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1. 发明申请

US20120214841A1 SOLID FORMS OF N-[2,4-BIS(1,1-DIMETHYLETHYL)-5-HYDROXYPHENYL]-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXAMIDE 有权
标题翻译： N- [2,4-BIS（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-羧酰胺的固体形式
公开(公告)号：US20120214841A1
公开(公告)日：2012-08-23
申请号：US13358778
申请日：2012-01-26
申请人： Patricia Hurter , William Rowe , Christopher R. Young , Adriana Costache , Patrick R. Connelly , Mariusz Krawiec , Yuchuan Gong , Yushi Feng , Martin Trudeau
发明人： Patricia Hurter , William Rowe , Christopher R. Young , Adriana Costache , Patrick R. Connelly , Mariusz Krawiec , Yuchuan Gong , Yushi Feng , Martin Trudeau
IPC分类号： A61K31/47 , A61P11/00 , A61P7/00 , A61P3/10 , A61P5/00 , A61P35/00 , A61P19/08 , A61P25/28 , A61P25/16 , A61P25/00 , A61P21/00 , A61P3/00 , A61P27/02 , A61P37/06 , A61P7/12 , C07D215/56
CPC分类号： A61K31/47 , A61K2300/00 , C07B2200/13 , C07D215/56 , Y10T428/2982
摘要： The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.
摘要翻译：本发明涉及N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺（化合物1）的固体形式，药物组合物及其方法。

2. 发明授权

US08076357B2 Compositions of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide 有权
标题翻译：正 - [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺
公开(公告)号：US08076357B2
公开(公告)日：2011-12-13
申请号：US12471950
申请日：2009-05-26
申请人： Christopher R. Young , Charles William Rowe
发明人： Christopher R. Young , Charles William Rowe
IPC分类号： A61K31/47
CPC分类号： A61K31/47 , A61K9/08 , A61K31/435 , A61K47/10 , A61K47/32 , C07D215/233
摘要： Pharmaceutical compositions including N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1) and methods of using such compositions are described herein.
摘要翻译：包括N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺（化合物1）的药物组合物和使用这些组合物的方法在本文中描述。

3. 发明申请

US20100256184A1 PHARMACEUTICAL COMPOSITION AND ADMINISTRATIONS THEREOF 审中-公开
标题翻译：药物组合物及其药理学
公开(公告)号：US20100256184A1
公开(公告)日：2010-10-07
申请号：US12708359
申请日：2010-02-18
申请人： William Rowe , Patricia Hurter , Christopher R. Young , Kirk Dinehart , Marinus Jacobus Verwijs , Kirk Overhoff , Peter D.J. Grootenhuis , Martyn Botfield , Alfredo Grossi , Gregor Zlokarnik , Fredrick F. Van Goor
发明人： William Rowe , Patricia Hurter , Christopher R. Young , Kirk Dinehart , Marinus Jacobus Verwijs , Kirk Overhoff , Peter D.J. Grootenhuis , Martyn Botfield , Alfredo Grossi , Gregor Zlokarnik , Fredrick F. Van Goor
IPC分类号： A61K31/47 , A61P19/10 , A61P19/08 , A61P11/00
CPC分类号： A61K31/47 , A61K9/146 , A61K9/1652 , A61K9/2018 , A61K9/2054 , A61K9/282 , A61K9/2866 , A61K47/38
摘要： The present invention relates to pharmaceutical compositions comprising a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide, methods of manufacturing pharmaceutical compositions of the present invention, and methods of administering pharmaceutical compositions of the present invention.
摘要翻译：本发明涉及包含N- [2,4-二（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺的固体分散体的药物组合物，制造方法本发明的药物组合物和本发明的药物组合物的给药方法。

