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1. 发明申请

US20110007955A1 Apparatus and Method for Barcoded Magnetic Beads Analysis 审中-公开
标题翻译：条形磁珠分析装置与方法
公开(公告)号：US20110007955A1
公开(公告)日：2011-01-13
申请号：US12832972
申请日：2010-07-08
申请人： Winston Z. Ho , John Collins , Chung-Jen Hou
发明人： Winston Z. Ho , John Collins , Chung-Jen Hou
IPC分类号： G06K9/00
CPC分类号： G06K19/06028 , B01J2219/00497 , B01J2219/00547 , B01J2219/00585 , B01J2219/00605 , B01J2219/00693 , B01J2219/00722 , B01L3/54 , C40B20/04 , C40B50/16
摘要： A Light Transmitted Assay Beads or digital magnetic microbead having a digitally coded structure that is partially transmissive and opaque to light. When hundreds or thousands of LITAB are settled down to the bottom of a microwell in a microplate or a planar surface, the barcode can be decoded by image processed accurately and reliable. Microplate is a standard bioassay format; each plate can have 96, 384, or 1536 patient samples. Therefore, a large number of targets in a sample can be analyzed in one single microwell. The image decoding algorithms comprise of four main processes (1) enhancement of image (2) segmentation of beads (3) extraction of barcode slits, and (4) decoding of barcodes. The bead image is taken from the bottom of an optically clear microplate, and barcode pattern can be decoded by image software. Therefore, the whole bead bioassay experiment can be performed in the microplate without taking the beads out.
摘要翻译：光透射测定具有数字编码结构的珠或数字磁微珠，其部分透射并且对于光不透明。当数百或数千个LITAB沉降到微孔板或平面表面的微孔底部时，条形码可以通过精确可靠的图像进行解码。微孔板是标准的生物测定方法; 每个板可以具有96,384或1536个患者样品。因此，可以在单个微孔中分析样品中的大量靶标。图像解码算法包括四个主要过程（1）图像增强（2）珠粒分割（3）条形码切片提取，以及（4）条形码解码。从光学透明微板的底部取出珠粒图像，并且可以通过图像软件对条形码图案进行解码。因此，可以在微量培养板中进行全部小珠生物测定实验，而不用将珠子取出。

2. 发明授权

US07094347B2 Positively charged membrane 有权
公开(公告)号：US07094347B2
公开(公告)日：2006-08-22
申请号：US11035950
申请日：2005-01-18
申请人： Xiaosong Wu , Chung-Jen Hou , Jayesh Dharia , Peter Konstantin , Yujing Yang
发明人： Xiaosong Wu , Chung-Jen Hou , Jayesh Dharia , Peter Konstantin , Yujing Yang
IPC分类号： B01D63/00 , B01D63/08 , B01D39/16 , B01D29/46 , B01D63/14
CPC分类号： B01D67/0088 , B01D15/361 , B01D15/363 , B01D61/00 , B01D61/14 , B01D69/02 , B01D69/10 , B01D69/125 , B01D71/40 , B01D71/44 , B01D71/60 , B01D71/82 , B01D2325/16 , B01D2325/30 , B01D2325/36 , B01J20/28033 , B01J20/28035 , B01J20/3272 , B01J20/3282 , B01J41/12 , B01J41/13 , B01J41/20 , B01J47/12 , C12N15/1017 , G01N33/54393
摘要： The present invention provides a positively charged microporous membrane having a protein binding capacity of about 25 mg/ml or greater comprising a hydrophilic porous substrate and a crosslinked coating that provides a fixed positive charge to the membrane. The present invention further provides a positively charged microporous membrane comprising a porous substrate and a crosslinked coating comprising pendant cationic groups. The membranes of the present invention find use in a variety of applications including ion-exchange chromatography, macromolecular transfer, as well as detection, filtration and purification of biomolecules such as proteins, nucleic acids, endotoxins, and the like.

