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1. 发明授权

US06770462B1 Methods for producing modified nucleic acid molecules 失效
标题翻译：生产修饰核酸分子的方法
公开(公告)号：US06770462B1
公开(公告)日：2004-08-03
申请号：US10009315
申请日：2001-11-05
申请人： Alison F. Chalker , David J. Holmes , Robert Dwayne Lunsford , James Yigong Ge
发明人： Alison F. Chalker , David J. Holmes , Robert Dwayne Lunsford , James Yigong Ge
IPC分类号： C12P1934
CPC分类号： C12N15/10 , C07K14/3156 , C12N15/102
摘要： A method for inserting a cassette into a nucleic acid molecule to produce a modified nucleic acid molecule, e.g., a nucleic acid-cassette fusion, is described. The method involves the use of polymerase chain reaction, thereby permitting precise targeting of the desired site in the molecule, but does not require ligation. Also described is the use of this method for high throughput screening the resulting modified nucleic acid molecules.
摘要翻译：描述了将盒插入核酸分子以产生修饰的核酸分子例如核酸盒融合体的方法。该方法涉及使用聚合酶链反应，从而允许分子中所需位点的精确靶向，但不需要连接。还描述了使用该方法对所得修饰的核酸分子进行高通量筛选。

2. 发明授权

US06204014B1 DnaB 失效
公开(公告)号：US06204014B1
公开(公告)日：2001-03-20
申请号：US09191879
申请日：1998-11-13
申请人： Alison F Chalker , David J Holmes , Karen A Ingraham , Deborah D Jaworski , Anna L Lenox , Earl W May , Marie J Mazzulla , Jennifer Ray , Min Wang , Richard L Warren, Jr.
发明人： Alison F Chalker , David J Holmes , Karen A Ingraham , Deborah D Jaworski , Anna L Lenox , Earl W May , Marie J Mazzulla , Jennifer Ray , Min Wang , Richard L Warren, Jr.
IPC分类号： C12P2106
CPC分类号： C12N9/90 , A61K38/00 , C07K2319/00
摘要： The invention provides DnaB polypeptides and polynucleotides encoding DnaB polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing DnaB polypeptides to screen for anibacterial compounds.
摘要翻译：本发明提供DnaB多肽和编码DnaB多肽的多核苷酸以及通过重组技术产生此类多肽的方法。还提供了利用DnaB多肽来筛选细菌化合物的方法。

3. 发明授权

US5858718A PCR A 失效
公开(公告)号：US5858718A
公开(公告)日：1999-01-12
申请号：US889711
申请日：1997-07-08
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard O Nicholas , Robert King Stodola , David J. Holmes
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard O Nicholas , Robert King Stodola , David J. Holmes
IPC分类号： G01N33/50 , A61K31/70 , A61K35/76 , A61K38/00 , A61K38/43 , A61K39/00 , A61K39/09 , A61K39/395 , A61K45/00 , A61K48/00 , A61P9/00 , A61P11/00 , A61P27/16 , A61P29/00 , A61P31/04 , A61P43/00 , C07K14/315 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N9/12 , C12N9/78 , C12N9/90 , C12N15/00 , C12N15/09 , C12N15/61 , C12P21/02 , C12Q1/68 , C12R1/19 , C12R1/46 , G01N33/15 , G01N33/566 , G01N33/569 , G01N33/68 , C12P21/06 , C07H21/04 , C12N1/00
CPC分类号： C07K14/3156 , C12N9/1205 , C12N9/78 , C12N9/90 , C12Y207/01002 , A61K2039/51 , A61K38/00 , A61K39/00
摘要： The invention provides pcrA polypeptides and DNA (RNA) encoding pcrA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pcrA polypeptides to screen for antibacterial compounds.
摘要翻译：本发明提供了pcrA多肽和编码pcrA多肽的DNA（RNA），以及通过重组技术产生此类多肽的方法。还提供了利用pcrA多肽筛选抗菌化合物的方法。

