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1. 发明授权

US07981646B2 Preparation of vanillin from microbial transformation media by extraction by means supercritical fluids or gases 有权
标题翻译：通过超临界流体或气体萃取从微生物转化培养基中制备香草醛
公开(公告)号：US07981646B2
公开(公告)日：2011-07-19
申请号：US10550945
申请日：2004-03-29
申请人： Steve Heald , Steve Myers , Tim Walford , Keith Robbins , Colin Hill
发明人： Steve Heald , Steve Myers , Tim Walford , Keith Robbins , Colin Hill
IPC分类号： C12P7/04
CPC分类号： C12R1/465 , C12P7/24 , C12R1/01 , Y02P20/544
摘要： Crude solid vanillin-containing material is precipitated from a solution obtained by biotransformation, and purified by a process comprising contacting it with a purification fluid selected from (a) a liquefied gas whose pressure exceeds its critical pressure and whose temperature is below its critical temperature; (b) a supercritical fluid; (c) a gas. The fluid is preferably liquid carbon dioxide. The temperature is maintained below 25°. The product may be further purified by treatment with CO2 in a fluid bed drier. The crude material is preferably one precipitated from a solution resulting from biotransformation of ferulic acid. A new strain of Amycolatopsis capable of generating high concentrations of vanillin with minimal odoriferous by-products (e.g. guaiacol) is also disclosed.
摘要翻译：从通过生物转化获得的溶液中沉淀含粗固体香草醛的材料，并通过包括使其与选自（a）压力超过其临界压力并且其温度低于其临界温度的液化气体的净化流体接触的方法纯化; （b）超临界流体; （c）气体。流体优选为液体二氧化碳。温度保持在25°以下。可以通过在流化床干燥器中用CO 2处理来进一步纯化产物。原料优选是从由阿魏酸的生物转化得到的溶液中沉淀出来的。还公开了能够产生高浓度香草醛的最新气味副产物（例如愈创木酚）的新型菌株。

2. 发明申请

US20110059060A1 THURICIN CD, AN ANTIMICROBIAL FOR SPECIFICALLY TARGETING CLOSTRIDIUM DIFFICILE 有权
标题翻译： THURICIN CD，用于特异性靶向抗菌药物的抗微生物剂
公开(公告)号：US20110059060A1
公开(公告)日：2011-03-10
申请号：US12745299
申请日：2008-11-28
申请人： Colin Hill , Mary Rea , Paul Ross
发明人： Colin Hill , Mary Rea , Paul Ross
IPC分类号： A61K35/74 , C12N1/20 , C07K14/32 , A61K38/16 , C12N1/21 , A61P31/04 , A61P1/00
CPC分类号： C07K14/32 , A61K38/00 , A61K2035/11 , C12N1/06 , C12R1/075 , Y10S435/832
摘要： The present invention relates to a new bacteriocin, to microbial strains which can produce it and to uses of the bacteriocin and the strains. The bacteriocin is effective against Clostridium difficile and Listeria monocytogenes amongst other organisms.
摘要翻译：本发明涉及一种新的细菌素，可以产生它的微生物菌株以及细菌素和菌株的用途。细菌素对其他生物体内的艰难梭菌和单核细胞增多性李斯特菌有效。

