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1. 发明授权

US09844543B2 Method of treating or preventing hyperlipidemia with caffeamide derivatives 有权
公开(公告)号：US09844543B2
公开(公告)日：2017-12-19
申请号：US14800206
申请日：2015-07-15
申请人： Chun-Ching Shih
发明人： Chun-Ching Shih , Yueh-Hsiung Kuo , Cheng-Hsiu Lin
IPC分类号： A61K31/4453 , A61K31/165 , A61K31/40
CPC分类号： A61K31/4453 , A61K31/165 , A61K31/40
摘要： The present invention provides a method of treating or preventing hyperlipidemia in a subject in need thereof. Such method includes, specifically, administrating to the subject a therapeutically effective amount of a caffeamide derivative. The present invention also provides a pharmaceutical composition containing, primarily, the caffeamide derivative. The method and pharmaceutical composition of the present invention can effectively and significantly lower the high-fat diet-induced body weight gain and absolute visceral fat weight as well as the concentration of triglycerides and free fatty acids in blood, and levels of total lipid and triacylglycerol in liver tissue. In addition, the caffeamide of the present invention also reduces size of adipocyte, hepatocellular ballooning phenomenon, and liver steatosis. Through promotion of phosphorylation of 5′ adenosine monophosphate-activated protein kinase (AMPK) in muscle and liver, the caffeamide derivatives of the present invention is suitable for ameliorating or remedying hyperlipidemia.

2. 发明申请

US20170049787A1 Derivatives of Ergostatrien-3-Beta-OL From Antrodia Camphorata and Antiglycemic, Antihyperlipidemic and Decreasing Hepatic Fat Use Thereof 有权
标题翻译：来自樟脑的抗坏血酸三酯-3-β-OL的衍生物和抗血清，抗高脂血症和减少其肝脂肪的使用
公开(公告)号：US20170049787A1
公开(公告)日：2017-02-23
申请号：US15011342
申请日：2016-01-29
申请人： Chun-Ching SHIH
发明人： Yueh-Hsiung KUO , Chun-Ching SHIH , Cheng-Hsiu LIN
IPC分类号： A61K31/575 , A61K36/07
CPC分类号： A61K31/575 , A61K36/07 , Y02P20/582
摘要： The present invention provides a method for treating diabetes, hyperlipidemia or hepatic total lipids by using ergostatrien-3β-ol and its derivatives, as well as a method for decreasing blood glucose and HbA1c levels and reducing blood total cholesterol and triglyceride levels, whereas increasing blood HDL-C levels; and a method for decreasing hepatic total lipid and triacylglycerol levels; and increasing expression levels of membrane glucose transporter 4 (GLUT4) and phospho-Akt in skeletal muscle tissue, and phospho-AMPK in both skeletal muscle and liver tissue using ergostatrien-3β-ol and its derivatives.
摘要翻译：本发明提供一种通过使用麦角高三烯-3β-醇及其衍生物治疗糖尿病，高脂血症或肝总脂质的方法，以及降低血糖和HbA1c水平并降低血液总胆固醇和甘油三酯水平的方法，而增加血液 HDL-C水平; 以及降低肝总脂质和甘油三酯水平的方法; 并增加骨骼肌组织中膜葡萄糖转运蛋白4（GLUT4）和磷酸化Akt的表达水平，并使用麦角苦参碱-3β-醇及其衍生物增加骨骼肌和肝组织中的磷酸化AMPK。

