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1. 发明授权

US07312048B2 Recombinant production of novel polyketides 失效
标题翻译：重组生产新型聚酮化合物
公开(公告)号：US07312048B2
公开(公告)日：2007-12-25
申请号：US11227404
申请日：2005-09-15
申请人： Chaitan Khosla , David A. Hopwood , Susanne Ebert-Khosla , Robert McDaniel , Hong Fu , Camilla M. Kao
发明人： Chaitan Khosla , David A. Hopwood , Susanne Ebert-Khosla , Robert McDaniel , Hong Fu , Camilla M. Kao
IPC分类号： C12P1/00 , C12P7/00 , C12N1/20
CPC分类号： C07D407/06 , C07D309/36 , C07D311/92 , C07K14/36 , C12N9/93 , C12N15/52 , C12P7/26 , C12P17/06 , C12P17/162
摘要： Novel polyketides and novel methods of efficiently producing both new and known polyketides, using recombinant technology, are disclosed. In particular, a novel host-vector system is described which is used to produce polyketide synthases which in turn catalyze the production of a variety of polyketides.
摘要翻译：公开了使用重组技术有效生产新的和已知的聚酮化合物的新型聚酮化合物和新方法。特别地，描述了一种新的宿主 - 载体系统，其用于产生聚酮化合物合酶，其又催化多种聚酮化合物的产生。

2. 发明授权

US06969611B2 Methods to prepare cells comprising heterologous polyketide synthase expression systems 失效
标题翻译：制备包含异源聚酮化合物表达系统的细胞的方法
公开(公告)号：US06969611B2
公开(公告)日：2005-11-29
申请号：US09925236
申请日：2001-08-08
申请人： Chaitan Khosla , David A. Hopwood , Suzanne Ebert-Khosla , Robert McDaniel , Hong Fu , Camilla Kao
发明人： Chaitan Khosla , David A. Hopwood , Suzanne Ebert-Khosla , Robert McDaniel , Hong Fu , Camilla Kao
IPC分类号： C12N15/09 , C07D309/36 , C07D309/38 , C07D311/02 , C07D311/86 , C07D311/92 , C07D407/06 , C12N1/15 , C12N1/21 , C12N9/00 , C12N15/52 , C12P7/26 , C12P17/06 , C12P17/16 , C12R1/465 , C12N15/74
CPC分类号： C07D407/06 , C07D309/36 , C07D311/92 , C07K14/36 , C12N9/93 , C12N15/52 , C12P7/26 , C12P17/06 , C12P17/162
摘要： Novel polyketides and novel methods of efficiently producing both new and known polyketides, using recombinant technology, are disclosed. In particular, a novel host-vector system is described which is used to produce polyketide synthases which in turn catalyze the production of a variety of polyketides.
摘要翻译：公开了使用重组技术有效生产新的和已知的聚酮化合物的新型聚酮化合物和新方法。特别地，描述了一种新的宿主 - 载体系统，其用于产生聚酮化合物合酶，其又催化多种聚酮化合物的产生。

3. 发明授权

US06077696A Recombinant production of novel polyketides 有权
公开(公告)号：US06077696A
公开(公告)日：2000-06-20
申请号：US263366
申请日：1999-03-05
申请人： Chaitan Khosla , David A. Hopwood , Suzanne Ebert-Khosla , Robert McDaniel , Hong Fu , Camilla Kao
发明人： Chaitan Khosla , David A. Hopwood , Suzanne Ebert-Khosla , Robert McDaniel , Hong Fu , Camilla Kao
IPC分类号： C12N15/09 , C07B61/00 , C07D309/36 , C07D309/38 , C07D311/02 , C07D311/86 , C07D311/92 , C07D323/00 , C07D407/06 , C07H17/08 , C12N1/15 , C12N1/21 , C12N9/00 , C12N15/52 , C12P7/26 , C12P17/06 , C12P17/08 , C12P17/16 , C12R1/465 , C12P7/62 , C12P7/24
CPC分类号： C12N9/93 , C07D309/36 , C07D311/92 , C07D323/00 , C07D407/06 , C07H17/08 , C12N15/52 , C12P17/06 , C12P17/08 , C12P17/162 , C12P7/26 , C40B40/00
摘要： Novel polyketides and novel methods of efficiently producing both new and known polyketides, using recombinant technology, are disclosed. In particular, a novel host-vector system is described which is used to produce polyketide synthases which in turn catalyze the production of a variety of polyketides.