3. 发明申请

US20050267720A1 Methods and systems for the identification of components of mammalian biochemical networks as targets for therapeutic agents 审中-公开
公开(公告)号：US20050267720A1
公开(公告)日：2005-12-01
申请号：US10990868
申请日：2004-11-17
申请人： Colin Hill , Iya Khalil , Guillermo Calero
发明人： Colin Hill , Iya Khalil , Guillermo Calero
IPC分类号： G06F19/00 , G06G7/48 , G06G7/58
CPC分类号： G16B5/00 , G01N2800/52 , Y10S707/99943
摘要： Systems and methods for modeling the interactions of the several genes, proteins and other components of a cell, employing mathematical techniques to represent the interrelationships between the cell components and the manipulation of the dynamics of the cell to determine which components of a cell may be targets for interaction with therapeutic agents. A first such method is based on a cell simulation approach in which a cellular biochemical network intrinsic to a phenotype of the cell is simulated by specifying its components and their interrelationships. The various interrelationships are represented with one or more mathematical equations which are solved to simulate a first state of the cell. The simulated network is then perturbed by deleting one or more components, changing the concentration of one or more components, or modifying one or more mathematical equations representing the interrelationships between one or more of the components. The equations representing the perturbed network are solved to simulate a second state of the cell which is compared to the first state to identify the effect of the perturbation on the state of the network, thereby identifying one or more components as targets. A second method for identifying components of a cell as targets for interaction with therapeutic agents is based upon an analytical approach, in which a stable phenotype of a cell is specified and correlated to the state of the cell and the role of that cellular state to its operation. A cellular biochemical network believed to be intrinsic to that phenotype is then specified by identifying its components and their interrelationships and representing those interrelationships in one or more mathematical equations. The network is then perturbed and the equations representing the perturbed network are solved to determine whether the perturbation is likely to cause the transition of the cell from one phenotype to another, thereby identifying one or more components as targets.

4. 发明授权

US09597362B2 Use of probiotic bacteria in the treatment of infection 有权
公开(公告)号：US09597362B2
公开(公告)日：2017-03-21
申请号：US10576010
申请日：2004-10-15
申请人： Paul Ross , Colin Hill , William Meaney
发明人： Paul Ross , Stephen Hallahan , Colin Hill , William Meaney
IPC分类号： A61K35/744
CPC分类号： A61K35/744
摘要： The disclosure relates to the live cultures of probiotic bacteria to treat infectious diseases in humans and animals. Food-grade or non-pathogenic cultures are used to treat localised infections.

5. 发明授权

US08563292B2 Preparation of vanillin from microbial transformation media by extraction by means supercritical fluids or gases 有权
标题翻译：通过超临界流体或气体萃取从微生物转化培养基中制备香草醛
公开(公告)号：US08563292B2
公开(公告)日：2013-10-22
申请号：US13182515
申请日：2011-07-14
申请人： Steve Heald , Steve Myers , Tim Walford , Keith Robbins , Colin Hill
发明人： Steve Heald , Steve Myers , Tim Walford , Keith Robbins , Colin Hill
IPC分类号： C12N1/20
CPC分类号： C12R1/465 , C12P7/24 , C12R1/01 , Y02P20/544
摘要： Crude solid vanillin-containing material is precipitated from a solution obtained by biotransformation, and purified by a process comprising contacting it with a purification fluid selected from (a) a liquefied gas whose pressure exceeds its critical pressure and whose temperature is below its critical temperature; (b) a supercritical fluid; (c) a gas. The fluid is preferably liquid carbon dioxide. The temperature is maintained below 25° . The product may be further purified by treatment with CO2 in a fluid bed drier. The crude material is preferably one precipitated from a solution resulting from biotransformation of ferulic acid. A new strain of Amycolatopsis capable of generating high concentrations of vanillin with minimal odoriferous by-products (e.g. guaiacol) is also disclosed.
摘要翻译：从通过生物转化获得的溶液中沉淀含粗固体香草醛的材料，并通过包括使其与选自（a）压力超过其临界压力并且其温度低于其临界温度的液化气体的净化流体接触的方法纯化; （b）超临界流体; （c）气体。流体优选为液体二氧化碳。温度保持在25°以下。可以通过在流化床干燥器中用CO 2处理来进一步纯化产物。原料优选是从由阿魏酸的生物转化得到的溶液中沉淀出来的。还公开了能够产生高浓度香草醛的最新气味副产物（例如愈创木酚）的新型菌株。