3. 发明授权

US08786942B2 Coherently phase combined, high contrast, pulsed optical fiber amplifier array 有权
标题翻译：相干相结合，高对比度，脉冲光纤放大器阵列
公开(公告)号：US08786942B2
公开(公告)日：2014-07-22
申请号：US13495374
申请日：2012-06-13
申请人： Stephen P. Palese , Eric C. Cheung , Gregory D. Goodno , Chun-Ching Shih , Mark E. Weber
发明人： Stephen P. Palese , Eric C. Cheung , Gregory D. Goodno , Chun-Ching Shih , Mark E. Weber
IPC分类号： H04B10/17 , H01S3/23 , H01S3/067
CPC分类号： H01S3/2383 , H01S3/0085 , H01S3/06754 , H01S3/1301 , H01S3/1305 , H01S3/1307 , H01S3/2308
摘要： A pulsed fiber array laser system that has actively stabilized coherent beam combination (CBC) is disclosed. The active stabilization is accomplished using both piston phase control and intra-pulse phase control, allowing a much greater increase in pulse energy. Further stabilization using intra-pulse amplitude control is also disclosed. A chirp profile can be written on the output pulse to enable specific applications. An amplitude profile of the amplifier array may optionally be tailored to match to a reference electrical pulse. Using the current invention, a much smaller number of amplifier chains will be needed to achieve certain pulse energy, resulting in a system with lower complexity, lower cost, smaller size, less weight, and higher reliability.
摘要翻译：公开了一种具有主动稳定的相干光束组合（CBC）的脉冲光纤阵列激光系统。主动稳定是使用活塞相位控制和脉冲内相位控制来实现的，允许脉冲能量增加更多。还公开了使用脉冲内幅度控制的进一步的稳定化。可以在输出脉冲上写入啁啾曲线，以实现特定应用。可以可选地调整放大器阵列的幅度分布以匹配参考电脉冲。使用本发明，需要更少数量的放大器链来实现某些脉冲能量，从而导致具有较低复杂性，较低成本，较小尺寸，较小重量和更高可靠性的系统。

4. 发明授权

US07715099B2 Optical birefringence coronagraph 有权
标题翻译：光学双折射冠
公开(公告)号：US07715099B2
公开(公告)日：2010-05-11
申请号：US11637517
申请日：2006-12-12
申请人： Chun-Ching Shih
发明人： Chun-Ching Shih
IPC分类号： G02B5/30 , G02B27/28
CPC分类号： G02B27/28 , G01J1/04 , G01J1/0414 , G01J1/0418 , G02B5/3083 , G02B23/00 , Y10S359/90
摘要： Systems and methods for attenuating light from undesired sources in a coronagraph apparatus are provided. The coronagraph includes a first imaging lens that receives light representing a desired image and an undesired central image and a reimaging system that mitigates the undesired central image. The reimaging system includes a composite half-wave plate assembly that includes a plurality of angular half-wave plate sections. Each of the plurality of angular half-wave plate sections have two congruent sides that meet at an apex substantially at a center of the composite half-wave plate. A characteristic c-axis associated with a given angular half-wave plate section is aligned differently from the respective characteristic c-axes of at least two angular half-wave plate sections in substantial contact with the two sides of the given angular half-wave plate section. A fixation element engages the half-wave plate sections to maintain the angular half-wave plate sections in a desired arrangement.
摘要翻译：提供了用于衰减冠状器械中不希望的来源的光的系统和方法。冠状物包括第一成像透镜，其接收表示期望图像的光和不期望的中心图像以及减轻不需要的中心图像的再成像系统。该再成像系统包括复合半波片组件，其包括多个角半波片部分。多个角度半波片部分中的每一个具有在复合半波片的中心处的顶点处相交的两个等同侧面。与给定角度半波片部分相关联的特征性c轴与至少两个角度半波片部分的相应特征c轴不同地对准，该角度半波片部分与给定角度半波片的两侧基本接触部分。固定元件与半波片部分接合以将角度半波片部分保持在期望的布置。

5. 发明授权

US07478021B2 Method and means for generating high-order hermite functions for simulation of electromagnetic wave devices 失效
标题翻译：用于产生用于模拟电磁波装置的高阶赫勒姆函数的方法和装置
公开(公告)号：US07478021B2
公开(公告)日：2009-01-13
申请号：US11074455
申请日：2005-03-07
申请人： Chun-Ching Shih
发明人： Chun-Ching Shih
IPC分类号： G06F17/10
CPC分类号： G06F17/5009 , G06F17/10
摘要： A technique for generating very-high-order Hermite functions needed for accurately simulating operation of various devices and structures involving propagation of electromagnetic waves. By using modified recursion formulas, the technique generates asymptotic Hermite functions, smooth Hermite functions or optimized smooth Hermite functions, allowing for very high orders of the functions to be generated without the intermediate function values becoming so large as to exceed the capacity of conventional computers. The disclosed method for generating smooth Hermite functions provides for generation of well-behaved functions of order 30,000 or higher.
摘要翻译：一种用于产生非常高阶Hermite功能的技术，用于准确模拟涉及电磁波传播的各种设备和结构的运行。通过使用修正的递归公式，该技术产生渐近的Hermite函数，平滑的Hermite函数或优化的平滑Hermite函数，允许生成非常高级的函数，而中间函数值不会超过常规计算机的容量。所公开的用于产生平滑的Hermite功能的方法提供了产生30,000或更高等级的良好的功能。

