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1. 发明申请

US20180187660A1 MAGNETIC GAS ENGINE AND METHOD OF EXTRACTING WORK 审中-公开
公开(公告)号：US20180187660A1
公开(公告)日：2018-07-05
申请号：US15902678
申请日：2018-02-22
申请人： Patrick Craig Muldoon
发明人： Patrick Craig Muldoon
IPC分类号： F03H1/00 , F02K1/28 , F02K7/00 , F02K7/10 , F02K1/00 , F02K9/00
CPC分类号： F03H1/0081 , F02K1/00 , F02K1/28 , F02K7/00 , F02K7/10 , F02K9/00 , F03H1/00 , F05D2210/12 , F05D2220/10 , F05D2220/34
摘要： The present subject matter overcomes the deficiencies in the prior art by introducing or generating charged particles in an air stream and manipulating the air stream with magnetic fields operating on the charged particles. Embodiments of the present subject mater compress the air stream by accelerating charged particles with a moving magnetic field, where the magnetic field has a velocity perpendicular to its flux lines. The increased velocity of the charged particles increases the statistical mean particle velocity and thereby increases the pressure in the air stream. The compressed air stream is then heated and expanded through a second magnetic field. The expansion of the air stream substantially increases the velocity of the air stream and the charged particles therein. The interaction of the high velocity charged particles and the magnetic field imparts a force perpendicular to the flux lines, this force powers the movement of the magnetic field.

2. 发明授权

US08673586B2 Compounds that interact with kinases 有权
标题翻译：与激酶相互作用的化合物
公开(公告)号：US08673586B2
公开(公告)日：2014-03-18
申请号：US13461692
申请日：2012-05-01
申请人： Wim Meutermans , Karl Schafer , Michael L. West , Craig Muldoon , Fiona Foley , Natalie Bouloc , Gerald Tometzki
发明人： Wim Meutermans , Karl Schafer , Michael L. West , Craig Muldoon , Fiona Foley , Natalie Bouloc , Gerald Tometzki
IPC分类号： C12Q1/48 , C07H19/02 , C07H7/06
CPC分类号： C07H17/02 , A61K31/7056 , A61K31/7076 , A61K31/708 , C07H17/08
摘要： A method of inhibiting or effecting the activity of protein kinase activity which comprises contacting a protein kinase with a compound of formula (I) being a derivative of a furanose or pyranose form of a monosaccharide, or a pharmaceutically acceptable salt thereof.
摘要翻译：一种抑制或影响蛋白激酶活性活性的方法，其包括使蛋白激酶与式（I）化合物接触，所述式（I）化合物是呋喃糖或吡喃糖形式的单糖衍生物或其药学上可接受的盐。

3. 发明申请

US20130011852A1 COMPOUNDS THAT INTERACT WITH KINASES 有权
标题翻译：与动物接触的化合物
公开(公告)号：US20130011852A1
公开(公告)日：2013-01-10
申请号：US13461692
申请日：2012-05-01
申请人： Wim Meutermans , Karl Schafer , Michael L. West , Craig Muldoon , Fiona Foley , Natalie Bouloc , Gerald Tometzki
发明人： Wim Meutermans , Karl Schafer , Michael L. West , Craig Muldoon , Fiona Foley , Natalie Bouloc , Gerald Tometzki
IPC分类号： G01N33/53
CPC分类号： C07H17/02 , A61K31/7056 , A61K31/7076 , A61K31/708 , C07H17/08
摘要： A method of inhibiting or effecting the activity of protein kinase activity which comprises contacting a protein kinase with a compound of formula (I) being a derivative of a furanose or pyranose form of a monosaccharide, or a pharmaceutically acceptable salt thereof.
摘要翻译：一种抑制或影响蛋白激酶活性活性的方法，其包括使蛋白激酶与式（I）化合物接触，所述式（I）化合物是呋喃糖或吡喃糖形式的单糖衍生物或其药学上可接受的盐。

