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1. 发明授权

US5559282A Method and apparatus for testing the effectiveness of an air barrier installation 失效
标题翻译：用于测试空气阻隔装置有效性的方法和装置
公开(公告)号：US5559282A
公开(公告)日：1996-09-24
申请号：US437072
申请日：1995-05-05
申请人： Kevin D. Knight , Graham A. Knight , Colin D. Knight
发明人： Kevin D. Knight , Graham A. Knight , Colin D. Knight
IPC分类号： G01M3/12 , G01M3/04 , G01M3/26
CPC分类号： G01M3/12
摘要： A method and apparatus for testing the effectiveness of a building air barrier, or part thereof, whereby an identification of any air leakage therethrough is provided. A soap solution (or other solution having a similar bubbling characteristic) is applied to a selected air barrier test area. An open-ended flask is positioned over the test area and a centrifugal (or standard) fan is activated at the head of the flask to create an air pressure differential across the air barrier. In the presence of the air pressure differential the soap solution will bubble if there is an air leakage in the air barrier within the test area and, therefore, the existence or non-existence of bubbles in this area identifies whether or not there is an air leakage (i.e. break) in the air barrier in that area.
摘要翻译：一种用于测试建筑物空气屏障或其一部分的有效性的方法和装置，由此提供了通过其识别任何空气泄漏。将肥皂溶液（或具有类似起泡特性的其它溶液）施加到所选择的空气阻挡试验区域。将开口的烧瓶放置在测试区域的上方，并且在烧瓶的头部处启动离心（或标准）风扇，以在空气屏障上产生气压差。在存在空气压差的情况下，如果在测试区域内的空气屏障中存在空气泄漏，则肥皂溶液将会起泡，因此在该区域中存在或不存在气泡来识别是否存在空气在该地区的空气屏障中泄漏（即断裂）。

2. 发明授权

US11608099B1 Hook attachment for footwear 有权
公开(公告)号：US11608099B1
公开(公告)日：2023-03-21
申请号：US17082257
申请日：2020-10-28
申请人： Kendall Gholston , Willie C. Knight , Christine Gholston , Dianne D. Knight
发明人： Kendall Gholston , Willie C. Knight , Christine Gholston , Dianne D. Knight
IPC分类号： A43C19/00 , B62B5/00 , A43B3/16
摘要： The hand truck foot hook may comprise a retaining strap and a hook. The hand truck foot hook may be adapted to pull the bottom of a hand truck out from under a load using a foot of a user. The retaining strap may detachably couple to a shoe worn on the foot of the user. The hook may be coupled to the retaining strap such that the hook is accessible on the top of the foot. The hook may removably engage the bottom of the hand truck such that the bottom of the hand truck is pulled back when the shoe is pulled back. As a non-limiting example, the hook may engage an axle of the hand truck.

3. 发明申请

US20120225050A1 METHODS FOR IMPROVING GUT HEALTH 有权
标题翻译：改善肠道健康的方法
公开(公告)号：US20120225050A1
公开(公告)日：2012-09-06
申请号：US13079541
申请日：2011-04-04
申请人： Chris D. Knight , Julia J. Dibner , Fenglan Yan
发明人： Chris D. Knight , Julia J. Dibner , Fenglan Yan
IPC分类号： A61K38/48 , A61P31/04 , A61P1/12 , A61P1/00 , A61P37/00
CPC分类号： A61K38/48 , A23K10/12 , A23K20/147 , A23K20/189 , A23K50/10 , A23K50/30 , A23K50/75 , A61K38/482 , A61K38/4873 , A61K38/488 , A61K38/4886 , C12Y304/00 , C12Y304/21 , C12Y304/22 , C12Y304/23 , C12Y304/24
摘要： The present invention provides methods for improving gut health. In particular, the invention provides methods for improving gut health by improving the digestibility of dietary proteins, decreasing the flow of protein to the lower gastrointestinal tract, and/or decreasing the levels of Clostridium bacteria the upper intestinal tract of a subject. The methods comprise administering to the subject a supplement consisting essentially of at least one protease.
摘要翻译：本发明提供了改善肠道健康的方法。特别地，本发明提供了通过改善膳食蛋白质的消化率，降低蛋白质向下胃肠道的流动和/或降低受试者上肠道的梭菌细菌的水平来改善肠道健康的方法。所述方法包括向受试者施用基本上由至少一种蛋白酶组成的补充物。

