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1. 发明申请

US20070292676A1 Microcapsules Loaded with Active Ingredients and a Method for Their Preparation 有权
标题翻译：装有活性成分的微胶囊及其制备方法
公开(公告)号：US20070292676A1
公开(公告)日：2007-12-20
申请号：US10566369
申请日：2004-08-01
申请人： Oleg Naigertsik , Sorel Rothschild , Claudio Rottman
发明人： Oleg Naigertsik , Sorel Rothschild , Claudio Rottman
IPC分类号： B01J13/18 , A61K8/18 , A61K8/44 , A61Q17/04
CPC分类号： B01J13/185 , A01N25/28 , A23P10/30 , A61K8/11 , A61K2800/412 , A61K2800/434 , A61Q1/02 , A61Q17/04 , C09B67/0097 , Y10T428/249995 , Y10T428/249997
摘要： The invention relates to microcapsules having a core material encapsulated within a microcapsular shell, the core material comprises at least one active ingredient, wherein the microcapsular shell comprises at least one inorganic polymer comprising polymerized precursors obtained by in-situ polymerization of the precursors; wherein the concentration of the core material based total weight of the microcapsules is above 95% w/w. The invention further relates to a composition and to a suspension comprising the microcapsules. The invention additionally relates to a process for preparing the microcapsules.
摘要翻译：本发明涉及具有包封在微胶囊壳内的芯材料的微胶囊，所述芯材料包含至少一种活性成分，其中所述微胶囊壳包含至少一种包含通过所述前体的原位聚合获得的聚合前体的无机聚合物; 其中所述芯材料基于所述微胶囊的总重量的浓度高于95％w / w。本发明还涉及包含微胶囊的组合物和悬浮液。本发明还涉及一种制备微胶囊的方法。

2. 发明申请

US20060251687A1 Agent-encapsulating micro-and nanoparticles, methods for preparation of same and products containing same 有权
标题翻译：封装微粒和纳米颗粒的方法及其制备方法及含有其的产品
公开(公告)号：US20060251687A1
公开(公告)日：2006-11-09
申请号：US10549148
申请日：2004-03-11
申请人： Noa Lapidot , Merav Blanca , Claudio Rottman , Oleg Naigertsik
发明人： Noa Lapidot , Merav Blanca , Claudio Rottman , Oleg Naigertsik
IPC分类号： A61K36/47 , A61K9/14 , A61K8/02
CPC分类号： A61K8/042 , A61K8/0241 , A61K8/11 , A61K9/1611 , A61K9/1652 , A61K9/5115 , A61K9/5123 , A61K9/5161 , A61K9/5192 , A61K2800/412 , A61K2800/56 , A61K2800/621 , A61Q1/02 , A61Q11/00 , Y10T428/2984
摘要： Substantially leachless, agent-encapsulating sol-gel particles, methods of preparing same and products containing same are provided
摘要翻译：提供了基本无浸剂，包封剂的溶胶 - 凝胶颗粒，其制备方法和含有其的产品