4. 发明申请

US20080009418A1 Selective Inhibitors 审中-公开
标题翻译：选择性抑制剂
公开(公告)号：US20080009418A1
公开(公告)日：2008-01-10
申请号：US11664632
申请日：2005-10-04
申请人： Gerald Tometzki , Wim Meutermans , Bernd Becker , Johannes Zuegg , Rajaratnam Premraj , Craig Muldoon , Declan McKeveney , Glenn Condie
发明人： Gerald Tometzki , Wim Meutermans , Bernd Becker , Johannes Zuegg , Rajaratnam Premraj , Craig Muldoon , Declan McKeveney , Glenn Condie
IPC分类号： C40B20/00 , C07H15/06 , C40B40/04
CPC分类号： C07H5/06 , C07H15/26 , C07H17/00 , G01N33/566
摘要： A method of identifying biologically active compounds with defined selectivity profile comprises: (c) designing a library of compounds of formula (1) to scan molecular diversity; and (d) assaying the library of compounds in at least two different biological assays.
摘要翻译：鉴定具有确定的选择性谱的生物活性化合物的方法包括：（c）设计式（1）化合物文库以扫描分子多样性; 和（d）在至少两种不同的生物测定中测定化合物文库。

5. 发明申请

US20050209176A1 Compounds that interact with kinases 有权
标题翻译：与激酶相互作用的化合物
公开(公告)号：US20050209176A1
公开(公告)日：2005-09-22
申请号：US10526388
申请日：2003-09-05
申请人： Wim Meutermans , Karl Schafer , Michael West , Craig Muldoon , Fiona Foley , Natalie Bouloc , Gerald Tometzki
发明人： Wim Meutermans , Karl Schafer , Michael West , Craig Muldoon , Fiona Foley , Natalie Bouloc , Gerald Tometzki
IPC分类号： A61K31/7056 , A61K31/7076 , A61K31/708 , A61P9/00 , A61P29/00 , C07H17/02 , C07H17/08 , A61K31/4178 , A61K31/4184 , A61K31/52
CPC分类号： C07H17/02 , A61K31/7056 , A61K31/7076 , A61K31/708 , C07H17/08
摘要： A method of inhibiting or effecting the activity of protein kinase activity which comprises contacting a protein kinase with a compound of formula (I) being a derivative of a furanose or pyranose form of a monosaccharide, or a pharmaceutically acceptable salt thereof.
摘要翻译：一种抑制或影响蛋白激酶活性活性的方法，其包括使蛋白激酶与式（I）化合物接触，所述式（I）化合物是呋喃糖或吡喃糖形式的单糖衍生物或其药学上可接受的盐。

6. 发明申请

US20080280837A1 Biologically Active Compounds with Anti-Angiogenic Properties 审中-公开
标题翻译：具有抗血管生成特性的生物活性化合物
公开(公告)号：US20080280837A1
公开(公告)日：2008-11-13
申请号：US11547343
申请日：2005-04-07
申请人： Judy Halliday , Wim Meutermans , Gerald Tometzki , Tracie E. Ramsdale , Johannes Zuegg , Bernd Becker , Craig Muldoon , Declan McKeveney , Rajaratnam Premraj , Glenn Condie
发明人： Judy Halliday , Wim Meutermans , Gerald Tometzki , Tracie E. Ramsdale , Johannes Zuegg , Bernd Becker , Craig Muldoon , Declan McKeveney , Rajaratnam Premraj , Glenn Condie
IPC分类号： A61K31/7034 , C12N5/06 , A61P9/00
CPC分类号： A61K31/7008 , A61K31/70
摘要： A method for inhibiting angiogenesis in a subject comprising administering to the subject at least one compound of General Formula (I), wherein the ring or any chiral center(s) may be of any configuration; Z is sulphur, oxygen, CH2, C(O), C(O)HN, NH, NRA or hydrogen, in the case where Z is hydrogen then R1 is not present, RA is selected from the set defined for R1 to R5, X and X′ are independently oxygen or nitrogen providing that at least one X of General Formula (I) is nitrogen, X or X′ may also combine independently with one of R1 to R5 to form an azide, R1 to R5 are independently selected from the following definition which includes but is not limited to H or an alkyl, acyl, alkenyl, alkynyl, heteroalkyl, aryl, heteroaryl, arylalkyl or heteroarylalkyl substituent of 1 to 20 atoms, which is optionally substituted, and can be branched or linear, and R6 and R7 are hydrogen, or may combine to form a carbonyl function.
摘要翻译：一种用于抑制受试者血管发生的方法，其包括向所述受试者施用至少一种通式（I）的化合物，其中所述环或任何手性中心可以是任何构型; Z是硫，氧，CH 2，C（O），C（O）HN，NH，NRA或氢时，在Z是氢的情况下，R1不存在，RA选自为R1至R5定义的集合， X和X'独立地是氧或氮，条件是至少一个通式（I）的X是氮，X或X'也可以独立地与R 1至R 5中的一个组合形成叠氮化物，R 1至R 5独立地选自包括但不限于H或任选取代的1-20个原子的烷基，酰基，烯基，炔基，杂烷基，芳基，杂芳基，芳烷基或杂芳基烷基取代基，并且可以是支链或直链的以下定义，和 R6和R7是氢，或者可以结合形成羰基官能团。

