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1. 发明申请

US20140045264A1 METHOD OF CRYOPRESERVATION OF STEM CELL-DERIVED RETINAL PIGMENT EPITHELIAL CELLS ON POLYMERIC SUBSTRATE 审中-公开
标题翻译：干细胞衍生的离子色素上皮细胞在聚合物基质上的重组方法
公开(公告)号：US20140045264A1
公开(公告)日：2014-02-13
申请号：US14114182
申请日：2012-04-27
申请人： Danhong Zhu , David Hinton , Ashish Ahuja , Mark Humayun
发明人： Danhong Zhu , David Hinton , Ashish Ahuja , Mark Humayun
IPC分类号： A01N1/02
CPC分类号： A47G25/904 , A41D19/0068 , A61B42/40 , A61B42/50
摘要： Disclosed herein are methods and compositions for the cryopreservation of stem cells, such as stem-cell derived retinal pigment epithelial cells, that have been seeded onto and cultured on a substrate, such as a polymeric substrate. Such cryopreserved stem cells are useful for cell therapies, such as treatment of ocular damage or disease.
摘要翻译：本文公开了已经接种到基质（例如聚合物基底）上并在其上培养的干细胞（例如干细胞衍生的视网膜色素上皮细胞）的低温保存的方法和组合物。这种冷冻保存的干细胞可用于细胞治疗，例如治疗眼部损伤或疾病。

2. 发明申请

US20120009159A1 BIOCOMPATIBLE SUBSTRATE FOR FACILITATING INTERCONNECTIONS BETWEEN STEM CELLS AND TARGET TISSUES AND METHODS FOR IMPLANTING SAME 有权
标题翻译：用于促进干细胞和靶组织之间的互连的生物成分基底及其相关的方法
公开(公告)号：US20120009159A1
公开(公告)日：2012-01-12
申请号：US13181279
申请日：2011-07-12
申请人： Mark Humayun , Ashish Ahuja , Yu-Chong Tai , David Hinton , Robert Grubbs , Dennis Clegg
发明人： Mark Humayun , Ashish Ahuja , Yu-Chong Tai , David Hinton , Robert Grubbs , Dennis Clegg
IPC分类号： A61K35/54 , A61F2/02 , B32B3/00
CPC分类号： A61L27/18 , A61K9/0051 , A61K35/30 , A61K35/545 , A61K47/34 , A61L27/3813 , A61L27/3834 , A61L27/56 , A61L2430/00 , A61L2430/16 , Y10T428/24479
摘要： Disclosed herein are substrates for cell delivery to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide seeded cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.
摘要翻译：本文公开了用于细胞递送至需要治疗诱发细胞死亡，损伤或丧失功能的各种疾病的靶组织的底物。衬底被配置成提供包括干细胞的种子细胞，其具有允许与细胞和靶组织之间的生物信号的互连和传输的结构支持物。

3. 发明授权

US6092628A Apparatus and method for controlling temperature of fluid in a differential assembly 有权
标题翻译：用于控制差动组件中流体温度的装置和方法
公开(公告)号：US6092628A
公开(公告)日：2000-07-25
申请号：US196043
申请日：1998-11-19
申请人： David Hinton , Douglas W. Bell , Charles N. Goloff
发明人： David Hinton , Douglas W. Bell , Charles N. Goloff
IPC分类号： F16H48/06 , F16H48/08 , F16H57/04 , F01M9/06
CPC分类号： F16H57/0412 , F16H57/0413 , Y10T74/2189
摘要： An apparatus for controlling temperature of fluid in a differential assembly. The apparatus includes a differential housing having a number of sidewalls which collectively define an internal component chamber, wherein (i) the internal component chamber has a differential sump located therein, and (ii) the differential sump has a sump input port defined therein. The apparatus also includes a first operational pressure source which advances fluid from the internal component chamber of the differential housing. The apparatus further includes a diverter valve which receives fluid advanced by the first operational pressure source from the internal component chamber. The diverter valve has a cold fluid output port and a hot fluid output port. A heating fluid return line is interposed between the cold fluid output port of the diverter valve and the sump input port of the differential sump. A cooling fluid return line is interposed between the hot fluid output port of the diverter valve and the housing input port of the differential housing. The diverter valve is selectively operable between (i) a heating position in which fluid advanced by the first operational fluid source is diverted to the differential sump of the differential housing via the heating fluid return line and (ii) a cooling position in which fluid advanced by the first operational fluid source is diverted to contact the number of sidewalls of the differential housing via the cooling fluid return line. A method of controlling temperature of fluid in a differential housing is also presented.
摘要翻译：一种用于控制差动组件中的流体温度的装置。该装置包括具有共同限定内部部件室的多个侧壁的差速器壳体，其中（i）内部部件室具有位于其中的差速器槽，并且（ii）差速槽具有限定在其中的贮槽输入端口。该装置还包括第一操作压力源，该压力源从差速器壳体的内部组件室推进流体。该装置还包括分流阀，其接收由第一操作压力源从内部组件室推进的流体。分流阀具有冷流体输出口和热流体输出口。在转向阀的冷流体输出端口和差压贮槽的贮槽输入口之间插入加热流体返回管线。冷却流体返回管路插入在转向阀的热流体输出端口和差速器壳体的壳体输入端口之间。分流阀可以选择性地在（i）加热位置之间选择性地操作，在该加热位置中，由第一操作流体源推进的流体经由加热流体返回管线转移到差速器壳体的差速油槽，以及（ii）流体前进的冷却位置通过第一操作流体源被转向以经由冷却流体返回管线接触差速器壳体的侧壁的数量。还提出了一种控制差速器壳体中的流体温度的方法。