3. 发明申请

US20050139537A1 Negatively charged membrane 有权
标题翻译：负电荷膜
公开(公告)号：US20050139537A1
公开(公告)日：2005-06-30
申请号：US11037356
申请日：2005-01-19
申请人： Chung-Jen Hou , Peter Konstantin , Yujing Yang
发明人： Chung-Jen Hou , Peter Konstantin , Yujing Yang
IPC分类号： B01D15/36 , B01D61/00 , B01D61/14 , B01D67/00 , B01D71/08 , B01D71/40 , B01J20/28 , B01J20/32 , B01J39/20 , B01J39/26 , B01J47/12 , C07K1/34 , C12M1/34 , C02F1/44
CPC分类号： B01D67/0088 , B01D15/362 , B01D61/00 , B01D61/007 , B01D61/14 , B01D67/0009 , B01D71/08 , B01D71/40 , B01D2323/12 , B01D2323/30 , B01D2325/14 , B01D2325/36 , B01J20/261 , B01J20/262 , B01J20/264 , B01J20/267 , B01J20/28035 , B01J20/2804 , B01J20/28078 , B01J20/2808 , B01J20/286 , B01J20/3208 , B01J20/3212 , B01J20/327 , B01J20/3274 , B01J20/3282 , B01J39/20 , B01J39/26 , B01J47/12 , B01J2220/44 , B01J2220/54 , C07K1/34 , Y10T436/143333
摘要： The present invention provides, in certain embodiments, a negatively charged microporous membrane comprising a porous substrate and a crosslinked coating having fixed negative charges. The crosslinked coating can be prepared, e.g., from a polymerized composition comprising an unsaturated monomer having an anionic group, an N-(hydroxymethyl)- and/or N-(alkoxymethyl)-acrylamide, a hydrophilic unsaturated monomer, and an initiator. The present invention further provides, in some embodiments, a negatively charged microporous membrane comprising a porous substrate and a crosslinked coating prepared from a polymerized composition comprising an unsaturated monomer having an anionic group, an N-(hydroxymethyl)- or N-(alkoxymethyl)-acrylamide, a polysaccharide, and an initiator. The membranes of the present invention are suitable for use in ion exchange chromatography, for example, in the separation and purification of positively charged species such as proteins.
摘要翻译：本发明在某些实施方案中提供了一种带负电荷的微多孔膜，其包含多孔基底和具有固定负电荷的交联涂层。交联涂层可以例如由含有阴离子基团的不饱和单体，N-（羟甲基） - 和/或N-（烷氧基甲基） - 丙烯酰胺，亲水性不饱和单体和引发剂的聚合组合物制备。在一些实施方案中，本发明进一步提供了一种带负电荷的微多孔膜，其包含多孔基材和由聚合组合物制备的交联涂层，所述聚合组合物包含具有阴离子基团的不饱和单体，N-（羟甲基） - 或N-（烷氧基甲基） - 丙烯酰胺，多糖和引发剂。本发明的膜适用于离子交换色谱法，例如分离和纯化带正电荷的物质如蛋白质。

4. 发明授权

US4791063A Polyionene transformed modified polysaccharide supports 失效
标题翻译：聚异戊二烯转化改性多糖载体
公开(公告)号：US4791063A
公开(公告)日：1988-12-13
申请号：US758064
申请日：1985-07-23
申请人： Kenneth C. Hou , Chung-Jen Hou , Haunn-Lin Chen
发明人： Kenneth C. Hou , Chung-Jen Hou , Haunn-Lin Chen
IPC分类号： B01J20/28 , B01J20/32 , B01J39/22 , B01J41/16 , B01J47/12 , C08F251/00 , C08G81/02 , G01N30/38 , G01N30/60 , C12N1/00
CPC分类号： B01J20/28026 , B01J20/28028 , B01J20/28033 , B01J20/28052 , B01J20/3212 , B01J20/3248 , B01J20/3251 , B01J20/3255 , B01J39/22 , B01J41/16 , B01J47/123 , C08F251/00 , C08G81/02 , G01N2030/386 , G01N30/6091 , Y10S435/803
摘要： Polyionene-transformed modified polymer-polysaccharide separation matrix and use thereof in removing contaminants of microorganism origin from biological liquids are disclosed.
摘要翻译：公开了聚苯乙烯转化的改性聚合物 - 多糖分离基质及其在从生物液体中除去微生物来源污染物的用途。

