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1. 发明申请

US20060083691A1 Intranasal opioid compositions, delivery devices and methods of using same 审中-公开
标题翻译：鼻内阿片样物质组合物，递送装置及其使用方法
公开(公告)号：US20060083691A1
公开(公告)日：2006-04-20
申请号：US11243613
申请日：2005-10-05
申请人： Daniel Wermeling
发明人： Daniel Wermeling
IPC分类号： A61L9/04 , A61M11/00
CPC分类号： A61M15/0045 , A61K9/0043 , A61K31/00 , A61K31/485 , A61K31/55 , A61M15/08
摘要： The present invention relates to pharmaceutical compositions comprising opioids and a liquid nasal carrier, to delivery devices comprising such compositions, and to methods of manufacture and use of such compositions.
摘要翻译：本发明涉及包含阿片样物质和液体鼻载体的药物组合物，包含这种组合物的递送装置，以及制备和使用该组合物的方法。

2. 发明申请

US20060147386A1 System and method for intranasal administration of lorazepam 审中-公开
公开(公告)号：US20060147386A1
公开(公告)日：2006-07-06
申请号：US11376979
申请日：2006-03-16
申请人： Daniel Wermeling
发明人： Daniel Wermeling
IPC分类号： A61L9/04
CPC分类号： A61K31/55 , A61K9/0043 , A61K31/485 , A61K47/10
摘要： A therapeutic composition of lorazepam and its pharmaceutically acceptable derivatives are provided for intranasal administration of at least one predetermined volumetric unit dose in the form of a spray by means that delivers one or more therapeutically prescribed unit doses that are highly accurate as to the volume discharged and which leave no significant quantity of the composition in the delivery means.

3. 发明申请

US20100113495A1 PHARMACEUTICAL COMPOSITIONS COMPRISING AN OPIOID RECEPTOR ANTAGONIST AND METHODS OF USING SAME 审中-公开
标题翻译：包含阿片受体拮抗剂的药物组合物及其使用方法
公开(公告)号：US20100113495A1
公开(公告)日：2010-05-06
申请号：US12477390
申请日：2009-06-03
申请人： Daniel Wermeling , Edwin A. Cohen , Anita C. Rudy
发明人： Daniel Wermeling , Edwin A. Cohen , Anita C. Rudy
IPC分类号： A61K31/485 , A61P25/32
CPC分类号： A61K9/0043 , A61K31/485
摘要： The present invention features compositions for intranasal administration comprising an opioid receptor antagonist. The invention also features methods of using such compositions in the treatment of various diseases and disorders, such as the treatment of alcoholism. In certain embodiments, the opioid receptor antagonist is naltrexone or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明的特征在于包含阿片受体拮抗剂的用于鼻内给药的组合物。本发明还涉及使用这些组合物治疗各种疾病和病症（例如酒精中毒治疗）的方法。在某些实施方案中，阿片受体拮抗剂是纳曲酮或其药学上可接受的盐。

4. 发明申请

US20060039869A1 Intranasal delivery of antipsychotic drugs 审中-公开
标题翻译：鼻内递送抗精神病药
公开(公告)号：US20060039869A1
公开(公告)日：2006-02-23
申请号：US10920153
申请日：2004-08-17
申请人： Daniel Wermeling , Jodi Miller
发明人： Daniel Wermeling , Jodi Miller
IPC分类号： A61K9/14 , A61K31/445 , A61L9/04
CPC分类号： A61K9/0043 , A61K9/08 , A61K31/445
摘要： An intranasal drug product is provided including an antipsychotic drug, such as haloperidol, in sprayable solution in an intranasal metered dose sprayer. Also provided is a method of administering an antipsychotic drug, such as haloperidol, to a patient, including the step of delivering an effective amount of the antipsychotic drug to a patient intranasally using an intranasal metered dose sprayer. A method of treating a psychotic episode also is provided, the method including the step of delivering an antipsychotic drug, such as haloperidol, intranasally in an amount effective to control the psychotic episode.
摘要翻译：提供鼻内药物产品，其包括抗精神病药物，例如氟哌啶醇，在鼻内计量剂量喷雾器中的可喷雾溶液中。还提供了向患者施用抗精神病药物（例如氟哌啶醇）的方法，包括使用鼻内计量剂量喷雾器鼻内递送有效量的抗精神病药物给患者的步骤。还提供了治疗精神病发作的方法，所述方法包括以有效控制精神病发作的量鼻内递送抗精神病药物（例如氟哌啶醇）的步骤。

