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1. 发明授权

US07645443B2 Polyether-based composition curable by metathesis reaction 有权
标题翻译：通过复分解反应可固化的聚醚基组合物
公开(公告)号：US07645443B2
公开(公告)日：2010-01-12
申请号：US11276270
申请日：2006-02-21
申请人： Christos Angeletakis
发明人： Christos Angeletakis
IPC分类号： A61K7/16 , C08L83/05 , C08L5/24 , C08L3/34
CPC分类号： C08G61/08 , A61K6/09 , A61K6/10 , C08G18/00 , C08G18/4825 , C08G18/4841 , C08G18/4854 , C08G18/6735 , C08G61/00 , C08K3/11 , C08K5/5425 , C08K5/56 , C08L45/00 , C08L75/14 , C08G18/48 , C08L75/16 , A61K6/083
摘要： One-part and two-part compositions curable by a metathesis reaction comprising a resin containing a polyether-based substrate with at least two cycloolefin groups per molecule curable by a metathesis reaction with a metathesis catalyst. These compositions may optionally contain a reaction control agent for slowing the progress of the metathesis reaction. The metathesis catalyst can be a ruthenium carbene complex catalyst. The substrate may be, for example, a difunctional urethane polyester or polyether carboxylate containing norbornenyl end groups.
摘要翻译：通过复分解反应可固化的一部分和两部分组合物，其包含含有每分子具有至少两个环烯烃基团的聚醚基底物的树脂，其通过与复分解催化剂的复分解反应可固化。这些组合物可任选地含有用于减慢复分解反应进程的反应控制剂。复分解催化剂可以是钌卡宾络合物催化剂。基材可以是例如含有降冰片烯基端基的双官能聚氨酯聚酯或聚醚羧酸酯。

2. 发明授权

US07001590B1 Metathesis-curable composition 有权
标题翻译：复分解固化组合物
公开(公告)号：US07001590B1
公开(公告)日：2006-02-21
申请号：US10988881
申请日：2004-11-15
申请人： Christos Angeletakis
发明人： Christos Angeletakis
IPC分类号： A61K7/16 , C08L83/05 , C08L5/24 , C08L3/34
CPC分类号： C08G61/00
摘要： One-part and two-part compositions curable by a metathesis reaction comprising a resin containing a substrate with at least two cycloolefin groups per molecule curable by a metathesis reaction with a metathesis catalyst. These compositions may optionally contain a reaction control agent for slowing the progress of the metathesis reaction. The metathesis catalyst can be a ruthenium carbene complex catalyst. The substrate may be, for example, a difunctional or trifunctional carboxylate ester containing norbornenyl end groups.
摘要翻译：通过复分解反应可固化的一部分和两部分组合物，其包含含有每分子具有至少两个环烯烃基团的基质的树脂，其通过与复分解催化剂的复分解反应可固化。这些组合物可任选地含有用于减慢复分解反应进程的反应控制剂。复分解催化剂可以是钌卡宾络合物催化剂。底物可以是例如含有降冰片烯基端基的二官能或三官能羧酸酯。

3. 发明授权

US06890968B2 Prepolymerized filler in dental restorative composite 有权
标题翻译：牙齿修复复合材料中预聚填料
公开(公告)号：US06890968B2
公开(公告)日：2005-05-10
申请号：US10234594
申请日：2002-09-04
申请人： Christos Angeletakis , Minh-Dang Son Nguyen , Alvin I. Kobashigawa
发明人： Christos Angeletakis , Minh-Dang Son Nguyen , Alvin I. Kobashigawa
IPC分类号： A61K6/083 , C08K3/22 , C08K3/34 , A61C13/08
CPC分类号： A61K6/0091 , A61K6/0073 , A61K6/0088 , A61K6/083 , C08L33/00
摘要： A dental composite having high filler loading and low shrinkage thereby providing good strength and marginal integrity. Through the use of prepolymerized filler particles in combination with a structural filler and a nanofiller, the composite exhibits very low shrinkage and is useful in stress bearing restorations and in cosmetic restorations. The structural filler used is ground to a mean particle size of less than 0.5 μm and the nanofiller has discrete particles of a mean particle size less than 100 nm to improve handling and mechanical characteristics. The prepolymerized filler particles also allow for less viscosity and better handling characteristics of the composite.
摘要翻译：具有高填料负荷和低收缩率的牙科复合材料，从而提供良好的强度和边缘完整性。通过使用与结构填料和纳米填料组合的预聚合填料颗粒，复合材料显示出非常低的收缩率，并且在应力承载修复体和化妆品修复体中是有用的。将所用的结构填料研磨成小于0.5μm的平均粒度，并且纳米填料具有平均粒度小于100nm的离散颗粒，以改善处理和机械特性。预聚合的填料颗粒还允许复合材料的粘度较低和处理性能更好。

