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1. 发明申请

US20050139469A1 Electrochemical test strip for reducing the effect of direct and mediated interference current 审中-公开
标题翻译：电化学测试条，用于减少直接和介导的干扰电流的影响
公开(公告)号：US20050139469A1
公开(公告)日：2005-06-30
申请号：US10977316
申请日：2004-10-29
申请人： Oliver Davies , Robert Marshall , Damian Baskeyfield , Lysney Whyte , Elaine Leiper
发明人： Oliver Davies , Robert Marshall , Damian Baskeyfield , Lysney Whyte , Elaine Leiper
IPC分类号： A61B5/00 , A61B5/145 , C12Q1/00 , G01N27/26 , G01N27/403 , G01N27/416 , G01N27/49 , G01N33/487 , G06F19/00
CPC分类号： C12Q1/001 , A61B5/14532 , A61B5/1486 , A61B5/150022 , A61B5/150282 , A61B5/150358 , A61B5/150435 , A61B5/150503 , C12Q1/006 , G01N27/3274
摘要： The present invention is directed to an electrochemical sensor or electrochemical strip which includes a substrate, a first working electrode disposed on the substrate, a second working electrode disposed on the substrate, a reference electrode, an active reagent layer disposed on the first working electrode, wherein the active reagent layer completely covers the first working electrode and an inactive reagent layer disposed on the second working electrode, wherein the inactive reagent completely covers the second working electrode. The present invention is also directed to an electrochemical sensor an electrochemical sensor including a substrate, a first working electrode disposed on the substrate, a second working electrode disposed on the substrate, a reference electrode, an active reagent layer disposed on the first working electrode, wherein the active reagent layer completely covers the first working electrode, the second working electrode having an active region and an inactive region, the active reagent layer disposed on a active region of the second working electrode and an inactive reagent layer disposed on the inactive region of the second working electrode.
摘要翻译：本发明涉及一种电化学传感器或电化学条带，其包括基板，设置在基板上的第一工作电极，设置在基板上的第二工作电极，参考电极，设置在第一工作电极上的活性试剂层，其中所述活性试剂层完全覆盖所述第一工作电极和设置在所述第二工作电极上的无活性试剂层，其中所述非活性试剂完全覆盖所述第二工作电极。本发明还涉及电化学传感器，其包括基板，设置在基板上的第一工作电极，设置在基板上的第二工作电极，参考电极，设置在第一工作电极上的活性试剂层，其中所述活性试剂层完全覆盖所述第一工作电极，所述第二工作电极具有有源区和非活性区，所述活性试剂层设置在所述第二工作电极的有源区上，第二工作电极。

2. 发明申请

US20050114062A1 Method of reducing the effect of direct interference current in an electrochemical test strip 审中-公开
标题翻译：降低电化学测试条中直接干扰电流影响的方法
公开(公告)号：US20050114062A1
公开(公告)日：2005-05-26
申请号：US10977292
申请日：2004-10-29
申请人： Oliver Davies , Robert Marshall , Damian Baskeyfield , Lynsey Whyte , Elaine Leiper
发明人： Oliver Davies , Robert Marshall , Damian Baskeyfield , Lynsey Whyte , Elaine Leiper
IPC分类号： A61B5/00 , A61B5/145 , C12Q1/00 , G01N27/26 , G01N27/403 , G01N27/416 , G01N27/49 , G01N33/487 , G06F19/00
CPC分类号： C12Q1/001 , A61B5/14532 , A61B5/1486 , A61B5/150022 , A61B5/150282 , A61B5/150358 , A61B5/150435 , A61B5/150503 , C12Q1/006 , G01N27/3274
摘要： This invention describes a method of reducing the effect of interfering compounds in a bodily fluid when measuring an analyte using an electrochemical sensor. In particular, the present method is applicable to electrochemical sensors where the sensor includes a substrate, first and second working electrodes, and a reference electrode and either the first and second or only the second working electrode include regions which are bare of reagent. In this invention, an algorithm is described with mathematically corrects for the interference effect using the test strip embodiments of the present invention.
摘要翻译：本发明描述了当使用电化学传感器测量分析物时减少干扰化合物在体液中的作用的方法。特别地，本方法适用于电化学传感器，其中传感器包括基板，第一和第二工作电极以及参考电极，第一和第二或仅第二工作电极包括裸露的试剂区域。在本发明中，使用本发明的测试条实施例来描述使用数学校正干扰效应的算法。