4. 发明授权

US5313508A Method of and apparatus for detecting and counting articles 失效
标题翻译：用于检测和计数物品的方法和装置
公开(公告)号：US5313508A
公开(公告)日：1994-05-17
申请号：US812010
申请日：1991-12-23
申请人： John L. Ditman , David J. Holmes, III
发明人： John L. Ditman , David J. Holmes, III
IPC分类号： G06M7/00
CPC分类号： G06M7/00
摘要： A method and apparatus for counting irregularly-shaped articles. A pair of light sources are provided at a sensing plane through which articles to be counted pass. Each of the light sources emits a light beam that is at an angle to the other light beam, such as an angle of about 90.degree.. Corresponding light sensors are positioned opposite the respective light sources to receive the light signals as the articles pass through the sensing plane. A time division multiplex circuit is provided to alternately operate the light sources, and the outputs from the respective light detectors are summed to provide a unitary signal that is provided to a counter to maintain a count of the number of articles passing through the sensing plane. The system provides combined output signals that are substantially independent of the orientation of the article at the sensing plane.
摘要翻译：用于计数不规则形状制品的方法和装置。在要被计数的物品通过的感测平面处设置一对光源。每个光源发射与另一光束成一角度的光束，例如约90°的角度。相应的光传感器与各个光源相对设置，以在物品通过传感平面时接收光信号。提供时分复用电路以交替地操作光源，并且来自各个光检测器的输出相加以提供提供给计数器的统一信号，以维持通过感测平面的物品数量的计数。该系统提供组合的输出信号，其基本上独立于物体在感测平面处的取向。

5. 发明授权

US07304152B2 metRS2 失效
公开(公告)号：US07304152B2
公开(公告)日：2007-12-04
申请号：US11424836
申请日：2006-06-16
申请人： Daniel R Gentry , David J Holmes , Karen A Ingraham
发明人： Daniel R Gentry , David J Holmes , Karen A Ingraham
IPC分类号： C07H21/04
CPC分类号： C12N9/93 , C07K14/3156 , C12Q1/689
摘要： The invention provides metRS2 polypeptides and polynucleotides encoding metRS2 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are preferred methods for utilizing metRS2 polypeptides and polynucleotides as diagnostic reagents and in diagnostic assays to screen for microbial infections in organisms and infections in materials.
摘要翻译：本发明提供了metRS2多肽和编码metRS2多肽的多核苷酸以及通过重组技术产生此类多肽的方法。还提供了利用metRS2多肽和多核苷酸作为诊断试剂和在诊断测定中筛选生物体中的微生物感染和材料感染的优选方法。

6. 发明授权

US06511839B1 Fucose kinase 有权
标题翻译：岩藻糖激酶
公开(公告)号：US06511839B1
公开(公告)日：2003-01-28
申请号：US09591041
申请日：2000-06-09
申请人： Pan Fong Chan , Sanjoy Biswas , David J. Holmes , Michael A. Lonetto , Leslie M. Palmer , Stephanie Van Horn , Richard L. Warren, Jr. , Magdalena Zalacain
发明人： Pan Fong Chan , Sanjoy Biswas , David J. Holmes , Michael A. Lonetto , Leslie M. Palmer , Stephanie Van Horn , Richard L. Warren, Jr. , Magdalena Zalacain
IPC分类号： C12N1511
CPC分类号： C12N9/1205 , A61K38/00
摘要： The invention provides fucose kinase promoter polynucleotides and methods for producing and using such polynucleotides, as well as their variants, agonists and antagonists, and their uses.
摘要翻译：本发明提供岩藻糖激酶启动子多核苷酸以及用于产生和使用这些多核苷酸的方法及其变体，激动剂和拮抗剂及其用途。

7. 发明授权

US06284878B1 def1 失效
公开(公告)号：US06284878B1
公开(公告)日：2001-09-04
申请号：US08991023
申请日：1997-12-15
申请人： Michael Arthur Lonetto , Deborah Dee Jaworski , Min Wang , Richard Lloyd Warren , Christopher Michael Traini , Anna Lisa Kosmatka , David Justin Charles Knowles , John Edward Hodgson , Michael Terence Black , David J. Holmes , Richard Oakley Nicholas , Robert King Stodola
发明人： Michael Arthur Lonetto , Deborah Dee Jaworski , Min Wang , Richard Lloyd Warren , Christopher Michael Traini , Anna Lisa Kosmatka , David Justin Charles Knowles , John Edward Hodgson , Michael Terence Black , David J. Holmes , Richard Oakley Nicholas , Robert King Stodola
IPC分类号： C07H2102
CPC分类号： C12N9/1205 , A61K38/00 , A61K39/00 , C07K14/3156 , C12N9/78 , C12N9/80 , C12Y207/01002
摘要： The invention provides def1 polypeptides and polynucleotides encoding def1 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing def1 polypeptides to screen for antibacterial compounds.
摘要翻译：本发明提供了def1多肽和编码def1多肽的多核苷酸以及通过重组技术产生此类多肽的方法。还提供了利用def1多肽筛选抗菌化合物的方法。

