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    • 1. 发明授权
    • Compositions and methods of nematode control
    • 线虫控制的组成和方法
    • US06863881B2
    • 2005-03-08
    • US10629201
    • 2003-07-29
    • David GreensteinMichael A. Miller
    • David GreensteinMichael A. Miller
    • A61K38/00C07K14/435G01N33/50A61K49/00
    • G01N33/5085A01K2217/05A61K38/00C07K14/4354
    • The present invention provides compositions and methods for identifying agents that stimulate or inhibit nematode reproduction, especially related to oocyte maturation, sheath cell contraction, and ovulation. It is disclosed that the major sperm protein (MSP) is acts in signal transduction of female sexual maturation in nematodes. Provided are compositions and methods for identifying anti-nematode agents with MSP as a target and for controlling nematode populations. MSP is an excellent target for identification of anti-nematode factors because it is highly conserved among members of the phylum Nematoda and is not known to exist in other organisms, especially crops, livestock, pets, and humans. Thus, anti-nematode agents that target MSP are less likely to induce severe side effects when administered to a host and the nematode is unlikely to develop resistance to a highly conserved molecule involved in sexual reproduction.
    • 本发明提供用于鉴定刺激或抑制线虫繁殖,特别是与卵母细胞成熟,鞘细胞收缩和排卵相关的药剂的组合物和方法。 据了解,主要精子蛋白(MSP)在线虫中女性性成熟的信号转导中起作用。 提供了用MSP作为靶标和用于控制线虫种群鉴定抗线虫剂的组合物和方法。 MSP是鉴定抗线虫因子的极好目标,因为它在门虫线虫成员中是高度保守的,不知道存在于其他生物体,尤其是作物,家畜,宠物和人类中。 因此,靶向MSP的抗线虫剂在施用于宿主时不太可能引起严重的副作用,并且线虫不太可能对涉及性繁殖的高度保守的分子产生抗性。
    • 2. 发明申请
    • SYSTEM AND METHOD FOR SOCIAL INTERACTION, SHARING AND COLLABORATION
    • 社会互动,共享与协作的系统与方法
    • US20120284638A1
    • 2012-11-08
    • US13465572
    • 2012-05-07
    • Matthew CutlerDavid Greenstein
    • Matthew CutlerDavid Greenstein
    • G06F3/01
    • G06Q10/00
    • A system and method for real-time, social networking, sharing and collaborating is disclosed. An application for the networking, sharing and collaborating is downloaded onto a mobile device, such as a smartphone, or onto a networked computer. Users log into the application and send invitations to other users to form groups for on-line sharing and collaboration. Persons may be invited to join a group via their e-mail addresses, other affinity address, or proximity to each other through a resident global positioning system. Once a group is formed, nearly instantaneous communications are maintained without e-mail or instant messaging systems. Participants may share files, notes, photos, videos, music, contacts and other items with each other and store shared items. Communications take place among group members via dual communications channels.
    • 披露了一种用于实时,社交网络,共享和协作的系统和方法。 将网络,共享和协作的应用程序下载到诸如智能电话之类的移动设备上,或被下载到联网的计算机上。 用户登录到应用程序并发送邀请给其他用户组成用于在线共享和协作的组。 可以邀请人们通过他们的电子邮件地址,其他亲和力地址或通过常驻全球定位系统彼此接近来加入组。 一旦成立了一个组织,几乎瞬间的通信维持没有电子邮件或即时消息系统。 参与者可以共享文件,笔记,照片,视频,音乐,联系人和其他项目并存储共享项目。 集团成员之间通过双重通信渠道进行沟通。