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1. 发明公开

US20240203266A9 Method of Estimating Blood Volume 有权
公开(公告)号：US20240203266A9
公开(公告)日：2024-06-20
申请号：US17942001
申请日：2022-09-09
申请人： Cypher Medical, LLC
发明人： Christopher A. CAREW , Jian LING
IPC分类号： G08G5/00
CPC分类号： G08G5/003 , G08G5/0021
摘要： Disclosed are methods, materials and devices for approximation of blood volume in a fluid, such as in a biological fluid collected during a surgical procedure. The method and devices may include a RBC flocculant, such as polyDADMAC, and provide for an approximate blood hematocrit for a selected type of animal, as well as provide for a calculated RBC packing ratio corresponding to the collection device receiving the fluid. Also provided is a Blood Indicator Panel (BIP), comprising a series of markings calculated from an observed red blood cell sedimentation volume, the average animal type hematocrit, and a calculated RBC packing ratio “η” value for the collection device. Pediatric (about 200 ml or 250 ml size container), adult human (about 1,000 ml-1,500 ml) and veterinary (about 500 ml-2,500 ml) collection containers are also disclosed, that may include a RBC flocculant, for use in approximating blood volume in a fluid. Methods of detecting blood in a sample, such as a fluid sample, and kits for performing the methods, are also provided.

2. 发明申请

US20230042775A1 BLOOD INDICATOR PANEL 有权
公开(公告)号：US20230042775A1
公开(公告)日：2023-02-09
申请号：US17960727
申请日：2022-10-05
申请人： Cypher Medical, LLC
发明人： Christopher A. CAREW , JIan LING
IPC分类号： G01N33/49 , G01N15/05 , G01N9/02 , G01N1/40 , A61J1/00
摘要： Disclosed are methods, materials and devices for approximation of blood volume in a fluid, such as in a biological fluid collected during a surgical procedure. The method and devices may include the use of an RBC flocculant, for example polyDADMAC, and an approximate blood hematocrit from the type of animal blood being evaluated, as well as a calculated RBC packing ratio corresponding to the collection device being used. Also provided is a Blood Indicator Panel (BIP), comprising a series of markings calculated from an observed red blood settlement volume, the average animal blood hematocrit, and a calculated RBC packing ratio “n” value for the collection device. A collection device with a BIP is disclosed. Pediatric (about 200 ml or 250 ml size container), adult human (about 1,000 ml -1,500 ml) and veterinary (about 500 ml - 2,500 ml) collection containers are also disclosed, that include a RBC flocculant, for use in approximating blood volume in a fluid.

3. 发明授权

US11493502B2 Collapsible container for blood loss assessment 有权
公开(公告)号：US11493502B2
公开(公告)日：2022-11-08
申请号：US16363674
申请日：2019-03-25
申请人： Cypher Medical, LLC
发明人： Christopher A. Carew , Jian Ling , Harold T. Duperier, III
IPC分类号： G01N33/49 , G01N1/40 , G01N9/02 , G01N15/05 , A61J1/00
摘要： Disclosed are methods, materials and devices for approximation of blood volume in a fluid, such as in a biological fluid collected during a surgical procedure. The method and devices include the use of a RBC flocculant, such as polyDADMAC, and an approximate blood hematocrit for the type of animal, as well as a calculated RBC packing ratio corresponding to the collection device being used. Also provided is a Blood Indicator Panel (BIP), comprising a series of markings calculated from an observed red blood settlement volume, the average animal type hematocrit, and a calculated RBC packing ratio “η” value for the collection device. Pediatric (about 200 ml or 250 ml size container), adult human (about 1,000 ml-1,500 ml) and veterinary (about 500 ml-2,500 ml) collection containers are also disclosed, that include a RBC flocculant, for use in approximating blood volume in a fluid.

