专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20120283218A1 MODIFICATIONS OF SOLID 3-sn-PHOSPHOGLYCERIDES 审中-公开
标题翻译：固体3-sn-磷酸酶的改性
公开(公告)号：US20120283218A1
公开(公告)日：2012-11-08
申请号：US13547306
申请日：2012-07-12
申请人： David W. Yesair , Walter A. Shaw , Stephen W. Burgess , Robert Travis McKee
发明人： David W. Yesair , Walter A. Shaw , Stephen W. Burgess , Robert Travis McKee
IPC分类号： A61K47/44 , A61P43/00 , A61K31/685
CPC分类号： A61K47/24 , A61K9/0014 , A61K9/1274 , C12P7/6481 , C12P9/00 , C12P13/001 , C12P13/06
摘要： Methods for hydrolyzing solid ungranulated lysophosphatidylcholine with phospholipase A2 are provided. Also disclosed are methods for making a lipid matrix of lysophosphatidylcholine, monoglyceride and fatty acid, and lipid matrices of particular structure.
摘要翻译：提供了用磷脂酶A2水解固体非成胶体溶血磷脂酰胆碱的方法。还公开了制备溶血磷脂酰胆碱，单甘油酯和脂肪酸的脂质基质以及特定结构的脂质基质的方法。

2. 发明授权

US5571517A Mixed lipid-bicarbonate colloidal particles for delivering drugs or calories 失效
标题翻译：用于输送药物或卡路里的混合脂质碳酸氢盐胶体颗粒
公开(公告)号：US5571517A
公开(公告)日：1996-11-05
申请号：US448878
申请日：1995-05-24
申请人： David W. Yesair
发明人： David W. Yesair
IPC分类号： A61K9/107 , A61K6/00 , A61K7/00
CPC分类号： A61K9/1075
摘要： A composition is disclosed containing nonesterified fatty acids having 14-18 carbon atoms, monoglycerides which are monoesters of glycerol and fatty acids having 14-18 carbon atoms, lysophosphatidylcholine in which the fatty acid moiety has 14-18 carbon atoms and bicarbonate. The compositions can optionally also contain bile salts. These compositions form submicron size colloidal particles and can act as vehicles for transporting orally administered drugs, sources of calories in the form of readily absorbable fats and as particles for topical application to the skin. A method of making these particles is also described.
摘要翻译：公开了一种组合物，其含有具有14-18个碳原子的非酯化脂肪酸，甘油单酯和具有14-18个碳原子的脂肪酸的单酸甘油酯，其中脂肪酸部分具有14-18个碳原子的溶血磷脂酰胆碱和碳酸氢盐。组合物还可任选地含有胆汁盐。这些组合物形成亚微米尺寸的胶体颗粒，并且可以作为运输口服药物，易于吸收的脂肪形式的卡路里来源和用于局部施用于皮肤的颗粒的载体。还描述了制备这些颗粒的方法。

3. 发明授权

US08222233B2 Modifications of solid 3-sn-phosphoglycerides 有权
标题翻译：固体3-sn-磷酸甘油酯的改性
公开(公告)号：US08222233B2
公开(公告)日：2012-07-17
申请号：US13087738
申请日：2011-04-15
申请人： David W. Yesair , Walter A. Shaw , Stephen W. Burgess , Robert Travis Mckee
发明人： David W. Yesair , Walter A. Shaw , Stephen W. Burgess , Robert Travis Mckee
IPC分类号： A61K31/662 , A61K47/12 , A61K9/00 , A61P11/00
CPC分类号： A61K47/24 , A61K9/0014 , A61K9/1274 , C12P7/6481 , C12P9/00 , C12P13/001 , C12P13/06
摘要： Methods for hydrolyzing solid ungranulated lysophosphatidylcholine with phospholipase A2 are provided. Also disclosed are methods for making a lipid matrix of lysophosphatidylcholine, monoglyceride and fatty acid, and lipid matrices of particular structure.
摘要翻译：提供了用磷脂酶A2水解固体非成胶体溶血磷脂酰胆碱的方法。还公开了制备溶血磷脂酰胆碱，单甘油酯和脂肪酸的脂质基质以及特定结构的脂质基质的方法。

4. 发明授权

US5707873A Method of accessing mixed lipid transport properties of a drug 失效
标题翻译：获取药物混合脂质转运性质的方法
公开(公告)号：US5707873A
公开(公告)日：1998-01-13
申请号：US449225
申请日：1995-05-24
申请人： David W. Yesair
发明人： David W. Yesair
IPC分类号： A61K9/107 , A61K47/02 , A61K47/12 , A61K47/14 , A61K47/24 , G01N30/02
CPC分类号： A61K9/1075
摘要： A method of assessing the mixed lipid transport properties of a drug is provided. The method includes providing a mixed lipid composition which incorporates a drug in colloidal particles, applying the particles to a size exclusion chromatography column, eluting free drug and drug incorporated into mixed lipid particles from the column, and determining the elution profiles of the free drug and the drug incorporated into mixed lipid particles. Drugs which elute with the mixed lipid particles are considered to have stable transport properties when incorporated into the mixed lipid particles.
摘要翻译：提供了评估药物的混合脂质运输性质的方法。该方法包括提供混合的脂质组合物，其将药物掺入胶体颗粒中，将颗粒施用于尺寸排阻色谱柱，将游离药物和药物从柱中加入到混合的脂质颗粒中，并测定游离药物的洗脱曲线和该药物掺入混合脂质颗粒中。与混合的脂质颗粒洗脱的药物在掺入混合脂质颗粒时被认为具有稳定的运输性能。

