudhir Srivastava
发明人： Vijai Lakshmi , Ajet Saxena , Rajesh Kumar , Raghwendra Pal , Satyawan Singh , Arvind Kumar Srivastava , Preeti Tiwari , Deepak Raina , Anil Kumar Rastogi , Mahendra Nath Srivastava , Ramesh Chandra , Anju Puri , Ram Raghubir , Poonam Gupta , Narender Tadigoppula , Brijendra Kumar Tripathi , Sudhir Srivastava
IPC分类号： A61K36/00 , A61K38/00
CPC分类号： A61K36/58 , C07D493/18
摘要： A bioactive fraction obtained from Xylocarpus that is useful for the treatment of diabetes and dyslipidemia. This fraction can be provided in a pharmaceutical composition that is useful as antidiabetic and antidyslipidemic agent, or can be used in a method of treating diabetes and dyslipidemia in a subject. Also, a process for the preparation of bioactive fraction from Xylocarpus. Isomeric xyloccensins and the preparation of such compounds. Also, pharmaceutical compositions comprising a therapeutically effective amount of such isomeric xyloccensins optionally along with one or more pharmaceutically acceptable carriers, additives, lubricant and diluents and the use of such pharmaceutical compositions in a method for treating dyslipidemia.
摘要翻译：从Xylocarpus得到的可用于治疗糖尿病和血脂异常的生物活性成分。该级分可以提供在可用作抗糖尿病和抗脂肪代谢剂的药物组合物中，或可用于治疗受试者的糖尿病和血脂异常的方法。另外，从Xylocarpus制备生物活性成分的方法。异构体的含氯木酚和这些化合物的制备。此外，药物组合物包含治疗有效量的这种异构的木糖蛋白，任选地与一种或多种药学上可接受的载体，添加剂，润滑剂和稀释剂一起使用，以及这些药物组合物在治疗血脂异常的方法中的用途。

3. 发明申请

US20060181829A1 APPARATUS AND METHOD FOR FILTERING CURRENT SENSOR OUTPUT SIGNALS 有权
标题翻译：用于过滤电流传感器输出信号的装置和方法
公开(公告)号：US20060181829A1
公开(公告)日：2006-08-17
申请号：US10906363
申请日：2005-02-16
申请人： Venkat Nadipuram , Deepak Raina
发明人： Venkat Nadipuram , Deepak Raina
IPC分类号： H02H3/08
CPC分类号： H02H1/0007 , H02H3/006 , H02H3/0935
摘要： An electronic filter for filtering the output signal of a current sensor of a circuit breaker is disclosed. The current sensor has an output signal characteristic similar to that of a Rogowski coil output signal characteristic that includes a third harmonic noise component in response to a switching primary current of the circuit breaker, and the circuit breaker has an electronic trip unit with an instantaneous pick-up setting responsive to the output signal of the current sensor. The electronic filter includes a first stage and a second stage. The first stage has a first transfer function that defines first characteristic poles and permits passage of the third harmonic noise component. The second stage has a second transfer function that defines second characteristic poles and filters the third harmonic noise component.
摘要翻译：公开了一种用于对断路器的电流传感器的输出信号进行滤波的电子滤波器。电流传感器具有类似于罗氏线圈输出信号特性的输出信号特征，该特性包括响应于断路器的开关初级电流的三次谐波噪声分量，并且断路器具有具有瞬时拾取的电子跳闸单元 - 响应于电流传感器的输出信号的设置。电子滤波器包括第一级和第二级。第一级具有第一传递函数，其定义第一特征极并允许三次谐波噪声分量的通过。第二级具有第二传递函数，其定义第二特征极并对三次谐波噪声分量进行滤波。

