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1. 发明申请

US20130295571A1 MARKER OF BREAST TUMORS FROM THE LUMINAL-B SUBTYPE 审中-公开
标题翻译：来自LUMINAL-B亚型的乳腺肿瘤标记物
公开(公告)号：US20130295571A1
公开(公告)日：2013-11-07
申请号：US13882200
申请日：2011-10-28
申请人： Daniel Birnbaum , Max Chaffanet , Christophe Ginestier , Jose Adelaide , Fabrice Sircoulomb
发明人： Daniel Birnbaum , Max Chaffanet , Christophe Ginestier , Jose Adelaide , Fabrice Sircoulomb
IPC分类号： C12Q1/68 , G01N33/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , C12Q2600/16 , G01N33/57415 , G01N33/6893 , G01N2333/47
摘要： An in vitro method for diagnosing a breast cancer from the luminal-B subtype in a female, includes the steps of analyzing a biological sample from the female by (i) determining the copies number of the ZNF703 gene, and/or (ii) determining the expression of the ZNF703 gene, wherein an increased copies number and/or an over-expression of the ZNF703 gene is indicative of a luminal B tumor; to a kit for diagnosing a breast cancer from the luminal-B subtype in a female including at least one nucleic acid probe or oligonucleotide or at least one antibody, which can be used in a method as defined previously, for determining the copies number of the ZNF703 gene, and/or determining the expression of the ZNF703 gene; and to the use of such a kit.
摘要翻译：一种用于从女性中的管腔B亚型诊断乳腺癌的体外方法包括以下步骤：通过（i）确定ZNF703基因的拷贝数和/或（ii）确定来分析来自女性的生物样品 ZNF703基因的表达，其中增加的拷贝数和/或ZNF703基因的过度表达指示管腔B肿瘤; 涉及一种用于诊断女性乳腺癌B亚型的试剂盒，包括至少一种核酸探针或寡核苷酸或至少一种抗体，其可以用于如前所定义的方法中，用于确定 ZNF703基因，和/或确定ZNF703基因的表达; 并使用这样一个工具包。

2. 发明申请

US20090286689A1 METHODS FOR ANALYZING DIFFERENTIAL GENE EXPRESSION ASSOCIATED WITH MYELOPROLIFERATIVE DISORDERS (MPD) CANCER DISEASE 审中-公开
标题翻译：用于分析与非侵入性疾病（MPD）癌症相关的差异基因表达的方法
公开(公告)号：US20090286689A1
公开(公告)日：2009-11-19
申请号：US11953899
申请日：2007-12-11
申请人： Daniel BIRNBAUM , Helene Lelievre , Nathalie Cervera
发明人： Daniel BIRNBAUM , Helene Lelievre , Nathalie Cervera
IPC分类号： C40B30/00 , C12Q1/68 , C40B40/06
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , C12Q2600/178
摘要： The present application relates to gene analysis and, in particular, to gene expression profiling for identifying molecular signature of cancer disease, in particular the G1 phase of the cell cycle, such as myeloproliferative disorders (MPD) or breast cancer and studying cancer.More particularly, the application is directed to a method for analyzing differential gene expression associated with cancer disease, in particular the G1 phase of the cell cycle, such as myeloproliferative disorders (MPD) or breast cancer comprising detection of upregulation and/or downregulation of a pool of polynucleotide sequences in a cell or tissue sample, said pool corresponding to all or part the polynucleotide sequences, subsequences or complements thereof, of the genes listed in Tables 1, 2 and 3.
摘要翻译：本申请涉及基因分析，特别是用于鉴定癌症疾病的分子特征的基因表达谱，特别是细胞周期的G1期，例如骨髓增生性疾病（MPD）或乳腺癌，并研究癌症。更具体地，本申请涉及用于分析与癌症疾病，特别是细胞周期的G1期（例如骨髓增生性疾病（MPD）或乳腺癌）相关的差异基因表达的方法，包括检测上调和/或下调细胞或组织样品中的多核苷酸序列池，所述池对应于表1,2和3所列基因的全部或部分多核苷酸序列，子序列或其互补序列。