7. 发明申请

US20080176815A1 Compounds that interact with kinases 审中-公开
标题翻译：与激酶相互作用的化合物
公开(公告)号：US20080176815A1
公开(公告)日：2008-07-24
申请号：US11902183
申请日：2007-09-19
申请人： Wim Meutermans , Karl Schafer , Michael L. West , Craig Muldoon , Fiona Foley , Natalie Bouloc , Gerald Tometzki
发明人： Wim Meutermans , Karl Schafer , Michael L. West , Craig Muldoon , Fiona Foley , Natalie Bouloc , Gerald Tometzki
IPC分类号： A61K31/7056 , A61K31/4178 , A61K31/4184 , A61P29/00 , A61P9/00 , A61P35/00 , A61K31/7076
CPC分类号： C07H17/02 , A61K31/7056 , A61K31/7076 , A61K31/708 , C07H17/08
摘要： A method of inhibiting or effecting the activity of protein kinase activity which comprises contacting a protein kinase with a compound of formula (I) being a derivative of a furanose or pyranose form of a monosaccharide, or a pharmaceutically acceptable salt thereof.
摘要翻译：一种抑制或影响蛋白激酶活性活性的方法，其包括使蛋白激酶与式（I）化合物接触，所述式（I）化合物是呋喃糖或吡喃糖形式的单糖衍生物或其药学上可接受的盐。

8. 发明授权

US09032705B2 Magnetic gas engine and method of extracting work 有权
公开(公告)号：US09032705B2
公开(公告)日：2015-05-19
申请号：US12578341
申请日：2009-10-13
申请人： Patrick Craig Muldoon
发明人： Patrick Craig Muldoon
IPC分类号： F03H1/00 , B63H11/00 , H05H1/00 , F02K7/00 , F02K7/10 , F02K1/00 , F02K9/00
CPC分类号： F03H1/0081 , F02K1/00 , F02K1/28 , F02K7/00 , F02K7/10 , F02K9/00 , F03H1/00 , F05D2210/12 , F05D2220/10 , F05D2220/34
摘要： The present subject matter overcomes the deficiencies in the prior art by introducing or generating charged particles in an air stream and manipulating the air stream with magnetic fields operating on the charged particles. Embodiments of the present subject matter compress the air stream by accelerating charged particles with a moving magnetic field, where the magnetic field has a velocity perpendicular to its flux lines. The increased velocity of the charged particles increases the statistical mean particle velocity and thereby increases the pressure in the air stream. The compressed air stream is then heated and expanded through a second magnetic field. The expansion of the air stream substantially increases the velocity of the air stream and the charged particles therein. The interaction of the high velocity charged particles and the magnetic field imparts a force perpendicular to the flux lines, this force powers the movement of the magnetic field and can also be extracted in the form of mechanical work.