4. 发明授权

US06579862B1 Method of treating hyperlipidemic and hyperglycemic conditions in mammals using pregnadienols and pregnadienones 有权
标题翻译：使用孕二烯醇和孕代孕酮治疗哺乳动物高脂血症和高血糖病症的方法
公开(公告)号：US06579862B1
公开(公告)日：2003-06-17
申请号：US09280448
申请日：1999-03-30
申请人： Ram Pratap , Ram Chandra Gupta , Ramesh Chander , Ashok Kumar Khanna , Arvind Kumar Srivastava , Deepak Raina , Satyavan Singh , Savita Srivastava , Anil Kumar Rastogi , Omkar Prasad Asthana , Swarn Nityanand , Nitya Anand , Ashim Ghatak , Narinder Kumar Kapoor , Sukh Dev
发明人： Ram Pratap , Ram Chandra Gupta , Ramesh Chander , Ashok Kumar Khanna , Arvind Kumar Srivastava , Deepak Raina , Satyavan Singh , Savita Srivastava , Anil Kumar Rastogi , Omkar Prasad Asthana , Swarn Nityanand , Nitya Anand , Ashim Ghatak , Narinder Kumar Kapoor , Sukh Dev
IPC分类号： A61K3158
CPC分类号： A61K31/573 , C07J13/005 , C07J13/007
摘要： The invention provides a method of using pregnadienones and pregnadienols represented by the structural formula (I): containing at least one olefinic bond in or on their D-ring for the treatment of hyperlipidemic and hyperglycemic conditions in mammals wherein X═OH or O and the olefinic bonds are at 4(5); 5(6); 16(17); or 17(20) or various combinations, and wherein the compounds contain at lest one olefinic bond in or on their D-ring. The method comprises administering an effective amount of said compounds to recipient mammals.
摘要翻译：本发明提供了一种使用由结构式（I）表示的孕ad酮和孕二烯醇的方法：在D环中或其D环上含有至少一个烯键，用于治疗哺乳动物中的高脂血症和高血糖病症，其中X = OH或O，烯键为4（5）; 5（6）; 16（17）; 或17（20）或各种组合，并且其中所述化合物在其D环中或其上含有至少一个烯键。该方法包括向受体哺乳动物施用有效量的所述化合物。

5. 发明授权

US07304829B2 Apparatus and method for filtering current sensor output signals 有权
标题翻译：滤波电流传感器输出信号的装置和方法
公开(公告)号：US07304829B2
公开(公告)日：2007-12-04
申请号：US10906363
申请日：2005-02-16
申请人： Venkat Nadipuram , Deepak Raina
发明人： Venkat Nadipuram , Deepak Raina
IPC分类号： H02H3/08
CPC分类号： H02H1/0007 , H02H3/006 , H02H3/0935
摘要： An electronic filter for filtering the output signal of a current sensor of a circuit breaker is disclosed. The current sensor has an output signal characteristic similar to that of a Rogowski coil output signal characteristic that includes a third harmonic noise component in response to a switching primary current of the circuit breaker, and the circuit breaker has an electronic trip unit with an instantaneous pick-up setting responsive to the output signal of the current sensor. The electronic filter includes a first stage and a second stage. The first stage has a first transfer function that defines first characteristic poles and permits passage of the third harmonic noise component. The second stage has a second transfer function that defines second characteristic poles and filters the third harmonic noise component.
摘要翻译：公开了一种用于对断路器的电流传感器的输出信号进行滤波的电子滤波器。电流传感器具有类似于罗氏线圈输出信号特性的输出信号特征，该特性包括响应于断路器的开关初级电流的三次谐波噪声分量，并且断路器具有具有瞬时拾取的电子跳闸单元 - 响应于电流传感器的输出信号的设置。电子滤波器包括第一级和第二级。第一级具有第一传递函数，其定义第一特征极并允许三次谐波噪声分量的通过。第二级具有第二传递函数，其定义第二特征极并对三次谐波噪声分量进行滤波。

6. 发明授权

US07160866B2 Isolation of tigogenin pentaglycoside from Chlorophytum nimonii 失效
标题翻译：从Chlorophytum nimonii中分离tigogenin五糖苷
公开(公告)号：US07160866B2
公开(公告)日：2007-01-09
申请号：US10806065
申请日：2004-03-22
申请人： Lakshmi Vijay , Kartikay Pandey , Raja Roy , Bhawani Shankar Joshi , Padmanabhan Madhusudanan Kunnath , Ramesh Chandra , Arvind Kumar Srivastava , Deepak Raina , Anil Kumar Rastogi
发明人： Lakshmi Vijay , Kartikay Pandey , Raja Roy , Bhawani Shankar Joshi , Padmanabhan Madhusudanan Kunnath , Ramesh Chandra , Arvind Kumar Srivastava , Deepak Raina , Anil Kumar Rastogi
IPC分类号： A61K31/70 , C07H1/06 , C07J41/00
CPC分类号： C07J17/00
摘要： The present invention provides a novel saponin tigogenin penta glycoside isolated from the aerial parts of Chlorophytum nimonii and a process for the isolation thereof as well as its use in anti-hyperglycemic and hypolipidemic activities.
摘要翻译：本发明提供了一种从Chlorophytum nimonii的地上部分分离的新型皂苷tigogenin penta糖苷及其分离方法及其在抗高血糖和降血脂活性中的应用。