4. 发明授权

US10478206B2 Instruments and methods for the implantation of cell-seeded substrates 有权
公开(公告)号：US10478206B2
公开(公告)日：2019-11-19
申请号：US14114160
申请日：2012-04-27
申请人： Mark Humayun , Ashish Ahuja , Yu-Chong Tai , Robert Grubbs , Rodrigo Brant , Trent Wells , Lincoln Vallance Johnson , Sherry T. Hikita , David Hinton
发明人： Mark Humayun , Ashish Ahuja , Yu-Chong Tai , Robert Grubbs , Rodrigo Brant , Trent Wells , Lincoln Vallance Johnson , Sherry T. Hikita , David Hinton
IPC分类号： A61B17/29 , A61F9/007 , A61L27/16 , A61L27/34 , A61L27/38 , A61L27/50 , A61K35/50 , C12N5/079 , A61F2/14 , A61F2/46 , A61F9/00 , A61M1/12 , A61M5/14 , A61B17/30
摘要： Disclosed herein are instruments and methods for delivery of substrates, including cell-seeded substrates, to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.

5. 发明申请

US20150147377A1 BIOCOMPATIBLE SUBSTRATE FOR FACILITATING INTERCONNECTIONS BETWEEN STEM CELLS AND TARGET TISSUES AND METHODS FOR IMPLANTING SAME 审中-公开
标题翻译：用于促进干细胞和靶组织之间的互连的生物成分基底及其相关的方法
公开(公告)号：US20150147377A1
公开(公告)日：2015-05-28
申请号：US14314994
申请日：2014-06-25
申请人： Mark Humayun , Ashish Ahuja , Yu-Chong Tai , David Hinton , Robert Grubbs , Dennis Clegg , Lincoln Vallance Johnson , Sherry T. Hikita
发明人： Mark Humayun , Ashish Ahuja , Yu-Chong Tai , David Hinton , Robert Grubbs , Dennis Clegg , Lincoln Vallance Johnson , Sherry T. Hikita
IPC分类号： A61L27/18 , A61L27/56
CPC分类号： A61L27/18 , A61K9/0051 , A61K35/30 , A61K35/545 , A61K47/34 , A61L27/3813 , A61L27/3834 , A61L27/56 , A61L2430/00 , A61L2430/16 , Y10T428/24479
摘要： Disclosed herein are substrates for cell delivery to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide seeded cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.
摘要翻译：本文公开了用于细胞递送至需要治疗诱发细胞死亡，损伤或丧失功能的各种疾病的靶组织的底物。衬底被配置成提供包括干细胞的种子细胞，其具有允许与细胞和靶组织之间的生物信号的互连和传输的结构支持物。