4. 发明授权

US06844409B2 Composition curable by metathesis reaction 有权
标题翻译：通过复分解反应可固化的组合物
公开(公告)号：US06844409B2
公开(公告)日：2005-01-18
申请号：US10430953
申请日：2003-05-06
申请人： Christos Angeletakis , Mingfei Chen
发明人： Christos Angeletakis , Mingfei Chen
IPC分类号： C07F15/00 , A61K6/10 , C08G61/08 , C08G77/20 , C08G77/38 , C08L83/07 , C08G77/08
CPC分类号： C08L83/04 , A61K6/10 , C08G61/08 , C08G77/045 , C08G77/20 , C08K5/56
摘要： A composition curable by a metathesis reaction and comprising an olefin-containing resin system and metathesis catalyst. The resin system comprises siloxane-based oligomers or polymers end-capped and/or tethered with olefin functional groups that are capable of undergoing a metathesis reaction. The composition also includes a ruthenium carbene complex catalyst, whereby the catalyst initiates the metathesis reaction of the composition. The oligomer or polymer may be, for example, one or a combination of a telechelic polydimethylsiloxane end-capped with norbornenylethyl groups, a polydimethylsiloxane tethered and end-capped with norbornenylethyl groups, a tri-functional polydimethylsiloxane end-capped with norbornenylethyl groups, or a quadri-functional polydimethylsiloxane end-capped with norbornenylethyl groups. The catalyst may be, for example, a ruthenium carbene complex, such as 1,3-bis-(2,4,6-trimethylphenyl)-2-(imidazolidinylidene) dichloro(o-isopropoxyphenylmethylene) ruthenium.
摘要翻译：通过复分解反应可固化的组合物，其包含含烯烃的树脂体系和复分解催化剂。树脂体系包含硅氧烷基低聚物或端基和/或与能够进行复分解反应的烯烃官能团连接的聚合物。该组合物还包括钌卡宾络合物催化剂，由此催化剂引发组合物的复分解反应。低聚物或聚合物可以是例如一种或其末端封端有降冰片烯乙基的遥爪聚二甲基硅氧烷，连接并用降冰片烯基乙基封端的聚二甲基硅氧烷，用降冰片烯乙基封端的三官能聚二甲基硅氧烷，或用降冰片烯乙基封端的四官能聚二甲基硅氧烷。催化剂可以是例如钌卡宾络合物，例如1,3-双 - （2,4,6-三甲基苯基）-2-（咪唑烷亚基）二氯（邻异丙氧基苯基亚甲基）钌。

5. 发明授权

US06649146B2 Dental impression material utilizing ruthenium metathesis catalyst 有权
公开(公告)号：US06649146B2
公开(公告)日：2003-11-18
申请号：US10010777
申请日：2001-12-06
申请人： Christos Angeletakis , Mingfei Chen
发明人： Christos Angeletakis , Mingfei Chen
IPC分类号： A61K716
CPC分类号： A61K6/10 , C08L51/085
摘要： A composition for use as a dental impression material including a polymerizable resin consisting of oligomers or polymers functionalized with groups curable by ring opening metathesis polymerization. These oligomers or polymers are end-capped and/or tethered with said functional groups. The composition also includes a ruthenium carbene complex catalyst, whereby the catalyst initiates ring-opening metathesis polymerization of the composition. The invention includes a paste/paste system in which a base paste includes the polymerizable oligomer or polymer and an inorganic dental filler system and in which a catalyst paste includes the catalyst dissolved in an inert solvent and an inorganic dental filler system. The oligomer or polymer may be, for example, one or a combination of a telechelic polydimethylsiloxane end-capped with norbornenyl groups, a polydimethylsiloxane tethered and end-capped with norbornenyl groups, a tri-functional polydimethylsiloxane end-capped with norbornenyl groups, or a quadri-functional polydimethylsiloxane end-capped with norbornenyl groups. The catalyst may be, for example, a ruthenium carbene complex with a ligand having a basicity higher than tricyclohexylphosphine. The composition of the present invention exhibits reduced sensitivity to sulfur impurities.