7. 发明申请

US20070178179A1 Pharmaceutical composition for treatment of diabetes and dyslipidemia 有权
标题翻译：用于治疗糖尿病和血脂异常的药物组合物
公开(公告)号：US20070178179A1
公开(公告)日：2007-08-02
申请号：US11519327
申请日：2006-09-11
申请人： Vijai Lakshmi , Ajet Saxena , Rajesh Kumar , Raghwendra Pal , Satyawan Singh , Arvind Srivastava , Preeti Tiwari , Deepak Raina , Anil Rastogi , Mahendra Srivastava , Ramesh Chandra , Anju Puri , Ram Raghubir , Poonam Gupta , Narender Tadigoppula , Brijendra Tripathi , Sudhir Srivastava
发明人： Vijai Lakshmi , Ajet Saxena , Rajesh Kumar , Raghwendra Pal , Satyawan Singh , Arvind Srivastava , Preeti Tiwari , Deepak Raina , Anil Rastogi , Mahendra Srivastava , Ramesh Chandra , Anju Puri , Ram Raghubir , Poonam Gupta , Narender Tadigoppula , Brijendra Tripathi , Sudhir Srivastava
IPC分类号： A61K36/185
CPC分类号： A61K36/58 , C07D493/18
摘要： A bioactive fraction obtained from Xylocarpus that is useful for the treatment of diabetes and dyslipidemia. This fraction can be provided in a pharmaceutical composition that is useful as antidiabetic and antidyslipidemic agent, or can be used in a method of treating diabetes and dyslipidemia in a subject. Also, a process for the preparation of bioactive fraction from Xylocarpus. Novel isomeric xyloccensins and the preparation of such compounds. Also, pharmaceutical compositions comprising a therapeutically effective amount of such novel isomeric xyloccensins optionally along with one or more pharmaceutically acceptable carriers, additives, lubricant and diluents and the use of such pharmaceutical compositions in a method for treating dyslipidemia.
摘要翻译：从Xylocarpus得到的可用于治疗糖尿病和血脂异常的生物活性成分。该级分可以提供在可用作抗糖尿病和抗脂肪代谢剂的药物组合物中，或可用于治疗受试者的糖尿病和血脂异常的方法。另外，从Xylocarpus制备生物活性成分的方法。新型异构体的木糖蛋白和这些化合物的制备。此外，药物组合物包含治疗有效量的这种新型异构的木糖蛋白，任选地与一种或多种药学上可接受的载体，添加剂，润滑剂和稀释剂一起使用，以及这些药物组合物在治疗血脂异常的方法中的用途。

8. 发明授权

US06875758B2 Method of treating hyperlipidemic and hyperglycemic conditions in mammals using pregnadienols and pregnadienones 有权
标题翻译：使用孕二烯醇和孕代孕酮治疗哺乳动物高脂血症和高血糖病症的方法
公开(公告)号：US06875758B2
公开(公告)日：2005-04-05
申请号：US10385936
申请日：2003-03-14
申请人： Ram Pratap , Ram Chandra Gupta , Ramesh Chander , Ashok Kumar Khanna , Arvind Kumar Srivastava , Deepak Raina , Satyavan Singh , Savita Srivastava , Anil Kumar Rastogi , Omkar Prasad Asthana , Swarn Nityanand , Nitya Anand , Ashim Ghatak , Narinder Kumar Kapoor , Sukh Dev
发明人： Ram Pratap , Ram Chandra Gupta , Ramesh Chander , Ashok Kumar Khanna , Arvind Kumar Srivastava , Deepak Raina , Satyavan Singh , Savita Srivastava , Anil Kumar Rastogi , Omkar Prasad Asthana , Swarn Nityanand , Nitya Anand , Ashim Ghatak , Narinder Kumar Kapoor , Sukh Dev
IPC分类号： C07J13/00 , A61K31/56 , A61K31/59
CPC分类号： A61K31/573 , C07J13/005 , C07J13/007
摘要： The invention provides a method of using pregnadienones and pregnadienols represented by the structural formula (I) as shown herein below Wherein X═OH or O or combination thereof and positioning of olefinic bonds are at 4(5); 5(6); 16(17); 17(20) or various combinations and said compounds containing at least one olefinic bond in or on their D-ring for the treatment of hyperlipidemic and hyperglycemic conditions in mammals, said method comprising administering an effective amount of the said compounds to the recipient mammals.
摘要翻译：本发明提供了一种使用由下式结构式（I）表示的孕ad酮和孕二烯醇的方法，其中X = OH或O或其组合，烯键的定位为4（5）; 5（6）; 16（17）; 17（20）或各种组合，并且所述化合物在其D环上或其D环上含有至少一个烯键，用于治疗哺乳动物中的高脂血症和高血糖病症，所述方法包括向受体哺乳动物施用有效量的所述化合物。

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