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1. 发明申请

US20220197004A1 Virtual Slide Stage (VSS) Method For Viewing Whole Slide Images 有权
公开(公告)号：US20220197004A1
公开(公告)日：2022-06-23
申请号：US17646133
申请日：2021-12-27
申请人： Corista ,LLC
发明人： Eric W. Wirch , David C. Wilbur , Richard Y. Wingard, II , Alexander Andryushkin
IPC分类号： G02B21/36 , G02B21/34 , G02B21/26 , G16H30/20 , G06V20/69
摘要： Embodiments provide slide navigation technology that addresses challenges in digital pathology of navigating and viewing high resolution slide images. Example systems comprise a virtual slide stage (VSS) having at least one sensor that detects user movement of a target placed on the VSS, and an input component, coupled to the VSS, which provides quick function movement control of the target via quick functions. The systems also comprise a connector component that connects the VSS to a user device and transmits output from the at least one sensor and input component to the user device. The systems further comprise a computer processor, in communication with the VSS, which processes the output using a computational model to generate data representing movement profiles of the target. The computer processor executes a software component, causing the output, translated based on the movement profiles, to be relayed via a viewing application on the user device.

2. 发明授权

US09710668B2 User targeted medical imaging and information packaging, compression and distribution system 有权
公开(公告)号：US09710668B2
公开(公告)日：2017-07-18
申请号：US14824315
申请日：2015-08-12
申请人： CORISTA, LLC
发明人： Charles P. Pace , Eric W. Wirch
IPC分类号： G06F15/16 , G06F21/62 , G06K9/00 , G06F17/30 , G06T7/00 , G06F19/00 , H04L29/08 , G06F17/22 , H04L29/06
CPC分类号： G06F21/6245 , G06F17/2235 , G06F17/301 , G06F17/30247 , G06F17/3028 , G06F17/30722 , G06F19/00 , G06F19/321 , G06F19/3418 , G06K9/00 , G06T7/0012 , G06T2200/24 , G06T2207/10056 , G06T2207/30004 , G06T2207/30072 , G16H10/60 , G16H15/00 , G16H50/20 , G16H80/00 , H04L63/108 , H04L67/10
摘要： A computer-based method and system of distributing biological sample data acquired as a digital image of a subject biological sample. The acquired digital image and image capture data are processed according to at least one user. This results in processed image data and capture metadata. The processed image data represents biological sample data of the subject biological sample. A package processing combines the processed image data and capture metadata into a working Package. The method and system enables simultaneous electronic access to the working Package by multiple users, across multiple sectors, in addition to the one user.

3. 发明申请

US20180188519A1 Virtual Slide Stage (VSS) Method For Viewing Whole Slide Images 审中-公开
公开(公告)号：US20180188519A1
公开(公告)日：2018-07-05
申请号：US15730296
申请日：2017-10-11
申请人： Corista, LLC
发明人： Eric W. Wirch , David C. Wilbur , Richard Y. Wingard, II , Michael Ryan Tomer , Kevin Christopher Dorosh , Jonathan Mitchell Gaines , Odell Christian Dotson , Aristana Olivia Scourtas
IPC分类号： G02B21/36 , G06K9/00 , G02B21/26 , G02B21/34
CPC分类号： G02B21/365 , G02B21/26 , G02B21/34 , G06K9/00127 , G16H30/20
摘要： Embodiments provide slide navigation technology that addresses challenges in digital pathology of navigating and viewing high resolution slide images. Example systems comprise a virtual slide stage (VSS) having at least one sensor that detects user movement of a target placed on the VSS, and an input component, coupled to the VSS, which provides quick function movement control of the target via quick functions. The systems also comprise a connector component that connects the VSS to a user device and transmits output from the at least one sensor and input component to the user device. The systems further comprise a computer processor, in communication with the VSS, which processes the output using a computational model to generate data representing movement profiles of the target. The computer processor executes a software component, causing the output, translated based on the movement profiles, to be relayed via a viewing application on the user device.

4. 发明申请

US20150142732A1 CONTINUOUS IMAGE ANALYTICS 审中-公开
标题翻译：连续图像分析
公开(公告)号：US20150142732A1
公开(公告)日：2015-05-21
申请号：US14543875
申请日：2014-11-17
申请人： CORISTA LLC
发明人： Charles P. Pace , Eric Wirch
IPC分类号： G06F17/30
CPC分类号： G06F16/5838
摘要： A method, system, and computer-readable set of instructions on a storage medium are provided for querying, analyzing, and processing image data and data/metadata associated with the image data. For example, a tissue sample is made into a slide. A digital or electronic image is made of the slide. That electronic image is then parsed with respect to color, brightness, magnification, intensity, and other available image parameters. The parsed information is then used in searching and reiteratively searching a database of images from one or more sources. If different magnification levels are observed, the images are normalized and/or color corrected. If different types or levels of results are desired, a difference magnification version of the image can be used, searched, and reiteratively searched for in a database of images from one or more sources. The database can be a dynamic database which is continuously being updated, enlarged, and/or reduced.
摘要翻译：提供存储介质上的方法，系统和计算机可读的指令集，用于查询，分析和处理与图像数据相关联的图像数据和数据/元数据。例如，将组织样品制成载玻片。数字或电子图像由幻灯片制成。然后，关于颜色，亮度，放大倍率，强度和其他可用的图像参数解析该电子图像。然后将解析的信息用于搜索并重复地搜索来自一个或多个源的图像的数据库。如果观察到不同的放大级别，则图像被归一化和/或颜色校正。如果需要不同类型或结果级别，则可以在来自一个或多个源的图像的数据库中使用，搜索和重复搜索图像的差异放大版本。数据库可以是不断更新，扩大和/或减少的动态数据库。

