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    • 7. 发明申请
    • B-LYMPHOCYTE STIMULATOR BINDING POLYPEPTIDES AND METHODS BASED THEREON
    • B-LYMPHOCYTE刺激物结合聚合物及其方法
    • US20100144058A1
    • 2010-06-10
    • US12701301
    • 2010-02-05
    • James P. BeltzerM. Daniel PotterTony J. FlemingCraig A. Rosen
    • James P. BeltzerM. Daniel PotterTony J. FlemingCraig A. Rosen
    • G01N33/53C07K7/08C07K14/00C07K16/00
    • C07K7/08A61K38/00A61K39/00C07K14/70578C07K14/7151C07K2319/00
    • Binding polypeptides that specifically bind B lymphocyte stimulator protein or B lymphocyte stimulator-like polypeptides can be used in methods of the invention for detecting, diagnosing, or prognosing a disease or disorder associated with aberrant B lymphocyte stimulator or B lymphocyte stimulator receptor expression or inappropriate function of B lymphocyte stimulator or B lymphocyte stimulator receptor, comprising B lymphocyte stimulator binding polypeptides or fragments or variants thereof, that specifically bind to B lymphocyte stimulator. The present invention further relates to methods and compositions for preventing, treating or ameliorating a disease or disorder associated with aberrant B lymphocyte stimulator or B lymphocyte stimulator receptor expression or inappropriate B lymphocyte stimulator function or B lymphocyte stimulator receptor function, comprising administering to an animal, preferably a human, an effective amount of one or more B lymphocyte stimulator binding polypeptides or fragments or variants thereof, that specifically bind to B lymphocyte stimulator.
    • 特异性结合B淋巴细胞刺激物蛋白或B淋巴细胞刺激物样多肽的结合多肽可用于本发明的用于检测,诊断或预测与异常B淋巴细胞刺激物或B淋巴细胞刺激受体表达或不适当功能相关的疾病或病症的方法 B淋巴细胞刺激剂或B淋巴细胞刺激物受体,其包含特异性结合B淋巴细胞刺激物的B淋巴细胞刺激物结合多肽或其片段或变体。 本发明还涉及用于预防,治疗或改善与异常B淋巴细胞刺激剂或B淋巴细胞刺激剂受体表达或不适当的B淋巴细胞刺激物功能或B淋巴细胞刺激因子受体功能相关的疾病或病症的方法和组合物,其包括向动物, 优选人,有效量的一种或多种B淋巴细胞刺激剂结合多肽或其片段或变体,其特异性结合B淋巴细胞刺激物。
    • 8. 发明申请
    • Splittable cannula having radiopaque marker
    • 具有不透射线标记的可分离插管
    • US20050149060A1
    • 2005-07-07
    • US11052617
    • 2005-02-04
    • Chad ThorstensonRichard StehrOmar AmiranaDaniel Potter
    • Chad ThorstensonRichard StehrOmar AmiranaDaniel Potter
    • A61M25/01A61M25/06A61F11/00
    • A61M25/0108A61M25/0668
    • A splittable cannula includes a radiopaque marker placed at or near the distal end of the cannula. The radiopaque marker may be a unitary piece, or may consist of several portions. The cannula may include a sheath or catheter body with a grooved score line running along a portion of the sheath body and a radiopaque marker located at a distal end of the body and abutting the body. The radiopaque marker may be located within the lumen of the sheath, may be embedded in the sheath wall, or may be affixed to the external sheath wall. The radiopaque marker may be scored, notched, grooved, or contain apertures longitudinally. The notches, grooves, apertures, and/or score lines in both the sheath or catheter body and the radiopaque marker serve to provide a weakened tear path. An electrode lead may be coupled with the radiopaque marker.
    • 可分开的插管包括放置在插管的远端处或附近的不透射线的标记。 不透射线的标记可以是整体的,或者可以由几个部分组成。 插管可以包括护套或导管主体,其具有沿护套主体的一部分延伸的开槽刻痕线和位于主体的远端并且抵靠身体的不透射线标记。 不透射线的标记可以位于护套的内腔内,可以嵌入鞘壁中,或者可以固定到外护套壁。 不透射线的标记可以被刻痕,切口,开槽或纵向包含孔。 鞘或导管主体和不透射线标记中的凹口,凹槽,孔和/或刻痕线用于提供弱化的撕裂路径。 电极引线可以与不透射线的标记物结合。