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1. 发明授权

US06684879B1 Inhaler 失效
标题翻译：吸入器
公开(公告)号：US06684879B1
公开(公告)日：2004-02-03
申请号：US09868266
申请日：2001-08-09
申请人： Ronald Alan Coffee , Alastair Bruce Pirrie , David Neville Davies
发明人： Ronald Alan Coffee , Alastair Bruce Pirrie , David Neville Davies
IPC分类号： A61M1100
CPC分类号： B05B12/004 , A61M15/0066 , A61M15/008 , A61M15/025 , A61M2205/8206 , B05B5/0255 , B05B5/053 , B05B5/1691 , B05B12/00
摘要： An inhaler has a housing containing a chamber (1a) providing a reservoir (8) for liquid providing an active ingredient to be supplied to a liquid outlet (10a). First and second electrodes are spaced apart (11 and 12) with the first electrode being spaced apart (11 and 12) with the first electrode being provided at or adjacent the liquid outlet (10a). A voltage supply (5, 7) is activated in response to air flowing through an air inlet (30) of the housing to provide a potential difference between the first and second electrodes (11 and 12) to create an electric field for causing comminution of liquid issuing from the liquid supply outlet (10a) to produce a stream of electrically charged comminuted matter for supply to the nasal passages of a user via an outlet (4) of the housing.
摘要翻译：吸入器具有容纳室（1a）的壳体，所述室（1a）提供用于液体的储存器（8），所述储存器提供要供应到液体出口（10a）的活性成分。第一和第二电极间隔开（11和12），其中第一电极间隔开（11和12），第一电极设置在液体出口（10a）处或邻近液体出口（10a）。响应于流过壳体的空气入口（30）的空气来激活电压源（5,7），以在第一和第二电极（11和12）之间提供电位差，以产生用于引起粉末的电场液体从液体供应出口（10a）排出，以产生一个带电的粉碎物质流，用于经由壳体的出口（4）供给用户的鼻通道。

2. 发明授权

US07883032B2 Devices and formulations 有权
标题翻译：设备和配方
公开(公告)号：US07883032B2
公开(公告)日：2011-02-08
申请号：US10240356
申请日：2001-04-03
申请人： Lee Adrian Davies , David Neville Davies , Margaret Sin Ka Wan , Ronald Alan Coffee
发明人： Lee Adrian Davies , David Neville Davies , Margaret Sin Ka Wan , Ronald Alan Coffee
IPC分类号： B05B5/00
CPC分类号： A61M15/00 , A61M11/00 , A61M11/001 , A61M15/02 , A61M15/08 , B05B5/0255 , B05B5/1691
摘要： Methods are described of delivering biological material, which methods include the steps of providing a liquid formulation containing the biological material, supplying the liquid formulation to an outlet and subjecting liquid issuing from the outlet to an electrical field thereby causing electrohydrodynamic processing of the liquid without denaturing the biological material. In one example, the liquid formulation is provided by removing salts from a formulation containing biological material that does not denature in alcohol and then adding an alcohol to the formulation before supplying the liquid formulation to the outlet. An acid may be added to the liquid formulation before supplying the liquid formulation to the outlet.
摘要翻译：描述了递送生物材料的方法，该方法包括以下步骤：提供含有生物材料的液体制剂，将液体制剂供应到出口并使从出口发出的液体经受电场，从而引起液体的电流动力学处理而不变性生物材料。在一个实例中，通过从含有在醇中不变性的生物材料的制剂中除去盐，然后在将液体制剂供应到出口之前向制剂中加入醇来提供液体制剂。在将液体制剂供应到出口之前，可以向液体制剂中加入酸。

3. 发明授权

US08074640B2 Aroma dispensing device 有权
标题翻译：香气分配装置
公开(公告)号：US08074640B2
公开(公告)日：2011-12-13
申请号：US10539487
申请日：2003-12-18
申请人： David Neville Davies , Alastair Bruce Pirrie , Ronald Alan Coffee
发明人： David Neville Davies , Alastair Bruce Pirrie , Ronald Alan Coffee
IPC分类号： A61M15/00 , B05B17/06
CPC分类号： A01M1/2044 , A61L9/145 , A61L9/22 , A61L2209/22
摘要： A housing has a dispensing outlet (400) and contains: a liquid supplier (7) for supplying liquid containing at least one volatile component to a liquid outlet (7a); an electric field provider (41, 42, 7) for causing liquid issuing from the liquid outlet to provide electrically charged droplets from which at least a part of the at least one volatile component evaporates to produce vapour; a collection receptacle (92) for collecting electrically charged droplets to inhibit the electrically charged droplets from passing through the dispensing outlet; an attraction electrode (91) for attracting electrically charged droplets into the collection receptacle (90); and a flow director (95) for directing vapour away from the collection receptacle (92) and towards the dispensing outlet (400).
摘要翻译：壳体具有分配出口（400）并且包含：用于将含有至少一种挥发性组分的液体供应到液体出口（7a）的液体供应器（7）; 用于使液体从液体出口发出的液体提供带电液滴的电场提供器（41,42,7），所述至少一个挥发性组分的至少一部分从该液滴蒸发以产生蒸气; 收集容器（92），用于收集带电液滴以阻止带电液滴通过分配出口; 用于将带电液滴吸引到收集容器（90）中的吸引电极（91）; 以及用于将蒸气引导从收集容器（92）并朝向分配出口（400）的导流器（95）。