4. 发明申请

US20110072693A1 Excavator tooth retention device 有权
标题翻译：挖掘机齿保持装置
公开(公告)号：US20110072693A1
公开(公告)日：2011-03-31
申请号：US12923491
申请日：2010-09-23
申请人： Garrett D. Knight
发明人： Garrett D. Knight
IPC分类号： E02F9/28
CPC分类号： E02F9/2833 , E02F9/2825
摘要： A tooth retention device for attachment to an excavator bucket, which has a tooth mounting portion, a fork shaped body fitting over the edge of the bucket, a clamp passing through the body and the bucket, and a wedge holding the clamp in position, in which the wedge has a threaded rod and a threaded block on the rod. The rod is rotatable to move the block between locked and released positions.
摘要翻译：一种用于附接到挖掘机铲斗的齿保持装置，其具有齿安装部分，配合在铲斗边缘上的叉形体，穿过主体和铲斗的夹具以及将夹具保持在适当位置的楔形物楔形件具有螺纹杆和杆上的螺纹块。杆可旋转以在锁定位置和释放位置之间移动块。

5. 发明授权

US07582668B2 Imidazoyl-benzamide anti-cancer agents 有权
标题翻译：咪唑酰苯甲酰胺抗癌剂
公开(公告)号：US07582668B2
公开(公告)日：2009-09-01
申请号：US11598250
申请日：2006-11-08
申请人： Xiangping Qian , Luke W. Ashcraft , Jianchao Wang , Bing Yao , Hong Jiang , Gustave Bergnes , Bradley P. Morgan , David J. Morgans, Jr. , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin J. Duffy , Duke Fitch , Rosanna Tedesco
发明人： Xiangping Qian , Luke W. Ashcraft , Jianchao Wang , Bing Yao , Hong Jiang , Gustave Bergnes , Bradley P. Morgan , David J. Morgans, Jr. , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin J. Duffy , Duke Fitch , Rosanna Tedesco
IPC分类号： A61K31/4178 , C07D403/10
CPC分类号： C07D233/64 , C07C235/48 , C07C235/50 , C07C235/52 , C07C237/22 , C07C255/57 , C07C255/59 , C07C255/60 , C07C257/08 , C07C257/18 , C07C259/18 , C07C271/20 , C07C271/24 , C07C271/28 , C07C275/26 , C07C275/40 , C07C275/42 , C07C281/06 , C07C307/10 , C07C311/37 , C07C311/46 , C07C2601/02 , C07C2601/14 , C07D207/273 , C07D211/34 , C07D211/76 , C07D213/30 , C07D231/12 , C07D231/14 , C07D233/61 , C07D233/70 , C07D235/06 , C07D235/16 , C07D235/18 , C07D235/26 , C07D239/36 , C07D249/08 , C07D257/04 , C07D261/08 , C07D263/10 , C07D263/12 , C07D263/32 , C07D271/06 , C07D271/07 , C07D271/10 , C07D271/113 , C07D277/30 , C07D277/42 , C07D277/56 , C07D285/02 , C07D285/125 , C07D295/145 , C07D295/155 , C07D333/38 , C07D403/10 , C07D403/12 , C07D413/06 , C07D471/04 , C07D498/04 , C07F9/6506 , C07F9/6561
摘要： Provided are compounds of Formula I and pharmaceutically acceptable salts thereof which may be useful for the treatment of cancer or other proliferative disorders.
摘要翻译：提供了可用于治疗癌症或其它增殖性疾病的式I化合物及其药学上可接受的盐。

