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1. 发明授权

US07411664B2 Cytological imaging system and method 有权
标题翻译：细胞成像系统及方法
公开(公告)号：US07411664B2
公开(公告)日：2008-08-12
申请号：US10726336
申请日：2003-12-01
申请人： David J. Zahniser , Matthew S. Zelinski , Thomas M. Dolash , Garrick L. Maenle , Mark Fleming , John S. Laudo
发明人： David J. Zahniser , Matthew S. Zelinski , Thomas M. Dolash , Garrick L. Maenle , Mark Fleming , John S. Laudo
IPC分类号： G01N33/48 , G01N21/00 , G01N21/75 , G02B21/06 , F21V9/00
CPC分类号： G01N21/3151 , G01N1/30 , G01N15/147 , G01N15/1475 , G01N15/1484 , G01N2015/1472 , G01N2015/1488
摘要： The present invention relates to the analysis of cytological material. Specifically, the invention relates to stains and methods of producing the stains, methods of staining cells for cytological or histological analysis to contrast the nuclear portion of the cell from the cytoplasmic portion, and systems and methods for illuminating a cytological sample. The analysis can be automated or manual.
摘要翻译：本发明涉及细胞学材料的分析。具体地说，本发明涉及染色剂的制造方法，染色细胞的细胞学或组织学分析方法，以将细胞的核部分与细胞质部分进行比较，以及用于照射细胞学样品的系统和方法。分析可以是自动的或手动的。

2. 发明授权

US06665060B1 Cytological imaging system and method 有权
公开(公告)号：US06665060B1
公开(公告)日：2003-12-16
申请号：US09430117
申请日：1999-10-29
申请人： David J. Zahniser , Matthew S. Zelinski , Thomas Dolash , Garrick L. Maenle , Mark Fleming , John Laudo
发明人： David J. Zahniser , Matthew S. Zelinski , Thomas Dolash , Garrick L. Maenle , Mark Fleming , John Laudo
IPC分类号： G01N3348
CPC分类号： G01N21/3151 , G01N1/30 , G01N15/147 , G01N15/1475 , G01N15/1484 , G01N2015/1472 , G01N2015/1488
摘要： The present invention relates to the analysis of cytological material. Specifically, the invention relates to stains and methods of producing the stains, methods of staining cells for cytological or histological analysis to contrast the nuclear portion of the cell from the cytoplasmic portion, and systems and methods for illuminating a cytological sample. The analysis can be automated or manual.

3. 发明授权

US06593102B2 Cytological stain composition 有权
公开(公告)号：US06593102B2
公开(公告)日：2003-07-15
申请号：US10054578
申请日：2001-11-12
申请人： David J. Zahniser , Louise M. Isenstein , Norman W. Soule , Katherine K. Mui , Daniel C. Lapen
发明人： David J. Zahniser , Louise M. Isenstein , Norman W. Soule , Katherine K. Mui , Daniel C. Lapen
IPC分类号： C12Q100
CPC分类号： G01N1/30 , G01N15/1468 , G01N15/147 , G01N15/1475 , G01N21/3151 , G01N2015/1006 , G01N2015/1472 , G01N2015/1488 , G06T7/0012 , G06T2207/30024
摘要： The present invention relates to the analysis of cytological material. Specifically, the invention relates to stains and methods of producing the stains, methods of staining cells for cytological or histological analysis to contrast the nuclear portion of the cell from the cytoplasmic portion, and systems and methods for illuminating and imaging a cytological sample. The analysis can be automated or manual.