3. 发明申请

US20120199498A1 ELECTROCHEMICAL-BASED ANALYTICAL TEST STRIP WITH GRADED ENZYMATIC REAGENT LAYER AND RELATED METHODS 审中-公开
标题翻译：电化学分析测试条与分级酶试剂层及相关方法
公开(公告)号：US20120199498A1
公开(公告)日：2012-08-09
申请号：US13021994
申请日：2011-02-07
申请人： Manuel Alvarez-Icaza , Alan McNeilage , Zuifang Liu , Damian Baskeyfield
发明人： Manuel Alvarez-Icaza , Alan McNeilage , Zuifang Liu , Damian Baskeyfield
IPC分类号： G01N27/26
CPC分类号： G01N27/3272 , G01N27/3274
摘要： An electrochemical-based analytical test strip for the determination of an analyte (such as glucose) in a bodily fluid sample (e.g., a whole blood sample) includes an electrically-insulating substrate, at least one working electrode disposed on the electrically-insulating substrate and a graded enzymatic reagent layer disposed on the at least one working electrode. The graded enzymatic reagent layer includes an upper reaction grade that contains an enzyme. The graded enzymatic layer also has a lower spacer grade devoid of the enzyme, the lower spacer grade disposed between the upper reaction grade and the working electrode such that the upper reaction grade is spaced equidistant from the working electrode by the lower spacer grade by a predetermined distance during use of the electrochemical-based analytical test strip. In addition, the upper reaction grade is configured and constituted such that an enzymatic reaction between the enzyme and a bodily fluid sample applied to the electrochemical-based analytical test strip is localized in the upper reaction grade and the lower spacer grade has predetermined mass transport characteristics for a component of the enzymatic reaction that cause mass transport of the component through the lower spacer grade to the working electrode to be slower than mass transport of the analyte through the bodily fluid sample to the upper reaction grade. A method for determining an analyte (such as glucose) in a bodily fluid sample (for example, a whole blood sample) includes applying a bodily fluid sample to such an electrochemical-based analytical test strip.
摘要翻译：用于测定体液样品（例如全血样品）中的分析物（例如葡萄糖）的基于电化学的分析测试条包括电绝缘基底，设置在电绝缘基底上的至少一个工作电极以及设置在所述至少一个工作电极上的分级酶试剂层。分级的酶试剂层包括含有酶的上反应级。分级酶层还具有较低的不含酶的间隔物级别，下部间隔物级别位于上部反应级别和工作电极之间，使得上部反应级别通过下部间隔物等级与工作电极等距预定的预定在使用电化学分析测试条时的距离。此外，上反应级被配置和构成使得酶和施加到基于电化学的分析测试条上的体液样品之间的酶反应定位在上反应级中，下隔离物级具有预定的质量传递特性对于通过下部间隔物等级将组分质量输送到工作电极的酶反应的组分比通过体液样品的分析物质量输送到上部反应级要慢。用于测定体液样品（例如，全血样品）中的分析物（例如葡萄糖）的方法包括将体液样品施加到这种基于电化学的分析测试条上。

4. 发明申请

US20050133368A1 Electrochemical test strip for reducing the effect of direct interference current 审中-公开
标题翻译：电化学试片，用于降低直接干扰电流的影响
公开(公告)号：US20050133368A1
公开(公告)日：2005-06-23
申请号：US10976489
申请日：2004-10-29
申请人： Oliver Davies , Robert Marshall , Damian Baskeyfield , Lynsey Whyte , Elaine Leiper
发明人： Oliver Davies , Robert Marshall , Damian Baskeyfield , Lynsey Whyte , Elaine Leiper
IPC分类号： A61B5/00 , A61B5/145 , C12Q1/00 , G01N27/26 , G01N27/403 , G01N27/416 , G01N27/49 , G01N33/487 , G06F19/00
CPC分类号： C12Q1/001 , A61B5/14532 , A61B5/1486 , A61B5/150022 , A61B5/150282 , A61B5/150358 , A61B5/150435 , A61B5/150503 , C12Q1/006 , G01N27/3274
摘要： This invention describes an electrochemical sensor which is adapted to reduce the effects of interfering compounds in bodily fluids when measuring an analyte in such fluids using an electrochemical strip. The sensor includes a substrate, a first and second working electrodes, and a reference electrode. A reagent layer is disposed on the electrodes such that, in one embodiment it completely covers all of the first working electrode, but only partially covers the second working electrode and, in a second embodiment, it only covers a portion of the first and the second working electrode. The portion of the working electrodes not covered by the reagent layer and is used to correct for the interference effect on the analyte measurement.
摘要翻译：本发明描述了一种电化学传感器，其适于在使用电化学条测量此类流体中的分析物时，减少干扰化合物对体液的影响。传感器包括基板，第一和第二工作电极以及参考电极。试剂层设置在电极上，使得在一个实施例中，其完全覆盖所有第一工作电极，但仅部分地覆盖第二工作电极，并且在第二实施例中，其仅覆盖第一和第二工作电极的一部分工作电极。工作电极的部分未被试剂层覆盖，用于校正分析物测量的干扰效应。