6. 发明申请

US20080255182A1 Certain chemical entities, compositions, and methods 审中-公开
标题翻译：某些化学实体，组合物和方法
公开(公告)号：US20080255182A1
公开(公告)日：2008-10-16
申请号：US12007143
申请日：2008-01-07
申请人： Xiangping Qian , Andrew I. McDonald , Han-Jie Zhou , Luke W. Ashcraft , Bing Yao , Hong Jiang , Jennifer Kuo Chen Huang , Jianchao Wang , David J. Morgans , Bradley P. Morgan , Gustave Bergnes , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
发明人： Xiangping Qian , Andrew I. McDonald , Han-Jie Zhou , Luke W. Ashcraft , Bing Yao , Hong Jiang , Jennifer Kuo Chen Huang , Jianchao Wang , David J. Morgans , Bradley P. Morgan , Gustave Bergnes , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
IPC分类号： A61K31/437 , A61P35/00
CPC分类号： C07D233/64 , C07C235/48 , C07C235/50 , C07C235/52 , C07C237/22 , C07C255/57 , C07C255/59 , C07C255/60 , C07C257/08 , C07C257/18 , C07C259/18 , C07C271/20 , C07C271/24 , C07C271/28 , C07C275/26 , C07C275/40 , C07C275/42 , C07C281/06 , C07C307/10 , C07C311/37 , C07C311/46 , C07C2601/02 , C07C2601/14 , C07D207/273 , C07D211/34 , C07D211/76 , C07D213/30 , C07D231/12 , C07D231/14 , C07D233/61 , C07D233/70 , C07D235/06 , C07D235/16 , C07D235/18 , C07D235/26 , C07D239/36 , C07D249/08 , C07D257/04 , C07D261/08 , C07D263/10 , C07D263/12 , C07D263/32 , C07D271/06 , C07D271/07 , C07D271/10 , C07D271/113 , C07D277/30 , C07D277/42 , C07D277/56 , C07D285/02 , C07D285/125 , C07D295/145 , C07D295/155 , C07D333/38 , C07D403/10 , C07D403/12 , C07D413/06 , C07D471/04 , C07D498/04 , C07F9/6506 , C07F9/6561
摘要： Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
摘要翻译：公开了通过调节一种或多种有丝分裂驱动蛋白的活性来治疗细胞增殖性疾病和病症的化合物。

7. 发明授权

US07041465B1 Anti-bacterial compounds directed against pilus biogenesis, adhesion and activity; co-crystals of pilus subunits and methods of use thereof 失效
标题翻译：针对菌毛生物发生的抗菌化合物，粘附和活性; 菌丝亚单位的共晶体及其使用方法
公开(公告)号：US07041465B1
公开(公告)日：2006-05-09
申请号：US09637216
申请日：2000-08-11
申请人： Scott J. Hultgren , Frederic G. Sauer , Gabriel Waksman , Klaus Fuetterer , Devapriya Choudhury , Stefan D. Knight , Michelle Barnhart
发明人： Scott J. Hultgren , Frederic G. Sauer , Gabriel Waksman , Klaus Fuetterer , Devapriya Choudhury , Stefan D. Knight , Michelle Barnhart
IPC分类号： C12Q1/68 , C12N1/20 , G01N33/554 , A61K38/00 , C07K1/00
CPC分类号： C12Q1/18 , A61K38/00 , C07K14/47 , Y02A50/406 , Y02A50/473
摘要： Many Gram-negative pathogens assemble adhesive pili structures on their surfaces that allow them to colonize host tissues and cause disease. The present invention relates to novel compounds that mimic a chaperone G1 beta-strand or an amino terminal motif of a pilus subunit. The present invention also relates to the complex formed from the binding of such mimic compounds to the hydrophobic groove of a pilus subunit. Competitively interacting with the binding site of pili subunits will negatively affect the chaperone/usher pathway, which is one molecular mechanism by which Gram-negative bacteria assemble adhesive pili structures, and thus prevent or inhibit pilus assembly.
摘要翻译：许多革兰氏阴性病原体在其表面上组装粘性纤毛结构，使其能够定居宿主组织并引起疾病。本发明涉及模拟伴侣蛋白G1β链或者一个真菌亚单位的氨基末端基序的新化合物。本发明还涉及由这种模拟化合物与真菌亚单位的疏水性凹槽的结合形成的复合物。与pili亚基的结合位点的竞争性相互作用将对分子伴侣/启动子通路产生负面影响，这是革兰氏阴性细菌组装粘性纤毛结构的一种分子机制，从而防止或抑制肠组织。

