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1. 发明授权

US11103467B2 Method for treating depression 有权
公开(公告)号：US11103467B2
公开(公告)日：2021-08-31
申请号：US16437467
申请日：2019-06-11
申请人： DEVELCO PHARMA SCHWEIZ AG
发明人： Sascha Manthei , Helene Rey , Marc Fischer , Olaf Mundszinger
IPC分类号： A61K31/135 , A61K9/20 , A61K9/50 , A61K9/00
摘要： A method for treating depression in patients with depression and bipolar disorder who have not responded to antidepressants and to avoid dose dumping upon ingestion of alcohol. The present invention also relates to an oral dosage form for administration of ketamine and a method of preparing an oral dosage form for administration of ketamine, preferably once or twice a day.

2. 发明授权

US3817234A Adjustable distributor 失效
标题翻译：可调节分配器
公开(公告)号：US3817234A
公开(公告)日：1974-06-18
申请号：US34123773
申请日：1973-03-14
申请人： DEVELCO MFG CO
发明人： JIROUSEK T
IPC分类号： F02P5/00 , F02P5/02
CPC分类号： F02P5/00 , F02P5/02
摘要： A conventional distributor for an internal combustion engine is modified for automobile racing purposes by removing the vacuum spark advance unit and replacing it with an inexpensive manually adjustable unit having an identical mounting bracket, a horizontal adjusting screw mounted for rotation on said bracket and having an adjustable vertical pin mounted thereon, said screw being turned by a knob having means for indicating the amount of angular adjustment of the breaker plate.
摘要翻译：用于内燃机的常规分配器通过移除真空火花提前单元而被修改用于汽车赛车目的，并且用具有相同安装支架的便宜的手动可调节单元来替换，水平调节螺钉安装成用于在所述支架上旋转并具有可调节垂直销安装在其上，所述螺钉由具有用于指示断路器板的角度调节量的装置的旋钮转动。

3. 发明授权

US11723883B2 Hydroxynorketamine for the use in the treatment of depression 有权
公开(公告)号：US11723883B2
公开(公告)日：2023-08-15
申请号：US16625845
申请日：2018-06-22
申请人： DEVELCO PHARMA SCHWEIZ AG
发明人： Helene Rey
IPC分类号： A61K31/135 , A61K9/28
CPC分类号： A61K31/135 , A61K9/2866
摘要： The present invention relates to hydroxynorketamine for the use in the treatment of depression. In particular, the present invention concerns hydroxynorketamine for use in the treatment of depression, wherein hydroxynorketamine is administered in form of at least one prodrug, and wherein the at least one prodrug is orally administered in a modified-release dosage form. The prodrug is selected from (S)-Ketamine, (R)-Ketamine, (R,S)-Ketamine, (S)-Norketamine, (R)-Norketamine, (R,S)-Norketamine, (S)-Hydroxyketamine, (R)-Hydroxyketamine, (R,S)-Hydroxyketamine.

4. 发明申请

US20190290600A1 Method for Treating Depression 审中-公开
公开(公告)号：US20190290600A1
公开(公告)日：2019-09-26
申请号：US16437467
申请日：2019-06-11
申请人： DEVELCO PHARMA SCHWEIZ AG
发明人： Sascha MANTHEI , Helene REY , Marc FISCHER , Olaf MUNDSZINGER
IPC分类号： A61K31/135 , A61K9/00 , A61K9/50 , A61K9/20
摘要： A method for treating depression in patients with depression and bipolar disorder who have not responded to antidepressants and to avoid dose dumping upon ingestion of alcohol. The present invention also relates to an oral dosage form for administration of ketamine and a method of preparing an oral dosage form for administration of ketamine, preferably once or twice a day.

5. 发明申请

US20160256452A1 Composition Of Opioid Receptor Antagonists For Use In Treatment Of Constipation With Highly Increased Whole Gut Transit Time 审中-公开
标题翻译：用于治疗便秘的阿片样物质受体拮抗剂的组成，具有高度增加的全肠道运输时间
公开(公告)号：US20160256452A1
公开(公告)日：2016-09-08
申请号：US14828034
申请日：2015-08-17
申请人： Develco Pharma Schweiz AG
发明人： Helene Rey , Marc Fischer , Isabelle Golfier , Christian Holl
IPC分类号： A61K31/485
CPC分类号： A61K31/485
摘要： The present invention relates to a composition comprising an opioid receptor antagonist in an extended release formulation for use in treating a patient with severe constipation characterised by a defined whole gut transit time.
摘要翻译：本发明涉及一种组合物，其包含延长释放制剂中的阿片样物质受体拮抗剂，其用于治疗特征在于确定的肠道通过时间的严重便秘患者。

6. 发明申请

US20210386691A1 Oral Dosage Forms of Ketamine 有权
公开(公告)号：US20210386691A1
公开(公告)日：2021-12-16
申请号：US17460476
申请日：2021-08-30
申请人： DEVELCO PHARMA SCHWEIZ AG
发明人： Sascha MANTHEI , Helene REY , Marc FISCHER , Olaf MUNDSZINGER
IPC分类号： A61K31/135 , A61K9/20 , A61K9/50 , A61K9/00
摘要： The present invention relates to an oral dosage form for administration of ketamine and a method of preparing an oral dosage form for administration of ketamine, preferably once or twice a day.