4. 发明授权

US06330614B1 Internet and related networks, a method of and system for substitute use of checksum field space in information processing datagram headers for obviating processing speed and addressing space limitations and providing other features 失效
标题翻译：互联网和相关网络，用于在信息处理数据报头中替代使用校验和场空间的方法和系统，以避免处理速度和寻址空间限制并提供其他特征
公开(公告)号：US06330614B1
公开(公告)日：2001-12-11
申请号：US09044999
申请日：1998-03-20
申请人： Vijay K. Aggarwal , Christopher R. Young , Himanshu C. Shah
发明人： Vijay K. Aggarwal , Christopher R. Young , Himanshu C. Shah
IPC分类号： G06F15177
CPC分类号： H04L29/06 , H04L69/22
摘要： In Internet and related networks, a method of and system for substitute use of the normal checksum field space in information processing (IP) datagram headers for obviating current processing time and addressing space limitations, involving replacing the current checksum usage in the checksum field with its attendant processing time with further source host and destination host addresses of lesser processing time, thereby increasing the address space for the network and decreasing the require header processing time, and/or providing space for autonomous system numbers, a higher layer protocol-based routing information (including of the MPLS type) or for Virtual Private Networks Indentifiers in the header.
摘要翻译：在互联网和相关网络中，一种用于替代使用信息处理（IP）数据报头中的正常校验和字段空间的方法和系统，用于消除当前处理时间和寻址空间限制，包括用校验和字段替换校验和字段中的当前校验和使用具有较少处理时间的进一步的源主机和目标主机地址的处理时间，从而增加网络的地址空间并减少需求头处理时间，和/或为自主系统号提供空间，基于更高层协议的路由信息（包括MPLS类型）或标题中的虚拟专用网络标识符。

5. 发明申请

US20110064811A1 Solid forms of N-[2,4-BIS(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide 审中-公开
标题翻译：固体形式的N- [2,4-BIS（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺
公开(公告)号：US20110064811A1
公开(公告)日：2011-03-17
申请号：US11647505
申请日：2006-12-28
申请人： Patricia Hurter , William Rowe , Christopher R. Young , Adriana Costache , Patrick R. Connelly , Mariusz Krawiec , Yuchuan Gong , Yushi Feng , Martin Trudeau
发明人： Patricia Hurter , William Rowe , Christopher R. Young , Adriana Costache , Patrick R. Connelly , Mariusz Krawiec , Yuchuan Gong , Yushi Feng , Martin Trudeau
IPC分类号： A61K9/14 , C07D215/56 , A61K31/47 , A61P3/10 , A61P11/00 , A61P7/10 , A61P3/00 , A61P35/00 , A61P25/28 , A61P25/16 , A61P27/04 , A61P7/00
CPC分类号： A61K31/47 , A61K2300/00 , C07B2200/13 , C07D215/56 , Y10T428/2982
摘要： The present invention relates to solid state forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1), pharmaceutical compositions thereof and methods therewith.
摘要翻译：本发明涉及N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺（化合物1）的固体形式，药物组合物及其方法。

6. 发明授权

US07553855B2 Compositions of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide 有权
标题翻译： N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺的组合物
公开(公告)号：US07553855B2
公开(公告)日：2009-06-30
申请号：US11748073
申请日：2007-05-14
申请人： Christopher R. Young , Charles William Rowe
发明人： Christopher R. Young , Charles William Rowe
IPC分类号： A61K31/47
CPC分类号： A61K31/47 , A61K9/08 , A61K31/435 , A61K47/10 , A61K47/32 , C07D215/233
摘要： Pharmaceutical compositions including N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1) and methods of using such compositions are described herein.
摘要翻译：包括N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺（化合物1）的药物组合物和使用这些组合物的方法在本文中描述。