8. 发明授权

US07019008B2 Pyrrolidine sulfonamides 失效
标题翻译：吡咯烷磺酰胺
公开(公告)号：US07019008B2
公开(公告)日：2006-03-28
申请号：US11119026
申请日：2005-04-29
申请人： Dashyant Dhanak , Steven D. Knight , Jian Jin , Ralph A. Rivero , Anthony Sapienza
发明人： Dashyant Dhanak , Steven D. Knight , Jian Jin , Ralph A. Rivero , Anthony Sapienza
IPC分类号： A61K31/496 , C07D409/14
CPC分类号： C07D409/12
摘要： A compound of Formula (I): wherein: R1 is C1-6 alkyl, benzyl, or (CH2)n—C(O)NH2; wherein the benzyl may be unsubstituted or substituted by one or two C1-6 alkyl, halogen, C1-6 alkoxy, or methylenedioxy groups; R2 is benzimidazolyl, quinolinyl, benzofuranyl, napthyl, indolyl, benzothiophenyl, phenyl, furanyl, thienyl, or pyridyl substituted or unsubstituted by one, two or three halogen, C1-3 alkyl, C1-3 alkoxy, or methylenedioxy groups; X1 and X2 are independently hydrogen, halogen, C1-3 alkyl, C1-3 alkoxy, nitro, CF3, or CN; n is 1, 2, or 3; m is 1, 2 or 3; or a pharmaceutically acceptable salt thereof.
摘要翻译：式（I）的化合物：其中：R 1是C 1-6烷基，苄基或（CH 2 CH 2） -C（O）NH 2; 其中苄基可以是未取代的或被一个或两个C 1-6烷基，卤素，C 1-6烷氧基或亚甲二氧基取代; R 2是苯并咪唑基，喹啉基，苯并呋喃基，萘基，吲哚基，苯并噻吩基，苯基，呋喃基，噻吩基或被1,2或3个卤素取代或未取代的吡啶基，亚烷基，C 1-3烷氧基或亚甲二氧基; X 1和X 2独立地是氢，卤素，C 1-3烷基，C 1-3烷氧基，硝基，CF 3或CN; n为1,2或3; m为1,2或3; 或其药学上可接受的盐。

9. 发明授权

US06733759B2 Nutrient formulation and process for enhancing the health, livability, cumulative weight gain or feed efficiency in poultry and other animals 失效
标题翻译：营养配方和加工方法，用于增强家禽和其他动物的健康，活力，累积体重增加或饲料效率
公开(公告)号：US06733759B2
公开(公告)日：2004-05-11
申请号：US09792998
申请日：2001-02-26
申请人： Francis J. Ivey , Julia J. Dibner , Christopher D. Knight
发明人： Francis J. Ivey , Julia J. Dibner , Christopher D. Knight
IPC分类号： A61K3905
CPC分类号： A61K39/39 , A23K10/18 , A23K20/10 , A23K40/00 , A23K40/20 , A23K40/25 , A23K50/75 , A61K2039/521 , A61K2039/55505 , A61K2039/55516 , A61K2039/5555 , A61K2039/55566 , A61K2039/55577 , A61K2039/55583 , A61K2039/55594 , Y10S426/807
摘要： A nutrient formulation including moisture, a coloring agent, a palatability modifier, and/or an adjuvant which is designed for use in poultry and other animals, and a method of feeding it which improves subsequent livability, cumulative feed efficiency, weight gain, and resistance to disease challenge or other stresses is disclosed.
摘要翻译：包括水分，着色剂，适口性调节剂和/或设计用于家禽和其他动物的佐剂的营养配方及其喂养方法，其提高随后的活力，累积饲料效率，体重增加和抗性公开了疾病挑战或其它应力。

10. 发明授权

US06370109B1 CDMA signal power control using quadrature signal calculations 有权
标题翻译： CDMA信号功率控制采用正交信号计算
公开(公告)号：US06370109B1
公开(公告)日：2002-04-09
申请号：US09265205
申请日：1999-03-10
申请人： Bruce S. Schwartz , Brian K. Harms , Anthony C. K. Soong , Todd A. Pressley , Robin D. Knight
发明人： Bruce S. Schwartz , Brian K. Harms , Anthony C. K. Soong , Todd A. Pressley , Robin D. Knight
IPC分类号： H04B7216
CPC分类号： H04W52/52
摘要： The invention is CDMA quadrature signal technology that controls the transmit power of a CDMA signal. The CDMA quadrature signal technology receives a CDMA signal, and in response, process quadrature components of the CDMA signal to generate a power control signal. The CDMA quadrature signal technology adjusts the gain of the CDMA signal in response to the power control signal. A CDMA transmitter transmits the CDMA signal after the gain is adjusted. One example of the CDMA transmitter is a CDMA base station. Using the invention, a multi-sector CDMA base station can control power without transferring gain information to base station components for all sectors. The invention eliminates unnecessary data transfer and storage.
摘要翻译：本发明是控制CDMA信号发射功率的CDMA正交信号技术。 CDMA正交信号技术接收CDMA信号，作为响应，处理CDMA信号的正交分量以产生功率控制信号。 CDMA正交信号技术响应于功率控制信号来调整CDMA信号的增益。增益调整后，CDMA发射机发送CDMA信号。 CDMA发射机的一个例子是CDMA基站。使用本发明，多扇区CDMA基站可以控制功率而不向所有扇区的基站组件传输增益信息。本发明消除了不必要的数据传输和存储。

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