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1. 发明申请

US20090202630A1 ORALLY DISINTEGRATING TABLET COMPOSITIONS OF RANITIDINE AND METHODS OF MANUFACTURE 审中-公开
标题翻译： ORALYATGITTING RANTETIINE的片剂组合物及其制备方法
公开(公告)号：US20090202630A1
公开(公告)日：2009-08-13
申请号：US12370852
申请日：2009-02-13
申请人： Gopi Venkatesh , Craig Kramer , Julius Dave King, JR. , Bennie L. Young
发明人： Gopi Venkatesh , Craig Kramer , Julius Dave King, JR. , Bennie L. Young
IPC分类号： A61K31/341 , A61K9/50 , A61K9/20
CPC分类号： A61K31/341 , A61K9/0056 , A61K9/1641 , A61K9/1652 , A61K9/5026 , A61K9/5042
摘要： The present invention is directed to pharmaceutical compositions comprising taste-masked microcapsules comprising ranitidine, orally disintegrating tablets comprising such compositions, and methods of making the pharmaceutical compositions and dosage forms of the present invention. The present invention is also directed to methods of administering the pharmaceutical compositions and orally disintegrating tablets to treat or prevent gastrointestinal disorders.
摘要翻译：本发明涉及药物组合物，其包含含有雷尼替丁的口罩微胶囊，包含该组合物的口腔崩解片，以及制备本发明的药物组合物和剂型的方法。本发明还涉及给药药物组合物和口腔崩解片剂治疗或预防胃肠道疾病的方法。

2. 发明申请

US20090155360A1 ORALLY DISINTEGRATING TABLETS COMPRISING DIPHENHYDRAMINE 审中-公开
标题翻译：包含二苯甲酰胺的外用消毒片
公开(公告)号：US20090155360A1
公开(公告)日：2009-06-18
申请号：US12331963
申请日：2008-12-10
申请人： Gopi M. VENKATESH , Jin-Wang Lai , Phillip Percel , Craig Kramer
发明人： Gopi M. VENKATESH , Jin-Wang Lai , Phillip Percel , Craig Kramer
IPC分类号： A61K9/20 , A61K9/16 , A61K31/135
CPC分类号： A61K9/5078 , A61K9/0056 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/2077 , A61K9/5047 , A61K31/135 , A61K45/06
摘要： The compositions of the present invention comprise a therapeutically effective amount of particles consisting of diphenhydramine or pharmaceutically acceptable salts thereof, optionally in combination with another drug such as pseudoephedrine, or phenylephrine and hydrocodone, in combination with rapidly-dispersing microgranules comprising a disintegrant and a sugar alcohol and/or a saccharide. These compositions are useful in treating the symptoms of one or more diseases or conditions in which diphenhydramine (alone or in combination with one or two other drugs) is a therapeutically effective, e.g. allergic rhinitis, sinusitis, upper respiratory tract infections, motion sickness, Parkinson's disease, insomnia, the common cold, and nighttime pain management, particularly for subjects or patients with dysphagia, and people ‘on the move’.
摘要翻译：本发明的组合物包含治疗有效量的由苯海拉明或其药学上可接受的盐组成的颗粒，任选地与另一种药物如伪麻黄碱或去氧肾上腺素和氢可酮组合，与包含崩解剂和糖的快速分散的微粒组合醇和/或糖。这些组合物可用于治疗其中苯海拉明（单独或与一种或两种其它药物组合）治疗有效的一种或多种疾病或病症的症状，例如，过敏性鼻炎，鼻窦炎，上呼吸道感染，运动病，帕金森病，失眠，普通感冒和夜间疼痛管理，特别是对于受试者或吞咽困难的患者，以及人们的“移动”。

