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1. 发明授权

US08425878B2 Plasma membrane biomarkers preferentially expressed in pancreatic beta cells useful in imaging or targeting beta cells 有权
标题翻译：血浆膜生物标志物优先在用于成像或靶向β细胞的胰腺β细胞中表达
公开(公告)号：US08425878B2
公开(公告)日：2013-04-23
申请号：US12735731
申请日：2009-02-13
申请人： Decio L. Eizirik , Daisy Flamez , Isabelle Salmon , Alix Berton , Isabelle Roland , Daniel Marechal , Marie-Claire Beckers , Leroy Hood , Nathan Goodman , Burak Kutlu
发明人： Decio L. Eizirik , Daisy Flamez , Isabelle Salmon , Alix Berton , Isabelle Roland , Daniel Marechal , Marie-Claire Beckers , Leroy Hood , Nathan Goodman , Burak Kutlu
IPC分类号： A61K49/00
CPC分类号： G01N33/573 , C07K14/705 , G01N33/57438 , G01N2800/042
摘要： The present invention is directed to the identification of a biomarker specifically located in the plasma membrane of pancreatic beta cells. It was selected by a Systems Biology approach on Massively Parallel Signal Sequencing datasets obtained in human islets and Affymetrix microarray datasets on human islets, purified rat primary beta and non beta cells and insulinoma cells. Based on a set of specific features the biomarker is a unique candidate for imaging and targeting strategies to study the pancreatic beta cell mass in health and disease (T1 D, T2D, pancreatic cancers, obesity, islet transplantation, beta cell regeneration). The five specific features of the selected biomarkers are: 1) Preferentially expressed in pancreatic islets as compared to surrounding tissues; 2) Higher expression in pancreatic beta cells than in pancreatic alpha cells or than in other islet non-beta cells; 3) Expression levels in pancreatic beta cells are higher or comparable to glucokinase which is an enzyme specifically expressed in the pancreatic beta cell; 4) Located in the membrane and as such targetable with antibodies, peptides or small molecules which allows imaging, targeting and immunohistochemistry; and 5) Expression is not induced during the process of inflammation of the beta cell mass and the protein is not enriched in T-cells and dendritic cells or in other cells participating in the inflammation process.
摘要翻译：本发明涉及特异性位于胰β细胞质膜中的生物标志物的鉴定。它是通过系统生物学方法在人胰岛获得的大规模并行信号测序数据集和人胰岛，纯化的大鼠原代β和非β细胞和胰岛素瘤细胞的Affymetrix微阵列数据集中选择的。基于一组具体特征，生物标志物是研究胰腺β细胞在健康和疾病（T1D，T2D，胰腺癌，肥胖，胰岛移植，β细胞再生）中成像和靶向策略的独特候选。所选生物标志物的五个特征是：1）与周围组织相比，胰岛中优先表达; 2）胰腺β细胞中的表达高于胰腺α细胞或其他胰岛β细胞; 3）胰腺β细胞中的表达水平较高，或与胰腺β细胞特异性表达的酶的葡萄糖激酶相当; 4）位于膜中并且因此可靶向抗体，肽或小分子，其允许成像，靶向和免疫组织化学; 和5）在β细胞质量的炎症过程中不诱导表达，并且蛋白质不富含T细胞和树突状细胞或参与炎症过程的其它细胞中。

2. 发明申请

US20050112572A1 Process for the detection of oxidative stress and kit for its implementation 有权
标题翻译：检测氧化应激的过程及其实施工具包
公开(公告)号：US20050112572A1
公开(公告)日：2005-05-26
申请号：US10487091
申请日：2002-08-13
申请人： Joel Pincemail , Jacques Piette , Daniel Marechal
发明人： Joel Pincemail , Jacques Piette , Daniel Marechal
IPC分类号： C12N15/10 , C12Q1/68 , G01N33/53 , G01N33/537 , G01N33/543
CPC分类号： C12N15/1034 , C12Q1/6876 , C12Q1/6883 , C12Q2600/158
摘要： The present invention relates to a process for detecting oxidative stress in a sample and to a kit for this implementation. According to one embodiment the present invention provides a method for the detection of oxidative stress in an individual carrying a risk factor for oxidative stress comprising determining the risk factor for oxidative stress of said individual; selecting at least two oxidative stress markers being increased or decreased for said risk factor relative to healthy individuals; and measuring the amount of said at least two oxidative stress markers in a sample obtained from said individual.
摘要翻译：本发明涉及一种用于检测样品中氧化应激的方法和用于该实施的试剂盒。根据一个实施方案，本发明提供了一种检测携带氧化应激危险因素的个体的氧化应激的方法，包括确定所述个体的氧化应激的危险因素; 选择至少两种相对于健康个体的所述风险因子增加或减少的氧化应激标记物; 以及测量从所述个体获得的样品中所述至少两种氧化应激标记物的量。