6. 发明申请

US20150032207A1 INSTRUMENTS AND METHODS FOR THE IMPLANTATION OF CELL-SEEDED SUBSTRATES 审中-公开
标题翻译：用于植入细胞基底的仪器和方法
公开(公告)号：US20150032207A1
公开(公告)日：2015-01-29
申请号：US14114160
申请日：2012-04-27
申请人： Mark Humayun , Ashish Ahuja , Yu-Chong Tai , Robert Grubbs , Rodrigo Brant , Trent Wells , Lincoln Vallance Johnson , Sherry T. Hikita , David Hinton
发明人： Mark Humayun , Ashish Ahuja , Yu-Chong Tai , Robert Grubbs , Rodrigo Brant , Trent Wells , Lincoln Vallance Johnson , Sherry T. Hikita , David Hinton
IPC分类号： A61B17/29 , A61F2/46 , C12N5/079 , A61M5/14 , A61F9/00 , A61F2/14 , A61M1/12
CPC分类号： A61B17/2909 , A61B2017/2937 , A61B2017/2945 , A61B2017/305 , A61F2/14 , A61F2/4601 , A61F9/0017 , A61F9/00736 , A61K35/50 , A61L27/16 , A61L27/34 , A61L27/3813 , A61L27/50 , A61L2430/16 , A61M1/12 , A61M5/14 , A61M2202/09 , C12N5/0621 , C12N2506/02 , C12N2533/30 , C12N2533/40 , C12N2533/50 , C08L65/04 , C08L89/00
摘要： Disclosed herein are instruments and methods for delivery of substrates, including cell-seeded substrates, to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.
摘要翻译：本文公开了用于将底物（包括细胞接种的底物）递送至需要治疗诱导细胞死亡，损伤或功能丧失的各种疾病的靶组织的仪器和方法。衬底被配置为提供包括干细胞的细胞，其具有允许与细胞和靶组织之间的生物信号的互连和传输的结构支持物。

7. 发明授权

US06869935B2 Gene Therapy for proliferative vitreoretinopathy 失效
标题翻译：增生性玻璃体视网膜病变的基因治疗
公开(公告)号：US06869935B2
公开(公告)日：2005-03-22
申请号：US09174210
申请日：1998-10-16
申请人： David Hinton , W. French Anderson , Stephen J Ryan
发明人： David Hinton , W. French Anderson , Stephen J Ryan
IPC分类号： C12N15/09 , A61K31/00 , A61K31/52 , A61K31/522 , A61K31/70 , A61K31/7042 , A61K31/7052 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K38/45 , A61K38/50 , A61K48/00 , A61P27/00 , A61P27/04 , A01N43/04 , C12N15/00 , C12N15/63 , C12N15/86 , C12P21/06
CPC分类号： A61K48/00 , A61K38/45 , A61K38/50
摘要： A method of treating ocular disorders (such as, for example, proliferative vitreoretinopathy or PVR) associated with replicating ocular cells by transfecting replicating ocular cells in vivo with a polynucleotide encoding an agent which is capable of providing for the inhibition, prevention, or destruction of the growth of the replicating ocular cells upon expression of the agent. The agent may be a viral thymidine kinase, and the polynucleotide encoding the agent may be contained in a retroviral vector. Once the replicating ocular cells are transduced with the retroviral vector, the patient is given a chemotherapeutic or interaction agent, such as ganciclovir, which kills the transfected replicating ocular cells.
摘要翻译：一种治疗与复制眼细胞相关的眼部疾病（例如增殖性玻璃体视网膜病变或PVR）的方法，其通过用编码能够提供抑制，预防或破坏的药物的多核苷酸体内转染复制性眼细胞复制眼细胞在试剂表达时的生长。试剂可以是病毒胸苷激酶，编码该试剂的多核苷酸可以包含在逆转录病毒载体中。一旦复制的眼细胞用逆转录病毒载体转导，给予患者化学治疗剂或相互作用剂，如更昔洛韦，其杀死转染的复制性眼细胞。