5. 发明授权

US4874795A Composition for delivery of orally administered drugs and other substances 失效
标题翻译：用于口服给药的药物和其他物质的组合物
公开(公告)号：US4874795A
公开(公告)日：1989-10-17
申请号：US843058
申请日：1986-03-24
申请人： David W. Yesair
发明人： David W. Yesair
IPC分类号： A61K47/12 , A61K47/24
CPC分类号： A61K47/24 , A61K47/12 , Y10S514/946 , Y10S514/947
摘要： A composition comprised of non-esterified fatty acids having 14-18 carbon atoms; monoglycerides which are monoesters of glycerol and fatty acids having 14-18 carbon atoms; lysophosphatidyl choline in which the fatty acid moiety has 14-18 carbon atoms and a drug is disclosed. The composition is useful for the delivery of orally-administered drugs. The composition is also useful as a source of readily absorbable fat. When used in this manner, the composition is comprised of non-esterified fatty acids having 14-18 carbon atoms; monoglycerides which are monoesters of glycerol and fatty acids having 14-18 carbon atoms; lysophosphatidyl choline in which the fatty acid moiety has 14-18 carbon atoms. A method of making the compositions disclosed is also described.
摘要翻译：由具有14-18个碳原子的非酯化脂肪酸组成的组合物; 单酸甘油酯，它们是甘油和具有14-18个碳原子的脂肪酸的单酯; 公开了其中脂肪酸部分具有14-18个碳原子的溶血磷脂酰胆碱和药物。该组合物可用于口服给药。该组合物也可用作易吸收脂肪的来源。当以这种方式使用时，组合物由具有14-18个碳原子的非酯化脂肪酸组成; 单酸甘油酯，它们是甘油和具有14-18个碳原子的脂肪酸的单酯; 溶脂磷脂酰胆碱，其中脂肪酸部分具有14-18个碳原子。还描述了制备所公开的组合物的方法。

6. 发明授权

US07947306B2 Modifications of solid 3-sn-phosphoglycerides 有权
标题翻译：固体3-sn-磷酸甘油酯的改性
公开(公告)号：US07947306B2
公开(公告)日：2011-05-24
申请号：US12142370
申请日：2008-06-19
申请人： David W. Yesair , Walter A. Shaw , Stephen W. Burgess , Robert Travis McKee
发明人： David W. Yesair , Walter A. Shaw , Stephen W. Burgess , Robert Travis McKee
IPC分类号： A61K9/00 , A61K47/12
CPC分类号： A61K47/24 , A61K9/0014 , A61K9/1274 , C12P7/6481 , C12P9/00 , C12P13/001 , C12P13/06
摘要： Methods for hydrolyzing solid ungranulated lysophosphatidylcholine with phospholipase A2 are provided. Also disclosed are methods for making a lipid matrix of lysophosphatidylcholine, monoglyceride and fatty acid, and lipid matrices of particular structure.
摘要翻译：提供了用磷脂酶A2水解固体非成胶体溶血磷脂酰胆碱的方法。还公开了制备溶血磷脂酰胆碱，单甘油酯和脂肪酸的脂质基质以及特定结构的脂质基质的方法。

7. 发明申请

US20090017119A1 MODIFICATIONS OF SOLID 3-SN-PHOSPHOGLYCERIDES 有权
标题翻译：固体3-SN-磷酸酶的修饰
公开(公告)号：US20090017119A1
公开(公告)日：2009-01-15
申请号：US12142370
申请日：2008-06-19
申请人： David W. Yesair , Walter A. Shaw , Stephen W. Burgess , Robert Travis McKee
发明人： David W. Yesair , Walter A. Shaw , Stephen W. Burgess , Robert Travis McKee
IPC分类号： A61K47/12 , A61K9/10 , A61P11/00
CPC分类号： A61K47/24 , A61K9/0014 , A61K9/1274 , C12P7/6481 , C12P9/00 , C12P13/001 , C12P13/06
摘要： Methods for hydrolyzing solid ungranulated lysophosphatidylcholine with phospholipase A2 are provided. Also disclosed are methods for making a lipid matrix of lysophosphatidylcholine, monoglyceride and fatty acid, and lipid matrices of particular structure.
摘要翻译：提供了用磷脂酶A2水解固体非成胶体溶血磷脂酰胆碱的方法。还公开了制备溶血磷脂酰胆碱，单甘油酯和脂肪酸的脂质基质以及特定结构的脂质基质的方法。