4. 发明授权

US5843718A Recombinant production of novel polyketides 失效
公开(公告)号：US5843718A
公开(公告)日：1998-12-01
申请号：US829244
申请日：1997-03-31
申请人： Chaitan Khosla , David A. Hopwood , Susanne Ebert-Khosla , Robert McDaniel , Hong Fu
发明人： Chaitan Khosla , David A. Hopwood , Susanne Ebert-Khosla , Robert McDaniel , Hong Fu
IPC分类号： C12N15/09 , C07D309/36 , C07D309/38 , C07D311/02 , C07D311/86 , C07D311/92 , C07D407/06 , C12N1/15 , C12N1/21 , C12N9/00 , C12N15/52 , C12P7/26 , C12P17/06 , C12P17/16 , C12R1/465 , C12N5/10 , C12P21/02
CPC分类号： C07D407/06 , C07D309/36 , C07D311/92 , C07K14/36 , C12N15/52 , C12N9/93 , C12P17/06 , C12P17/162 , C12P7/26
摘要： Novel polyketides and novel methods of efficiently producing both new and known polyketides, using recombinant technology, are disclosed. In particular, a novel host-vector system is described which is used to produce polyketide synthases which in turn catalyze the production of a variety of polyketides.

5. 发明授权

US06461838B2 Recombinant production of novel polyketides 失效
公开(公告)号：US06461838B2
公开(公告)日：2002-10-08
申请号：US09755653
申请日：2001-01-05
申请人： Chaitan Khosla , David A. Hopwood , Suzanne Ebert-Khosla , Robert McDaniel , Hong Fu , Camilla Kao
发明人： Chaitan Khosla , David A. Hopwood , Suzanne Ebert-Khosla , Robert McDaniel , Hong Fu , Camilla Kao
IPC分类号： C12P1934
CPC分类号： C12N9/93 , C07D309/36 , C07D311/92 , C07D323/00 , C07D407/06 , C07H17/08 , C12N15/52 , C12P7/26 , C12P17/06 , C12P17/08 , C12P17/162 , C40B40/00
摘要： Novel polyketides and novel methods of efficiently producing both new and known polyketides, using recombinant technology, are disclosed. In particular, a novel host-vector system is described which is used to produce polyketide synthases which in turn catalyze the production of a variety of polyketides.

6. 发明授权

US5712146A Recombinant combinatorial genetic library for the production of novel polyketides 失效
标题翻译：用于生产新型聚酮化合物的重组组合遗传文库
公开(公告)号：US5712146A
公开(公告)日：1998-01-27
申请号：US486645
申请日：1995-06-07
申请人： Chaitan Khosla , David A. Hopwood , Suzanne Ebert-Khosla , Robert McDaniel , Hong Fu , Camilla Kao
发明人： Chaitan Khosla , David A. Hopwood , Suzanne Ebert-Khosla , Robert McDaniel , Hong Fu , Camilla Kao
IPC分类号： C12N15/09 , C07B61/00 , C07D309/36 , C07D309/38 , C07D311/02 , C07D311/86 , C07D311/92 , C07D323/00 , C07D407/06 , C07H17/08 , C12N1/15 , C12N1/21 , C12N9/00 , C12N15/52 , C12P7/26 , C12P17/06 , C12P17/08 , C12P17/16 , C12R1/465 , C12N1/20
CPC分类号： C12N9/93 , C07D309/36 , C07D311/92 , C07D323/00 , C07D407/06 , C07H17/08 , C12N15/52 , C12P17/06 , C12P17/08 , C12P17/162 , C12P7/26 , C40B40/00
摘要： Novel polyketides and novel methods of efficiently producing both new and known polyketides, using recombinant technology, are disclosed. In particular, a novel host-vector system is described which is used to produce polyketide synthases which in turn catalyze the production of a variety of polyketides.
摘要翻译：公开了使用重组技术有效生产新的和已知的聚酮化合物的新型聚酮化合物和新方法。特别地，描述了一种新的宿主 - 载体系统，其用于产生聚酮化合物合酶，其又催化多种聚酮化合物的产生。

7. 发明授权

US06215007B1 Recombinant production of novel polyketides 失效
公开(公告)号：US06215007B1
公开(公告)日：2001-04-10
申请号：US09264162
申请日：1999-03-05
申请人： Chaitan Khosla , David A. Hopwood , Suzanne Ebert-Khosla , Robert McDaniel , Hong Fu
发明人： Chaitan Khosla , David A. Hopwood , Suzanne Ebert-Khosla , Robert McDaniel , Hong Fu
IPC分类号： C07D31500
CPC分类号： C12N9/93 , C07D309/36 , C07D311/92 , C07D323/00 , C07D407/06 , C07H17/08 , C12N15/52 , C12P7/26 , C12P17/06 , C12P17/08 , C12P17/162 , C40B40/00
摘要： Novel polyketides and novel methods of efficiently producing both new and known polyketides, using recombinant technology, are disclosed. In particular, a novel host-vector system is described which is used to produce polyketide synthases which in turn catalyze the production of a variety of polyketides.

