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1. 发明授权

US08449466B2 System and method for locating medical devices in vivo using ultrasound Doppler mode 有权
标题翻译：使用超声多普勒模式在体内定位医疗器械的系统和方法
公开(公告)号：US08449466B2
公开(公告)日：2013-05-28
申请号：US12789156
申请日：2010-05-27
申请人： Francis G. Duhay , David Zollinger
发明人： Francis G. Duhay , David Zollinger
IPC分类号： A61B8/00
CPC分类号： A61B8/0841 , A61B8/0883 , A61B8/483 , A61B8/488
摘要： A system for locating a medical device in vivo includes an ultrasound scanner having a scan head and being capable of operating in a 3D Doppler mode, a medical device having a distal end configured to be inserted in vivo, and a vibratory element coupled to the medical device to induce vibrations in the first distal end. When the scan head is positioned over the distal end inserted in vivo to obtain scan data of the tissue volume, the ultrasound scanner is configured to generate 3D Doppler data in the form of a plurality of slices from the scan data and to identify a location of the distal end within the slices based upon localized data within one of the slices meeting predetermined criteria.
摘要翻译：用于在体内定位医疗装置的系统包括具有扫描头并且能够以3D多普勒模式操作的超声波扫描器，具有被配置为在体内插入的远端的医疗装置和耦合到医疗的振动元件在第一远端引起振动的装置。当扫描头位于插入体内的远端上以获得组织体积的扫描数据时，超声扫描器被配置为从扫描数据生成多个切片形式的3D多普勒数据，并且识别基于片段中的一个片段内的局部化数据满足预定标准的切片内的远端。

2. 发明申请

US20110182942A1 MENINGOCOCCAL MULTIVALENT NATIVE OUTER MEMBRANE VESICLE VACCINE, METHODS OF MAKING AND USE THEREOF 有权
标题翻译：肉毒杆菌多功能外膜外膜疫苗，其制备方法及用途
公开(公告)号：US20110182942A1
公开(公告)日：2011-07-28
申请号：US12995268
申请日：2009-06-01
申请人： Wendell David Zollinger
发明人： Wendell David Zollinger
IPC分类号： A61K39/095 , C12N1/21 , C12N15/74 , A61P31/04 , A61P37/04
CPC分类号： A61K39/095 , A61K2039/522 , A61K2039/55505 , A61K2039/55561 , A61K2039/55572 , C12N1/36
摘要： The present technology provides vaccine compositions comprising native outer membrane vesicles (NOMVs) from at least one genetically modified strain of Neisseria which provides protective immunity to meningococcal disease, more preferably subtype B meningococcal disease. The present technology further provides methods of immunizing an animal or human against meningococcal disease comprising administering the vaccine composition of the present invention.
摘要翻译：本技术提供疫苗组合物，其包含来自至少一种遗传修饰的奈瑟氏球菌菌株的天然外膜囊泡（NOMV），其提供对脑膜炎球菌疾病的保护性免疫，更优选亚型B脑膜炎球菌病。本技术还提供免疫动物或人类免疫脑膜炎球菌疾病的方法，包括给予本发明的疫苗组合物。

3. 发明授权

US06199385B1 Polarized gas accumulators and heating jackets and associated gas collection and thaw methods and polarized gas products 有权
标题翻译：极化气体储存器和加热夹套及相关的气体收集和解冻方法和极化气体产品
公开(公告)号：US06199385B1
公开(公告)日：2001-03-13
申请号：US09210020
申请日：1998-12-11
申请人： Bastiaan Driehuys , David Zollinger , Daniel Deaton , K. C. Hasson , Alan Langhorn
发明人： Bastiaan Driehuys , David Zollinger , Daniel Deaton , K. C. Hasson , Alan Langhorn
IPC分类号： F25B1900
CPC分类号： G02F1/133723 , A61K49/1815 , B01J19/26 , B01J2219/00099 , F17C2221/07 , F25J3/0685 , F25J2205/20 , F25J2210/42 , F25J2215/36 , F25J2270/904 , G01R33/282 , Y10S62/919 , Y10S62/925
摘要： Methods of collecting, thawing, and extending the useful polarized life of frozen polarized gases include heating a portion of the flow path and/or directly liquefying the frozen gas during thawing. A polarized noble gas product with an extended polarized life product is also included. Associated apparatus such as an accumulator and heating jacket for collecting, storing, and transporting polarized noble gases include a secondary flow channel which provides heat to a portion of the collection path during accumulation and during thawing.
摘要翻译：收集，解冻和延长冷冻极化气体的有用极化寿命的方法包括在解冻期间加热流路的一部分和/或直接液化冷冻气体。还包括具有延长的极化寿命产品的极化惰性气体产品。用于收集，储存和运输极化惰性气体的诸如蓄能器和加热套的相关装置包括二次流动通道，其在积聚期间和在融化期间向收集路径的一部分提供热量。

