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1. 发明申请

US20100167943A1 System and Method for Hybridization Slide Processing 审中-公开
标题翻译：杂交幻灯片处理系统与方法
公开(公告)号：US20100167943A1
公开(公告)日：2010-07-01
申请号：US12207343
申请日：2008-09-09
申请人： Nils Adey , Tom Moyer , Rob Parry , Dale Emery
发明人： Nils Adey , Tom Moyer , Rob Parry , Dale Emery
IPC分类号： C40B30/04 , C40B60/12
CPC分类号： G01N35/00029 , G01N2035/00089 , G01N2035/00138
摘要： A system for the automated hybridization of a plurality of microarray slides. The system comprises an enclosure with a wash basin having an open top end, a lower carrier rotor disposed within the wash basin on a support axle for receiving a plurality of microarray slide substrates, and an upper clamp rotor disposed above the lower carrier rotor on the support axle for receiving a plurality of disposable mixers. The system is further configured so that lowering the upper clamp rotor to engage with the lower carrier rotor couples the plurality of mixers to the plurality of slide substrates to form a plurality of sealed reaction chambers, and raising the upper clamp rotor to disengage from the lower carrier rotor de-couples the plurality of mixers from the plurality of slide substrates to unseal the plurality of reaction chambers.
摘要翻译：用于多个微阵列载玻片的自动杂交的系统。该系统包括具有开放顶端的洗手盆的外壳，设置在洗手盆内的下托架转子，用于容纳多个微阵列滑动基板的支撑轴上，以及设置在下载架转子上方的上夹具转子用于接收多个一次性混合器的支撑轴。该系统进一步被构造成使得下夹具转子与下载体转子相接合将多个混合器耦合到多个滑动基板以形成多个密封的反应室，并且将上夹具转子升高以从下部载体转子将多个混合器从多个滑动基板解耦，以便打开多个反应室。

2. 发明申请

US20100200021A1 Slide Conditioning Systems and Methods 审中-公开
标题翻译：滑动调节系统和方法
公开(公告)号：US20100200021A1
公开(公告)日：2010-08-12
申请号：US12247408
申请日：2008-10-08
申请人： Nils Adey , Tom Moyer , Dale Emery , Michael Worthen , Wanyuan Ao
发明人： Nils Adey , Tom Moyer , Dale Emery , Michael Worthen , Wanyuan Ao
IPC分类号： B08B11/02
CPC分类号： B08B11/02 , B08B3/04 , G01N35/1095 , G01N2035/00237
摘要： A slide conditioning system comprises a basin, suitable to retain fluids therein, and a slide carrier having a bidirectional valve formed therein, the slide carrier adapted to carry a plurality of slides therein. A rotor arm is rotatable relative to the basin, the rotor arm being capable of carrying the slide carrier and applying centrifugal forces to the slide carrier as the rotor arm rotates. A fluidics system is also provided and a fluid coupling port is operable to selectively and fluidly mate with the bidirectional valve of the slide carrier while the slide carrier is carried by the rotor arm to fluidly couple the slide carrier to the fluidics system.
摘要翻译：滑动调节系统包括适于在其中保留流体的盆，以及其中形成有双向阀的滑动载体，所述滑动载体适于在其中承载多个载玻片。转子臂相对于盆可旋转，转子臂能够承载滑动载体并且当转子臂旋转时将离心力施加到滑动载体。还提供流体系统，并且流体联接口可操作以选择性地和流体地配合滑动载体的双向阀，同时滑动载体由转子臂承载以将滑动载体流体耦合到流体系统。