4. 发明授权

US07590492B2 Method and system for organizing multiple objects of interest in field of interest 有权
标题翻译：在感兴趣的领域组织多个感兴趣对象的方法和系统
公开(公告)号：US07590492B2
公开(公告)日：2009-09-15
申请号：US10866397
申请日：2004-06-10
申请人： David J. Zahniser , Garrick L. Maenle , William J. Knox, Jr. , Ted S. Geiselman , Howard L. Greene , Matthew S. Zelinski , Joseph E. Zambanini
发明人： David J. Zahniser , Garrick L. Maenle , William J. Knox, Jr. , Ted S. Geiselman , Howard L. Greene , Matthew S. Zelinski , Joseph E. Zambanini
IPC分类号： G01N33/48
CPC分类号： G02B21/367 , G01N15/1475 , G01N2015/1006 , G06K9/00134 , G06K9/3233
摘要： Methods, systems, and computer software for screening and assisting in screening biological specimens. Images of a biological specimen are obtained, and image data is generated from the images. Objects of interest (OOI) are identified from the image data. The OOIs are assigned to each of a plurality of fields of interest (FOIs), at least partially based on the assignment of OOIs to other FOIs. For example, OOIs that have not previously been assigned to other FOIs can be assigned to a selected FOI. In this manner, the OOIs can be grouped within the FOIs to maximize the number of OOIs included within FOIs, or alternatively, to minimize the number of FOIs required to include all of the OOIs. Once assignment of the OOIs is complete, a field of view (FOV) can be scanned relative to each FOI in order to present the OOIs to a technician, such as a cytotechnologist.
摘要翻译：用于筛选和协助筛选生物标本的方法，系统和计算机软件。获得生物样本的图像，并从图像生成图像数据。从图像数据中识别感兴趣对象（OOI）。 OOI被分配给多个感兴趣的领域（FOI）中的每一个，至少部分地基于对其他FOI的OOI的分配。例如，以前没有分配给其他FOI的OOI可以分配给所选的FOI。以这种方式，OOI可以分组在政府信息公开范围内，以最大限度地增加政府信息公开范围内的OOI数量，或者替代地将包含所有OOI所需的政府信息公开数量最小化。一旦OOI的分配完成，可以相对于每个FOI扫描视野（FOV），以便向技术人员（例如细胞学技术人员）呈现OOI。

5. 发明授权

US07538861B2 Cytological imaging system and method 有权
标题翻译：细胞成像系统及方法
公开(公告)号：US07538861B2
公开(公告)日：2009-05-26
申请号：US12177003
申请日：2008-07-21
申请人： David J. Zahniser , Matthew S. Zelinski , Thomas M. Dolash , Garrick L. Maenle , Mark Fleming , John S. Laudo
发明人： David J. Zahniser , Matthew S. Zelinski , Thomas M. Dolash , Garrick L. Maenle , Mark Fleming , John S. Laudo
IPC分类号： G01N33/48 , G02B21/06 , G01N21/00 , G01N21/75 , F21V9/00
CPC分类号： G01N21/3151 , G01N1/30 , G01N15/147 , G01N15/1475 , G01N15/1484 , G01N2015/1472 , G01N2015/1488
摘要： The present invention relates to the analysis of cytological material. Specifically, the invention relates to stains and methods of producing the stains, methods of staining cells for cytological or histological analysis to contrast the nuclear portion of the cell from the cytoplasmic portion, and systems and methods for illuminating a cytological sample. The analysis can be automated or manual.
摘要翻译：本发明涉及细胞学材料的分析。具体地说，本发明涉及染色剂的制造方法，染色细胞的细胞学或组织学分析方法，以将细胞的核部分与细胞质部分进行比较，以及用于照射细胞学样品的系统和方法。分析可以自动或手动。