4. 发明授权

US6079213A Methods of collecting, thawing, and extending the useful life of polarized gases and associated accumulators and heating jackets 失效
标题翻译：收集，解冻和延长极化气体和相关蓄热器和加热夹套的使用寿命的方法
公开(公告)号：US6079213A
公开(公告)日：2000-06-27
申请号：US989604
申请日：1997-12-12
申请人： Bastiaan Driehuys , David Zollinger , Daniel Deaton , K. C. Hasson
发明人： Bastiaan Driehuys , David Zollinger , Daniel Deaton , K. C. Hasson
IPC分类号： A61K49/18 , F17C13/00 , F25J1/00 , F25J3/06 , G01R33/28 , F25B21/00
CPC分类号： G01R33/282 , A61K49/1815 , F25J1/0276 , F25J3/06 , F25J3/0685 , F25J2215/36 , Y10S62/919
摘要： Methods of collecting, thawing, and extending the useful polarized life of frozen polarized gases include heating a portion of the flow path and/or directly liquefying the frozen gas during thawing. A polarized noble gas product with an extended polarized life product is also included. Associated apparatus such as an accumulator and heating jacket for collecting, storing, and transporting polarized noble gases include a secondary flow channel which provides heat to a portion of the collection path during accumulation and during thawing.
摘要翻译：收集，解冻和延长冷冻极化气体的有用极化寿命的方法包括在解冻期间加热流路的一部分和/或直接液化冷冻气体。还包括具有延长的极化寿命产品的极化惰性气体产品。用于收集，储存和运输极化惰性气体的诸如蓄能器和加热套的相关装置包括二次流动通道，其在积聚期间和在融化期间向收集路径的一部分提供热量。

5. 发明申请

US20100305432A1 System and Method for Locating Medical Devices in Vivo Using Ultrasound Doppler Mode 有权
标题翻译：使用超声多普勒模式定位医疗器械体内系统和方法
公开(公告)号：US20100305432A1
公开(公告)日：2010-12-02
申请号：US12789156
申请日：2010-05-27
申请人： Francis G. Duhay , David Zollinger
发明人： Francis G. Duhay , David Zollinger
IPC分类号： A61B8/00
CPC分类号： A61B8/0841 , A61B8/0883 , A61B8/483 , A61B8/488
摘要： A system for locating a medical device in vivo includes an ultrasound scanner having a scan head and being capable of operating in a 3D Doppler mode, a medical device having a distal end configured to be inserted in vivo, and a vibratory element coupled to the medical device to induce vibrations in the first distal end. When the scan head is positioned over the distal end inserted in vivo to obtain scan data of the tissue volume, the ultrasound scanner is configured to generate 3D Doppler data in the form of a plurality of slices from the scan data and to identify a location of the distal end within the slices based upon localized data within one of the slices meeting predetermined criteria.
摘要翻译：用于在体内定位医疗装置的系统包括具有扫描头并且能够以3D多普勒模式操作的超声波扫描器，具有被配置为在体内插入的远端的医疗装置和耦合到医疗的振动元件在第一远端引起振动的装置。当扫描头位于插入体内的远端上以获得组织体积的扫描数据时，超声扫描器被配置为从扫描数据生成多个切片形式的3D多普勒数据，并且识别基于片段中的一个片段内的局部化数据满足预定标准的切片内的远端。

