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    • 7. 发明授权
    • Method and apparatus for the dissolution and filtration of a hyperpolarized agent with a neutral dissolution media
    • 用中性溶出介质溶解和过滤超极化剂的方法和装置
    • US08763410B2
    • 2014-07-01
    • US12106570
    • 2008-04-21
    • David Brandon WhittAndrew Michael LeachPeter MillerEric Telfeyan
    • David Brandon WhittAndrew Michael LeachPeter MillerEric Telfeyan
    • F25B19/00A61B5/055
    • G01R33/30G01R33/282G01R33/62
    • Methods and apparatuses that facilitate dissolving a hyperpolarized agent within a polarizer and transporting it to a receiver is provided. The methods include delivering water to a hyperpolarized agent contained within a polarizer, forming a hyperpolarized aqueous solution, transporting the aqueous solution through a fluid path system out of the polarizer, filtering the aqueous solution through a partical size exclusion filter to a receiver, and modifying the pH of the filtered hyperpolarized aquous solution with a dissolution medium contained in the receiver. Also disclosed herein are apparatuses for dissolving a hyperpolarized agent comprising a vial for containing a hyperpolarized imaging agent therein, a dissolution fluid path, a delivery fluid path, a particle size exclusion filter, and a receiver connected to the particle size exclusion filter and positioned to receive the filtered aqueous solution of the hyperpolarized imaging agent.
    • 提供了有助于将偏振器内的超极化剂溶解并将其输送到接收器的方法和装置。 所述方法包括将水输送到偏振器内所含的超极化剂,形成超极化水溶液,将水溶液通过流体路径系统输送出偏振器,将水溶液通过部分尺寸排阻滤器过滤到接受器,并修改 过滤的超极化水溶液的pH值,其中溶解介质包含在接收器中。 本文还公开了用于溶解超极化剂的装置,其包含其中含有超极化成像剂的小瓶,溶解流体路径,输送流体路径,粒度排阻过滤器和连接到粒度排阻过滤器的接收器,并且定位成 接收过滤的超极化成像剂的水溶液。