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1. 发明授权

US10932907B2 Semi-flexible annuloplasty ring 有权
公开(公告)号：US10932907B2
公开(公告)日：2021-03-02
申请号：US13576982
申请日：2011-02-01
申请人： David H. Adams , John T. M. Wright
发明人： David H. Adams , John T. M. Wright
IPC分类号： A61F2/24
摘要： An annuloplasty ring for attachment to an annulus of a tricuspid valve comprises an elongate tube of suturable material comprising a central segment and first and second end segments. An arcuate stiff ener is received in the central segment of the tube and extends the length thereof. The arcuate stiffener is circumferentially confined within the central segment to prevent circumferential movement of the stiffener relative to the tube. The first and second end segments of the tube lack a stiffener and are axially deformable.

2. 发明授权

US09011529B2 Mitral annuloplasty rings with sewing cuff 有权
标题翻译：二尖瓣瓣环成形术与缝合袖口
公开(公告)号：US09011529B2
公开(公告)日：2015-04-21
申请号：US13095039
申请日：2011-04-27
申请人： Alain F. Carpentier , David H. Adams , Wesley Vazo Adzich
发明人： Alain F. Carpentier , David H. Adams , Wesley Vazo Adzich
IPC分类号： A61F2/24
CPC分类号： A61F2/2448 , A61F2/24 , A61F2/2409 , A61F2/2445 , A61F2230/0034 , A61F2230/0065 , A61F2250/0018 , A61F2250/0037 , Y10T29/49
摘要： Annuloplasty rings optimally sized to take into account more of the common degenerative valve pathologies. Each ring has a structural ring body with a shape that complies with predicted shapes of degenerative valvular diseases, such as fibroelastic deficiency (FED), Marfan's or Barlow's. The predicted shapes are obtained through careful echocardiographic and intraoperative measurements, and often differ for different annulus orifice sizes. For instance, in mitral rings the larger rings have larger minor axis and oblique axis dimensions relative to their major axis dimensions, and are more circular as opposed to D-shaped. The rings may also be three-dimensional and the relative heights around the rings may change for different sized rings. A mitral ring may have a higher anterior saddle relative to a posterior saddle, with the relative heights varying across the ring sizes. The ring may have varying flexibility around the ring periphery which also changes for different ring sizes. A bulge on the sewing cuff forms a step on the outflow side for ease of suturing, which may be indicated by a suture line.
摘要翻译：瓣膜成形术环最优化以考虑更多的常见的退行性瓣膜病变。每个环具有结构环体，其形状符合退化性瓣膜疾病的预测形状，例如纤维弹性不足（FED），Marfan's或Barlow's。通过仔细的超声心动图和术中测量获得预测的形状，并且对于不同的环形孔尺寸通常是不同的。例如，在二尖瓣环中，较大的环相对于其长轴尺寸具有较大的短轴和倾斜轴尺寸，并且与D形相反更圆。环也可以是三维的，并且围绕环的相对高度可以针对不同尺寸的环而改变。二尖瓣环可能具有相对于后鞍座的较高的前鞍座，相对高度在环尺寸之间变化。环可能围绕环周围具有不同的柔性，这也适用于不同的环尺寸。缝合套管上的凸起在流出侧形成一个便于缝合的步骤，这可以由缝合线表示。

3. 发明授权

US08764821B2 Degenerative vavlular disease specific annuloplasty ring sets 有权
标题翻译：退行性膀胱疾病特异性瓣环成形术
公开(公告)号：US08764821B2
公开(公告)日：2014-07-01
申请号：US13422706
申请日：2012-03-16
申请人： Alain F. Carpentier , David H. Adams , W. Vaso Adzich
发明人： Alain F. Carpentier , David H. Adams , W. Vaso Adzich
IPC分类号： A61F2/24
CPC分类号： A61F2/2448 , A61F2/24 , A61F2/2409 , A61F2/2445 , A61F2230/0034 , A61F2230/0065 , A61F2250/0018 , A61F2250/0037 , Y10T29/49
摘要： Annuloplasty rings optimally sized to take into account more of the common degenerative valve pathologies. Each ring has a structural ring body with a shape that complies with predicted shapes of degenerative valvular diseases. The predicted shapes are obtained through careful echocardiographic and intraoperative measurements, and often differ for different annulus orifice sizes. For instance, in mitral rings the larger rings have larger minor axis and oblique axis dimensions relative to their major axis dimensions, and are more circular as opposed to D-shaped. The rings may also be three-dimensional and the relative heights around the rings may change for different sized rings. A mitral ring may have a higher anterior saddle relative to a posterior saddle, with the relative heights varying across the ring sizes. The ring may have varying flexibility around the ring periphery which also changes for different ring sizes.
摘要翻译：瓣膜成形术环最优化以考虑更多的常见的退行性瓣膜病变。每个环具有结构环体，其形状符合退化性瓣膜疾病的预测形状。通过仔细的超声心动图和术中测量获得预测的形状，并且对于不同的环形孔尺寸通常是不同的。例如，在二尖瓣环中，较大的环相对于其长轴尺寸具有较大的短轴和倾斜轴尺寸，并且与D形相反更圆。环也可以是三维的，并且围绕环的相对高度可以针对不同尺寸的环而改变。二尖瓣环可能具有相对于后鞍座的较高的前鞍座，相对高度在环尺寸之间变化。环可能围绕环周围具有不同的柔性，这也适用于不同的环尺寸。