7. 发明申请

US20120220625A1 PHARMACEUTICAL COMPOSITION AND ADMINISTRATIONS THEREOF 审中-公开
标题翻译：药物组合物及其药理学
公开(公告)号：US20120220625A1
公开(公告)日：2012-08-30
申请号：US13370540
申请日：2012-02-10
申请人： William Rowe , Patricia Hurter , Christopher R. Young , Kirk Dinehart , Marinus Jacobus Verwijs , Kirk Overhoff , Peter D.J. Grootenhuis , Martyn Botfield , Alfredo Grossi , Gregor Zlokarnik , Fredrick F. Van Goor
发明人： William Rowe , Patricia Hurter , Christopher R. Young , Kirk Dinehart , Marinus Jacobus Verwijs , Kirk Overhoff , Peter D.J. Grootenhuis , Martyn Botfield , Alfredo Grossi , Gregor Zlokarnik , Fredrick F. Van Goor
IPC分类号： A61K31/47 , A61P19/08 , A61P11/00 , A61P19/10
CPC分类号： A61K9/1652 , A61K9/1635 , A61K9/2054 , A61K9/282 , A61K31/47
摘要： The present invention relates to pharmaceutical compositions comprising a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide, methods of manufacturing pharmaceutical compositions of the present invention, and methods of administering pharmaceutical compositions of the present invention.
摘要翻译：本发明涉及包含N- [2,4-二（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺的固体分散体的药物组合物，制造方法本发明的药物组合物和本发明的药物组合物的给药方法。

8. 发明授权

US5611833A Method and apparatus for producing spheroidal glass particles 失效
标题翻译：用于生产球状玻璃颗粒的方法和装置
公开(公告)号：US5611833A
公开(公告)日：1997-03-18
申请号：US229215
申请日：1994-04-18
申请人： Sudhir R. Brahmbhatt , Christopher R. Young
发明人： Sudhir R. Brahmbhatt , Christopher R. Young
IPC分类号： C03B19/10
CPC分类号： C03B19/1025
摘要： One forms spherical or spheroidal glass particles by entraining a powder of glass particles in a carrier gas and injecting the entrained particles into the center of the flame of an oxygen-fuel burner. Separate conduits carry fuel, such as natural gas, and substantially pure oxygen into the burner to support combustion. The temperature in the burner flame does not exceed about 5000.degree. F. Heat from the flame causes the particles to become spheroidal, due to surface tension, but the particles do not remain in the flame long enough to melt. By adjusting a valve in the line which conveys the carrier gas and glass particles, one varies the time during which the particles reside in the flame. If the pressure becomes too high, the residence time decreases, and the particles may not become entirely spheroidal. If the pressure becomes too low, the residence time increases, and the particles may melt and/or form undesirable filaments. One can retrieve the product particles from the bottom of the burner chamber, and also by filtering the exhaust gases to recover particles entrained by the exhaust. The oxygen used to support combustion can also be used as a carrier gas. The invention also includes an apparatus for automatically regulating the flow of oxygen and fuel, so as to maintain both the desired flame temperature and the optimal ratio of oxygen to fuel.
摘要翻译：一种通过将载体气体中的玻璃颗粒的粉末夹带并将夹带的颗粒注入氧 - 燃料燃烧器的火焰的中心而形成球形或球状玻璃颗粒。单独的管道将诸如天然气的燃料和基本上纯的氧气输送到燃烧器中以支持燃烧。燃烧器火焰中的温度不超过约5000°F。由于表面张力，来自火焰的热量导致颗粒变为球形，但是颗粒不会残留在火焰中足够长的时间以熔化。通过调节输送载气和玻璃颗粒的管线中的阀，可以改变粒子驻留在火焰中的时间。如果压力变得太高，停留时间减少，并且颗粒可能不会变成完全球形。如果压力变得太低，则停留时间增加，并且颗粒可能熔化和/或形成不期望的长丝。可以从燃烧室的底部检索产品颗粒，也可以通过过滤废气以回收排气夹带的颗粒。用于支持燃烧的氧气也可以用作载气。本发明还包括一种用于自动调节氧气和燃料的流动的装置，以便保持期望的火焰温度和氧气与燃料的最佳比例。