6. 发明授权

US06593395B2 Dental composition containing discrete nanoparticles 有权
公开(公告)号：US06593395B2
公开(公告)日：2003-07-15
申请号：US09859106
申请日：2001-05-16
申请人： Christos Angeletakis , Minh-Dang Son Nguyen
发明人： Christos Angeletakis , Minh-Dang Son Nguyen
IPC分类号： A61K6083
CPC分类号： A61K6/083 , A61K6/0073 , C08L33/00
摘要： The present invention provides a dental composite which has the high strength required for load-bearing restorations, yet maintains a glossy appearance, even after substantial wear. Through the use of particles having a mean particle size between about 0.05 &mgr;m and about 0.50 &mgr;m, the composite is useful in stress bearing restorations and in cosmetic restorations. The structural filler used is typically ground to a mean particle size of less than 0.5 &mgr;m and also includes a nanofiller having discrete particles of a mean particle size less than 100 nm to improve handling and mechanical characteristics. The preferred dental composites maintain their surface finish even after substantial use and also have the strength properties of hybrid composite resins.

7. 发明授权

US07683148B2 Metathesis-curable composition with a reaction control agent 有权
标题翻译：具有反应控制剂的易位固化组合物
公开(公告)号：US07683148B2
公开(公告)日：2010-03-23
申请号：US11428105
申请日：2006-06-30
申请人： Christos Angeletakis
发明人： Christos Angeletakis
IPC分类号： C08F4/80
CPC分类号： A61K6/10 , B01J31/2265 , B01J31/2273 , B01J2231/122 , B01J2231/54 , B01J2531/821 , B01J2531/825 , C08G61/08 , C08G77/20
摘要： A composition curable by a metathesis reaction upon mixing its components and comprising an olefin-containing substrate, a metathesis catalyst, and a reaction control agent for slowing the progress of the metathesis reaction. The metathesis catalyst is a ruthenium or osmium carbene complex catalyst having high activity and good air stability. In one embodiment, the catalyst is free of phosphine ligands. The reaction control agent is an organic compound that contains carbon-carbon double and/or triple bonds and one or more Group 14 atoms and is present in an amount effective to slow the progress of the metathesis reaction. In one embodiment, the olefin-containing substrate may comprise one or more oligomers or polymers having a >20 wt. % linear siloxane (Si—O—Si) backbone tethered and/or end-capped with functional olefin groups, such as cycloalkenyl group.
摘要翻译：通过复分解反应混合其组分可固化的组合物，其包含含烯烃的底物，复分解催化剂和用于减缓复分解反应进程的反应控制剂。复分解催化剂是具有高活性和良好的空气稳定性的钌或咔啉络合物催化剂。在一个实施方案中，催化剂不含膦配体。反应控制剂是含有碳 - 碳双键和/或三键和一个或多个第14族原子并且以有效减缓复分解反应进程的量存在的有机化合物。在一个实施方案中，含烯烃的底物可以包含一种或多种低聚物或具有> 20wt。用线性硅氧烷（Si-O-Si）骨架连接和/或用功能烯烃基团例如环烯基封端的（或）封端的直链硅氧烷（Si-O-Si）骨架。

8. 发明申请

US20060173091A1 POLYETHER-BASED DENTAL IMPRESSION MATERIAL CURABLE BY METATHESIS REACTION 有权
标题翻译：基于聚合物的牙齿印模材料可通过细菌反应固化
公开(公告)号：US20060173091A1
公开(公告)日：2006-08-03
申请号：US11276273
申请日：2006-02-21
申请人： Christos Angeletakis
发明人： Christos Angeletakis
IPC分类号： A61K6/10
CPC分类号： C08G61/00 , A61K6/10 , C08G77/46 , C08L83/12
摘要： Two-part dental impression material curable by a metathesis reaction comprising a base paste with first and second resin components each containing at least two cycloolefin groups per molecule curable by a metathesis reaction with a metathesis catalyst. The first resin includes a urethane polyether or polyester carboxylate backbone terminated with the cycloolefin groups and the second resin includes an alkoxy-siloxane polyether or polyester carboxylate backbone terminated with the cycloolefin groups. The metathesis catalyst can be a ruthenium carbene complex catalyst.
摘要翻译：通过复分解反应可固化的两部分牙科印模材料，其包含具有第一和第二树脂组分的基础糊料，每个分子含有每分子至少两个环烯烃基团，其通过与复分解催化剂的复分解反应固化。第一树脂包括用环烯基封端的氨基甲酸酯聚醚或聚酯羧酸酯主链，第二树脂包括用环烯基封端的烷氧基 - 硅氧烷聚醚或聚酯羧酸酯主链。复分解催化剂可以是钌卡宾络合物催化剂。