4. 发明授权

US07972622B1 Method and apparatus for manufacturing dissolvable tablets 失效
标题翻译：用于制造可溶性片剂的方法和装置
公开(公告)号：US07972622B1
公开(公告)日：2011-07-05
申请号：US10018160
申请日：2000-05-05
申请人： Ronald Alan Coffee , Alastair Bruce Pirrie , David Neville Davies
发明人： Ronald Alan Coffee , Alastair Bruce Pirrie , David Neville Davies
IPC分类号： A61K9/20 , A61K9/64
CPC分类号： D01D5/0007 , A61J3/00 , A61J3/06 , A61K9/0056 , A61K9/2095
摘要： Consumable or dissolvable tablets are manufactured by supplying a liquid containing a biodissolvable carrier to an outlet; establishing an electric field between the outlet and a support surface to cause liquid issuing from the outlet to form at least one fiber or fibrils of the biodissolvable carrier which fiber or fibrils deposit(s) onto the surface to form a fiber web or mat; separating the web or mat into a plurality of individual tablets; and incorporating at least one active ingredient on or in the tablets.
摘要翻译：通过将含有生物可溶性载体的液体供给到出口来制造消耗或可溶性片剂; 在所述出口和支撑表面之间建立电场以使得从所述出口发出的液体形成所述生物可溶性载体的至少一种纤维或原纤维，所述纤维或原纤维将所述纤维或原纤维沉积在所述表面上以形成纤维网或垫; 将网或垫分离成多个单独的片剂; 并将至少一种活性成分掺入片剂上或片剂中。

5. 发明申请

US20100266668A1 Manufacturing Dissolvable Dosage Forms 审中-公开
标题翻译：制造可溶性剂型
公开(公告)号：US20100266668A1
公开(公告)日：2010-10-21
申请号：US12788602
申请日：2010-05-27
申请人： Ronald Alan Coffee , David Neville Davies , Johnathan Essex-Lopresti , Margaret Sin Ka Wan , Anna Busby
发明人： Ronald Alan Coffee , David Neville Davies , Johnathan Essex-Lopresti , Margaret Sin Ka Wan , Anna Busby
IPC分类号： A61K9/70 , A61K38/02 , A61K31/711 , A61K31/616 , A61K31/192 , A61K39/00 , A61K39/42 , A61P31/14 , A61P35/00 , A61P37/08 , A61P11/00 , B01J19/08
CPC分类号： A61K9/0036 , A61J3/00 , A61J3/005 , A61J3/06 , A61J3/07 , A61K9/70
摘要： A method of manufacturing a dosage form is described wherein a liquid solution of a biologically compatible polymer containing a suspension of particulate material that is insoluble in the polymer is supplied to a liquid supply tube (2) having an outlet (2a) and an electrical field is established between the outlet (2a) and a surface (19) spaced from the outlet (2a) to cause liquid issuing from the outlet to form a jet which dries to form a polymer fibre containing particles of the particulate material and which deposits onto the surface (19) to form a dosage which consists of said particulate containing fibre which fibre dissolves or disintegrates in a wet environment such as the mouth.
摘要翻译：描述了制备剂型的方法，其中将含有不溶于聚合物的颗粒材料的悬浮液的生物相容性聚合物的液体溶液供应到具有出口（2a）和电场的液体供应管（2）在出口（2a）和与出口（2a）间隔开的表面（19）之间建立，以使得从出口排出的液体形成干燥的射流，以形成含有颗粒材料颗粒的聚合物纤维，并且沉积在表面（19）以形成由所述含纤维颗粒组成的剂量，所述纤维在纤维在诸如口腔的湿润环境中溶解或分解。

6. 发明授权

US07891578B2 Liquid formations for electrohydrodymanic spraying containing polymer and suspended particles 失效
标题翻译：含有聚合物和悬浮颗粒的电动水喷雾的液体组成
公开(公告)号：US07891578B2
公开(公告)日：2011-02-22
申请号：US10472721
申请日：2002-03-22
申请人： David Neville Davies , Marie Pollard , Ronald Alan Coffee
发明人： David Neville Davies , Marie Pollard , Ronald Alan Coffee
IPC分类号： B05B5/025
CPC分类号： A61K9/0078 , A61K9/0073 , A61K9/12 , A61M11/00 , A61M15/02 , B05B5/1691
摘要： A method of providing a droplet spray, includes supplying a liquid polymer formulation within which substantially inert particulate material is suspended to an outlet and subjecting liquid issuing from the outlet to an electric field that causes the liquid to break up into droplets.
摘要翻译：提供液滴喷雾的方法包括提供液体聚合物制剂，其中将基本上惰性的颗粒材料悬浮在出口处并使从出口释放的液体经受使液体分解成液滴的电场。

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