6. 发明授权

US06305190B1 Polarized gas accumulators and heating jackets and associated gas collection methods and thaw methods and polarized gas products 失效
标题翻译：极化气体储存器和加热夹套及相关的气体收集方法和解冻方法和极化气体产品
公开(公告)号：US06305190B1
公开(公告)日：2001-10-23
申请号：US09712374
申请日：2000-11-14
申请人： Bastiaan Driehuys , David Zollinger , Daniel Deaton , K. C. Hasson , Alan Langhorn
发明人： Bastiaan Driehuys , David Zollinger , Daniel Deaton , K. C. Hasson , Alan Langhorn
IPC分类号： F25J100
CPC分类号： G02F1/133723 , A61K49/1815 , B01J19/26 , B01J2219/00099 , F17C2221/07 , F25J3/0685 , F25J2205/20 , F25J2210/42 , F25J2215/36 , F25J2270/904 , G01R33/282 , Y10S62/919 , Y10S62/925
摘要： Methods of collecting, thawing, and extending the useful polarized life of frozen polarized gases include heating a portion of the flow path and/or directly liquefying the frozen gas during thawing. A polarized noble gas product with an extended polarized life product is also included. Associated apparatus such as an accumulator and heating jacket for collecting, storing, and transporting polarized noble gases include a secondary flow channel which provides heat to a portion of the collection path during accumulation and during thawing.
摘要翻译：收集，解冻和延长冷冻极化气体的有用极化寿命的方法包括在解冻期间加热流路的一部分和/或直接液化冷冻气体。还包括具有延长的极化寿命产品的极化惰性气体产品。用于收集，储存和运输极化惰性气体的诸如蓄能器和加热套的相关装置包括二次流动通道，其在积聚期间和在融化期间向收集路径的一部分提供热量。

7. 发明授权

US09387239B2 Meningococcal multivalent native outer membrane vesicle vaccine, methods of making and use thereof 有权
标题翻译：脑膜炎球菌多价天然外膜囊泡疫苗，其制备和使用方法
公开(公告)号：US09387239B2
公开(公告)日：2016-07-12
申请号：US12995268
申请日：2009-06-01
申请人： Wendell David Zollinger , Mikhail Donets , Deborah Schmiel , Boris Ionin , Ryan Marques , Elizabeth Ellen Moran
发明人： Wendell David Zollinger , Mikhail Donets , Deborah Schmiel , Boris Ionin , Ryan Marques , Elizabeth Ellen Moran
IPC分类号： A61K39/095 , A61K39/00 , C12N1/36
CPC分类号： A61K39/095 , A61K2039/522 , A61K2039/55505 , A61K2039/55561 , A61K2039/55572 , C12N1/36
摘要： The present technology provides vaccine compositions comprising native outer membrane vesicles (NOMVs) from at least one genetically modified strain of Neisseria which provides protective immunity to meningococcal disease, more preferably subtype B meningococcal disease. The present technology further provides methods of immunizing an animal or human against meningococcal disease comprising administering the vaccine composition of the present invention.
摘要翻译：本技术提供疫苗组合物，其包含来自至少一种遗传修饰的奈瑟氏球菌菌株的天然外膜囊泡（NOMV），其提供对脑膜炎球菌疾病的保护性免疫，更优选亚型B脑膜炎球菌病。本技术还提供免疫动物或人类免疫脑膜炎球菌疾病的方法，包括给予本发明的疫苗组合物。