8. 发明授权

US06168797A FabF 失效
公开(公告)号：US06168797A
公开(公告)日：2001-01-02
申请号：US09376689
申请日：1999-08-18
申请人： Sanjoy Biswas , Martin K R Burnham , Jason C Fedon , David J Holmes , Karen A Ingraham , Howard Kallender , John T Lonsdale , Marie J Mazzulla , Karen M O'Dwyer , Leslie M Palmer , Chi Young So , Christopher M Traini , Glenn S Van Aller , Stephanie Van Horn , Magdalena Zalacain
发明人： Sanjoy Biswas , Martin K R Burnham , Jason C Fedon , David J Holmes , Karen A Ingraham , Howard Kallender , John T Lonsdale , Marie J Mazzulla , Karen M O'Dwyer , Leslie M Palmer , Chi Young So , Christopher M Traini , Glenn S Van Aller , Stephanie Van Horn , Magdalena Zalacain
IPC分类号： A61K3909
CPC分类号： C12N9/1029
摘要： The invention provides fabF polypeptides and polynucleotides encoding fabF polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing fabF polypeptides to screen for antibacterial compounds.
摘要翻译：本发明提供了fabF多肽和编码fabF多肽的多核苷酸以及通过重组技术产生此类多肽的方法。还提供了利用fabF多肽筛选抗菌化合物的方法。

9. 发明授权

US6121414A pcrA protein from Streptococcus pneumoniae 失效
标题翻译：来自肺炎链球菌的pcrA蛋白
公开(公告)号：US6121414A
公开(公告)日：2000-09-19
申请号：US185825
申请日：1998-11-04
申请人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard O Nicholas , Robert King Stodola , David J Holmes
发明人： Michael Terence Black , John Edward Hodgson , David Justin Charles Knowles , Michael Arthur Lonetto , Richard O Nicholas , Robert King Stodola , David J Holmes
IPC分类号： G01N33/50 , A61K31/70 , A61K35/76 , A61K38/00 , A61K38/43 , A61K39/00 , A61K39/09 , A61K39/395 , A61K45/00 , A61K48/00 , A61P9/00 , A61P11/00 , A61P27/16 , A61P29/00 , A61P31/04 , A61P43/00 , C07K14/315 , C07K16/40 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/00 , C12N9/12 , C12N9/78 , C12N9/90 , C12N15/00 , C12N15/09 , C12N15/61 , C12P21/02 , C12Q1/68 , C12R1/19 , C12R1/46 , G01N33/15 , G01N33/566 , G01N33/569 , G01N33/68 , C07K14/00
CPC分类号： C07K14/3156 , C12N9/1205 , C12N9/78 , C12N9/90 , C12Y207/01002 , A61K2039/51 , A61K38/00 , A61K39/00
摘要： The invention provides pcrA polypeptides and DNA (RNA) encoding pcrA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pcrA polypeptides to screen for antibacterial compounds.
摘要翻译：本发明提供了pcrA多肽和编码pcrA多肽的DNA（RNA），以及通过重组技术产生此类多肽的方法。还提供了利用pcrA多肽筛选抗菌化合物的方法。

10. 发明授权

US5454016A Method and apparatus for detecting and counting articles 失效
标题翻译：用于检测和计数物品的方法和装置
公开(公告)号：US5454016A
公开(公告)日：1995-09-26
申请号：US238861
申请日：1994-05-06
申请人： David J. Holmes
发明人： David J. Holmes
IPC分类号： G06M7/00
CPC分类号： G06M7/00 , G06M1/101
摘要： A method and apparatus for counting irregularly-shaped articles. A pair of light sources are provided at a sensing plane through which articles to be counted are adapted to pass. Each of the light sources emits a light beam that is at an angle to the other light beam, such as an angle of about 90.degree.. Corresponding solar cells are positioned opposite the respective light sources to receive the light signals as the articles pass through the sensing plane. The light sources are alternately operated and the outputs from the respective light detectors are used to calculate an equivalent volume for the article for comparison with a predetermined article volume range to decide whether to count the article. The method and apparatus permit accurate counts of irregularly shaped articles and are substantially independent of the orientation of the article at the sensing plane.
摘要翻译：用于计数不规则形状制品的方法和装置。一对光源设置在感测平面上，待计数的物品将通过该平面通过。每个光源发射与另一光束成一角度的光束，例如约90°的角度。对应的太阳能电池与各个光源相对设置，以在物品通过传感平面时接收光信号。交替地操作光源，并且使用来自各个光检测器的输出来计算用于与预定物品体积范围进行比较的物品的等效体积以决定是否对物品进行计数。该方法和设备允许不规则形状制品的精确计数，并且基本上与制品在感测平面处的取向无关。

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