9. 发明授权

US07060769B2 Method of curing composition by metathesis reaction using reaction control agent 失效
标题翻译：使用反应控制剂通过复分解反应固化组合物的方法
公开(公告)号：US07060769B2
公开(公告)日：2006-06-13
申请号：US10430590
申请日：2003-05-06
申请人： Christos Angeletakis
发明人： Christos Angeletakis
IPC分类号： C08F4/80
CPC分类号： C08G61/06
摘要： A method of controlled curing by a metathesis reaction upon mixing its components, the method including the step of mixing an olefin-containing substrate, a metathesis catalyst, and a reaction control agent. The metathesis catalyst is a ruthenium or osmium carbene complex catalyst, such as one containing an alkylidene ligand with basicity higher than that of tricyclohexylphosphine (PCy3) and a neutral electron donor ligand with a basicity lower than that of PCy3, whereby the catalyst initiates the metathesis reaction of the composition upon mixing with the substrate. The reaction control agent is effective to slow the progress of the metathesis reaction and prevent its completion in the absence of an elevated temperature. The control agent may be a hydrocarbon containing carbon-carbon double bonds and/or triple bonds, or maybe a modified hydrocarbon with one or more Group 14 or 15 atoms. Prior to catalyst deactivation, the mixture is exposed to an elevated temperature to accelerate the catalyst and allow the metathesis reaction to proceed toward completion.
摘要翻译：在混合其组分时通过复分解反应控制固化的方法，所述方法包括混合含烯烃底物，复分解催化剂和反应控制剂的步骤。复分解催化剂是钌或锇卡宾络合物催化剂，例如含有碱性高于三环己基膦（PCY 3 N 3）的亚烷基配体的碱金属配合物催化剂，和碱性低于 PCy 3，由此催化剂在与基材混合时引发组合物的复分解反应。反应控制剂有效地减缓复分解反应的进行并防止其在没有升高的温度下完成。控制剂可以是含有碳 - 碳双键和/或三键的烃，或者可以是具有一个或多个14或15族原子的改性烃。在催化剂失活之前，将混合物暴露于升高的温度以加速催化剂并允许复分解反应进行到完成。

10. 发明授权

US06861386B2 Accelerator for metathesis catalyst 有权
标题翻译：复分解催化剂加速剂
公开(公告)号：US06861386B2
公开(公告)日：2005-03-01
申请号：US10313359
申请日：2002-12-06
申请人： Christos Angeletakis , Mingfei Chen
发明人： Christos Angeletakis , Mingfei Chen
IPC分类号： C08G61/02 , C08G61/06 , B01J31/00
CPC分类号： C08G61/06
摘要： A polymerizable composition including a resin system comprising oligomers or polymers functionalized with groups curable by ring opening metathesis polymerization, a metathesis catalyst, and a catalyst accelerator. In examples of the present invention, the composition includes a ruthenium carbene complex catalyst capable of initiating ring-opening metathesis polymerization of the composition and a silicone-based sulfosuccinate salt capable of accelerating the polymerization initiated by the catalyst. In another example, the invention includes a paste/paste system in which a base paste includes the polymerizable oligomer or polymer and the catalyst accelerator and in which a catalyst paste includes the catalyst dissolved in an inert solvent.
摘要翻译：一种可聚合组合物，其包含含有通过开环易位聚合可固化的基团官能化的低聚物或聚合物的树脂体系，复分解催化剂和催化剂促进剂。在本发明的实施例中，组合物包括能够引发组合物的开环易位聚合的钌卡宾络合物催化剂和能够促进由催化剂引发的聚合的硅氧烷基磺基琥珀酸盐。在另一个实例中，本发明包括糊状物/糊剂系统，其中基质糊料包括可聚合低聚物或聚合物和催化促进剂，其中催化剂浆料包含溶解在惰性溶剂中的催化剂。

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