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    • 4. 发明申请
    • Dental modeling and articulating system and method
    • 牙科建模与关节系统及方法
    • US20060210944A1
    • 2006-09-21
    • US11361835
    • 2006-02-24
    • Yunoh JungDaniel Jung
    • Yunoh JungDaniel Jung
    • A61C11/00A61C19/00
    • A61C11/08A61C9/002
    • A dental articulating system to duplicate a patient's teeth for producing a dental prosthesis includes a pair of trays pivotally coupled together. A plurality of registration pins is disposable in a plurality of registration pin holes formed in at least one of the trays. A thin cover is disposed across a registration pin hole to close off the registration pin hole and resist dental casting material from substantially filling the registration pin hole. The thin cover is breakable by a registration pin inserted into the registration pin hole. A stop rod opening can be formed in a tray base or model base adjacent the hinge end. A posterior stop rod can be slidable into and securably disposable in the stop rod opening. The stop rod can have an end configured to provide a physical stop between the model bases to retain a desired occlusal relationship between the model bases.
    • 用于复制患者牙齿以产生牙科假体的牙科关节系统包括枢转地联接在一起的一对托盘。 多个配准销在多个配置销孔中是一次性的,形成在至少一个托盘中。 薄的盖子跨越配准销孔设置以封闭对准销孔并抵抗基本上填充对准销孔的牙科铸造材料。 薄盖可以通过插入对位销孔的对位销来破坏。 止动杆开口可以形成在邻近铰链端的托盘底座或模型底座中。 后停止杆可以在止动杆开口中滑动并可固定地一次性。 止动杆可以具有构造为在模型基座之间提供物理停止的端部,以在模型基座之间保持期望的咬合关系。
    • 5. 发明授权
    • &dgr;-sarcoglycan antibodies
    • δ-糖聚糖抗体
    • US06211340B1
    • 2001-04-03
    • US09119827
    • 1998-07-21
    • Kevin P. CampbellDaniel JungFranck DuclosVolker StraubJohn McPherson
    • Kevin P. CampbellDaniel JungFranck DuclosVolker StraubJohn McPherson
    • C07K1618
    • C07K14/4707
    • Disclosed herein is a substantially pure nucleic acid sequence encoding a mammalian 35 kDa non-dystrophin component (&dgr;-sarcoglycan) of the dystrophin-glycoprotein complex. Also disclosed are the amino acid sequence and an immunogenic peptide of &dgr;-sarcoglycan. The peptide when used to immunize a mammal, stimulates the production of antibodies which bind specifically to the &dgr;-sarcoglycan. Methods to identify mutations in the &dgr;-sarcoglycan gene associated with autosomal recessive limb-girdle muscular dystrophy are also disclosed. The identification of such mutations enables the design of nucleic acid probes which hybridize specifically to a mutant form of &dgr;-sarcoglycan, or the complement thereof, but not to the DNA of the wild-type form of the gene (or the complement thereof), under stringent hybridization conditions. Such probes are useful, for example, in connection with the diagnosis of autosomal recessive limb-girdle muscular dystrophy. In addition, the identification of such mutations enables the diagnosis of autosomal recessive limb-girdle muscular dystrophy through the use of direct DNA sequencing techniques.