3. 发明授权

US06303149B1 Method for the preparation of oxide microcapsules loaded with functional molecules and the products obtained thereof 有权
标题翻译：制备负载有功能分子的氧化物微胶囊的方法及其获得的产品
公开(公告)号：US06303149B1
公开(公告)日：2001-10-16
申请号：US09372176
申请日：1999-08-11
申请人： Shlomo Magdassi , David Avnir , Alon Seri-Levy , Noa Lapidot , Claudio Rottman , Yoram Sorek , Orit Gans
发明人： Shlomo Magdassi , David Avnir , Alon Seri-Levy , Noa Lapidot , Claudio Rottman , Yoram Sorek , Orit Gans
IPC分类号： A61K914
CPC分类号： A61K8/042 , A23L27/72 , A61K8/11 , A61K8/35 , A61K8/37 , A61K9/5146 , A61K2800/412 , A61Q17/04 , Y10S514/937 , Y10S514/951 , Y10T428/2984
摘要： The present invention relates to a novel process for preparing sol-gel microcapsules loaded with up to 95% (w/w) functional molecules or substances and to the products obtained by said process. Said process is conducted in two steps: (a) creating an oil-in-water emulsion by emulsification of a water insoluble solution comprising the sol-gel precursors and the molecules to be loaded, in an aqueous solution under appropriate shear forces; (b) mixing and stirring said emulsion with an aqueous solution at a suitably selected pH to obtain loaded sol-gel microcapsules in suspension. The microcapsules so obtained can further be subjected to cycles of isolation and rinsing. Incorporation of the final product, either in the form of a suspension or a powder, in cosmetic formulations affords a transparent cream when applying to skin and has a smooth and pleasant contact.
摘要翻译：本发明涉及一种制备负载高达95％（w / w）功能分子或物质的溶胶 - 凝胶微胶囊以及通过所述方法获得的产品的新方法。所述方法分两步进行：（a）通过在适当的剪切力下在水溶液中乳化包含溶胶 - 凝胶前体和待加载的分子的水不溶性溶液来产生水包油乳液; （b）在适当选择的pH下用水溶液混合和搅拌所述乳液，以得到负载的溶胶 - 凝胶微胶囊悬浮液。如此获得的微胶囊可以进一步进行分离和漂洗的循环。在化妆品配方中以悬浮液或粉末的形式加入最终产品，当应用于皮肤并具有光滑和愉快的接触时，可提供透明的乳膏。

4. 发明申请

US20120321685A1 COMPOSITIONS CONTAINING OILS HAVING A SPECIFIC GRAVITY HIGHER THAN THE SPECIFIC GRAVITY OF WATER 审中-公开
标题翻译：具有高于特定重力水平的特定重量的油的组合物
公开(公告)号：US20120321685A1
公开(公告)日：2012-12-20
申请号：US13597219
申请日：2012-08-28
申请人： Noa LAPIDOT , Claudio ROTTMAN , Ludmila SOSONKIN , Fabio BIAGINI , Oleg NAIGERTSIK
发明人： Noa LAPIDOT , Claudio ROTTMAN , Ludmila SOSONKIN , Fabio BIAGINI , Oleg NAIGERTSIK
IPC分类号： A61K8/11 , A61Q17/04 , A61K38/43 , A01N25/28 , A61Q19/02 , A61Q5/02 , A61Q19/10 , A61Q1/02 , A61Q1/06 , A61P17/00 , A61P31/04 , A61P31/10 , A61P17/06 , A61P1/02 , A61K9/50
CPC分类号： A61Q19/00 , A61K8/042 , A61K8/11 , A61K8/25 , A61K8/37 , A61K2800/412 , A61Q17/04
摘要： The invention relates to pharmaceutical or cosmetic compositions preferably in the form of microcapsules or microparticles which include at least one active ingredient and an oil or a mixture of oils wherein the oil or mixture of oils alone or in combination with the active ingredient have a specific gravity higher than the specific gravity of water. The invention further relates to a process for preparing said compositions.
摘要翻译：本发明涉及药物或化妆品组合物，其优选为微胶囊或微粒形式，其包括至少一种活性成分和油或油的混合物，其中单独或与活性成分组合的油或油的混合物具有比重高于水的比重。本发明还涉及制备所述组合物的方法。