3. 发明申请

US20120093938A1 ORALLY DISINTEGRATING TABLETS COMPRISING DIPHENHYDRAMINE 审中-公开
标题翻译：包含二苯甲酰胺的外用消毒片
公开(公告)号：US20120093938A1
公开(公告)日：2012-04-19
申请号：US13183125
申请日：2011-07-14
申请人： Gopi M. VENKATESH , Jin-Wang LAI , Phillip PERCEL , Craig KRAMER
发明人： Gopi M. VENKATESH , Jin-Wang LAI , Phillip PERCEL , Craig KRAMER
IPC分类号： A61K9/14 , A61K31/485 , A61K31/167 , A61K31/192 , A61K31/5415 , A61K31/616 , A61K31/635 , A61K31/407 , A61K31/405 , A61K31/196 , A61P25/16 , A61P31/00 , A61P29/00 , A61P25/00 , A61P1/08 , A61J3/10 , A61K31/135
CPC分类号： A61K9/5078 , A61K9/0056 , A61K9/2018 , A61K9/2027 , A61K9/2054 , A61K9/2077 , A61K9/5047 , A61K31/135 , A61K45/06
摘要： The compositions of the present invention comprise a therapeutically effective amount of particles consisting of diphenhydramine or pharmaceutically acceptable salts thereof, optionally in combination with another drug such as pseudoephedrine, or phenylephrine and hydrocodone, in combination with rapidly-dispersing microgranules comprising a disintegrant and a sugar alcohol and/or a saccharide. These compositions are useful in treating the symptoms of one or more diseases or conditions in which diphenhydramine (alone or in combination with one or two other drugs) is a therapeutically effective, e.g. allergic rhinitis, sinusitis, upper respiratory tract infections, motion sickness, Parkinson's disease, insomnia, the common cold, and nighttime pain management, particularly for subjects or patients with dysphagia, and people ‘on the move’.
摘要翻译：本发明的组合物包含治疗有效量的由苯海拉明或其药学上可接受的盐组成的颗粒，任选地与另一种药物如伪麻黄碱或去氧肾上腺素和氢可酮组合，与包含崩解剂和糖的快速分散的微粒组合醇和/或糖。这些组合物可用于治疗其中苯海拉明（单独或与一种或两种其它药物组合）治疗有效的一种或多种疾病或病症的症状，例如，过敏性鼻炎，鼻窦炎，上呼吸道感染，运动病，帕金森病，失眠，普通感冒和夜间疼痛管理，特别是对于受试者或吞咽困难的患者，以及人们的“移动”。

4. 发明申请

US20110129530A1 Compressible-Coated Pharmaceutical Compositions and Tablets and Methods of Manufacture 审中-公开
标题翻译：可压缩涂层药物组合物和片剂及其制造方法
公开(公告)号：US20110129530A1
公开(公告)日：2011-06-02
申请号：US12956543
申请日：2010-11-30
申请人： Gopi M. Venkatesh , Jin-Wang Lai , James M. Clevenger , Craig Kramer
发明人： Gopi M. Venkatesh , Jin-Wang Lai , James M. Clevenger , Craig Kramer
IPC分类号： A61K9/26 , A61K9/50 , A61K9/28 , A61K31/485 , A61K31/445 , A61K31/455 , A61K31/341 , A61K31/215 , A61K31/138 , A61P25/00 , A61P29/00 , A61P3/04 , A61P31/00 , A61P3/10 , A61P9/00 , A61P1/00 , A61P25/28 , A61P25/26 , A61P25/18 , A61P25/24
CPC分类号： A61K9/0056 , A61K9/2081 , A61K9/5015 , A61K9/5073 , A61K9/5078 , A61K31/137 , A61K31/167 , A61K31/192 , A61K31/221 , A61K31/341 , A61K31/455 , A61K31/485 , A61K45/06 , A61K2300/00
摘要： There is provided a method for preparing a pharmaceutical composition comprising compressible coated, taste-masked and/or controlled-release coated drug-containing particles, rapidly-dispersing microgranules comprising a disintegrant and a sugar alcohol, a saccharide, or a mixture thereof, and other optional, pharmaceutically acceptable excipients wherein the orally disintegrating tablet (ODT) or rapidly dispersing tablet (RDT) composition having acceptable tableting, organoleptic, and pharmacokinetic properties.
摘要翻译：提供了一种制备药物组合物的方法，所述药物组合物包含可压缩涂覆，掩味和/或控释包衣的含药颗粒，包含崩解剂和糖醇，糖或其混合物的快速分散微粒，以及其它任选的药学上可接受的赋形剂，其中具有可接受的压片，感官和药代动力学性质的口腔崩解片（ODT）或快速分散片剂（RDT）组合物。