5. 发明申请

US20130219027A1 User Targeted Medical Imaging And Information Packaging, Compression And Distribution System 有权
标题翻译：用户目标医疗成像和信息包装，压缩和分配系统
公开(公告)号：US20130219027A1
公开(公告)日：2013-08-22
申请号：US13856226
申请日：2013-04-03
申请人： Corista, LLC
发明人： Charles P. Pace , Eric W. Wirch
IPC分类号： G06F17/30
CPC分类号： G06F21/6245 , G06F17/2235 , G06F17/301 , G06F17/30247 , G06F17/3028 , G06F17/30722 , G06F19/00 , G06F19/321 , G06F19/3418 , G06K9/00 , G06T7/0012 , G06T2200/24 , G06T2207/10056 , G06T2207/30004 , G06T2207/30072 , G16H10/60 , G16H15/00 , G16H50/20 , G16H80/00 , H04L63/108 , H04L67/10
摘要： A computer-based method and system of distributing biological sample data acquired as a digital image of a subject biological sample. The acquired digital image and image capture data are processed according to at least one user. This results in processed image data and capture metadata. The processed image data represents biological sample data of the subject biological sample. A package processing combines the processed image data and capture metadata into a working Package. The method and system enables simultaneous electronic access to the working Package by multiple users, across multiple sectors, in addition to the one user.
摘要翻译：一种基于计算机的方法和系统，其分配作为受试者生物样品的数字图像获取的生物样本数据。所获取的数字图像和图像捕获数据根据至少一个用户进行处理。这导致处理的图像数据和捕获元数据。经处理的图像数据表示对象生物样品的生物样本数据。包处理将处理的图像数据和捕获元数据组合到工作包中。除了一个用户之外，该方法和系统还允许跨多个扇区同时电子访问多个用户的工作包。

6. 发明申请

US20210407076A1 Multi-sample Whole Slide Image Processing in Digital Pathology via Multi-resolution Registration and Machine Learning 有权
公开(公告)号：US20210407076A1
公开(公告)日：2021-12-30
申请号：US17192658
申请日：2021-03-04
申请人： Corista, LLC
发明人： Eric W. Wirch , Alexander Andryushkin , Richard Y. Wingard, II , Nigel Lee , Aristana Olivia Scourtas , David C. Wilbur
IPC分类号： G06T7/00 , G06K9/00 , G06K9/62 , G06T3/00 , G06F3/0485 , G06F3/0484 , G06T3/40 , G06T7/194
摘要： When reviewing digital pathology tissue specimens, multiple slides may be created from thin, sequential slices of tissue. These slices may then be prepared with various stains and digitized to generate a Whole Slide Image (WSI). Review of multiple WSIs is challenging because of the lack of homogeneity across the images. In embodiments, to facilitate review, WSIs are aligned with a multi-resolution registration algorithm, normalized for improved processing, annotated by an expert user, and divided into image patches. The image patches may be used to train a Machine Learning model to identify features useful for detection and classification of regions of interest (ROIs) in images. The trained model may be applied to other images to detect and classify ROIs in the other images, which can aid in navigating the WSIs. When the resulting ROIs are presented to the user, the user may easily navigate and provide feedback through a display layer.

7. 发明申请

US20200348503A1 Virtual Slide Stage (VSS) Method For Viewing Whole Slide Images 审中-公开
公开(公告)号：US20200348503A1
公开(公告)日：2020-11-05
申请号：US16849766
申请日：2020-04-15
申请人： Corista, LLC
发明人： Eric W. Wirch , David C. Wilbur , Richard Y. Wingard, II , Michael Ryan Tomer , Kevin Christopher Dorosh , Jonathan Mitchell Gaines , Odell Christian Dotson , Aristana Olivia Scourtas
IPC分类号： G02B21/36 , G02B21/34 , G02B21/26 , G06K9/00 , G16H30/20
摘要： Embodiments provide slide navigation technology that addresses challenges in digital pathology of navigating and viewing high resolution slide images. Example systems comprise a virtual slide stage (VSS) having at least one sensor that detects user movement of a target placed on the VSS, and an input component, coupled to the VSS, which provides quick function movement control of the target via quick functions. The systems also comprise a connector component that connects the VSS to a user device and transmits output from the at least one sensor and input component to the user device. The systems further comprise a computer processor, in communication with the VSS, which processes the output using a computational model to generate data representing movement profiles of the target. The computer processor executes a software component, causing the output, translated based on the movement profiles, to be relayed via a viewing application on the user device.