6. 发明申请

US20080278707A1 CYTOLOGICAL IMAGING SYSTEM AND METHOD 有权
标题翻译：细胞成像系统及方法
公开(公告)号：US20080278707A1
公开(公告)日：2008-11-13
申请号：US12177003
申请日：2008-07-21
申请人： David J. Zahniser , Matthew S. Zelinski , Thomas Dolash , Garrick L. Maenle , Mark Fleming , John S. Laudo
发明人： David J. Zahniser , Matthew S. Zelinski , Thomas Dolash , Garrick L. Maenle , Mark Fleming , John S. Laudo
IPC分类号： G01N33/48
CPC分类号： G01N21/3151 , G01N1/30 , G01N15/147 , G01N15/1475 , G01N15/1484 , G01N2015/1472 , G01N2015/1488
摘要： The present invention relates to the analysis of cytological material. Specifically, the invention relates to stains and methods of producing the stains, methods of staining cells for cytological or histological analysis to contrast the nuclear portion of the cell from the cytoplasmic portion, and systems and methods for illuminating a cytological sample. The analysis can be automated or manual.
摘要翻译：本发明涉及细胞学材料的分析。具体地说，本发明涉及染色剂的制造方法，染色细胞的细胞学或组织学分析方法，以将细胞的核部分与细胞质部分进行比较，以及用于照射细胞学样品的系统和方法。分析可以是自动的或手动的。

7. 发明授权

US4395493A Monolayer device using filter techniques 失效
标题翻译：使用过滤技术的单层设备
公开(公告)号：US4395493A
公开(公告)日：1983-07-26
申请号：US263712
申请日：1981-05-14
申请人： David J. Zahniser , Gerardo L. Garcia
发明人： David J. Zahniser , Gerardo L. Garcia
IPC分类号： G01N33/48 , G01N1/28 , C12M1/36 , C12M1/00 , C12M1/34 , G01N1/00
CPC分类号： G01N1/2813 , Y10S435/808
摘要： Disclosed is a monolayering device comprising a cell sensor arrangement for receiving a liquid suspension of cells and for controlling the number of cells passing through to an application vessel, a filter tape having the application vessel positioned thereabove at a first station, a vacuum source for sucking the liquid of the liquid suspension from the application vessel through the tape, a tape moving arrangement for moving the portion of the tape having the cells deposited thereon from the first station to a second station whereat a slide is positioned, and a sponge having a fixative therein mounted on a block for biasing the tape against the slide so that the cells will adhere to the slide.
摘要翻译：公开了一种单层装置，其包括用于接收细胞的液体悬浮液并用于控制通过施用容器的细胞数量的细胞传感器装置，具有位于第一站上方的施加容器的滤纸带，用于吸入的真空源来自施加容器的液体悬浮液通过带的液体，用于将具有从第一站沉积在其上的细胞的带的部分移动到放置载玻片的第二站的带移动装置和具有固定剂的海绵其中安装在块上用于将胶带偏压在滑块上，使得电池将粘附到滑块上。

8. 发明申请

US20130021461A1 SAMPLE APPLICATOR SENSING AND POSITIONING 有权
标题翻译：样品申请人感觉和定位
公开(公告)号：US20130021461A1
公开(公告)日：2013-01-24
申请号：US13549251
申请日：2012-07-13
申请人： Russell Zahniser , David J. Zahniser , Stephen Conroy , Eric Leknes , Michael Zahniser , Frank L. Pawlowski
发明人： Russell Zahniser , David J. Zahniser , Stephen Conroy , Eric Leknes , Michael Zahniser , Frank L. Pawlowski
IPC分类号： G06K9/00 , H04N7/18
CPC分类号： G01N35/00584 , G01B11/14 , G01N1/31 , G01N35/00029 , G01N35/1011 , G06K9/0014 , G06T7/11 , G06T7/12 , G06T7/50 , G06T7/70 , G06T2207/30004
摘要： Systems and methods for positioning a sample applicator relative to a substrate include: (a) obtaining an image of the sample applicator in proximity to the substrate, where the image includes a direct image region corresponding to the sample applicator and a first reflected image region corresponding to an image of the sample applicator reflected from a surface of the substrate; (b) determining a position of an edge of the sample applicator in the direct image region; (c) determining a position of a reflected edge of the sample applicator in the first reflected image region; (d) determining a distance between the edge of the sample applicator and the reflected edge of the sample applicator; and (e) determining the position of the sample applicator relative to the substrate based on the distance between the edges.
摘要翻译：用于定位样品施加器相对于基底的系统和方法包括：（a）获得样品施加器在基底附近的图像，其中图像包括对应于样品施加器的直接图像区域和对应于样品施加器的第一反射图像区域涉及从基板的表面反射的样品施加器的图像; （b）确定所述直接图像区域中所述样品施加器的边缘的位置; （c）确定所述第一反射图像区域中所述样品施加器的反射边缘的位置; （d）确定样品施加器的边缘与样品施加器的反射边缘之间的距离; 和（e）基于边缘之间的距离来确定样品施加器相对于基底的位置。