5. 发明申请

US20100255107A1 COMPOSITION EXHIBITING ENHANCED FORMULATION STABILITY AND DELIVERY OF TOPICAL ACTIVE INGREDIENTS 有权
标题翻译：组合物展示增强配方稳定性和局部活性成分的输送
公开(公告)号：US20100255107A1
公开(公告)日：2010-10-07
申请号：US12818924
申请日：2010-06-18
申请人： Noa Lapidot , Shlomo Magdassi , David Avnir , Claudio Rottman , Orit Gans , Alon Seri-Levy
发明人： Noa Lapidot , Shlomo Magdassi , David Avnir , Claudio Rottman , Orit Gans , Alon Seri-Levy
IPC分类号： A61K9/50 , A61K8/11 , A61K31/235 , A61K8/37 , A61K31/7048 , A61P17/06 , A61P17/10 , A61P29/00 , A61P31/12 , A61P31/04 , A61Q90/00 , A61K8/60
CPC分类号： A61K8/042 , A61K8/11 , A61K8/25 , A61K8/37 , A61K8/38 , A61K8/602 , A61K8/671 , A61K9/501 , A61K9/5031 , A61K9/5115 , A61K9/5138 , A61K2800/412 , A61K2800/75 , A61Q1/00 , A61Q5/02 , A61Q5/12 , A61Q11/00 , A61Q17/04 , A61Q19/00 , B82Y5/00 , Y10S514/844 , Y10S514/937 , Y10S514/944 , Y10S514/945
摘要： A therapeutic, cosmetic or cosmeceutic composition for topical application, capable of stabilizing an active ingredient and delivering the active ingredient, comprising a plurality of microcapsules having a core-shell structure. The microcapsules have a diameter of approximately 0.1 to 100 micron. The core of each microcapsule includes at least one active ingredient, and is encapsulated within a microcapsular shell. The shell is comprised of at least one inorganic polymer obtained by a sol-gel process, and the shell protects the active ingredient before topical application and is designed to release the active ingredient from the microcapsules following application. The composition is useful in encapsulating active ingredients, such as benzoyl peroxide, that are unstable in other formulation, or are irritating to the skin.
摘要翻译：一种用于局部施用的治疗性，化妆品或药妆组合物，其能够稳定活性成分并递送活性成分，其包含多个具有核 - 壳结构的微胶囊。微胶囊的直径约为0.1至100微米。每个微胶囊的核心包含至少一种活性成分，并被包封在微胶囊壳内。壳由至少一种通过溶胶 - 凝胶法获得的无机聚合物组成，并且外壳在局部施用之前保护活性成分，并被设计成在施用后从微胶囊中释放活性成分。该组合物可用于包封在其它制剂中不稳定或对皮肤有刺激性的活性成分，例如过氧化苯甲酰。

6. 发明申请

US20090247685A1 NANO-METAL PARTICLE-CONTAINING POLYMER COMPOSITES, METHODS FOR PRODUCING SAME, AND USES FOR SAME 审中-公开
标题翻译：纳米金属颗粒聚合物复合材料，其生产方法及其用途
公开(公告)号：US20090247685A1
公开(公告)日：2009-10-01
申请号：US11909707
申请日：2006-03-23
申请人： Fernando De La Vega , Arkady Garbar , Claudio Rottman
发明人： Fernando De La Vega , Arkady Garbar , Claudio Rottman
IPC分类号： C08K3/08 , C09K3/00 , C08K7/18
CPC分类号： C08K9/04
摘要： Composites featuring nano-metal particles in a polymer matrix, as well as methods and compositions, for making such composites and uses for such composites (e.g., as masterbatches) are described.
摘要翻译：在聚合物基质中具有纳米金属颗粒的复合材料以及用于制备这种复合材料的方法和组合物以及用于这种复合材料（例如，作为母料）的方法和组合物。