3. 发明申请

US20100322850A1 NEW PLASMA MEMBRANE BIOMARKERS PREFERENTIALLY EXPRESSED IN PANCREATIC BETA CELLS USEFUL IN IMAGING OR TARGETING BETA CELLS 有权
标题翻译：新型等离子体膜生物标志物优于在胰腺癌细胞中表达，有用于成像或靶向细胞
公开(公告)号：US20100322850A1
公开(公告)日：2010-12-23
申请号：US12735731
申请日：2009-02-13
申请人： Decio L. Eizirik , Daisy Flamez , Isabelle Salmon , Alix Berton , Isabelle Roland , Daniel Marechal , Marie-Claire Beckers , Leroy Hood , Nathan Goodman , Burak Kutlu
发明人： Decio L. Eizirik , Daisy Flamez , Isabelle Salmon , Alix Berton , Isabelle Roland , Daniel Marechal , Marie-Claire Beckers , Leroy Hood , Nathan Goodman , Burak Kutlu
IPC分类号： A61K51/00 , C12Q1/02 , G01N33/53 , C07K16/40 , A61K49/00 , A61B5/055 , C12N5/071 , C12N13/00
CPC分类号： G01N33/573 , C07K14/705 , G01N33/57438 , G01N2800/042
摘要： The present invention is directed to the identification of a biomarker specifically located in the plasma membrane of pancreatic beta cells. It was selected by a Systems Biology approach on Massively Parallel Signal Sequencing datasets obtained in human islets and Affymetrix microarray datasets on human islets, purified rat primary beta and non beta cells and insulinoma cells. Based on a set of specific features the biomarker is a unique candidate for imaging and targeting strategies to study the pancreatic beta cell mass in health and disease (T1 D, T2D, pancreatic cancers, obesity, islet transplantation, beta cell regeneration). The five specific features of the selected biomarkers are: 1) Preferentially expressed in pancreatic islets as compared to surrounding tissues; 2) Higher expression in pancreatic beta cells than in pancreatic alpha cells or than in other islet non-beta cells; 3) Expression levels in pancreatic beta cells are higher or comparable to glucokinase which is an enzyme specifically expressed in the pancreatic beta cell; 4) Located in the membrane and as such targetable with antibodies, peptides or small molecules which allows imaging, targeting and immunohistochemistry; and 5) Expression is not induced during the process of inflammation of the beta cell mass and the protein is not enriched in T-cells and dendritic cells or in other cells participating in the inflammation process.
摘要翻译：本发明涉及特异性位于胰β细胞质膜中的生物标志物的鉴定。它是通过系统生物学方法在人胰岛获得的大规模并行信号测序数据集和人胰岛，纯化的大鼠原代β和非β细胞和胰岛素瘤细胞的Affymetrix微阵列数据集中选择的。基于一组具体特征，生物标志物是研究胰腺β细胞在健康和疾病（T1D，T2D，胰腺癌，肥胖，胰岛移植，β细胞再生）中成像和靶向策略的独特候选。所选生物标志物的五个特征是：1）与周围组织相比，胰岛中优先表达; 2）胰腺β细胞中的表达高于胰腺α细胞或其他胰岛β细胞; 3）胰腺β细胞中的表达水平较高，或与胰腺β细胞特异性表达的酶的葡萄糖激酶相当; 4）位于膜中并且因此可靶向抗体，肽或小分子，其允许成像，靶向和免疫组织化学; 和5）在β细胞质量的炎症过程中不诱导表达，并且蛋白质不富含T细胞和树突状细胞或参与炎症过程的其它细胞中。

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