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1. 发明申请

US20150050216A1 Uses and Compositions for Treatment of Psoriasis 审中-公开
标题翻译：用于治疗牛皮癣的用途和组成
公开(公告)号：US20150050216A1
公开(公告)日：2015-02-19
申请号：US14326061
申请日：2014-07-08
申请人： Mary Kaye Willian , Martin M. Okun , Rebecca S. Hoffman , Yihua Gu , Lisa E. Melilli , Kenneth B. Gordon , Subhashis Banerjee , Lori K. Taylor , Daniel E. Tracey , Elliot K. Chartash , William T. Barchuk , Philip Yan , Anwar Murtaza , Jochen G. Salfeld , Steven A. Fischkoff , George R. Granneman
发明人： Mary Kaye Willian , Martin M. Okun , Rebecca S. Hoffman , Yihua Gu , Lisa E. Melilli , Kenneth B. Gordon , Subhashis Banerjee , Lori K. Taylor , Daniel E. Tracey , Elliot K. Chartash , William T. Barchuk , Philip Yan , Anwar Murtaza , Jochen G. Salfeld , Steven A. Fischkoff , George R. Granneman
IPC分类号： C07K16/24
CPC分类号： C07K16/241 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K2317/21 , C07K2317/76 , Y02A50/388
摘要： The invention provides methods, uses and compositions for the treatment of psoriasis. The invention describes methods and uses for treating psoriasis, wherein a TNFα inhibitor, such as a human TNFα antibody, or antigen-binding portion thereof, is used to treat psoriasis in a subject. Also described are methods for determining the efficacy of a TNFα inhibitor for treatment psoriasis in a subject.
摘要翻译：本发明提供治疗牛皮癣的方法，用途和组合物。本发明描述了用于治疗牛皮癣的方法和用途，其中使用TNFα抑制剂，例如人TNFα抗体或其抗原结合部分来治疗受试者的牛皮癣。还描述了确定受试者中TNFα抑制剂治疗牛皮癣的功效的方法。

2. 发明申请

US20130058943A1 BOVINE POLYCLONAL ANTIBODY SPECIFIC FOR HUMAN TNF 审中-公开
标题翻译：用于人TNF的BoVINE多克隆抗体特异性
公开(公告)号：US20130058943A1
公开(公告)日：2013-03-07
申请号：US13564566
申请日：2012-08-01
申请人： Barbara S. Fox , Eileen F. Bostwick , Daniel E. Tracey , Lisa D. Schlehuber , Michael S. Quesenberry
发明人： Barbara S. Fox , Eileen F. Bostwick , Daniel E. Tracey , Lisa D. Schlehuber , Michael S. Quesenberry
IPC分类号： C07K16/24 , C07K1/36 , A61P1/00 , A61K39/395 , A61P29/00
CPC分类号： C07K16/241 , C07K2317/12 , C07K2317/34 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The invention provides a composition comprising polyclonal antibodies that specifically bind to with human tumor necrosis factor (hTNF) wherein the polyclonal antibodies are derived from the serum, milk or colostrum of a bovine animal that has been immunized hTNF or an immunogenic portion thereof. The antigenic specificity analysis of the anti-hTNF polyclonal antibodies of the invention is unique and has not been previously described for anti-hTNF polyclonal or monoclonal antibodies of the prior art.
摘要翻译：本发明提供包含与人肿瘤坏死因子（hTNF）特异性结合的多克隆抗体的组合物，其中所述多克隆抗体衍生自已被免疫的hTNF或其免疫原性部分的牛动物的血清，牛奶或初乳。本发明的抗hTNF多克隆抗体的抗原特异性分析是独特的，以前没有描述过用于现有技术的抗hTNF多克隆或单克隆抗体。

3. 发明授权

US6054487A Methods and compositions for modulating responsiveness to corticosteroids 失效
标题翻译：调节对皮质类固醇反应的方法和组合物
公开(公告)号：US6054487A
公开(公告)日：2000-04-25
申请号：US820692
申请日：1997-03-18
申请人： Les Sekut , Adam Carter , Tariq Ghayur , Subhashis Banerjee , Daniel E. Tracey
发明人： Les Sekut , Adam Carter , Tariq Ghayur , Subhashis Banerjee , Daniel E. Tracey
IPC分类号： A61K31/18
CPC分类号： A61K31/18
摘要： Method for modulating responsiveness to corticosteroids in a subject are provided. In the method of the invention, an agent which antagonizes a factor that regulates production of IFN-.gamma. in the subject is administered to the subject in combination with a corticosteroid such that responsiveness of the subject to the corticosteroid is modulated as compared to when a corticosteroid alone is administered to the subject. In one embodiment, the agent is an interferon-.gamma. inducing factor (IGIF) antagonist. In another embodiment, the agent is an interleukin-12 (IL-12) antagonist. In a preferred embodiment, the agent is an inhibitor of a caspase family protease, preferably an ICE inhibitor. In another preferred embodiment, the agent is an anti-IL-12 monoclonal antibody. Other preferred agents include phosphodiesterase IV inhibitors and beta-2 agonists. The methods of the invention can be used in the treatment of a variety of inflammatory and immunological diseases and disorders. Pharmaceutical compositions comprising an agent which antagonizes a factor that regulates production of IFN-.gamma. in a subject, a corticosteroid and a pharmaceutically acceptable carrier are also provided. A preferred composition comprises an ICE inhibitor, a corticosteroid and a pharmaceutically acceptable carrier.
摘要翻译：提供了调节受试者对皮质类固醇的反应性的方法。在本发明的方法中，将拮抗受试者中IFN-γ产生的因子拮抗的药物与皮质类固醇组合给予受试者，使得受试者对皮质类固醇的反应性与皮质类固醇相比被调节单独对受试者施用。在一个实施方案中，所述试剂是干扰素-γ诱导因子（IGIF）拮抗剂。在另一个实施方案中，该药剂是白细胞介素-12（IL-12）拮抗剂。在优选的实施方案中，所述试剂是半胱天冬酶家族蛋白酶，优选ICE抑制剂的抑制剂。在另一个优选的实施方案中，所述试剂是抗IL-12单克隆抗体。其它优选的试剂包括磷酸二酯酶IV抑制剂和β-2激动剂。本发明的方法可用于治疗各种炎症和免疫疾病和病症。还提供了包含拮抗受试者中的IFN-γ生成因子，皮质类固醇和药学上可接受的载体的药剂的药物组合物。优选的组合物包含ICE抑制剂，皮质类固醇和药学上可接受的载体。

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