5. 发明授权

US07632521B2 Controlled release potassium chloride tablets 失效
标题翻译：控释氯化钾片
公开(公告)号：US07632521B2
公开(公告)日：2009-12-15
申请号：US10619924
申请日：2003-07-15
申请人： Gopi Venkatesh , Craig Kramer
发明人： Gopi Venkatesh , Craig Kramer
IPC分类号： A61K9/14 , A61K9/16 , A61K9/20 , A61K9/22 , A61K9/26
CPC分类号： A61K33/14 , A61K9/2081 , A61K9/5073
摘要： A unit dosage form, such as a tablet for delivering potassium into the body in a controlled release fashion, comprises of a multiplicity of microencapsulated potassium chloride crystals, which are further coated with a plasticized polymer to improve compressibility of the microcapsules. The compressible microcapsules are blended with a compression aid, such as microcrystalline cellulose and a glidant, such as colloidal silicon dioxide, to form controlled release potassium chloride tablets. The tablets may optionally include other excipients such as surfactants and disintegrants. The tablets thus produced exhibit not only high crushing strength and low friability but also release potassium in humans in a desired controlled release fashion similar to commercially available potassium chloride tablets.
摘要翻译：单位剂型，例如以控制释放方式将钾输送到体内的片剂，包含多个微胶囊化的氯化钾晶体，其进一步用增塑聚合物涂覆以改善微胶囊的压缩性。可压缩微胶囊与压缩助剂如微晶纤维素和助流剂如胶体二氧化硅混合，形成控制释放的氯化钾片。片剂可以任选地包括其它赋形剂，例如表面活性剂和崩解剂。如此生产的片剂不仅具有高的抗碎强度和低脆性，而且以类似于市售的氯化钾片剂的所需的控制释放方式释放人体中的钾。

6. 发明申请

US20050013860A1 Controlled release potassium chloride tablets 失效
标题翻译：控释氯化钾片
公开(公告)号：US20050013860A1
公开(公告)日：2005-01-20
申请号：US10619924
申请日：2003-07-15
申请人： Gopi Venkatesh , Craig Kramer
发明人： Gopi Venkatesh , Craig Kramer
IPC分类号： A61K9/20 , A61K9/22 , A61K9/26 , A61K9/50 , A61K33/14
CPC分类号： A61K33/14 , A61K9/2081 , A61K9/5073
摘要： In accordance with the present invention, controlled release potassium chloride tablets are prepared from a pharmaceutical composition comprised of potassium chloride particles coated with a membrane of plasticized water swellable/soluble polymer. The coated Potassium chloride particles are blended with pharmaceutical excipients and compressed into tablets.
摘要翻译：根据本发明，控释氯化钾片剂由包覆有增塑水溶胀性/可溶性聚合物膜的氯化钾颗粒组成的药物组合物制备。将涂覆的氯化钾颗粒与药物赋形剂混合并压制成片剂。

7. 发明申请

US20080279937A2 CONTROLLED RELEASE POTASSIUM CHLORIDE TABLETS 失效
标题翻译：控制释放氯化钾片
公开(公告)号：US20080279937A2
公开(公告)日：2008-11-13
申请号：US10619924
申请日：2003-07-15
申请人： Gopi VENKATESH , Craig KRAMER
发明人： Gopi VENKATESH , Craig KRAMER
IPC分类号： A61K33/14 , A61K9/22 , A61K9/26
CPC分类号： A61K33/14 , A61K9/2081 , A61K9/5073
摘要： A unit dosage form, such as a tablet for delivering potassium into the body in a controlled release fashion, comprises of a multiplicity of microencapsulated potassium chloride crystals, which are further coated with a plasticized polymer to improve compressibility of the microcapsules. The compressible microcapsules are blended with a compression aid, such as microcrystalline cellulose and a glidant, such as colloidal silicon dioxide, to form controlled release potassium chloride tablets. The tablets may optionally include other excipients such as surfactants and disintegrants. The tablets thus produced exhibit not only high crushing strength and low friability but also release potassium in humans in a desired controlled release fashion similar to commercially available potassium chloride tablets.
摘要翻译：单位剂型，例如以控制释放方式将钾输送到体内的片剂，包含多个微囊化氯化钾晶体，其进一步用增塑聚合物涂覆以改善微胶囊的压缩性。可压缩微胶囊与压缩助剂如微晶纤维素和助流剂如胶体二氧化硅混合，形成控制释放的氯化钾片。片剂可以任选地包括其它赋形剂，例如表面活性剂和崩解剂。如此生产的片剂不仅具有高的抗碎强度和低脆性，而且以类似于市售的氯化钾片剂的所需的控制释放方式释放人体中的钾。

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