6. 发明申请

US20130005647A1 MUTANT NISIN SER 29 DERIVATIVES AND THE USE THEREOF 有权
标题翻译： MUTANT NISIN SER 29衍生物及其用途
公开(公告)号：US20130005647A1
公开(公告)日：2013-01-03
申请号：US13517179
申请日：2010-12-22
申请人： Colin Hill , Paul Cotter , Paul R. Ross , Desmond Field
发明人： Colin Hill , Paul Cotter , Paul R. Ross , Desmond Field
IPC分类号： C07K14/195 , C12N15/31 , A61P1/04 , C12N1/21 , A61P31/04 , A61P17/10 , A61K38/12 , C12N15/63
CPC分类号： C07K14/315 , A61K38/00
摘要： A Nisin derivative or variant, comprising an amino acid substitution at amino acid position 29 in the amino acid sequence. The Nisin derivative exhibits enhanced antimicrobial activity when compared to wild type Nisin. The Nisin derivative has an application as a natural food additive and as a therapeutic agent.
摘要翻译：乳链菌素衍生物或变体，其包含氨基酸序列中氨基酸位置29处的氨基酸取代。当与野生型乳链菌肽相比时，乳链菌素衍生物表现出增强的抗微生物活性。乳链菌肽衍生物作为天然食品添加剂和治疗剂具有应用。

7. 发明申请

US20120177608A1 PSEUDOMONAS AERUGINOSA BACTERIOPHAGE(S) AND USES THEREOF 审中-公开
标题翻译： PSEUDOMONAS AERUGINOSA BACTERIOPHAGE（S）及其用途
公开(公告)号：US20120177608A1
公开(公告)日：2012-07-12
申请号：US13330744
申请日：2011-12-20
申请人： Paul Ross , Debebe Alemayehu , Colin Hill , James Gerard Martin
发明人： Paul Ross , Debebe Alemayehu , Colin Hill , James Gerard Martin
IPC分类号： A61K35/76 , A61P31/04 , C12N7/00
CPC分类号： C12N7/00 , A61K35/76 , C12N2795/10132 , C12N2795/10232
摘要： An isolated bacteriophage MR299-2 or NH-4 deposited under NCIMB Deposit Accession Nos. 41729 and 41730, respectively, is described. The phages have lytic activity against P. aeruginosa strains, including mucoid and CF clinical isolate strains. Variant hages are also described, wherein said variants retain the phenotypic characteristics of said phage and wherein said phage and variants thereof have lytic activity against P. aeruginosa strains.
摘要翻译：描述了分别在NCIMB沉积物登录号41729和41730下沉积的分离的噬菌体MR299-2或NH-4。噬菌体对铜绿假单胞菌菌株具有裂解活性，包括粘液样和CF临床分离菌株。还描述了变体hage，其中所述变体保留所述噬菌体的表型特征，并且其中所述噬菌体及其变体具有针对铜绿假单胞菌菌株的裂解活性。

8. 发明申请

US20110268858A1 PREPARATION OF VANILLIN FROM MICROBIAL TRANSFORMATION MEDIA BY EXTRACTION BY MEANS SUPERCRITICAL FLUIDS OR GASES 有权
标题翻译：通过超临界流体或气体萃取从微生物转化介质中制备凡尼宁
公开(公告)号：US20110268858A1
公开(公告)日：2011-11-03
申请号：US13182515
申请日：2011-07-14
申请人： Steve Heald , Steve Myers , Tim Walford , Keith Robbins , Colin Hill
发明人： Steve Heald , Steve Myers , Tim Walford , Keith Robbins , Colin Hill
IPC分类号： A23L1/221 , C12N1/20 , C12N1/21
CPC分类号： C12R1/465 , C12P7/24 , C12R1/01 , Y02P20/544
摘要： Crude solid vanillin-containing material is precipitated from a solution obtained by biotransformation, and purified by a process comprising contacting it with a purification fluid selected from (a) a liquefied gas whose pressure exceeds its critical pressure and whose temperature is below its critical temperature; (b) a supercritical fluid; (c) a gas. The fluid is preferably liquid carbon dioxide. The temperature is maintained below 25° . The product may be further purified by treatment with CO2 in a fluid bed drier. The crude material is preferably one precipitated from a solution resulting from biotransformation of ferulic acid. A new strain of Amycolatopsis capable of generating high concentrations of vanillin with minimal odoriferous by-products (e.g. guaiacol) is also disclosed.
摘要翻译：从通过生物转化获得的溶液中沉淀含粗固体香草醛的材料，并通过包括使其与选自（a）压力超过其临界压力并且其温度低于其临界温度的液化气体的净化流体接触的方法纯化; （b）超临界流体; （c）气体。流体优选为液体二氧化碳。温度保持在25°以下。可以通过在流化床干燥器中用CO 2处理来进一步纯化产物。原料优选是从由阿魏酸的生物转化得到的溶液中沉淀出来的。还公开了能够产生高浓度香草醛的最新气味副产物（例如愈创木酚）的新型菌株。