5. 发明授权

US08084553B2 Curable adhesive compositions, process, and applications 有权
标题翻译：可固化的粘合剂组合物，工艺和应用
公开(公告)号：US08084553B2
公开(公告)日：2011-12-27
申请号：US12008375
申请日：2008-01-10
申请人： Rong-Chang Liang , John J. McNamara , Yurong Ying , Chung-Jen Hou
发明人： Rong-Chang Liang , John J. McNamara , Yurong Ying , Chung-Jen Hou
IPC分类号： C08L61/34 , C08L63/00 , C08L63/02 , C08L63/04 , H01L23/29
CPC分类号： C08G59/245 , C08G59/3218 , C08L63/00 , C09J163/00 , C08L2666/22
摘要： The invention provides an improvement to the useable lifetimes of phenolic-epoxy, phenolic-benzoxazine, phenolic-epoxy-benzoxazine mixtures and other phenolic mixtures through the use of protected phenolics, where a phenolic compound, polymer, or resin is released on demand by the addition of a deblocking agent.
摘要翻译：本发明通过使用受保护的酚醛树脂来改进酚醛环氧树脂，酚 - 苯并恶嗪，酚 - 环氧 - 苯并恶嗪混合物和其它酚类混合物的使用寿命，其中根据需要释放酚类化合物，聚合物或树脂加入去块剂。

6. 发明申请

US20090181165A1 Curable adhesive compositions, Process, and applications 有权
标题翻译：可固化的粘合剂组合物，工艺和应用
公开(公告)号：US20090181165A1
公开(公告)日：2009-07-16
申请号：US12008375
申请日：2008-01-10
申请人： Rong-Chang Liang , John J. McNamara , Yurong Ying , Chung-Jen Hou
发明人： Rong-Chang Liang , John J. McNamara , Yurong Ying , Chung-Jen Hou
IPC分类号： B05D5/12 , C07D303/16 , C08G59/02 , C08G65/22
CPC分类号： C08G59/245 , C08G59/3218 , C08L63/00 , C09J163/00 , C08L2666/22
摘要： The invention provides an improvement to the useable lifetimes of phenolic-epoxy, phenolic-benzoxazine, phenolic-epoxy-benzoxazine mixtures and other phenolic mixtures through the use of protected phenolics, where a phenolic compound, polymer, or resin is released on demand by the addition of a deblocking agent.
摘要翻译：本发明通过使用受保护的酚醛树脂来改进酚醛环氧树脂，酚 - 苯并恶嗪，酚 - 环氧 - 苯并恶嗪混合物和其它酚类混合物的使用寿命，其中根据需要释放酚类化合物，聚合物或树脂加入去块剂。

7. 发明授权

US07396465B2 Positively charged membrane 有权
标题翻译：带正电荷的膜
公开(公告)号：US07396465B2
公开(公告)日：2008-07-08
申请号：US11742749
申请日：2007-05-01
申请人： Xiaosong Wu , Chung-Jen Hou , Jayesh Dharia , Peter Konstantin , Yujing Yang
发明人： Xiaosong Wu , Chung-Jen Hou , Jayesh Dharia , Peter Konstantin , Yujing Yang
IPC分类号： B01D71/26 , B01D71/28 , B01D71/40 , B01D71/44 , B01D71/06
CPC分类号： B01D67/0088 , B01D15/361 , B01D15/363 , B01D61/00 , B01D61/14 , B01D69/02 , B01D69/10 , B01D69/125 , B01D71/40 , B01D71/44 , B01D71/60 , B01D71/82 , B01D2325/16 , B01D2325/30 , B01D2325/36 , B01J20/28033 , B01J20/28035 , B01J20/3272 , B01J20/3282 , B01J41/12 , B01J41/13 , B01J41/20 , B01J47/12 , C12N15/1017 , G01N33/54393
摘要： The present invention provides a positively charged microporous membrane having a protein binding capacity of about 25 mg/ml or greater comprising a hydrophilic porous substrate and a crosslinked coating that provides a fixed positive charge to the membrane. The present invention further provides a positively charged microporous membrane comprising a porous substrate and a crosslinked coating comprising pendant cationic groups. The membranes of the present invention find use in a variety of applications including ion-exchange chromatography, macromolecular transfer, as well as detection, filtration and purification of biomolecules such as proteins, nucleic acids, endotoxins, and the like.
摘要翻译：本发明提供了具有约25mg / ml或更大的蛋白结合能力的带正电荷的微多孔膜，其包含亲水性多孔基底和向膜提供固定的正电荷的交联涂层。本发明还提供一种带正电的微多孔膜，其包括多孔基材和包含阳离子阳离子基团的交联涂层。本发明的膜可用于各种应用，包括离子交换层析，大分子转移，以及生物分子如蛋白质，核酸，内毒素等的检测，过滤和纯化。