7. 发明授权

US06238650B1 Sunscreen composition containing sol-gel microcapsules 有权
标题翻译：含有溶胶 - 凝胶微胶囊的防晒组合物
公开(公告)号：US06238650B1
公开(公告)日：2001-05-29
申请号：US09318828
申请日：1999-05-26
申请人： Noa Lapidot , Shlomo Magdassi , David Avnir , Claudio Rottman , Orit Gans , Alon Seri-Levy
发明人： Noa Lapidot , Shlomo Magdassi , David Avnir , Claudio Rottman , Orit Gans , Alon Seri-Levy
IPC分类号： A61K742
CPC分类号： A61K8/042 , A61K8/11 , A61K8/25 , A61K8/35 , A61K8/37 , A61K8/40 , A61K8/445 , A61K2800/412 , A61Q17/04 , Y10S514/962
摘要： The present invention generally relates to safe and stable sunscreen compositions comprising of at least one sunscreen active ingredient in the form of an inert sol-gel microcapsules encapsulating ultraviolet absorbing compounds in any acceptable cosmetic vehicle. The composition according to the present invention can comprise several ultraviolet absorbers that may be encapsulated in the same sol-gel microcapsule or in different capsules. The encapsulation of the ultraviolet absorbers reduces or even prevents the contact between the sunscreen compounds and the human tissue, thus reducing various adverse effects that are associated with the use of sunscreens, such as photoallergy and phototoxicity, and makes the composition safer for use. The encapsulation also reduces or even prevents cross reactivity between the sunscreen compounds and the packaging material and between the sunscreen compounds and any other component present in the composition, thus enhance the compositions stability. The hydophobicity/hydrophilicity character of the sol-gel microcapsules can be controlled by selecting suitable sol-gel precursors and suitable reaction conditions and can be chosen to be compatible with the cosmetic vehicle to be used in the sunscreen composition, thus, the present invention facilitates an easy incorporation of the composite sol-gel encapsulated sunscreen in all types of cosmetic vehicles including oil free compositions, with no necessary steps of heating or high shear forces. The sunscreen compositions of the present invention can comprise any acceptable UVA and/or UVB absorbing compounds at any desired ratio to obtain a desired accumulative ultraviolet screening spectrum.
摘要翻译：本发明一般涉及安全和稳定的防晒组合物，其包含至少一种防霉活性成分，其形式为在任何可接受的化妆品载体中包封紫外线吸收化合物的惰性溶胶 - 凝胶微胶囊形式。根据本发明的组合物可以包含几种可以包封在相同溶胶 - 凝胶微胶囊或不同胶囊中的紫外线吸收剂。紫外线吸收剂的封装减少或甚至防止防晒化合物与人体组织之间的接触，从而减少与防晒剂的使用相关的各种不利影响，例如光过敏和光毒性，并使组合物更安全地使用。封装还降低或甚至防止防晒化合物和包装材料之间以及防晒化合物和组合物中存在的任何其它组分之间的交叉反应性，从而增强组合物的稳定性。可以通过选择合适的溶胶 - 凝胶前体和合适的反应条件来控制溶胶 - 凝胶微胶囊的疏水性/亲水性，并且可以选择与化妆品相容以用于防晒组合物，因此本发明有利于将复合溶胶 - 凝胶包胶的防晒剂容易地并入包括无油组合物的所有类型的化妆品载体中，没有必要的加热步骤或高剪切力。本发明的防晒组合物可以以任何所需的比例包含任何可接受的UVA和/或UVB吸收化合物，以获得所需的累积紫外线屏蔽谱。

8. 发明授权

US08110284B2 Microcapsules loaded with active ingredients and a method for their preparation 有权
标题翻译：装有活性成分的微胶囊及其制备方法
公开(公告)号：US08110284B2
公开(公告)日：2012-02-07
申请号：US10566369
申请日：2004-08-01
申请人： Oleg Naigertsik , Sorel Rothschild , Claudio Rottman
发明人： Oleg Naigertsik , Sorel Rothschild , Claudio Rottman
IPC分类号： B01J13/18 , A61K8/18 , A61K8/44 , A61Q17/04
CPC分类号： B01J13/185 , A01N25/28 , A23P10/30 , A61K8/11 , A61K2800/412 , A61K2800/434 , A61Q1/02 , A61Q17/04 , C09B67/0097 , Y10T428/249995 , Y10T428/249997
摘要： The invention relates to microcapsules having a core material encapsulated within a microcapsular shell, the core material comprises at least one active ingredient, wherein the microcapsular shell comprises at least one inorganic polymer comprising polymerized precursors obtained by in-situ polymerization of the precursors; wherein the concentration of the core material based total weight of the microcapsules is above 95% w/w. The invention further relates to a composition and to a suspension comprising the microcapsules. The invention additionally relates to a process for preparing the microcapsules.
摘要翻译：本发明涉及具有包封在微胶囊壳内的芯材料的微胶囊，所述芯材料包含至少一种活性成分，其中所述微胶囊壳包含至少一种包含通过所述前体的原位聚合获得的聚合前体的无机聚合物; 其中所述芯材料基于所述微胶囊的总重量的浓度高于95％w / w。本发明还涉及包含微胶囊的组合物和悬浮液。本发明还涉及一种制备微胶囊的方法。