8. 发明授权

US5989143A Arrangement for lubricating a differential assembly of a work machine 有权
标题翻译：用于润滑作业机的差动组件的布置
公开(公告)号：US5989143A
公开(公告)日：1999-11-23
申请号：US162214
申请日：1998-09-28
申请人： Douglas W. Bell , David Hinton
发明人： Douglas W. Bell , David Hinton
IPC分类号： F16H57/04 , F16H97/04
CPC分类号： F16H57/0421 , F16H57/043 , F16H57/0483 , F16H2048/085 , F16H48/08
摘要： A differential assembly which includes a differential housing is disclosed. The differential housing defines an internal component chamber, a fluid housing inlet, and a fluid housing outlet. The differential assembly also includes a spider structure positioned within the internal component chamber. The spider structure has (i) a spider hub and (ii) a spider shaft which extends from the spider hub. The differential assembly further includes a pinion gear positioned within the internal component chamber and around the spider shaft. The differential assembly also includes a bearing assembly positioned within the internal component chamber. The bearing assembly is interposed between the pinion gear and the spider shaft, wherein (i) the spider structure has a fluid spider channel having a fluid spider inlet and a fluid spider outlet, (ii) the fluid housing inlet is in fluid communication with the fluid spider inlet, and (iii) the fluid spider outlet is in fluid communication with the fluid housing outlet. The differential assembly also includes a fluid pump which advances a flow of oil through the fluid housing inlet, the fluid spider inlet, the fluid spider outlet, and the fluid housing outlet.
摘要翻译：公开了一种包括差速器壳体的差动组件。差速器壳体限定内部部件腔室，流体壳体入口和流体壳体出口。差速器组件还包括定位在内部部件室内的蜘蛛结构。蜘蛛结构具有（i）一个蜘蛛轮毂和（ii）从蜘蛛轮毂延伸的一个蜘蛛轴。差速器组件还包括定位在内部部件腔室内并且围绕着圆锥形轴的小齿轮。差速器组件还包括定位在内部组件室内的轴承组件。所述轴承组件设置在所述小齿轮和所述蜘蛛轴之间，其中，（i）所述蜘蛛结构具有具有流体蜘蛛入口和流体蜘蛛出口的流体蜘蛛通道，（ii）所述流体壳体入口与流体蜘蛛入口，和（iii）流体蜘蛛出口与流体容器出口流体连通。差速器组件还包括流体泵，其使油流通过流体壳体入口，流体蜘蛛入口，流体蜘蛛出口和流体壳体出口。

9. 发明授权

US08808687B2 Biocompatible substrate for facilitating interconnections between stem cells and target tissues and methods for implanting same 有权
标题翻译：用于促进干细胞和靶组织之间的互连的生物相容性底物及其植入方法
公开(公告)号：US08808687B2
公开(公告)日：2014-08-19
申请号：US13181279
申请日：2011-07-12
申请人： Mark Humayun , Ashish Ahuja , Yu-Chong Tai , David Hinton , Robert Grubbs , Dennis Clegg , Lincoln V. Johnson , Sherry T. Hikita
发明人： Mark Humayun , Ashish Ahuja , Yu-Chong Tai , David Hinton , Robert Grubbs , Dennis Clegg , Lincoln V. Johnson , Sherry T. Hikita
IPC分类号： A61F2/02 , A61K35/30 , B32B3/00 , A61K47/34 , A61K9/00 , A61L27/38
CPC分类号： A61L27/18 , A61K9/0051 , A61K35/30 , A61K35/545 , A61K47/34 , A61L27/3813 , A61L27/3834 , A61L27/56 , A61L2430/00 , A61L2430/16 , Y10T428/24479
摘要： Disclosed herein are substrates for cell delivery to target tissues requiring treatment for various diseases that induce cell death, damage or loss of function. The substrates are configured to provide seeded cells, including stem cells, with a structural support that allows interconnection with and transmission of biological signals between the cells and the target tissue.
摘要翻译：本文公开了用于细胞递送至需要治疗诱发细胞死亡，损伤或丧失功能的各种疾病的靶组织的底物。衬底被配置成提供包括干细胞的种子细胞，其具有允许与细胞和靶组织之间的生物信号的互连和传输的结构支持物。

10. 发明申请

US20120151094A1 Method and Apparatus for Internet Browsing 审中-公开
标题翻译：互联网浏览的方法和装置
公开(公告)号：US20120151094A1
公开(公告)日：2012-06-14
申请号：US13390941
申请日：2010-08-20
申请人： David Hinton Cooke
发明人： David Hinton Cooke
IPC分类号： G06F15/16
CPC分类号： G06F16/95 , G06F13/12 , H04L63/1441
摘要： The present application relates to a method and apparatus for digital data processing systems suitable for providing Internet browsing within a computer network. In particular, the present application provides a method of operating a data processing system. The method may include the step of operatively divesting the browsing of web sites from the central processing of applications. In another aspect, the present application provides a data processing system that may include: central processing means adapted to operate in accordance with a predetermined instruction set and an Internet browser function; the central processing means, in conjunction with the Internet browser function, being adapted to perform web browsing wherein the Internet browser function is operatively divested from the central processing means.
摘要翻译：本申请涉及适用于在计算机网络内提供因特网浏览的数字数据处理系统的方法和装置。特别地，本申请提供了一种操作数据处理系统的方法。该方法可以包括从应用程序的中央处理中有效地剥离网站浏览的步骤。在另一方面，本申请提供了一种数据处理系统，其可以包括：适于根据预定指令集和互联网浏览器功能进行操作的中央处理装置; 中央处理装置结合互联网浏览器功能适于执行网络浏览，其中互联网浏览器功能与中央处理装置可操作地分离。

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