4. 发明申请

US20190302096A1 COLLAPSIBLE CONTAINER FOR BLOOD LOSS ASSESSMENT 审中-公开
公开(公告)号：US20190302096A1
公开(公告)日：2019-10-03
申请号：US16363674
申请日：2019-03-25
申请人： Cypher Medical, LLC
发明人： Christopher A. Carew , Jian Ling , Harold T. Duperier, III
IPC分类号： G01N33/49 , G01N1/40 , G01N9/02 , G01N15/05 , A61J1/00
摘要： Disclosed are methods, materials and devices for approximation of blood volume in a fluid, such as in a biological fluid collected during a surgical procedure. The method and devices include the use of a RBC flocculant, such as polyDADMAC, and an approximate blood hematocrit for the type of animal, as well as a calculated RBC packing ratio corresponding to the collection device being used. Also provided is a Blood Indicator Panel (BIP), comprising a series of markings calculated from an observed red blood settlement volume, the average animal type hematocrit, and a calculated RBC packing ratio “η” value for the collection device. Pediatric (about 200 ml or 250 ml size container), adult human (about 1,000 ml-1,500 ml) and veterinary (about 500 ml-2,500 ml) collection containers are also disclosed, that include a RBC flocculant, for use in approximating blood volume in a fluid.

5. 发明授权

US12133716B2 Method of monitoring and/or measuring blood loss 有权
公开(公告)号：US12133716B2
公开(公告)日：2024-11-05
申请号：US17943126
申请日：2022-09-12
申请人： Cypher Medical, LLC
发明人： Christopher A. Carew , Jian Ling
IPC分类号： G08G5/00 , A61B5/02 , G01F22/00 , G01N33/49 , G01N1/40
CPC分类号： A61B5/02042 , G01F22/00 , G01N33/49 , G08G5/0021 , G08G5/003 , G01N2001/4083
摘要： Disclosed are methods, materials and devices for approximation of blood volume in a fluid, such as in a biological fluid collected during a surgical procedure. In particular applications, methods of estimating blood loss from a subject are provided. The method and devices may include a RBC flocculant, such as polyDADMAC, and provide for an approximate blood hematocrit for a selected type of animal, as well as provide for a calculated RBC packing ratio corresponding to the collection device receiving the fluid. Also provided is a Blood Indicator Panel (BIP), comprising a series of markings calculated from an observed red blood cell sedimentation volume, the average animal type hematocrit, and a calculated RBC packing ratio “η” value for the collection device. Pediatric (about 200 ml or 250 ml size container), adult human (about 1,000 ml-1,500 ml) and veterinary (about 500 ml-2,500 ml) collection containers are also disclosed, that may include a RBC flocculant, for use in approximating blood volume in a fluid. Methods of detecting blood in a sample, such as a fluid sample, and kits for performing the methods, are also provided.

6. 发明公开

US20230408487A1 BLOOD INDICATOR PANEL 审中-公开
公开(公告)号：US20230408487A1
公开(公告)日：2023-12-21
申请号：US18239748
申请日：2023-08-29
申请人： Cypher Medical, LLC
发明人： Christopher A. CAREW , Jian LING , David HANDLEY
IPC分类号： G01N33/49 , G01N15/05 , G01N9/02 , G01N1/40 , A61J1/00
CPC分类号： G01N33/491 , G01N15/05 , G01N9/02 , G01N1/4077 , A61J1/00 , G01N2009/026 , G01N2001/4083
摘要： Disclosed are methods, materials and devices for approximation of blood volume in a fluid, such as in a biological fluid collected during a surgical procedure. The method and devices may include the use of an RBC flocculant, for example polyDADMAC, and an approximate blood hematocrit from the type of animal blood being evaluated, as well as a calculated RBC packing ratio corresponding to the collection device being used. Also provided is a Blood Indicator Panel (BIP), comprising a series of markings calculated from an observed red blood settlement volume, the average animal blood hematocrit, and a calculated RBC packing ratio “η” value for the collection device. A collection device with a BIP is disclosed. Pediatric (about 200 ml or 250 ml size container), adult human (about 1,000 ml-1,500 ml) and veterinary (about 500 ml-2,500 ml) collection containers are also disclosed, that include a RBC flocculant, for use in approximating blood volume in a fluid.

7. 发明授权

US11493501B2 Blood indicator panel 有权
公开(公告)号：US11493501B2
公开(公告)日：2022-11-08
申请号：US16257673
申请日：2019-01-25
申请人： Cypher Medical, LLC
发明人： Christopher A. Carew , Jian Ling
IPC分类号： G01N33/49 , G01N1/40 , G01N9/02 , G01N15/05 , A61J1/00
摘要： Disclosed are methods, materials and devices for approximation of blood volume in a fluid, such as in a biological fluid collected during a surgical procedure. The method and devices include the use of a RBC flocculant, such as polyDADMAC, and an approximate blood hematocrit for the type of animal, as well as a calculated RBC packing ratio corresponding to the collection device being used. Also provided is a Blood Indicator Panel (BIP), comprising a series of markings calculated from an observed red blood settlement volume, the average animal type hematocrit, and a calculated RBC packing ratio “η” value for the collection device. Pediatric (about 200 ml or 250 ml size container), adult human (about 1,000 ml-1,500 ml) and veterinary (about 500 ml-2,500 ml) collection containers are also disclosed, that include a RBC flocculant, for use in approximating blood volume in a fluid.