3. 发明授权

US06537220B1 Ultrasound imaging with acquisition of imaging data in perpendicular scan planes 失效
标题翻译：在垂直扫描平面上采集成像数据进行超声成像
公开(公告)号：US06537220B1
公开(公告)日：2003-03-25
申请号：US09944650
申请日：2001-08-31
申请人： Barry Hugh Friemel , Charles Dale Emery
发明人： Barry Hugh Friemel , Charles Dale Emery
IPC分类号： A61B800
CPC分类号： A61B8/145 , A61B8/14 , A61B8/4483 , B06B1/0629 , G01S15/8925 , G01S15/8927 , G01S15/8993 , G10K11/30
摘要： An ultrasonic imaging array has two independent, interleaved linear subarrays occupying a common array face. The subarrays are independently steerable and focusable in different imaging planes. The subelements making up the elements in of the subarrays is preferably quadrilateral. Adjacent subelements in each element are electrically connected via an interconnect portion such that the interconnect portion connecting each pair of adjacent subelements in each element is substantially linear and is aligned with the diagonals of the adjacent subelements. A preferred acoustic lens is curved in both azimuth and elevation directions, whereby the subarrays are independently focusable. By transmitting in one plane and simultaneously receiving in a different, orthogonal plane, a system including the array can image a 3-D region of interest (ROI). In a volumetric embodiment of the invention two orthogonal B-mode images of a structure within the ROI are displayed simultaneously. The user may then trace the outlines of the images and the system therefrom calculates the volume of the structure.
摘要翻译：超声波成像阵列具有两个占据共同阵列面的独立的交错线性子阵列。子阵列在不同的成像平面中独立可控并可聚焦。构成子阵列中的元素的子元素优选为四边形。每个元件中的相邻子元件通过互连部分电连接，使得连接每个元件中的每对相邻子元件的互连部分基本上是线性的并且与相邻子元件的对角线对齐。优选的声透镜在方位角和高度方向都是弯曲的，由此子阵列可独立调焦。通过在一个平面中发送并同时在不同的正交平面中接收包括该阵列的系统可以对3-D感兴趣区域（ROI）进行成像。在本发明的体积实施例中，同时显示ROI内的结构的两个正交B模式图像。然后，用户可以跟踪图像的轮廓，并且系统从其计算结构的体积。

4. 发明申请

US20110190153A1 SYSTEM AND METHOD FOR HYBRIDIZATION SLIDE PROCESSING 审中-公开
标题翻译：用于混合滑动加工的系统和方法
公开(公告)号：US20110190153A1
公开(公告)日：2011-08-04
申请号：US12997238
申请日：2009-06-09
申请人： Nils Adey , Tom Moyer , Rob Parry , Dale Emery
发明人： Nils Adey , Tom Moyer , Rob Parry , Dale Emery
IPC分类号： C40B30/04 , C40B60/12
CPC分类号： C40B30/04 , C40B60/12
摘要： A system 300 for the substantially-automated hybridization of a plurality of microarray slides. The system comprises an enclosure 310 with a wash basin 312 having an open top end, a lower carrier rotor 330 disposed within the wash basin on a support axle 318 for receiving a plurality of microarray slide substrates 362, and an upper clamp rotor 340 disposed above the lower carrier rotor on the support axle for receiving a plurality of disposable chamber assemblies 240. The system is further configured so that lowering the upper clamp rotor to engage with the lower carrier rotor couples the plurality of chamber assemblies to the plurality of slide substrates to form a plurality of sealed reaction chambers 244, and raising the upper clamp rotor to disengage from the lower carrier rotor de-couples the plurality of chamber assemblies from the plurality of slide substrates to unseal the plurality of reaction chambers.
摘要翻译：一种用于多个微阵列载片的基本上自动化杂交的系统300。该系统包括具有敞开的顶端的洗手盆312的外壳310，设置在洗手盆内的下托架转子330，其位于支撑轴318上，用于容纳多个微阵列滑动基板362，以及设置在上方的上夹具转子340 支撑轴上的下承载转子用于容纳多个一次性室组件240.该系统进一步构造成使得下夹具转子与下承载转子相接合将多个室组件连接到多个滑动衬底上形成多个密封反应室244，并且升高上夹具转子以与下载体转子脱离，使多个室组件与多个滑动基板脱离接合以开启多个反应室。

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