9. 发明申请

US20100089027A1 MAGNETIC GAS ENGINE AND METHOD OF EXTRACTING WORK 审中-公开
标题翻译：磁性发动机及其提取方法
公开(公告)号：US20100089027A1
公开(公告)日：2010-04-15
申请号：US12578341
申请日：2009-10-13
申请人： Patrick Craig Muldoon
发明人： Patrick Craig Muldoon
IPC分类号： F03H1/00
CPC分类号： F03H1/0081 , F02K1/00 , F02K1/28 , F02K7/00 , F02K7/10 , F02K9/00 , F03H1/00 , F05D2210/12 , F05D2220/10 , F05D2220/34
摘要： The present subject matter overcomes the deficiencies in the prior art by introducing or generating charged particles in an air stream and manipulating the air stream with magnetic fields operating on the charged particles. Embodiments of the present subject mater compress the air stream by accelerating charged particles with a moving magnetic field, where the magnetic field has a velocity perpendicular to its flux lines. The increased velocity of the charged particles increases the statistical mean particle velocity and thereby increases the pressure in the air stream. The compressed air stream is then heated and expanded through a second magnetic field. The expansion of the air stream substantially increases the velocity of the air stream and the charged particles therein. The interaction of the high velocity charged particles and the magnetic field imparts a force perpendicular to the flux lines, this force powers the movement of the magnetic field and can also be extracted in the form of mechanical work.
摘要翻译：本发明通过在空气流中引入或产生带电粒子并利用在带电粒子上运行的磁场来操纵空气流来克服现有技术中的缺陷。本发明的实施例通过用移动磁场加速带电粒子来压缩空气流，其中磁场具有垂直于其通量线的速度。带电粒子的增加的速度增加统计平均粒子速度，从而增加空气流中的压力。然后将压缩空气流通过第二磁场加热和膨胀。空气流的膨胀大大增加了空气流和其中的带电粒子的速度。高速带电粒子与磁场的相互作用赋予垂直于磁通线的力，该力为磁场的运动提供动力，也可以以机械作业的形式提取。

10. 发明授权

US07602096B2 Magnetic gas engine and method of extracting work 有权
标题翻译：磁性气体发动机及其提取方法
公开(公告)号：US07602096B2
公开(公告)日：2009-10-13
申请号：US11362928
申请日：2006-02-28
申请人： Patrick Craig Muldoon
发明人： Patrick Craig Muldoon
IPC分类号： H02K1/22
CPC分类号： F03H1/0081 , F02K1/00 , F02K1/28 , F02K7/00 , F02K7/10 , F02K9/00 , F03H1/00 , F05D2210/12 , F05D2220/10 , F05D2220/34
摘要： The present subject matter overcomes the deficiencies in the prior art by introducing or generating charged particles in an air stream and manipulating the air stream with magnetic fields operating on the charged particles. Embodiments of the present subject matter compress the air stream by accelerating charged particles with a moving magnetic field, where the magnetic field has a velocity perpendicular to its flux lines. The increased velocity of the charged particles increases the statistical mean particle velocity and thereby increases the pressure in the air stream. The compressed air stream is then heated and expanded through a second magnetic field. The expansion of the air stream substantially increases the velocity of the air stream and the charged particles therein. The interaction of the high velocity charged particles and the magnetic field imparts a force perpendicular to the flux lines, this force powers the movement of the magnetic field and can also be extracted in the form of mechanical work.
摘要翻译：本发明通过在空气流中引入或产生带电粒子并利用在带电粒子上运行的磁场来操纵空气流来克服现有技术中的缺陷。本主题的实施例通过用移动磁场加速带电粒子来压缩空气流，其中磁场具有垂直于其磁通线的速度。带电粒子的增加的速度增加统计平均粒子速度，从而增加空气流中的压力。然后将压缩空气流通过第二磁场加热和膨胀。空气流的膨胀大大增加了空气流和其中的带电粒子的速度。高速带电粒子与磁场的相互作用赋予垂直于磁通线的力，该力为磁场的运动提供动力，也可以以机械作业的形式提取。

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