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1. 发明申请

US20090054363A1 Genetic markers and methods for detecting and treating cancers 有权
标题翻译：用于检测和治疗癌症的遗传标记和方法
公开(公告)号：US20090054363A1
公开(公告)日：2009-02-26
申请号：US11907697
申请日：2007-10-16
申请人： Chin-Tarng Lin , Han-Chung Wu , Dah-Yeou Huang
发明人： Chin-Tarng Lin , Han-Chung Wu , Dah-Yeou Huang
IPC分类号： A61K31/70 , A61P35/00 , C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158
摘要： The present invention provides genetic markers, SOX5 and SPARC, for distant metastasis and poor prognosis of detection of the high risk potential for cancer patients. In addition, the present invention also provides a method to predict the risk potential for cancer patients with distant metastasis and poor prognosis. This method comprises obtaining a tissue sample from a patient, evaluating the expression levels of the SOX5 and/or SPARC genetic markers in the sample; and comparing the expression levels of genetic markers with those of non-cancerous tissues. The patient is determined to have the high risk of distant metastasis or poor prognosis when the expression level of SOX5 is higher, or when the expression level of SPARC is lower, than that of non-cancerous tissue. Furthermore, the identified genetic marker SOX5 and/or SPARC can also be used for cancer targeted therapy, because down regulation of SOX5 and/or up regulation of SPARC expression in NOD-SCID can retard tumor growth and inhibit cell proliferation, migration, invasion and metastasis.
摘要翻译：本发明提供用于远处转移的遗传标记物SOX5和SPARC，并且对癌症患者的高潜力检测的预后差。此外，本发明还提供了一种预测远端转移癌症患者和预后不良的潜在风险的方法。该方法包括从患者获得组织样本，评估样品中SOX5和/或SPARC遗传标记的表达水平; 并比较遗传标记的表达水平与非癌组织的表达水平。当SOX5的表达水平较高时，或者当SPARC的表达水平低于非癌组织的表达水平时，患者被确定为具有远处转移的高风险或不良预后。此外，所鉴定的遗传标记SOX5和/或SPARC也可用于癌症靶向治疗，因为SOX5的下调和/或NOD-SCID中SPARC表达的上调可以延缓肿瘤生长并抑制细胞增殖，迁移，侵袭和转移。

2. 发明授权

US07901877B2 Genetic markers and methods for detecting and treating cancers 有权
标题翻译：用于检测和治疗癌症的遗传标记和方法
公开(公告)号：US07901877B2
公开(公告)日：2011-03-08
申请号：US11907697
申请日：2007-10-16
申请人： Chin-Tarng Lin , Han-Chung Wu , Dah-Yeou Huang
发明人： Chin-Tarng Lin , Han-Chung Wu , Dah-Yeou Huang
IPC分类号： C12Q1/00 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158
摘要： The present invention provides genetic markers, SOX5 and SPARC, for distant metastasis and poor prognosis of detection of the high risk potential for cancer patients. In addition, the present invention also provides a method to predict the risk potential for cancer patients with distant metastasis and poor prognosis. This method comprises obtaining a tissue sample from a patient; evaluating the expression levels of the SOX5 and/or SPARC genetic markers in the sample; and comparing the expression levels of genetic markers with those of non-cancerous tissues. The patient is determined to have the high risk of distant metastasis or poor prognosis when the expression level of SOX5 is higher, or when the expression level of SPARC is lower, than that of non-cancerous tissue. Furthermore, the identified genetic marker SOX5 and/or SPARC can also be used for cancer targeted therapy, because down regulation of SOX5 and/or up regulation of SPARC expression in NOD-SCID can retard tumor growth and inhibit cell proliferation, migration, invasion and metastasis.
摘要翻译：本发明提供用于远处转移的遗传标记物SOX5和SPARC，并且对癌症患者的高潜力检测的预后差。此外，本发明还提供了一种预测远端转移癌症患者和预后不良的潜在风险的方法。该方法包括从患者获得组织样品; 评估样品中SOX5和/或SPARC遗传标记的表达水平; 并比较遗传标记的表达水平与非癌组织的表达水平。当SOX5的表达水平较高时，或者当SPARC的表达水平低于非癌组织的表达水平时，患者被确定为具有远处转移的高风险或不良预后。此外，所鉴定的遗传标记SOX5和/或SPARC也可用于癌症靶向治疗，因为SOX5的下调和/或NOD-SCID中SPARC表达的上调可以延缓肿瘤生长并抑制细胞增殖，迁移，侵袭和转移。

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