    • 本文公开了编码肌营养不良蛋白 - 糖蛋白复合物的哺乳动物35kDa非肌营养不良蛋白成分(δ-莽草酸)的基本上纯的核酸序列。 还公开了δ-色氨酸的氨基酸序列和免疫原性肽。 当肽用于免疫哺乳动物时,刺激产生与δ-糖聚糖特异性结合的抗体。 还公开了鉴定与常染色体隐性遗传性肢体肌营养不良症相关的δ-色氨酸聚糖基因突变的方法。 这种突变的鉴定使得能够设计特异性地与δ-色氨酸聚糖或其互补体的突变形式杂交的核酸探针,而不与野生型形式的基因(或其互补物)的DNA杂交, 在严格的杂交条件下。 这样的探针可用于例如与常染色体隐性性腰带肌营养不良症的诊断有关。 此外,通过使用直接DNA测序技术,鉴定这种突变能够诊断常染色体隐性的腰带肌营养不良症。
    • 7. 发明申请
    • Dental modeling and articulating system and method
    • 牙科建模与关节系统及方法
    • US20060216667A1
    • 2006-09-28
    • US11361853
    • 2006-02-24
    • Yunoh JungDaniel Jung
    • Yunoh JungDaniel Jung
    • A61C11/00
    • A61C9/002
    • A dental articulating system configured to duplicate at least a portion of a patient's mouth for use in producing a dental prosthesis includes a tray base and a plate magnetically coupleable together. A magnet recess is carried by either the tray base or the plate, and a ferrous recess is carried by the other of the tray base or the plate. The magnet recess receiving a magnet element therein and the ferrous recess receiving a ferrous element therein. The magnet recess having a magnet opening configured to receive the magnet therethrough, the magnet opening facing away from the ferrous recess so that at least a lip is disposed between the magnet recess and the ferrous recess.
    • 构造成复制用于制造牙科假体的患者口腔的至少一部分的牙科关节运动系统包括托盘基座和可磁耦合在一起的板。 磁盘凹槽由托架底座或板托架承载,并且铁质凹槽由托架底座或板中的另一个承载。 磁体凹部在其中容纳磁性元件,并且铁质凹部在其中容纳铁元素。 所述磁体凹部具有构造成容纳磁体的磁体开口,所述磁体开口背离所述铁质凹部,使得至少一个唇缘设置在所述磁体凹部和所述铁质凹部之间。
    • 8. 发明授权
    • .delta.-sarcoglycan nucleic acid sequences
    • δ-聚糖核酸序列
    • US5837537A
    • 1998-11-17
    • US719758
    • 1996-09-25
    • Kevin P. CampbellDaniel JungFranck DuclosVolker StraubJohn McPherson
    • Kevin P. CampbellDaniel JungFranck DuclosVolker StraubJohn McPherson
    • C07K14/47C12N15/12C12N15/63C12N15/85
    • C07K14/4707
    • Disclosed herein is a substantially pure nucleic acid sequence encoding a mammalian 35 kDa non-dystrophin component (.delta.-sarcoglycan) of the dystrophin-glycoprotein complex. Also disclosed are the amino acid sequence and an immunogenic peptide of .delta.-sarcoglycan. The peptide when used to immunize a mammal, stimulates the production of antibodies which bind specifically to the .delta.-sarcoglycan. Methods to identify mutations in the .delta.-sarcoglycan gene associated with autosomal recessive limb-girdle muscular dystrophy are also disclosed. The identification of such mutations enables the design of nucleic acid probes which hybridize specifically to a mutant form of .delta.-sarcoglycan, or the complement thereof, but not to the DNA of the wild-type form of the gene (or the complement thereof), under stringent hybridization conditions. Such probes are useful, for example, in connection with the diagnosis of autosomal recessive limb-girdle muscular dystrophy. In addition, the identification of such mutations enables the diagnosis of autosomal recessive limb-girdle muscular dystrophy through the use of direct DNA sequencing techniques.
    • 本文公开了编码肌营养不良蛋白 - 糖蛋白复合物的哺乳动物35kDa非肌营养不良蛋白成分(δ-聚糖)的基本上纯的核酸序列。 还公开了δ-聚糖的氨基酸序列和免疫原性肽。 当肽用于免疫哺乳动物时,刺激产生与δ-聚糖结合特异性的抗体。 还公开了鉴定与常染色体隐性遗传性肢体肌营养不良症相关的δ-聚糖基因突变的方法。 这种突变的鉴定使得能够设计与δ-聚糖或其互补体的突变形式特异性杂交的核酸探针,而不与野生型形式的基因(或其补体)的DNA杂交, 在严格的杂交条件下。 这样的探针可用于例如与常染色体隐性性腰带肌营养不良症的诊断有关。 此外,通过使用直接DNA测序技术,鉴定这种突变能够诊断常染色体隐性的腰带肌营养不良症。