8. 发明授权

US5972911A Composition for the delivery of orally administered drugs and other substances 失效
标题翻译：用于口服给药的药物和其他物质的组成
公开(公告)号：US5972911A
公开(公告)日：1999-10-26
申请号：US890384
申请日：1992-05-26
申请人： David W. Yesair
发明人： David W. Yesair
IPC分类号： A61K47/12 , A61K47/24 , A61K31/685 , A61K31/20
CPC分类号： A61K47/24 , A61K47/12 , Y10S514/946 , Y10S514/947
摘要： A composition comprised of non-esterified fatty acids having 14-18 carbon atoms; monoglycerides which are monoesters of glycerol and fatty acids having 14-18 carbon atoms; lysophosphatidyl choline in which the fatty acid moiety has 14-18 carbon atoms and a drug is disclosed. The composition is useful for the delivery of orally-administered drugs. The composition is also useful as a source of readily absorbable fat. When used in this manner, the composition is comprised of non-esterified fatty acids having 14-18 carbon atoms; monoglycerides which are monoesters of glycerol and fatty acids having 14-18 carbon atoms; lysophosphatidyl choline in which the fatty acid moiety has 14-18 carbon atoms. A method of making the compositions disclosed is also described.
摘要翻译：由具有14-18个碳原子的非酯化脂肪酸组成的组合物; 单酸甘油酯，它们是甘油和具有14-18个碳原子的脂肪酸的单酯; 公开了其中脂肪酸部分具有14-18个碳原子的溶血磷脂酰胆碱和药物。该组合物可用于口服给药。该组合物也可用作易吸收脂肪的来源。当以这种方式使用时，组合物由具有14-18个碳原子的非酯化脂肪酸组成; 单酸甘油酯，它们是甘油和具有14-18个碳原子的脂肪酸的单酯; 溶脂磷脂酰胆碱，其中脂肪酸部分具有14-18个碳原子。还描述了制备所公开的组合物的方法。

9. 发明授权

US4298594A Xenobiotic delivery vehicles, method of forming them and method of using them 失效
标题翻译：异生物递送载体，形成方法和使用它们的方法
公开(公告)号：US4298594A
公开(公告)日：1981-11-03
申请号：US137312
申请日：1980-04-04
申请人： Barry Sears , David W. Yesair
发明人： Barry Sears , David W. Yesair
IPC分类号： A61K9/127 , A61K9/22 , A61K9/42 , A61K9/52
CPC分类号： A61K9/1271 , A61K9/127
摘要： A vehicle suitable for delivering a xenobiotic to a mammalian host to beneficially alter the pharmacodynamics (e.g., plasma kinetics, chemotherapeutic effectiveness, toxicity, oral absorption, tissue distribution, metabolism and the like) of the xenobiotic. The delivery vehicle is in the form of microreservoirs formed of a phospholipid constituent and a phospholipid-immiscible constituent. Xenobiotic binding agents and release agents may be added. Methods for preparing the microreservoirs containing the xenobiotic and for administering a xenobiotic to beneficially alter its pharmacodynamics are disclosed.
摘要翻译：一种适用于将异生素递送至哺乳动物宿主的载体，以有益地改变异生物的药效学（例如血浆动力学，化学治疗有效性，毒性，口服吸收，组织分布，代谢等）。递送载体是由磷脂成分和磷脂不混溶成分形成的微储层形式。可以加入异生物结合剂和脱模剂。公开了制备含有异生物的微储层和用于施用异生素以有益地改变其药效学的方法。

10. 发明申请

US20110190238A1 MODIFICATIONS OF SOLID 3-SN-PHOSPHOGLYCERIDES 有权
标题翻译：固体3-SN-磷酸酶的修饰
公开(公告)号：US20110190238A1
公开(公告)日：2011-08-04
申请号：US13087738
申请日：2011-04-15
申请人： David W. Yesair , Walter A. Shaw , Stephen W. Burgess , Robert Travis McKee
发明人： David W. Yesair , Walter A. Shaw , Stephen W. Burgess , Robert Travis McKee
IPC分类号： A61K31/662 , A61P11/00
CPC分类号： A61K47/24 , A61K9/0014 , A61K9/1274 , C12P7/6481 , C12P9/00 , C12P13/001 , C12P13/06
摘要： Methods for hydrolyzing solid ungranulated lysophosphatidylcholine with phospholipase A2 are provided. Also disclosed are methods for making a lipid matrix of lysophosphatidylcholine, monoglyceride and fatty acid, and lipid matrices of particular structure.
摘要翻译：提供了用磷脂酶A2水解固体非成胶体溶血磷脂酰胆碱的方法。还公开了制备溶血磷脂酰胆碱，单甘油酯和脂肪酸的脂质基质以及特定结构的脂质基质的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式