4. 发明授权

US07959673B2 Degenerative valvular disease specific annuloplasty rings 有权
标题翻译：退行性瓣膜疾病特异性瓣环成形术环
公开(公告)号：US07959673B2
公开(公告)日：2011-06-14
申请号：US12209148
申请日：2008-09-11
申请人： Alain F. Carpentier , David H. Adams , Vaso Adzich
发明人： Alain F. Carpentier , David H. Adams , Vaso Adzich
IPC分类号： A61F2/24
CPC分类号： A61F2/2448 , A61F2/24 , A61F2/2409 , A61F2/2445 , A61F2230/0034 , A61F2230/0065 , A61F2250/0018 , A61F2250/0037 , Y10T29/49
摘要： Annuloplasty rings optimally sized to take into account more of the common degenerative valve pathologies. Each ring has a structural ring body with a shape that complies with predicted shapes of degenerative valvular diseases, such as fibroelastic deficiency (FED), Marfan's or Barlow's. The predicted shapes are obtained through careful echocardiographic and intraoperative measurements, and often differ for different annulus orifice sizes. For instance, in mitral rings the larger rings have larger minor axis and oblique axis dimensions relative to their major axis dimensions, and are more circular as opposed to D-shaped. The rings may also be three-dimensional and the relative heights around the rings may change for different sized rings. A mitral ring may have a higher anterior saddle relative to a posterior saddle, with the relative heights varying across the ring sizes. The ring may have varying flexibility around the ring periphery which also changes for different ring sizes. A bulge on the sewing cuff forms a step on the outflow side for ease of suturing, which may be indicated by a suture line.
摘要翻译：瓣膜成形术环最优化以考虑更多的常见的退行性瓣膜病变。每个环具有结构环体，其形状符合退化性瓣膜疾病的预测形状，例如纤维弹性不足（FED），Marfan's或Barlow's。通过仔细的超声心动图和术中测量获得预测的形状，并且对于不同的环形孔尺寸通常是不同的。例如，在二尖瓣环中，较大的环相对于其长轴尺寸具有较大的短轴和倾斜轴尺寸，并且与D形相反更圆。环也可以是三维的，并且围绕环的相对高度可以针对不同尺寸的环而改变。二尖瓣环可能具有相对于后鞍座的较高的前鞍座，相对高度在环尺寸之间变化。环可能围绕环周围具有不同的柔性，这也适用于不同的环尺寸。缝合套管上的凸起在流出侧形成一个便于缝合的步骤，这可以由缝合线表示。

5. 发明授权

US06540781B2 Cryopreserved homografts and other stentless bioprosthetic heart valves having natural tissue sewing rings 失效
公开(公告)号：US06540781B2
公开(公告)日：2003-04-01
申请号：US09738805
申请日：2000-12-14
申请人： David H. Adams
发明人： David H. Adams
IPC分类号： A61F224
CPC分类号： A61F2/2415 , A61F2/2412
摘要： Pre-trimmed, cryopreserved homografts and other stentless bioprosthetic heart valves having natural tissue sewing rings formed thereon. The sewing ring may be formed of strip of pericardium or other suitable tissue. Material may be captured between the natural tissue sewing ring and a sub-valvular lip formed on the valve to impart a desired size or shape to the sewing ring. In the case of cryopreserved embodiments of the invention (e.g., cryopreserved human homografts) the sewing ring is attached to the valve by way of a natural tissue suture, biological glue or other attachment component that is capable of undergoing cryopreservation without breaking, excessive weakening, or other changes that prevent it from performing its attachment function.

6. 发明授权

US5540928A Extraluminal regulation of the growth and repair of tubular structures in vivo 失效
公开(公告)号：US5540928A
公开(公告)日：1996-07-30
申请号：US234714
申请日：1994-04-28
申请人： Elazer R. Edelman , David H. Adams , Morris J. Karnovsky
发明人： Elazer R. Edelman , David H. Adams , Morris J. Karnovsky
IPC分类号： A61K9/00 , A61F2/00 , A61K9/22
CPC分类号： A61K9/0024
摘要： A method of regulating repair in a physiological system following injury to the lumen of a tubular structure in that system, and of testing the effectiveness of regulatory agent, is presented. The method includes administering a modulator of cell or tissue growth to an extraluminal site adjacent the injured tissue.