3. 发明授权

US07537932B1 Antibodies that bind purified mammalian FLT3 ligands 失效
标题翻译：结合纯化的哺乳动物FLT3配体的抗体
公开(公告)号：US07537932B1
公开(公告)日：2009-05-26
申请号：US08472168
申请日：1995-06-07
申请人： Charles H. Hannum , Janice A. Culpepper , Frank D. Lee , Daniel Birnbaum
发明人： Charles H. Hannum , Janice A. Culpepper , Frank D. Lee , Daniel Birnbaum
IPC分类号： C07K16/24
CPC分类号： A61K38/02
摘要： Flt3 ligand from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said ligand. Methods of using said reagents and diagnostic kits are also provided.
摘要翻译：来自哺乳动物的Flt3配体，与其相关的试剂，包括纯化的蛋白质，特异性抗体和编码所述配体的核酸。还提供了使用所述试剂和诊断试剂盒的方法。

4. 发明申请

US20050287544A1 Gene expression profiling of colon cancer with DNA arrays 审中-公开
标题翻译：用DNA阵列进行大肠癌基因表达谱分析
公开(公告)号：US20050287544A1
公开(公告)日：2005-12-29
申请号：US11000688
申请日：2004-12-01
申请人： Francois Bertucci , Remi Houlgatte , Daniel Birnbaum , Stephane Debono
发明人： Francois Bertucci , Remi Houlgatte , Daniel Birnbaum , Stephane Debono
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6837 , C12Q2600/106 , C12Q2600/158
摘要： Differential gene expression associated with histopathologic features of colorectal disease can be performed with nucleic acid arrays. Such arrays can comprise a pool of polynucleotide sequences from colon tissues, and the detection of the overexpression or underexpression of polynucleotide sequences (or subsequences or complements thereof) from this pool can provide information relating to the detection, diagnosis, stage, classification, monitoring, prediction, prevention or treatment of colorectal disease.
摘要翻译：与结肠直肠疾病组织病理学特征相关的差异基因表达可以用核酸阵列进行。这样的阵列可以包含来自结肠组织的多核苷酸序列池，并且从该池中检测多核苷酸序列（或其子序列或其互补序列）的过表达或低表达可以提供与检测，诊断，分期，分类，监测，预测，预防或治疗结肠直肠疾病。

5. 发明申请

US20130079234A1 GENE EXPRESSION PROFILING OF PRIMARY BREAST CARCINOMAS USING ARRAYS OF CANDIDATE GENES 审中-公开
标题翻译：使用候选基因阵列的原始乳腺癌基因表达谱
公开(公告)号：US20130079234A1
公开(公告)日：2013-03-28
申请号：US13116518
申请日：2011-05-26
申请人： Francois Bertucci , Rémi Houlgatte , Daniel Birnbaum , Catherine Nguyen , Patrice Viens , Vincent Fert
发明人： Francois Bertucci , Rémi Houlgatte , Daniel Birnbaum , Catherine Nguyen , Patrice Viens , Vincent Fert
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/156
摘要： A method for predicting the sensitivity of tumor cells to an anthracycline-based chemotherapy includes determining the differential expression level of a MYBL2 gene in tumors cells. A polynucleotide library is useful to predict the sensitivity of tumor cells to an anthracycline-based chemotherapy and includes a pool of polynucleotide sequences or subsequences thereof wherein the sequences or subsequences correspond substantially to any of the polynucleotide sequences SEQ ID No: 308, SEQ ID No: 309 and/or SEQ ID No: 310 or the complements thereof.
摘要翻译：用于预测肿瘤细胞对蒽环类化疗的敏感性的方法包括测定肿瘤细胞中MYBL2基因的差异表达水平。多核苷酸文库可用于预测肿瘤细胞对基于蒽环霉素的化疗的敏感性，并且包括多核苷酸序列或其子序列库，其中所述序列或子序列基本上对应于任何多核苷酸序列SEQ ID No：308，SEQ ID No ：309和/或SEQ ID No：310或其互补序列。