9. 发明授权

US07006674B1 Apparatus and methods for verifying the location of areas of interest within a sample in an imaging system 有权
标题翻译：用于验证成像系统中样品内感兴趣区域的位置的装置和方法
公开(公告)号：US07006674B1
公开(公告)日：2006-02-28
申请号：US09430198
申请日：1999-10-29
申请人： David J. Zahniser , Theodore S. Geiselman
发明人： David J. Zahniser , Theodore S. Geiselman
IPC分类号： G06K9/00
CPC分类号： G06K9/00134
摘要： An apparatus and method for verifying the location of an area of interest within a sample are disclosed. An imaging system includes an optical system and a stage movable relative to the optical system. A computer server is in communication with the imaging system and with a review station. The imaging system is capable of spatially locating a datum mark on the sample and determining a spatial offset value of the mark relative to a nominal position thereof. The coordinate systems of a respective one of the imaging system and the review station can be standardized. The method includes locating a datum mark on the sample, and identifying an area of interest within the sample. The method further includes determining the location of the area of interest relative to the mark. The method further includes locating again the datum, and checking that a dimensional error in locating the datum mark is less than a tolerance value to verify location of the area of interest.
摘要翻译：公开了一种用于验证样本内的感兴趣区域的位置的装置和方法。成像系统包括光学系统和相对于光学系统可移动的台。计算机服务器与成像系统和检查站通信。成像系统能够在样本上空间定位基准标记，并且确定标记相对于标称位置的空间偏移值。可以对成像系统和检查站中的相应一个的坐标系进行标准化。该方法包括在样本上定位基准标记，以及识别样品内感兴趣的区域。该方法还包括确定感兴趣区域相对于该标记的位置。该方法还包括再次定位基准，以及检查定位基准标记的尺寸误差是否小于公差值以验证感兴趣区域的位置。

10. 发明授权

US06661501B1 Cytological stain composition including verification characteristic 有权
标题翻译：细胞色素组成包括验证特征
公开(公告)号：US06661501B1
公开(公告)日：2003-12-09
申请号：US09430196
申请日：1999-10-29
申请人： David J. Zahniser , Norman W. Soule , Louise M. Isenstein
发明人： David J. Zahniser , Norman W. Soule , Louise M. Isenstein
IPC分类号： G01N3348
CPC分类号： G01N15/1475 , G01N1/30 , G01N15/147 , G01N21/3151 , G01N2015/1472 , G01N2015/1488 , G06T7/0012 , G06T7/70 , G06T2207/30024
摘要： The present invention relates to the analysis of cytological material. Specifically, the invention relates to stains and methods of producing the stains, methods of staining cells for cytological or histological analysis to contrast the nuclear portion of the cell from the cytoplasmic portion, and systems and methods for illuminating a cytological sample. The analysis can be automated or manual.
摘要翻译：本发明涉及细胞学材料的分析。具体地说，本发明涉及染色剂的制造方法，染色细胞的细胞学或组织学分析方法，以将细胞的核部分与细胞质部分进行比较，以及用于照射细胞学样品的系统和方法。分析可以是自动的或手动的。

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