6. 发明申请

US20080137174A1 Adaptive phase mask for producing a phase shift in incident light 有权
公开(公告)号：US20080137174A1
公开(公告)日：2008-06-12
申请号：US11637350
申请日：2006-12-12
申请人： Chun-Ching Shih
发明人： Chun-Ching Shih
IPC分类号： G02B26/06
CPC分类号： G02B26/06
摘要： Systems and methods for shifting the phase of incident light to induce a continuous phase variation in an azimuthal direction. A phase mask apparatus includes a conical mirror assembly and a flexible annular reflector that substantially surrounds at least a portion of the conical mirror assembly. The flexible annular reflector is configured to receive reflected light from the conical mirror assembly. A plurality of driver assemblies are operative to deform the flexible annular reflector as to produce the desired phase response in light reflected from the annular reflector.

7. 发明授权

US5375130A Azimuthal and radial polarization free-electron laser system 失效
标题翻译：方位角和径向偏振自由电子激光系统
公开(公告)号：US5375130A
公开(公告)日：1994-12-20
申请号：US62642
申请日：1993-05-13
申请人： Chun-Ching Shih
发明人： Chun-Ching Shih
IPC分类号： H01S3/09 , H01S3/10 , G02F1/09
CPC分类号： H01S3/0903
摘要： A free-electron laser system and optical polarization conversion are provided for producing azimuthal polarization and radial polarization laser beams. The free-electron laser system includes a helical wiggler for generating a transverse magnetic field around a beam axis. An electron beam is projected along the beam axis and interacts with the transverse magnetic field so as to induce spontaneous and stimulated emission of optical radiation. A resonator cavity is formed by a pair of mirrors in which the optical radiation oscillates therein. The laser system directly produces an azimuthal polarization laser beam as an output. The laser system may further be coupled to an optical polarization converter which includes a pair of optical half-wave plates having a forty-five degree (45.degree.) optical axis difference therebetween. The azimuthal polarization laser beam is transmitted through the optical polarization converter so as to generate a radial polarization output beam. The optical polarization converter may further operate as a bi-directional optical polarization converter for converting between azimuthal polarization and radial polarization laser beams. In addition, optical polarization converter may further operate with other optical axis differences so as to provide a general polarization rotator for rotating polarization according to directions based on selected arbitrary angles.
摘要翻译：提供自由电子激光系统和光学偏振转换，用于产生方位偏振和径向偏振激光束。自由电子激光系统包括用于在光束轴线周围产生横向磁场的螺旋状摆动器。电子束沿着光束轴线投射并与横向磁场相互作用，以引起光辐射的自发和受激发射。谐振器腔由其中光辐射在其中振荡的一对反射镜形成。激光系统直接产生方位偏振激光束作为输出。激光系统还可以耦合到光偏振转换器，该偏振转换器包括一对在其间具有45度（45度）光轴差的光学半波片。方位极化激光束通过光学偏振转换器传输，以产生径向偏振输出光束。光偏振转换器可进一步作为双向光学偏振转换器进行操作，用于在方位极化和径向偏振激光束之间进行转换。此外，光偏振转换器可以进一步与其他光轴差异进行操作，以便根据所选择的任意角度的方向提供用于旋转极化的通用偏振旋转器。

8. 发明申请

US20170014400A1 METHOD OF TREATING OR PREVENTING HYPERLIPIDEMIA WITH CAFFEAMIDE DERIVATIVES 有权
标题翻译：用CAFFEAMIDE衍生物治疗或预防高脂血症的方法
公开(公告)号：US20170014400A1
公开(公告)日：2017-01-19
申请号：US14800206
申请日：2015-07-15
申请人： Chun-Ching Shih
发明人： Chun-Ching Shih , Yueh-Hsiung Kuo , Cheng-Hsiu Lin
IPC分类号： A61K31/4453 , A61K31/40 , A61K31/165
CPC分类号： A61K31/4453 , A61K31/165 , A61K31/40
摘要： The present invention provides a method of treating or preventing hyperlipidemia in a subject in need thereof. Such method includes, specifically, administrating to the subject a therapeutically effective amount of a caffeamide derivative. The present invention also provides a pharmaceutical composition containing, primarily, the caffeamide derivative. The method and pharmaceutical composition of the present invention can effectively and significantly lower the high-fat diet-induced body weight gain and absolute visceral fat weight as well as the concentration of triglycerides and free fatty acids in blood, and levels of total lipid and triacylglycerol in liver tissue. In addition, the caffeamide of the present invention also reduces size of adipocyte, hepatocellular ballooning phenomenon, and liver steatosis. Through promotion of phosphorylation of 5′ adenosine monophosphate-activated protein kinase (AMPK) in muscle and liver, the caffeamide derivatives of the present invention is suitable for ameliorating or remedying hyperlipidemia.
摘要翻译：本发明提供了在有需要的受试者中治疗或预防高脂血症的方法。该方法具体包括向受试者施用治疗有效量的咖啡因衍生物。本发明还提供了主要含有咖啡因衍生物的药物组合物。本发明的方法和药物组合物可以有效和显着地降低高脂肪饮食诱导的体重增加和绝对内脏脂肪重量以及血液中甘油三酯和游离脂肪酸的浓度，以及总脂质和三酰基甘油的水平在肝组织。此外，本发明的咖啡因还可以减少脂肪细胞的大小，肝细胞膨胀现象和肝脂肪变性。通过促进肌肉和肝脏中5'腺苷单磷酸激活蛋白激酶（AMPK）的磷酸化，本发明的咖啡因衍生物适用于改善或补救高脂血症。