8. 发明授权

US07132049B2 Negatively charged membrane 有权
标题翻译：负电荷膜
公开(公告)号：US07132049B2
公开(公告)日：2006-11-07
申请号：US11037356
申请日：2005-01-19
申请人： Chung-Jen Hou , Peter Konstantin , Yujing Yang
发明人： Chung-Jen Hou , Peter Konstantin , Yujing Yang
IPC分类号： B01D39/00 , B01D63/00 , B01D11/00 , C02F1/44
CPC分类号： B01D67/0088 , B01D15/362 , B01D61/00 , B01D61/007 , B01D61/14 , B01D67/0009 , B01D71/08 , B01D71/40 , B01D2323/12 , B01D2323/30 , B01D2325/14 , B01D2325/36 , B01J20/261 , B01J20/262 , B01J20/264 , B01J20/267 , B01J20/28035 , B01J20/2804 , B01J20/28078 , B01J20/2808 , B01J20/286 , B01J20/3208 , B01J20/3212 , B01J20/327 , B01J20/3274 , B01J20/3282 , B01J39/20 , B01J39/26 , B01J47/12 , B01J2220/44 , B01J2220/54 , C07K1/34 , Y10T436/143333
摘要： The present invention provides, in certain embodiments, a negatively charged microporous membrane comprising a porous substrate and a crosslinked coating having fixed negative charges. The crosslinked coating can be prepared, e.g., from a polymerized composition comprising an unsaturated monomer having an anionic group, an N-(hydroxymethyl)- and/or N-(alkoxymethyl)-acrylamide, a hydrophilic unsaturated monomer, and an initiator. The present invention further provides, in some embodiments, a negatively charged microporous membrane comprising a porous substrate and a crosslinked coating prepared from a polymerized composition comprising an unsaturated monomer having an anionic group, an N-(hydroxymethyl)- or N-(alkoxymethyl)-acrylamide, a polysaccharide, and an initiator. The membranes of the present invention are suitable for use in ion exchange chromatography, for example, in the separation and purification of positively charged species such as proteins.
摘要翻译：本发明在某些实施方案中提供了一种带负电荷的微多孔膜，其包含多孔基底和具有固定负电荷的交联涂层。交联涂层可以例如由含有阴离子基团的不饱和单体，N-（羟甲基） - 和/或N-（烷氧基甲基） - 丙烯酰胺，亲水性不饱和单体和引发剂的聚合组合物制备。在一些实施方案中，本发明进一步提供了一种带负电荷的微多孔膜，其包含多孔基材和由聚合组合物制备的交联涂层，所述聚合组合物包含具有阴离子基团的不饱和单体，N-（羟甲基） - 或N-（烷氧基甲基） - 丙烯酰胺，多糖和引发剂。本发明的膜适用于离子交换色谱法，例如分离和纯化带正电荷的物质如蛋白质。

9. 发明申请

US20050211621A1 Positively charged membrane 有权
标题翻译：带正电荷的膜
公开(公告)号：US20050211621A1
公开(公告)日：2005-09-29
申请号：US11035950
申请日：2005-01-18
申请人： Xiaosong Wu , Chung-Jen Hou , Jayesh Dharia , Peter Konstantin , Yujing Yang
发明人： Xiaosong Wu , Chung-Jen Hou , Jayesh Dharia , Peter Konstantin , Yujing Yang
IPC分类号： B01D15/36 , B01D61/00 , B01D61/14 , B01D63/14 , B01D67/00 , B01D69/02 , B01D69/10 , B01D69/12 , B01D71/40 , B01D71/44 , B01D71/60 , B01D71/82 , B01J20/28 , B01J41/12 , B01J41/20 , B01J47/12
CPC分类号： B01D67/0088 , B01D15/361 , B01D15/363 , B01D61/00 , B01D61/14 , B01D69/02 , B01D69/10 , B01D69/125 , B01D71/40 , B01D71/44 , B01D71/60 , B01D71/82 , B01D2325/16 , B01D2325/30 , B01D2325/36 , B01J20/28033 , B01J20/28035 , B01J20/3272 , B01J20/3282 , B01J41/12 , B01J41/13 , B01J41/20 , B01J47/12 , C12N15/1017 , G01N33/54393
摘要： The present invention provides a positively charged microporous membrane having a protein binding capacity of about 25 mg/ml or greater comprising a hydrophilic porous substrate and a crosslinked coating that provides a fixed positive charge to the membrane. The present invention further provides a positively charged microporous membrane comprising a porous substrate and a crosslinked coating comprising pendant cationic groups. The membranes of the present invention find use in a variety of applications including ion-exchange chromatography, macromolecular transfer, as well as detection, filtration and purification of biomolecules such as proteins, nucleic acids, endotoxins, and the like.
摘要翻译：本发明提供了具有约25mg / ml或更大的蛋白结合能力的带正电荷的微多孔膜，其包含亲水性多孔基底和向膜提供固定的正电荷的交联涂层。本发明还提供一种带正电的微多孔膜，其包括多孔基材和包含阳离子阳离子基团的交联涂层。本发明的膜可用于各种应用，包括离子交换层析，大分子转移，以及生物分子如蛋白质，核酸，内毒素等的检测，过滤和纯化。