6. 发明申请

US20130059301A1 ASXL1 AS A NEW DIAGNOSTIC MARKER OF MYELOID NEOPLASMS 审中-公开
标题翻译： ASXL1作为一种新的诊断标记的MYELOID NEOPLASMS
公开(公告)号：US20130059301A1
公开(公告)日：2013-03-07
申请号：US13578667
申请日：2011-02-11
申请人： Véronique Gelsi-Boyer , Daniel Birnbaum
发明人： Véronique Gelsi-Boyer , Daniel Birnbaum
IPC分类号： C12Q1/68 , G01N33/574 , C07K16/18 , C07H21/04
CPC分类号： C12Q1/6886 , C07K16/32 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/156
摘要： A method for diagnosing a myeloid cancer in a subject, includes the step of analyzing a biological sample from the subject by determining the presence or the absence of a mutation in the ASXL1 (additional sex combs like 1) gene coding for the polypeptide having the sequence SEQ ID N°2. A kit for diagnosing myeloid cancer in a subject including at least one nucleic acid probe or oligonucleotide or at least one antibody, which can be used in a such a method is also described.
摘要翻译：用于诊断受试者中骨髓瘤的方法包括通过确定编码具有序列的多肽的ASXL1（附加性别的梳子1）基因中存在或不存在突变来分析来自受试者的生物样品的步骤 SEQ ID N°2。还描述了可以在这种方法中使用的用于诊断受试者中骨髓瘤的试剂盒，包括至少一种核酸探针或寡核苷酸或至少一种抗体。

7. 发明申请

US20110086765A1 GENE EXPRESSION PROFILING OF PRIMARY BREAST CARCINOMAS USING ARRAYS OF CANDIDATE GENES 审中-公开
标题翻译：使用候选基因阵列的原始乳腺癌基因表达谱
公开(公告)号：US20110086765A1
公开(公告)日：2011-04-14
申请号：US12903594
申请日：2010-10-13
申请人： Francois Bertucci , Rémi Houlgatte , Daniel Birnbaum , Catherine Nguyen , Patrice Viens , Vincent Fert
发明人： Francois Bertucci , Rémi Houlgatte , Daniel Birnbaum , Catherine Nguyen , Patrice Viens , Vincent Fert
IPC分类号： C40B30/00 , C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/156
摘要： Method for molecular characterization of a carcinoma including: (i) detecting in tumor cells corresponding to breast tumor cells at least one polynucleotide selected from a first group determining expression level of the polynucleotide from the first group to differentiate a tumor in which a lymph node has been invaded by a tumor cell from a tumor in which a lymph node has not been invaded by a tumor cell; (ii) detecting in tumor cells corresponding to breast tumor cells at least one polynucleotide selected from a second group determining expression level of the polynucleotide from the second group to distinguish tumors sensitive to anthracycline from tumors insensitive to anthracycline; (iii) detecting in tumor cells corresponding to breast tumor cells at least one polynucleotide selected from a third group determining expression levels of the polynucleotide from the third group to classify good and poor prognosis primary breast tumors.
摘要翻译：用于癌症的分子表征的方法，包括：（i）在与肿瘤细胞相对应的肿瘤细胞中检测至少一种选自第一组的多核苷酸，所述第一组确定来自第一组的多核苷酸的表达水平以区分其中淋巴结具有的肿瘤被肿瘤细胞侵入，其中淋巴结未被肿瘤细胞侵袭的肿瘤; （ii）在对应于乳腺肿瘤细胞的肿瘤细胞中检测至少一种选自第二组的多核苷酸，其确定来自第二组的多核苷酸的表达水平，以将对蒽环霉素敏感的肿瘤与对蒽环霉素不敏感的肿瘤区分开; （iii）在相应于乳腺肿瘤细胞的肿瘤细胞中检测至少一种选自第三组的多核苷酸，其确定来自第三组的多核苷酸的表达水平以分类良好和不良预后的原发性乳腺肿瘤。