9. 发明授权

US08039020B2 Composition exhibiting enhanced formulation stability and delivery of topical active ingredients 有权
标题翻译：表现出增强的制剂稳定性和局部活性成分递送的组合物
公开(公告)号：US08039020B2
公开(公告)日：2011-10-18
申请号：US12818924
申请日：2010-06-18
申请人： Noa Lapidot , Shlomo Magdassi , David Avnir , Claudio Rottman , Orit Gans , Alon Seri-Levy
发明人： Noa Lapidot , Shlomo Magdassi , David Avnir , Claudio Rottman , Orit Gans , Alon Seri-Levy
IPC分类号： A61K9/14 , A61K9/00 , A61K31/07 , A61K31/19 , A61K31/327
CPC分类号： A61K8/042 , A61K8/11 , A61K8/25 , A61K8/37 , A61K8/38 , A61K8/602 , A61K8/671 , A61K9/501 , A61K9/5031 , A61K9/5115 , A61K9/5138 , A61K2800/412 , A61K2800/75 , A61Q1/00 , A61Q5/02 , A61Q5/12 , A61Q11/00 , A61Q17/04 , A61Q19/00 , B82Y5/00 , Y10S514/844 , Y10S514/937 , Y10S514/944 , Y10S514/945
摘要： A therapeutic, cosmetic or cosmeceutic composition for topical application, capable of stabilizing an active ingredient and delivering the active ingredient, comprising a plurality of microcapsules having a core-shell structure. The microcapsules have a diameter of approximately 0.1 to 100 micron. The core of each microcapsule includes at least one active ingredient, and is encapsulated within a microcapsular shell. The shell is comprised of at least one inorganic polymer obtained by a sol-gel process, and the shell protects the active ingredient before topical application and is designed to release the active ingredient from the microcapsules following application. The composition is useful in encapsulating active ingredients, such as benzoyl peroxide, that are unstable in other formulation, or are irritating to the skin.
摘要翻译：一种用于局部施用的治疗性，化妆品或药妆组合物，其能够稳定活性成分并递送活性成分，其包含多个具有核 - 壳结构的微胶囊。微胶囊的直径约为0.1至100微米。每个微胶囊的核心包含至少一种活性成分，并被包封在微胶囊壳内。壳由至少一种通过溶胶 - 凝胶法获得的无机聚合物组成，并且外壳在局部施用之前保护活性成分，并被设计成在施用后从微胶囊中释放活性成分。该组合物可用于包封在其它制剂中不稳定或对皮肤有刺激性的活性成分，例如过氧化苯甲酰。

10. 发明申请

US20050037087A1 Compositions containing oils having a specific gravity higher than the specific gravity of water 审中-公开
标题翻译：含有比重比水重的油的组合物
公开(公告)号：US20050037087A1
公开(公告)日：2005-02-17
申请号：US10494969
申请日：2002-11-06
申请人： Noa Lapidot , Claudio Rottman , Ludmila Sosonkin , Fabio Biagini , Oleg Naigertsik
发明人： Noa Lapidot , Claudio Rottman , Ludmila Sosonkin , Fabio Biagini , Oleg Naigertsik
IPC分类号： A61K9/50 , A61K8/00 , A61K8/04 , A61K8/11 , A61K8/25 , A61K8/30 , A61K8/33 , A61K8/35 , A61K8/37 , A61K8/38 , A61K8/72 , A61K8/92 , A61K9/16 , A61K31/121 , A61K31/125 , A61K31/235 , A61K31/327 , A61K31/785 , A61K47/10 , A61K47/14 , A61K47/34 , A61P17/00 , A61P17/06 , A61P17/10 , A61P17/16 , A61P29/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61Q1/00 , A61Q1/04 , A61Q1/10 , A61Q1/12 , A61Q5/02 , A61Q17/04 , A61Q19/00
CPC分类号： A61Q19/00 , A61K8/042 , A61K8/11 , A61K8/25 , A61K8/37 , A61K2800/412 , A61Q17/04
摘要： The invention relates to pharmaceutical or cosmetic compositions preferably in the form of microcapsules or microparticles which include at least one active ingredient and an oil or a mixture of oils wherein the oil or mixture of oils alone or in combination with the active ingredient have a specific gravity higher than the specific gravity of water. The invention further relates to a process for preparing said compositions.
摘要翻译：本发明涉及药物或化妆品组合物，其优选为微胶囊或微粒形式，其包括至少一种活性成分和油或油的混合物，其中单独或与活性成分组合的油或油的混合物具有比重高于水的比重。本发明还涉及制备所述组合物的方法。

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