9. 发明授权

US4931013A High-temperature burner 失效
标题翻译：高温燃烧器
公开(公告)号：US4931013A
公开(公告)日：1990-06-05
申请号：US375953
申请日：1989-07-06
申请人： Sudhir R. Brahmbhatt , Christopher R. Young
发明人： Sudhir R. Brahmbhatt , Christopher R. Young
IPC分类号： C21C5/52 , C21C5/56 , F23D14/22 , F23D14/32 , F23L7/00
CPC分类号： F23D14/32 , C21C5/5217 , C21C5/562 , F23D14/22 , F23L7/00 , F23C2900/07021 , Y02E20/344 , Y02P10/143 , Y02P10/216 , Y02P10/34
摘要： This invention concerns the burning of fuels, such as natural gas, at high temperatures. The invention includes a high-efficiency burner which achieves substantially complete combusiton at modest cost. The burner of the present invention includes a generally cylindrical housing having a central bore and two concentric annular regions. A lance is inserted through the central bore, and protrudes slightly from the front face of the burner housing. The fuel is directed through the inner annular region, and oxygen-enriched combustion air is directed through the outer annular region. Substantially pure oxygen is directed through the lance. The gases in the lance and the annular regions do not communicate with each other within the burner housing, and all burnign takes place outside the housing. The same supply of oxygen can be used to supply the lance and to enrich the combustion air. The present invention achieves overall results which are substantially comparable to the results obtained from pure oxygen burners, but at a greatly reduced equipment cost, and with reduced operating cost.
摘要翻译：本发明涉及在高温下燃烧诸如天然气的燃料。本发明包括一种高效率的燃烧器，其以适中的成本实现了基本上完全的燃烧。本发明的燃烧器包括具有中心孔和两个同心环形区域的大致圆柱形壳体。喷枪穿过中心孔插入，并从燃烧器壳体的前表面略微突出。燃料被引导通过内部环形区域，并且富氧燃烧空气被引导通过外部环形区域。基本上纯的氧被引导通过喷枪。喷枪和环形区域中的气体在燃烧器壳体内不彼此连通，并且所有燃烧都发生在壳体外部。可以使用相同的氧气供应来提供喷枪并富集燃烧空气。本发明实现了与从纯氧燃烧器获得的结果基本相当的整体结果，但是大大降低了设备成本，并降低了运行成本。

10. 发明申请

US20120258983A1 Pharmaceutical Composition and Administrations Thereof 审中-公开
标题翻译：药物组成及其主管部门
公开(公告)号：US20120258983A1
公开(公告)日：2012-10-11
申请号：US13418927
申请日：2012-03-13
申请人： William Rowe , Patricia Hurter , Christopher R. Young , Kirk Dinehart , Marinus Jacobus Verwijs , Kirk Overhoff , Peter D.J. Grootenhuis , Martyn Botfield , Alfredo Grossi , Gregor Zlokarnik , Fredrick F. Van Goor
发明人： William Rowe , Patricia Hurter , Christopher R. Young , Kirk Dinehart , Marinus Jacobus Verwijs , Kirk Overhoff , Peter D.J. Grootenhuis , Martyn Botfield , Alfredo Grossi , Gregor Zlokarnik , Fredrick F. Van Goor
IPC分类号： A61K31/47 , A61P37/00 , A61P11/00 , A61P19/10 , A61P19/08
CPC分类号： A61K31/47 , A61K9/146 , A61K9/1652 , A61K9/2018 , A61K9/2054 , A61K9/282 , A61K9/2866 , A61K47/38
摘要： The present invention relates to pharmaceutical compositions comprising a solid dispersion of N-[2,4-Bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide, methods of manufacturing pharmaceutical compositions of the present invention, and methods of administering pharmaceutical compositions of the present invention.
摘要翻译：本发明涉及包含N- [2,4-二（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺的固体分散体的药物组合物，制造方法本发明的药物组合物和本发明的药物组合物的给药方法。

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