9. 发明申请

US20140268306A1 DISTRIBUTED THERMAL SYSTEM FOR NONLINEAR OPTICAL FREQUENCY CONVERSION 有权
标题翻译：用于非线性光学频率转换的分布式热系统
公开(公告)号：US20140268306A1
公开(公告)日：2014-09-18
申请号：US13916266
申请日：2013-06-12
申请人： Hiroshi KOMINE , Joseph M. FUKUMOTO , Chun-Ching SHIH , William H. LONG
发明人： Hiroshi KOMINE , Joseph M. FUKUMOTO , Chun-Ching SHIH , William H. LONG
IPC分类号： G02F1/355 , G02F1/35
CPC分类号： G02F1/3556 , B82Y20/00 , G02F1/353 , G02F1/365 , G02F2001/3507 , G02F2201/16 , G02F2203/60 , Y10S977/755
摘要： A laser frequency converter includes a first substrate material forming a first planar surface that includes a first nonlinear material situated along a portion of the first planar surface of the first substrate material to perform a frequency conversion of a laser signal. The frequency converter includes a second substrate material forming a second planar surface and separated by a distance from the first planar surface of the first substrate material. The second substrate material includes a second nonlinear material situated along a portion of the second planar surface of the second substrate material to perform the frequency conversion of the laser signal in conjunction with the first non-linear material. The second nonlinear material is offset from the first nonlinear material along an axis of propagation for the laser signal.
摘要翻译：激光变频器包括形成第一平面的第一衬底材料，该第一衬底材料包括沿着第一衬底材料的第一平坦表面的一部分设置的第一非线性材料，以执行激光信号的频率转换。变频器包括形成第二平坦表面并与第一基板材料的第一平坦表面分开一段距离的第二基板材料。第二衬底材料包括沿着第二衬底材料的第二平坦表面的一部分设置的第二非线性材料，以与第一非线性材料一起执行激光信号的频率转换。第二非线性材料沿着激光信号的传播轴线偏离第一非线性材料。

10. 发明授权

US07434947B2 Adaptive phase mask for producing a phase shift in incident light 有权
标题翻译：用于产生入射光相移的自适应相位掩模
公开(公告)号：US07434947B2
公开(公告)日：2008-10-14
申请号：US11637350
申请日：2006-12-12
申请人： Chun-Ching Shih
发明人： Chun-Ching Shih
IPC分类号： G02B5/10 , G02B5/08
CPC分类号： G02B26/06
摘要： Systems and methods for shifting the phase of incident light to induce a continuous phase variation in an azimuthal direction. A phase mask apparatus includes a conical mirror assembly and a flexible annular reflector that substantially surrounds at least a portion of the conical mirror assembly. The flexible annular reflector is configured to receive reflected light from the conical mirror assembly. A plurality of driver assemblies are operative to deform the flexible annular reflector as to produce the desired phase response in light reflected from the annular reflector.
摘要翻译：用于移动入射光的相位以在方位角方向上引起连续相位变化的系统和方法。相位掩模装置包括锥形镜组件和基本上围绕锥形镜组件的至少一部分的柔性环形反射器。柔性环形反射器被配置为接收来自锥形反射镜组件的反射光。多个驱动器组件可操作以使柔性环形反射器变形，以在从环形反射器反射的光中产生期望的相位响应。

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