8. 发明申请

US20190355113A1 Multi-sample Whole Slide Image Processing in Digital Pathology via Multi-resolution Registration and Machine Learning 审中-公开
公开(公告)号：US20190355113A1
公开(公告)日：2019-11-21
申请号：US16393876
申请日：2019-04-24
申请人： Corista, LLC
发明人： Eric W. Wirch , Alexander Andryushkin , Richard Y. Wingard, II , Nigel Lee , Aristana Olivia Scourtas , David C. Wilbur
IPC分类号： G06T7/00 , G06T7/194 , G06K9/00 , G06K9/62 , G06T3/00 , G06F3/0485 , G06F3/0484 , G06T3/40
摘要： When reviewing digital pathology tissue specimens, multiple slides may be created from thin, sequential slices of tissue. These slices may then be prepared with various stains and digitized to generate a Whole Slide Image (WSI). Review of multiple WSIs is challenging because of the lack of homogeneity across the images. In embodiments, to facilitate review, WSIs are aligned with a multi-resolution registration algorithm, normalized for improved processing, annotated by an expert user, and divided into image patches. The image patches may be used to train a Machine Learning model to identify features useful for detection and classification of regions of interest (ROIs) in images. The trained model may be applied to other images to detect and classify ROIs in the other images, which can aid in navigating the WSIs. When the resulting ROIs are presented to the user, the user may easily navigate and provide feedback through a display layer.

9. 发明授权

US09110924B2 User targeted medical imaging and information packaging, compression and distribution system 有权
标题翻译：用户定位医学影像和信息包装，压缩和分配系统
公开(公告)号：US09110924B2
公开(公告)日：2015-08-18
申请号：US13856226
申请日：2013-04-03
申请人： Corista, LLC
发明人： Charles P. Pace , Eric W. Wirch
IPC分类号： G06F15/16 , G06F17/30 , G06F19/00 , H04L29/08
CPC分类号： G06F21/6245 , G06F17/2235 , G06F17/301 , G06F17/30247 , G06F17/3028 , G06F17/30722 , G06F19/00 , G06F19/321 , G06F19/3418 , G06K9/00 , G06T7/0012 , G06T2200/24 , G06T2207/10056 , G06T2207/30004 , G06T2207/30072 , G16H10/60 , G16H15/00 , G16H50/20 , G16H80/00 , H04L63/108 , H04L67/10
摘要： A computer-based method and system of distributing biological sample data acquired as a digital image of a subject biological sample. The acquired digital image and image capture data are processed according to at least one user. This results in processed image data and capture metadata. The processed image data represents biological sample data of the subject biological sample. A package processing combines the processed image data and capture metadata into a working Package. The method and system enables simultaneous electronic access to the working Package by multiple users, across multiple sectors, in addition to the one user.
摘要翻译：一种基于计算机的方法和系统，其分配作为受试者生物样品的数字图像获取的生物样本数据。所获取的数字图像和图像捕获数据根据至少一个用户进行处理。这导致处理的图像数据和捕获元数据。经处理的图像数据表示对象生物样品的生物样本数据。包处理将处理的图像数据和捕获元数据组合到工作包中。除了一个用户之外，该方法和系统还允许跨多个扇区同时电子访问多个用户的工作包。

10. 发明授权

US11231575B2 Virtual slide stage (VSS) method for viewing whole slide images 有权
公开(公告)号：US11231575B2
公开(公告)日：2022-01-25
申请号：US16849766
申请日：2020-04-15
申请人： Corista, LLC
发明人： Eric W. Wirch , David C. Wilbur , Richard Y. Wingard, II , Michael Ryan Tomer , Kevin Christopher Dorosh , Jonathan Mitchell Gaines , Odell Christian Dotson , Aristana Olivia Scourtas
IPC分类号： G02B21/36 , G02B21/34 , G02B21/26 , G06K9/00 , G16H30/20
摘要： Embodiments provide slide navigation technology that addresses challenges in digital pathology of navigating and viewing high resolution slide images. Example systems comprise a virtual slide stage (VSS) having at least one sensor that detects user movement of a target placed on the VSS, and an input component, coupled to the VSS, which provides quick function movement control of the target via quick functions. The systems also comprise a connector component that connects the VSS to a user device and transmits output from the at least one sensor and input component to the user device. The systems further comprise a computer processor, in communication with the VSS, which processes the output using a computational model to generate data representing movement profiles of the target. The computer processor executes a software component, causing the output, translated based on the movement profiles, to be relayed via a viewing application on the user device.

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