8. 发明申请

US20110014191A1 BREAST CANCER EXPRESSION PROFILING 审中-公开
标题翻译：乳腺癌表达谱
公开(公告)号：US20110014191A1
公开(公告)日：2011-01-20
申请号：US12810576
申请日：2008-12-24
申请人： Francois Bertucci , Daniel Birnbaum , Pascal Finetti
发明人： Francois Bertucci , Daniel Birnbaum , Pascal Finetti
IPC分类号： A61K39/395 , C12Q1/68 , C40B40/06 , C40B30/04 , C12Q1/48 , A61P35/00
CPC分类号： C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158 , G01N33/57415 , G01N33/57484 , G01N2800/54 , G01N2800/56
摘要： The present invention relates to a method for analyzing cancer. e.g., breast cancer including detection of differential expression of at least one of the 16 genes encoding serine/threonine kinases listed in Table 1, or of the 16 genes, and to a polynucleotide library including at least one the 16 genes. This finds use in the development of novel applications, in particular in the development of prognosis or diagnostic of breast cancer or for monitoring the treatment of a patient with a breast cancer.
摘要翻译：本发明涉及癌症分析方法。包括乳腺癌的检测，包括检测编码表1所列的丝氨酸/苏氨酸激酶或16个基因的16个基因中的至少一个的差异表达，以及包含至少一个16个基因的多核苷酸文库。这可用于开发新型应用，特别是用于乳腺癌的预后或诊断的发展或用于监测患有乳腺癌的患者的治疗。

9. 发明申请

US20100234292A1 METHODS OF ASSESSING A PROPENSITY OF CLINICAL OUTCOME FOR A FEMALE MAMMAL SUFFERING FROM BREAST CANCER 审中-公开
标题翻译：评估乳腺癌女性乳腺癌临床观察结果的方法
公开(公告)号：US20100234292A1
公开(公告)日：2010-09-16
申请号：US12596143
申请日：2008-04-16
申请人： Francois Bertucci , Daniel Birnbaum , Patrice Viens , Vincent Fert , Fabienne Hermitte , Stephane Debono , Stephane Deraco , Nathalie Borie , Fanny Piette
发明人： Francois Bertucci , Daniel Birnbaum , Patrice Viens , Vincent Fert , Fabienne Hermitte , Stephane Debono , Stephane Deraco , Nathalie Borie , Fanny Piette
IPC分类号： C12Q1/68 , A61K38/16 , A61K38/22 , A61K38/02 , A61P35/00
CPC分类号： G06Q50/24 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , Y02A90/22
摘要： The present invention relates to a method of assessing a propensity of clinical outcome for a female mammal suffering from breast cancer in view of the expression of specific nucleic acid sequences in a biological sample.
摘要翻译：鉴于生物样品中特异性核酸序列的表达，本发明涉及评估患有乳腺癌的女性哺乳动物的临床结果倾向的方法。

10. 发明申请

US20050089899A1 Identification of an ERBB2 gene expression signature in breast cancers 审中-公开
标题翻译：鉴定乳腺癌中的ERBB2基因表达特征
公开(公告)号：US20050089899A1
公开(公告)日：2005-04-28
申请号：US10928465
申请日：2004-08-27
申请人： Daniel Birnbaum , Francois Bertucci , Jocelyne Jacquemier , Stephane Debono , Nathalie Borie , Christophe Ginestier
发明人： Daniel Birnbaum , Francois Bertucci , Jocelyne Jacquemier , Stephane Debono , Nathalie Borie , Christophe Ginestier
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/6837 , C12Q2600/106 , C12Q2600/112 , C12Q2600/158
摘要： The present invention relates to a method for analyzing differential gene expression associated with breast tumor, based on the analysis of the over-expression or under-expression of polynucleotide sequences in a biological sample. The analysis comprises the detection of the over-expression of at least one polynucleotide sequence(s), subsequence(s) or complement(s) thereof selected from predefined polynucleotide sequence sets.
摘要翻译：本发明涉及基于生物样品中多核苷酸序列的过表达或低表达的分析来分析与乳腺肿瘤相关的差异基因表达的方法。该分析包括检测选自预定多核苷酸序列组的至少一个多核苷酸序列，其子序列或其补体的过表达。

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