8. 发明授权

US07373782B2 Polarized gas accumulators and heating jackets and associated gas collection and thaw methods and polarized gas products 有权
标题翻译：极化气体储存器和加热夹套及相关的气体收集和解冻方法和极化气体产品
公开(公告)号：US07373782B2
公开(公告)日：2008-05-20
申请号：US10764834
申请日：2004-01-26
申请人： Bastiaan Driehuys , David Zollinger , Daniel Deaton , Kenton C. Hasson , Alan Langhorn
发明人： Bastiaan Driehuys , David Zollinger , Daniel Deaton , Kenton C. Hasson , Alan Langhorn
IPC分类号： F17C7/04 , A61B5/055
CPC分类号： G02F1/133723 , A61K49/1815 , B01J19/26 , B01J2219/00099 , F17C2221/07 , F25J3/0685 , F25J2205/20 , F25J2210/42 , F25J2215/36 , F25J2270/904 , G01R33/282 , Y10S62/919 , Y10S62/925
摘要： Methods of collecting, thawing, and extending the useful polarized life of frozen polarized gases include heating a portion of the flow path and/or directly liquefying the frozen gas during thawing. A polarized noble gas product with an extended polarized life product is also included. Associated apparatus such as an accumulator and heating jacket for collecting, storing, and transporting polarized noble gases include a secondary flow channel which provides heat to a portion of the collection path during accumulation and during thawing.
摘要翻译：收集，解冻和延长冷冻极化气体的有用极化寿命的方法包括在解冻期间加热流路的一部分和/或直接液化冷冻气体。还包括具有延长的极化寿命产品的极化惰性气体产品。用于收集，储存和运输极化惰性气体的诸如蓄能器和加热套的相关装置包括二次流动通道，其在积聚期间和在融化期间向收集路径的一部分提供热量。

9. 发明授权

US6128918A Containers for hyperpolarized gases and associated methods 失效
标题翻译：超极化气体容器及相关方法
公开(公告)号：US6128918A
公开(公告)日：2000-10-10
申请号：US126448
申请日：1998-07-30
申请人： Daniel M. Deaton , Patrick A. Cella , Kenton C. Hasson , David Zollinger , Bastiaan Driehuys
发明人： Daniel M. Deaton , Patrick A. Cella , Kenton C. Hasson , David Zollinger , Bastiaan Driehuys
IPC分类号： A61K49/18 , F17C1/00 , F17C1/16 , F25J1/00
CPC分类号： F17C1/16 , A61K49/1815 , F17C1/00 , F17C2201/018 , F17C2201/058 , F17C2203/0607 , F17C2203/0619 , F17C2203/0621 , F17C2203/0624 , F17C2203/0636 , F17C2203/0646 , F17C2203/066 , F17C2205/0323 , F17C2205/0382 , F17C2205/0394 , F17C2221/014 , F17C2221/017 , F17C2221/07 , F17C2223/0123 , F17C2223/0153 , F17C2223/033 , F17C2225/0123 , F17C2225/033 , F17C2227/0142 , F17C2227/044 , F17C2250/0473 , F17C2260/035 , F17C2270/02 , F17C2270/079 , G01R33/26 , Y10S62/919
摘要： A resilient container configured to receive a quantity of hyperpolarized noble gas includes a wall with at least two layers, a first layer with a surface which minimizes spin-relaxation and a first or second layer which is substantially impermeable to oxygen. The container is especially suitable for collecting and transporting .sup.3 He. The resilient container can be configured to directly deliver the hyperpolarized noble gas to a target interface by deflating or collapsing the inflated resilient container. Related collection and transporting methods include forming the wall of the container and collecting the hyperpolarized gas in a way which minimizes its exposure to de-polarizing impurities. Also, a container includes a quantity of polarized gas and extends the T.sub.1 life by configuring the wall of the container with a controlled thickness of the surface coating and overlays the interior with an exterior which is substantially impermeable to oxygen. In addition, an O-ring and seal is configured to minimize the depolarizing effect of the collection device. Also disclosed is a method for determining the gas solubility in an unknown polymer or liquid using the measured relaxation time of a hyperpolarized gas.
摘要翻译：构造成接收一定数量的超极化惰性气体的弹性容器包括具有至少两层的壁，具有使自旋松弛最小化的表面的第一层和基本上不透氧的第一或第二层。该容器特别适用于收集和运输3He。弹性容器可以构造成通过使膨胀的弹性容器膨胀或折叠来将超极化惰性气体直接传递到目标界面。相关的收集和运输方法包括形成容器的壁并且以使其暴露于去偏振杂质最小化的方式收集超极化气体。此外，容器包括一定数量的极化气体，并且通过以受控的表面涂层的厚度构造容器的壁并延伸至内部的外部，其基本上不透氧的外部延伸T1寿命。此外，O形环和密封件构造成使收集装置的去极化效果最小化。还公开了使用测量的超极化气体的弛豫时间来确定未知聚合物或液体中的气体溶解度的方法。

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