5. 发明申请

US20070276621A1 Method of Reducing the Effect of Direct Interference Current in an Electrochemical Test Strip 有权
标题翻译：减少直接干扰电流在电化学试片中的影响的方法
公开(公告)号：US20070276621A1
公开(公告)日：2007-11-29
申请号：US10577586
申请日：2004-10-29
申请人： Oliver William Davies , Robert Marshall , Damian Baskeyfield , Lynsey Whyte , Elaine Leiper
发明人： Oliver William Davies , Robert Marshall , Damian Baskeyfield , Lynsey Whyte , Elaine Leiper
IPC分类号： G01N27/327
CPC分类号： C12Q1/001 , A61B5/14532 , A61B5/1486 , A61B5/150022 , A61B5/150282 , A61B5/150358 , A61B5/150435 , A61B5/150503 , C12Q1/006 , G01N27/3274
摘要： This invention describes a method of reducing the effect of interfering compounds in a bodily fluid when measuring an analyte using an electrochemical sensor (62). In particular, the present method is applicable to electrochemical sensors where (62) the sensor includes a substrate (50), first and second working electrodes (10, 12), and a reference electrode (14) and either the first and second or only the second working electrode include regions which are bare of reagent (22). In this invention, an algorithm is described with mathematically corrects for the interference effect using the test strip embodiments of the present invention.
摘要翻译：本发明描述了当使用电化学传感器（62）测量分析物时减少干扰化合物在体液中的影响的方法。特别地，本方法适用于电化学传感器，其中（62）传感器包括基底（50），第一和第二工作电极（10,12）和参考电极（14），以及第一和第二或第二第二工作电极包括裸露的试剂（22）的区域。在本发明中，使用本发明的测试条实施例来描述使用数学校正干扰效应的算法。

6. 发明申请

US20060184189A1 Cap for a dermal tissue lancing device 审中-公开
标题翻译：用于皮肤组织穿刺装置的盖
公开(公告)号：US20060184189A1
公开(公告)日：2006-08-17
申请号：US10706166
申请日：2003-11-12
申请人： Lorin Olson , Anne Thomson , Damian Baskeyfield , Christopher Leach , Richard Day , Sebastian Bohm
发明人： Lorin Olson , Anne Thomson , Damian Baskeyfield , Christopher Leach , Richard Day , Sebastian Bohm
IPC分类号： A61B17/32
CPC分类号： A61B5/157 , A61B5/150022 , A61B5/150068 , A61B5/150183 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/15186
摘要： A cap for use with a dermal tissue lancing device (that includes a housing and a lancet movable with respect to the housing) includes a proximal end for engaging with the housing, a distal end for engaging with dermal tissue and an opening for a portion of the lancet to pass through. The distal end of the cap includes portions for engaging dermal tissue. These portions are resiliently deformable such that, when the cap contacts and is urged towards dermal tissue, the portions deform resiliently, engaging the dermal tissue and approaching theretogether. A process for the collection of a fluid sample (e.g., blood) from dermal tissue includes providing a dermal tissue lancing device with a housing, a cap and a lancet that is moveable with respect to the housing and the cap. The cap includes a proximal end for engaging with the housing, a distal end for engaging with dermal tissue, and an opening for a portion of the lancet to pass through. The distal end of the cap includes resiliently deformable portions for engaging dermal tissue. Next, the cap is contacted with the dermal tissue (e.g., dermal tissue of a fingertip, limb, or abdomen) such that the portions engage the dermal tissue. Subsequently, the cap is urged towards the dermal tissue such that at least first and second portions deform resiliently and approach theretogether to create a bulge in the dermal tissue. The bulge is then lanced to create a puncture from which a fluid sample is collected.
摘要翻译：用于真皮组织穿刺装置（包括壳体和相对于壳体可移动的刺血针）的帽包括用于与壳体接合的近端，用于与真皮组织接合的远端和用于部分刺血针通过。帽的远端包括用于接合皮肤组织的部分。这些部分是可弹性变形的，使得当帽接触并被推向真皮组织时，这些部分弹性变形，与真皮组织接合并且一起接近。用于从真皮组织收集流体样品（例如血液）的方法包括提供真皮组织切割装置，其具有可相对于壳体和盖移动的壳体，帽和刺血针。盖包括用于与壳体接合的近端，用于与真皮组织接合的远端和用于刺血针的一部分通过的开口。盖的远端包括用于接合皮肤组织的弹性变形部分。接下来，将盖与真皮组织（例如，指尖，肢体或腹部的真皮组织）接触，使得这些部分接合皮肤组织。随后，将帽推向真皮组织，使得至少第一和第二部分弹性变形并且一起接近以在真皮组织中产生凸起。然后将凸起切开以产生从中收集流体样品的穿刺。

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