8. 发明授权

US11439310B2 Method of estimating blood volume 有权
公开(公告)号：US11439310B2
公开(公告)日：2022-09-13
申请号：US16557708
申请日：2019-08-30
申请人： Cypher Medical, LLC
发明人： Christopher A. Carew , Jian Ling
IPC分类号： A61B5/02 , G01N33/49 , G01F22/00 , G01N1/40
摘要： Disclosed are methods, materials and devices for approximation of blood volume in a fluid, such as in a biological fluid collected during a surgical procedure. The method and devices include the use of a RBC flocculant, such as polyDADMAC, and an approximate blood hematocrit for the type of animal, as well as a calculated RBC packing ratio corresponding to the collection device being used. Also provided is a Blood Indicator Panel (BIP), comprising a series of markings calculated from an observed red blood settlement volume, the average animal type hematocrit, and a calculated RBC packing ratio “η” value for the collection device. Pediatric (about 200 ml or 250 ml size container), adult human (about 1,000 ml-1,500 ml) and veterinary (about 500 ml-2,500 ml) collection containers are also disclosed, that include a RBC flocculant, for use in approximating blood volume in a fluid. Methods of detecting blood in a sample, such as a fluid sample, and kits for performing the methods, are also provided.

9. 发明申请

US20230087527A1 METHOD OF MONITORING AND/OR MEASURING BLOOD LOSS 有权
公开(公告)号：US20230087527A1
公开(公告)日：2023-03-23
申请号：US17943126
申请日：2022-09-12
申请人： Cypher Medical, LLC
发明人： Christopher A. CAREW , Jian LING
IPC分类号： G08G5/00
摘要： Disclosed are methods, materials and devices for approximation of blood volume in a fluid, such as in a biological fluid collected during a surgical procedure. In particular applications, methods of estimating blood loss from a subject are provided. The method and devices may include a RBC flocculant, such as polyDADMAC, and provide for an approximate blood hematocrit for a selected type of animal, as well as provide for a calculated RBC packing ratio corresponding to the collection device receiving the fluid. Also provided is a Blood Indicator Panel (BIP), comprising a series of markings calculated from an observed red blood cell sedimentation volume, the average animal type hematocrit, and a calculated RBC packing ratio “η” value for the collection device. Pediatric (about 200 ml or 250 ml size container), adult human (about 1,000 ml-1,500 ml) and veterinary (about 500 ml-2,500 ml) collection containers are also disclosed, that may include a RBC flocculant, for use in approximating blood volume in a fluid. Methods of detecting blood in a sample, such as a fluid sample, and kits for performing the methods, are also provided.

10. 发明申请

US20220386880A1 METHOD OF ESTIMATING BLOOD VOLUME 有权
公开(公告)号：US20220386880A1
公开(公告)日：2022-12-08
申请号：US17871754
申请日：2022-07-22
申请人： Cypher Medical, LLC
发明人： Christopher A. Carew , Jian Ling
IPC分类号： A61B5/02 , G01F22/00 , G01N33/49
摘要： Disclosed are methods, materials and devices for approximation of blood volume in a fluid, such as in a biological fluid collected during a surgical procedure. The method and devices include the use of a RBC flocculant, such as polyDADMAC, and an approximate blood hematocrit for the type of animal, as well as a calculated RBC packing ratio corresponding to the collection device being used. Also provided is a Blood Indicator Panel (BIP), comprising a series of markings calculated from an observed red blood settlement volume, the average animal type hematocrit, and a calculated RBC packing ratio “η” value for the collection device. Pediatric (about 200 ml or 250 ml size container), adult human (about 1,000 ml-1,500 ml) and veterinary (about 500 ml-2,500 ml) collection containers are also disclosed, that include a RBC flocculant, for use in approximating blood volume in a fluid. Methods of detecting blood in a sample, such as a fluid sample, and kits for performing the methods, are also provided.

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