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1. 发明申请

US20110129813A1 2'-BRANCHED NUCLEOSIDES AND FLAVIVIRIDAE MUTATION 有权
标题翻译： 2分支核苷酸和FLAVIVIRIDAE突变
公开(公告)号：US20110129813A1
公开(公告)日：2011-06-02
申请号：US12914914
申请日：2010-10-28
申请人： Jean-Pierre Sommadossi , Paolo LaColla , David N. Standring , Vadim Bichko , Lin Qu
发明人： Jean-Pierre Sommadossi , Paolo LaColla , David N. Standring , Vadim Bichko , Lin Qu
IPC分类号： C12Q1/70 , C40B40/06
CPC分类号： A61K31/7072 , A61K31/7052 , A61K38/21 , A61K38/212 , A61K38/215 , A61K38/217 , A61K45/06 , C07H19/06 , C07H19/16 , C07K14/005 , C12N2770/24022 , C12N2770/24122 , C12N2770/24222 , C12Q1/04 , C12Q1/18 , C12Q1/701 , C12Q1/707 , C12Q2600/156 , C12Q2600/158 , G01N2333/186 , A61K2300/00
摘要： The present invention discloses a method for the treatment of Flaviviridae infection that includes the administration of a 2′-branched nucleoside, or a pharmaceutically acceptable prodrug and/or salt thereof, to a human in need of therapy in combination or alternation with a drug that directly or indirectly induces a mutation in the viral genome at a location other than a mutation of a nucleotide that results in a change from serine to a different amino acid in the highly conserved consensus sequence, XRXSGXXXT, of domain B of the RNA polymerase region, or is associated with such a mutation; The invention also includes a method to detect a mutant strain of Flaviviridae and a method for its treatment.
摘要翻译：本发明公开了一种治疗黄病毒科感染的方法，其包括将2支支链核苷或其药学上可接受的前药和/或盐给予需要与药物组合或替代的药物，直接或间接地诱导病毒基因组中突变的位置，其不是导致在RNA聚合酶区域B的高度保守的共有序列XRXSGXXXT中从丝氨酸到不同氨基酸的变化的突变，或与这种突变有关; 本发明还包括检测黄病毒科突变菌株的方法及其治疗方法。

2. 发明授权

US06518014B1 Hepadnavirus cores 失效
标题翻译：肝炎病毒核心
公开(公告)号：US06518014B1
公开(公告)日：2003-02-11
申请号：US08890735
申请日：1997-07-11
申请人： Maria Seifer , Robert Hamatake , David N. Standring
发明人： Maria Seifer , Robert Hamatake , David N. Standring
IPC分类号： C07K1402
CPC分类号： C12N7/00 , C12N2730/10023 , C12Q1/18
摘要： Provided in one embodiment is a non-infectious, recombinant hepadnavirus core particle composition comprising isolated hepadnavirus core particles, template RNA encapsidated in the same core particles and hepadnavirus polymerase encapsidated in the same core particles, wherein, upon addition of deoxynucleoside triphosphates to the composition, the hepadnavirus polymerase incorporates deoxynucleotides from the added deoxynucleosides into reverse transcripts of the template RNA beginning with the first deoxynucleotide of the reverse transcript or within about 10 deoxynucleotides of the first deoxynucleotide of the reverse transcript. Another embodiment provides hapadnaviral core particles with all three functional components: (1) P; (2) C; and (3) a nucleic acid that serves as a template. These core particles include for example (a) recombinant, insect-cell-derived core particles, (b) core particles produced in cells contacted with a reverse transcriptase inhibitor, and (c) core particles that are especially suitable for assays for (+)-strand synthesis.
摘要翻译：在一个实施方案中提供了一种非感染性重组肝炎病毒核心颗粒组合物，其包含分离的肝炎病毒核心颗粒，包裹在相同核心颗粒中的模板RNA和包裹在相同核心颗粒中的肝炎病毒聚合酶，其中在向组合物中加入脱氧核苷三磷酸时，肝炎病毒聚合酶将来自加入的脱氧核苷的脱氧核苷酸引入模板RNA的逆转录物，从逆转录物的第一脱氧核苷酸开始，或在逆转录物的第一脱氧核苷酸的约10个脱氧核苷酸内。另一个实施方案提供了具有所有三种功能组分的半脱乙酰病毒核心颗粒：（1）P; （2）C; 和（3）作为模板的核酸。这些核心颗粒包括例如（a）重组的昆虫细胞衍生的核心颗粒，（b）在与逆转录酶抑制剂接触的细胞中产生的核心颗粒，和（c）特别适用于（+）品牌综合。

3. 发明授权

US08674085B2 2′-branched nucleosides and Flaviviridae mutation 有权
标题翻译： 2'-支链核苷和黄病毒科突变
公开(公告)号：US08674085B2
公开(公告)日：2014-03-18
申请号：US12914914
申请日：2010-10-28
申请人： Jean-Pierre Sommadossi , Paolo LaColla , David N. Standring , Vadim Bichko , Lin Qu
发明人： Jean-Pierre Sommadossi , Paolo LaColla , David N. Standring , Vadim Bichko , Lin Qu
IPC分类号： C12Q1/68
CPC分类号： A61K31/7072 , A61K31/7052 , A61K38/21 , A61K38/212 , A61K38/215 , A61K38/217 , A61K45/06 , C07H19/06 , C07H19/16 , C07K14/005 , C12N2770/24022 , C12N2770/24122 , C12N2770/24222 , C12Q1/04 , C12Q1/18 , C12Q1/701 , C12Q1/707 , C12Q2600/156 , C12Q2600/158 , G01N2333/186 , A61K2300/00
摘要： The present invention discloses a method for the treatment of Flaviviridae infection that includes the administration of a 2′-branched nucleoside, or a pharmaceutically acceptable prodrug and/or salt thereof, to a human in need of therapy in combination or alternation with a drug that directly or indirectly induces a mutation in the viral genome at a location other than a mutation of a nucleotide that results in a change from serine to a different amino acid in the highly conserved consensus sequence, XRXSGXXXT (SEQ ID NO: 63), of domain B of the RNA polymerase region, or is associated with such a mutation. The invention also includes a method to detect a mutant strain of Flaviviridae and a method for its treatment.
摘要翻译：本发明公开了一种治疗黄病毒科感染的方法，其包括将2支支链核苷或其药学上可接受的前药和/或盐给予需要与药物组合或替代的药物，在高度保守的共有序列（XRXSGXXXT（SEQ ID NO：63））中，在导致从丝氨酸到不同氨基酸的变化的核苷酸突变以外的位置直接或间接诱导病毒基因组中的突变 B的RNA聚合酶区域，或与这样的突变有关。本发明还包括检测黄病毒科突变菌株的方法及其治疗方法。

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