8. 发明授权

US5672491A Recombinant production of novel polyketides 失效
标题翻译：重组生产新型聚酮化合物
公开(公告)号：US5672491A
公开(公告)日：1997-09-30
申请号：US238811
申请日：1994-05-06
申请人： Chaitan Khosla , David A. Hopwood , Suzanne Ebert-Khosla , Robert McDaniel , Hong Fu , Camilla Kao
发明人： Chaitan Khosla , David A. Hopwood , Suzanne Ebert-Khosla , Robert McDaniel , Hong Fu , Camilla Kao
IPC分类号： C12N15/09 , C07D309/36 , C07D309/38 , C07D311/02 , C07D311/86 , C07D311/92 , C07D407/06 , C12N1/15 , C12N1/21 , C12N9/00 , C12N15/52 , C12P7/26 , C12P17/06 , C12P17/16 , C12P19/62 , C12R1/465 , C12N15/63 , C12P19/34
CPC分类号： C07D407/06 , C07D309/36 , C07D311/92 , C12N15/52 , C12N9/93 , C12P17/06 , C12P17/162 , C12P19/62 , C12P7/26
摘要： Novel polyketides and novel methods of efficiently producing both new and known polyketides, using recombinant technology, are disclosed. In particular, a novel host-vector system is described which is used to produce polyketide synthases which in turn catalyze the production of a variety of polyketides.
摘要翻译：公开了使用重组技术有效生产新的和已知的聚酮化合物的新型聚酮化合物和新方法。特别地，描述了一种新的宿主 - 载体系统，其用于产生聚酮化合物合酶，其又催化多种聚酮化合物的产生。

9. 发明授权

US5830750A Recombinant production of novel polyketides 失效
公开(公告)号：US5830750A
公开(公告)日：1998-11-03
申请号：US828887
申请日：1997-03-31
申请人： Chaitan Khosla , David A. Hopwood , Suzanne Ebert-Khosla
发明人： Chaitan Khosla , David A. Hopwood , Suzanne Ebert-Khosla
IPC分类号： C12N15/09 , C07D309/36 , C07D309/38 , C07D311/02 , C07D311/86 , C07D311/92 , C07D407/06 , C12N1/15 , C12N1/21 , C12N9/00 , C12N15/52 , C12P7/26 , C12P17/06 , C12P17/16 , C12R1/465 , C12N5/10
CPC分类号： C07D407/06 , C07D309/36 , C07D311/92 , C07K14/36 , C12N15/52 , C12N9/93 , C12P17/06 , C12P17/162 , C12P7/26
摘要： Novel polyketides and novel methods of efficiently producing both new and known polyketides, using recombinant technology, are disclosed. In particular, a novel host-vector system is described which is used to produce polyketide synthases which in turn catalyze the production of a variety of polyketides.

10. 发明授权

US4360597A Streptomyces plasmid and culture 失效
标题翻译：链霉菌质粒和培养物
公开(公告)号：US4360597A
公开(公告)日：1982-11-23
申请号：US190322
申请日：1980-01-24
申请人： Mervyn J. Bibb , David A. Hopwood
发明人： Mervyn J. Bibb , David A. Hopwood
IPC分类号： C12P19/34 , C12N1/20 , C12N15/00 , C12N15/09 , C12N15/76 , C12N1/00 , C12N1/02 , C12Q1/04
CPC分类号： C12N15/76
摘要： Novel Streptomyces plasmids have the characteristic that their presence in non-integrated form in a micro-organism of the species Streptomyces lividans confers on that micro-organism the properties (a) of forming "pocks" when grown on a "lawn" of that strain of micro-organism deposited with the National Collection of Industrial Bacteria (NCIB) under the reference number 11416, and (b) of not forming "pocks" when grown on a "lawn" of that strain of micro-organism deposited with the NCIB under the reference number 11417, or which is derivable from a plasmid having such a characteristic by the removal or addition of DNA therefrom.The plasmids are prepared from micro-organisms containing them or by the manipulation of other plasmids of the group and are of value as vectors for the introduction of nucleic acid into micro-organisms.
摘要翻译： PCT No.PCT / GB79 / 00095 Sec。 371日期1980年1月24日 102（e）日期1980年1月24日PCT申请1979年6月1日PCT公布。出版物WO79 / 01169 日期：1979年12月27日。新型链霉菌质粒具有这样的特征：它们在物种链霉菌属（Streptomyces lividans）的微生物中以非整合形式的存在赋予该微生物在生长时形成“痘”的性质（a）在“参考编号11416”的国家工业细菌收集库（NCIB）上保藏的该微生物菌株的“草坪”，和（b）当在该微生物菌株的“草坪”上生长时不形成“痘苗” - 以参考号11417保藏在NCIB中的有机物，或者可通过从其中除去或添加DNA而具有这种特征的质粒衍生。质粒由含有它们的微生物或通过操作该组的其它质粒制备，并且作为用于将核酸引入微生物的载体是有价值的。

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