7. 发明授权

US5455039A Extraluminal regulation of the growth and repair of tubular structures in vivo 失效
标题翻译：体外管腔结构生长和修复的外腔调节
公开(公告)号：US5455039A
公开(公告)日：1995-10-03
申请号：US225429
申请日：1994-04-08
申请人： Elazer R. Edelman , David H. Adams , Morris J. Karnovsky
发明人： Elazer R. Edelman , David H. Adams , Morris J. Karnovsky
IPC分类号： A61F2/00 , A61F13/00 , A61K9/00 , A61K9/16 , A61K9/22 , A61K9/50 , A61K31/40 , A61L15/58 , A61K9/12
CPC分类号： A61K9/0019 , A61K31/40 , A61K9/0024 , A61L15/58 , A61K9/1641 , A61K9/5036
摘要： A method of regulating repair in a physiological system following injury to the lumen of a tubular structure in that system, and of testing the effectiveness of regulatory agent, is presented. The method includes administering a modulator of cell or tissue growth to an extraluminal site adjacent the injured tissue.
摘要翻译：提出了一种在该系统中对管状结构的内腔损伤后的生理系统中的修复的调节方法和测试调节剂的有效性的方法。所述方法包括将细胞或组织生长调节剂施用于邻近受损组织的外腔部位。

8. 发明公开

US20230285611A1 SANITIZING APPARATUS FOR CARD EXCHANGE 审中-公开
公开(公告)号：US20230285611A1
公开(公告)日：2023-09-14
申请号：US18113695
申请日：2023-02-24
申请人： Robert G. Tegel , Turan Erdogan , David H. Adams
发明人： Robert G. Tegel , Turan Erdogan , David H. Adams
IPC分类号： A61L2/10 , A61L2/26
CPC分类号： A61L2/10 , A61L2/26 , A61L2202/122 , A61L2202/123 , A61L2202/11 , A61L2202/14
摘要： An apparatus for exposing a flat card to sanitizing radiant energy, has an enclosure that has an exposure chamber having a source of sanitizing radiation. A first insert slot and a second insert slot, disposed along an input surface of the enclosure are each configured to accept insertion of the flat card. A transport apparatus defines a first transport path to convey the flat card from the first insert slot, and through the exposure chamber, to emerge from a first output that opens on a first side surface of the enclosure and a second transport path to convey the flat card from the second insert slot, and through the exposure chamber, to emerge from a second output that opens on a second side surface of the enclosure that is opposite the first side surface.

9. 发明申请

US20220088242A1 EXPOSURE AND DECONTAMINATION CAROUSEL 有权
公开(公告)号：US20220088242A1
公开(公告)日：2022-03-24
申请号：US17471515
申请日：2021-09-10
申请人： Robert G. Tegel , Turan Erdogan , David H. Adams
发明人： Robert G. Tegel , Turan Erdogan , David H. Adams
IPC分类号： A61L2/10 , G03F7/20
摘要： An apparatus for exposing an article to radiant energy has a rotating carousel having an article support in a support sector defined between a first energy-blocking feature of the rotating carousel and a second energy-blocking feature of the rotating carousel. An actuator is energizable to rotate the carousel and to revolve the article support along a circular transport path. An enclosure has a stationary hood that defines an enclosed sector of the transport path and an unenclosed sector of the transport path. There is at least a first radiant energy source energizable to direct the radiant exposure energy toward the carousel along the enclosed sector of the transport path.

10. 发明申请

US20130204361A1 SEMI-FLEXIBLE ANNULOPLASTY RING 审中-公开
标题翻译：半柔性安抚环
公开(公告)号：US20130204361A1
公开(公告)日：2013-08-08
申请号：US13576982
申请日：2011-02-01
申请人： David H. Adams , John T.M. Wright
发明人： David H. Adams , John T.M. Wright
IPC分类号： A61F2/24
CPC分类号： A61F2/2445 , A61F2/2466 , A61F2250/0018
摘要： An annuloplasty ring for attachment to an annulus of a tricuspid valve comprises an elongate tube of suturable material comprising a central segment and first and second end segments. An arcuate stiff ener is received in the central segment of the tube and extends the length thereof. The arcuate stiffener is circumferentially confined within the central segment to prevent circumferential movement of the stiffener relative to the tube. The first and second end segments of the tube lack a stiffener and are axially deformable.
摘要翻译：用于附接到三尖瓣环的瓣环成形术环包括可缝合材料的细长管，其包括中心段和第一和第二端段。弧形刚性塞接纳在管的中心部分并延伸其长度。弧形加强件周向地限制在中心段内，以防止加强件相对于管的周向移动。管的第一和第二端段缺少加强件并且可轴向变形。

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