5. 发明申请

US20080004305A1 Intranasal Opioid Compositions 审中-公开
标题翻译：鼻内阿片类药物
公开(公告)号：US20080004305A1
公开(公告)日：2008-01-03
申请号：US11674803
申请日：2007-02-14
申请人： Daniel Wermeling
发明人： Daniel Wermeling
IPC分类号： A61K31/485 , A61P25/04
CPC分类号： A61K31/55 , A61K9/0043 , A61K31/485
摘要： The present invention relates to pharmaceutical compositions for intranasal administration to a mammal that contain an effective amount of an opioid, a liquid nasal carrier for the opioid, and optionally a sweetener, flavoring agent or masking agent. In some embodiments of the present invention, the pharmaceutical compositions have improved bioavailability. In other embodiments of the present invention, the opioid compositions improve patient compliance.
摘要翻译：本发明涉及鼻内给予哺乳动物的药物组合物，其含有有效量的阿片样物质，用于阿片样物质的液体鼻载体，以及任选的甜味剂，调味剂或掩蔽剂。在本发明的一些实施方案中，药物组合物具有改善的生物利用度。在本发明的其它实施方案中，阿片样物质组合物改善患者依从性。

6. 发明申请

US20070071687A1 INTRANASAL BENZODIAZEPINE COMPOSITIONS 审中-公开
标题翻译：国内苯并噻唑类组合物
公开(公告)号：US20070071687A1
公开(公告)日：2007-03-29
申请号：US11457403
申请日：2006-07-13
申请人： Daniel Wermeling
发明人： Daniel Wermeling
IPC分类号： A61K31/5513 , A61K9/12
CPC分类号： A61K9/0043 , A61K31/55 , A61K47/10
摘要： A pharmaceutical composition for intranasal administration to a mammal. The pharmaceutical composition comprises an effective amount of a benzodiazepine or pharmaceutically acceptable salt thereof; and a nasal carrier. In some embodiments, the pharmaceutical composition when administered intranasally produces a rapid physiological response. Pharmaceutical compositions may also include at least one or more sweeteners, flavoring agents, or masking agents or combinations thereof.
摘要翻译：一种用于鼻内给予哺乳动物的药物组合物。药物组合物包含有效量的苯并二氮杂或其药学上可接受的盐; 和鼻载体。在一些实施方案中，药物组合物在鼻内施用时会产生快速的生理反应。药物组合物还可以包括至少一种或多种甜味剂，调味剂或掩蔽剂或其组合。

7. 发明申请

US20070060639A1 Compositions and methods for intranasal delivery of tricyclic cannabinoids 审中-公开
标题翻译：用于鼻内输送三环大麻素的组合物和方法
公开(公告)号：US20070060639A1
公开(公告)日：2007-03-15
申请号：US11515607
申请日：2006-09-05
申请人： Daniel Wermeling
发明人： Daniel Wermeling
IPC分类号： A61K31/353
CPC分类号： A61K9/0043 , A61K31/00 , A61K31/353
摘要： A pharmaceutical composition for intranasal administration to a human or non-human subject is provided, comprising a therapeutically active component that comprises at least one tricyclic cannabinoid in a liquid to semi-solid medium that comprises a pharmaceutically acceptable solubilizing agent in an amount effective to solubilize the cannabinoid. An amount of the composition intranasally administrable as a single dose, upon intranasal administration in a rat model, provides a systemic plasma cannabinoid concentration (i) that, at least at one time point during a period from about 15 minutes to about 2 hours after said administration, is at least about 0.5 ng/ml, but (ii) that at no time exceeds about 100 ng/ml.
摘要翻译：提供了一种用于向人或非人受试者鼻内施用的药物组合物，其包含治疗活性成分，所述治疗活性成分在液体至半固体培养基中包含至少一种三环类大麻素，所述药物组合物包含有效溶解量的药学上可接受的增溶剂大麻素。在大鼠模型中鼻内给药时，鼻内给药作为单一剂量的组合物的量提供全身性血浆大麻素浓度（i）至少在所述第一个时间点之后约15分钟至约2小时的时间点至少约0.5ng / ml，但（ii）在任何时候超过约100ng / ml。