10. 发明授权

US06860393B2 Filter device and filter element comprising at least one negatively charged membrane 有权
标题翻译：过滤装置和过滤元件包括至少一个带负电荷的膜
公开(公告)号：US06860393B2
公开(公告)日：2005-03-01
申请号：US10895048
申请日：2004-07-21
申请人： Chung-Jen Hou , Peter Konstantin , Yujing Yang
发明人： Chung-Jen Hou , Peter Konstantin , Yujing Yang
IPC分类号： B01D15/36 , B01D61/00 , B01D61/14 , B01D67/00 , B01D71/08 , B01D71/40 , B01J20/28 , B01J20/32 , B01J39/20 , B01J39/26 , B01J47/12 , C07K1/34 , B01D63/14 , B01D63/10 , B01D71/00
CPC分类号： B01D67/0088 , B01D15/362 , B01D61/00 , B01D61/007 , B01D61/14 , B01D67/0009 , B01D71/08 , B01D71/40 , B01D2323/12 , B01D2323/30 , B01D2325/14 , B01D2325/36 , B01J20/261 , B01J20/262 , B01J20/264 , B01J20/267 , B01J20/28035 , B01J20/2804 , B01J20/28078 , B01J20/2808 , B01J20/286 , B01J20/3208 , B01J20/3212 , B01J20/327 , B01J20/3274 , B01J20/3282 , B01J39/20 , B01J39/26 , B01J47/12 , B01J2220/44 , B01J2220/54 , C07K1/34 , Y10T436/143333
摘要： The present invention provides, in certain embodiments, a negatively charged microporous membrane comprising a porous substrate and a crosslinked coating having fixed negative charges. The crosslinked coating can be prepared, e.g., from a polymerized composition comprising an unsaturated monomer having an anionic group, an N-(hydroxymethyl)- and/or N-(alkoxymethyl)-acrylamide, a hydrophilic unsaturated monomer, and an initiator. The present invention further provides, in some embodiments, a negatively charged microporous membrane comprising a porous substrate and a crosslinked coating prepared from a polymerized composition comprising an unsaturated monomer having an anionic group, an N-(hydroxymethyl)- or N-(alkoxymethyl)-acrylamide, a polysaccharide, and an initiator. The membranes of the present invention are suitable for use in ion exchange chromatography, for example, in the separation and purification of positively charged species such as proteins.
摘要翻译：本发明在某些实施方案中提供了一种带负电荷的微多孔膜，其包含多孔基底和具有固定负电荷的交联涂层。交联涂层可以例如由含有阴离子基团的不饱和单体，N-（羟甲基） - 和/或N-（烷氧基甲基） - 丙烯酰胺，亲水性不饱和单体和引发剂的聚合组合物制备。在一些实施方案中，本发明进一步提供了一种带负电荷的微多孔膜，其包含多孔基材和由聚合组合物制备的交联涂层，所述聚合组合物包含具有阴离子基团的不饱和单体，N-（羟甲基） - 或N-（烷氧基甲基） - 丙烯酰胺，多糖和引发剂。本发明的膜适用于离子交换色谱法，例如分离和纯化带正电荷的物质如蛋白质。

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