9. 发明授权

US07713020B2 Extracting energy from flowing fluids 有权
标题翻译：从流动的液体中提取能量
公开(公告)号：US07713020B2
公开(公告)日：2010-05-11
申请号：US10564490
申请日：2004-07-12
申请人： Aaron Davidson , Craig Colin Hill
发明人： Aaron Davidson , Craig Colin Hill
IPC分类号： F04D27/02
CPC分类号： F03D3/0418 , F03B3/183 , F03D1/04 , F05B2210/18 , F05B2240/133 , Y02E10/223 , Y02E10/28 , Y02E10/38 , Y02E10/72 , Y02E10/74 , Y10S415/907
摘要： A method and apparatus (10) for extracting energy from flowing fluids using a diffuser (11) which has side walls (14) formed from a series of aerofoil section members (15) with gaps (29) provided between the leading and trailing ends of the members (15) to allow introduction of fluid from outside of the diffuser (11) into the diffuser flow passage (16) such that increased energy can be extracted from the flowing fluid by a prime mover (20) located in the flow passage (16).
摘要翻译：一种用于使用扩散器（11）从流动流体中提取能量的方法和装置（10），所述扩散器具有由一系列翼型部件（15）形成的侧壁（14），间隙（29）设置在前端和后端所述构件（15）允许将流体从所述扩散器（11）的外部引入所述扩散器流动通道（16），使得能够通过位于所述流动通道中的原动机（20）从流动流体中提取增加的能量 16）。

10. 发明授权

US06833150B1 Spray -dried bacteriocin powder with anti-microbial activity 失效
标题翻译：喷雾干燥的细菌素粉末具有抗微生物活性
公开(公告)号：US06833150B1
公开(公告)日：2004-12-21
申请号：US09720382
申请日：2001-03-07
申请人： Reynolds Paul Ross , Colin Hill
发明人： Reynolds Paul Ross , Colin Hill
IPC分类号： A23L33526
CPC分类号： A23C9/13 , A23C9/1232 , A23C19/11 , A23L3/3463 , A23L3/34635 , A23Y2240/41 , C07K14/315
摘要： The production of a spray-dried bacteriocin lacticin 3147 powder is described. The powder is shown to have effective anti-microbial activity in a range of foodstuffs, namely infant milk formulations, powdered soup, yoghurt and cottage cheese. Increased anti-microbial activity was demonstrated when the lacticin 3147 powder was used in conjunction with increased hydrostatic pressure. The process comprises: inoculating a medium with a lacticin 3147-producing strain of bacteria, fermenting the inoculated medium, adjusting the pH of the fermentation to 6.3-6.7, inactivating the bacterial fermentate and evaporating the fermentate.
摘要翻译：描述了喷雾干燥的细菌素乳酸菌3147粉末的生产。该粉末显示在一系列食品中具有有效的抗微生物活性，即婴儿奶粉配方，汤粉，酸奶和酸奶酪。当乳酸3147粉末与增加的静水压力结合使用时，证明了增加的抗微生物活性。该方法包括：将培养基接种于生产菌的产菌菌株3147，发酵接种的培养基，调节发酵pH至6.3-6.7，灭活细菌发酵液并蒸发发酵液。

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