8. 发明授权

US08198291B2 Intranasal opioid compositions 有权
标题翻译：鼻内阿片样物质组成
公开(公告)号：US08198291B2
公开(公告)日：2012-06-12
申请号：US12755691
申请日：2010-04-07
申请人： Daniel Wermeling
发明人： Daniel Wermeling
IPC分类号： A01N43/42 , A61K31/44
CPC分类号： A61K31/55 , A61K9/0043 , A61K31/485
摘要： The present invention relates to pharmaceutical compositions for intranasal administration to a mammal that contain an effective amount of an opioid, a liquid nasal carrier for the opioid, and optionally a sweetener, flavoring agent or masking agent. In some embodiments of the present invention, the pharmaceutical compositions have improved bioavailability. In other embodiments of the present invention, the opioid compositions improve patient compliance.
摘要翻译：本发明涉及鼻内给予哺乳动物的药物组合物，其含有有效量的阿片样物质，用于阿片样物质的液体鼻载体，以及任选的甜味剂，调味剂或掩蔽剂。在本发明的一些实施方案中，药物组合物具有改善的生物利用度。在本发明的其它实施方案中，阿片样物质组合物改善患者依从性。

9. 发明申请

US20070212307A1 Pharmaceutical Compositions Comprising an Opioid Receptor Antagonist and Methods of Using Same 审中-公开
标题翻译：包含阿片受体拮抗剂的药物组合物及其使用方法
公开(公告)号：US20070212307A1
公开(公告)日：2007-09-13
申请号：US11673874
申请日：2007-02-12
申请人： Daniel Wermeling , Edwin Cohen , Anita Rudy
发明人： Daniel Wermeling , Edwin Cohen , Anita Rudy
IPC分类号： A61K31/485 , A61K9/12
CPC分类号： A61K9/0043 , A61K31/485
摘要： The present invention features compositions for intranasal administration comprising an opioid receptor antagonist. The invention also features methods of using such compositions in the treatment of various diseases and disorders, such as the treatment of alcoholism. In certain embodiments, the opioid receptor antagonist is naltrexone or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明的特征在于包含阿片受体拮抗剂的用于鼻内给药的组合物。本发明还涉及使用这些组合物治疗各种疾病和病症（例如酒精中毒治疗）的方法。在某些实施方案中，阿片受体拮抗剂是纳曲酮或其药学上可接受的盐。

10. 发明申请

US20070209660A1 Intranasal Opioid Compositions, Delivery Devices and Methods of Using Same 审中-公开
标题翻译：鼻内阿片类药物组合物，输送装置及其使用方法
公开(公告)号：US20070209660A1
公开(公告)日：2007-09-13
申请号：US11674787
申请日：2007-02-14
申请人： Daniel Wermeling
发明人： Daniel Wermeling
IPC分类号： A61M11/00 , A61K31/00
CPC分类号： A61M15/0045 , A61K9/0043 , A61K31/00 , A61K31/485 , A61K31/55 , A61M15/08
摘要： The present invention relates to pharmaceutical compositions comprising opioids and a liquid nasal carrier, to delivery devices comprising such compositions, and to methods of manufacture and use of such compositions.
摘要翻译：本发明涉及包含阿片样物质和液体鼻载体的药物组合物，包含这种组合物的递送装置，以及制备和使用该组合物的方法。

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