7. 发明授权

US10058547B2 Naloxone single agent and multilayer tablets 有权
公开(公告)号：US10058547B2
公开(公告)日：2018-08-28
申请号：US15255856
申请日：2016-09-02
申请人： Develco Pharma Schweiz AG
发明人： Hélène Rey , Olaf Mundszinger , Isabelle Golfier , Silvia Jakob , Oliver Rusch
IPC分类号： A61K9/20 , A61K31/485 , A61K9/00 , A61K9/50 , A61K9/24 , A61K9/28
CPC分类号： A61K31/485 , A61K9/0004 , A61K9/0053 , A61K9/0056 , A61K9/2009 , A61K9/2013 , A61K9/2027 , A61K9/2054 , A61K9/2077 , A61K9/209 , A61K9/2095 , A61K9/28 , A61K9/5084
摘要： The present invention relates to a solid oral pharmaceutical composition comprising naloxone, or a pharmaceutical acceptable salt thereof, as an active substance, wherein the composition releases the active substance in a prolonged manner. In order to provide a composition that is suitable for an administration period of at least twelve-hours for the treatment of opioid-induced constipation, it is proposed that the composition should have an in vitro release rate of the active substance measured using the paddle stirrer method according to Ph. Eur. at 75 rpm in 500 ml 0.1 N hydrochloric acid at 37° C., of 0% to 75% in 2 h, of 3% to 95 % in 4 h, of 20% to 100% in 10 h, of 30% to 100% in 16 h, of 50% to 100% in 24 h, and of more than 80% in 36 h, wherein the composition has a IC50/Cmax value of at least 40. In an alternative embodiment, the composition can be a multilayer tablet.

8. 发明授权

US3614630A Radio frequency standard and voltage controlled oscillator 失效
标题翻译：无线电频率标准和电压控制振荡器
公开(公告)号：US3614630A
公开(公告)日：1971-10-19
申请号：US3614630D
申请日：1969-02-04
申请人： DEVELCO
发明人： RORDEN LOUIS H
IPC分类号： G04F5/06 , G04G7/02 , H03B5/36 , H03L7/081 , H03L7/087 , H03L7/14 , H04B1/16
CPC分类号： G04F5/06 , G04R40/02 , H03B5/36 , H03B2200/0012 , H03L7/081 , H03L7/087 , H03L7/14
摘要： A radio signal controlled oscillator is provided as a local frequency standard by synchronizing the oscillator using a phaselock servosystem comprising a long term integrating device as a voltage variable capacitor in the resonant circuit of the oscillator. The device consists of two columns of mercury separated by a substantial gap of electrolyte in a chamber made of dielectric material. Upon comparison of the oscillator signal with the radio signal, any error signal developed is applied across the electrolyte gap to the mercury column to transfer mercury from one to the other by the process of electrolysis. Conductive material wrapped around the chamber serves as a second plate of a capacitor for each of the columns one of which is used as part of the voltage variable capacitor. Means is provided for detecting the loss of the radio signal to interrupt any further change in the variable capacitor until the radio signal is restored.

9. 发明申请

US20210059944A1 NOVEL DOSAGE FORM 有权
公开(公告)号：US20210059944A1
公开(公告)日：2021-03-04
申请号：US16492450
申请日：2018-03-08
申请人： DEVELCO PHARMA SCHWEIZ AG
发明人： Mathias Scheer , Helene Rey
IPC分类号： A61K9/16 , A61K31/4458 , A61K9/20
摘要： The present invention relates to a solid oral pharmaceutical dosage form with a novel and well defined order of specific coatings allowing for the very defined and controlled release of at least one pharmaceutical active ingredient (API) and a broad range of potential uses. Particularly, the dosage form according to the invention comprises an immediate release active core, a first delayed-release layer comprising an enteric coating, a second sustained release layer comprising a retard polymer, and a third immediate release layer comprising an active pharmaceutical ingredient. The solid oral pharmaceutical dosage form as such is characterized in having a bi-modal release profile of the at least one API with a much less variable second delayed release than known prior art pharmaceutical compositions, allowing for the application of different APIs or combinations thereof in for a variety of indications.

10. 发明授权

US10335379B2 Oral dosage forms of ketamine 有权
公开(公告)号：US10335379B2
公开(公告)日：2019-07-02
申请号：US15304613
申请日：2015-04-16
申请人： DEVELCO PHARMA SCHWEIZ AG
发明人： Sascha Andor Manthei , Helene Rey , Marc Fischer , Olaf Mundszinger
IPC分类号： A61K9/00 , A61K9/20 , A61K9/50 , A61K31/135
摘要： The present invention relates to an oral dosage form for administration of ketamine and a method of preparing an oral dosage form for administration of ketamine, preferably once or twice a day.

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