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1. 发明授权

US08609103B2 Megalin-based delivery of therapeutic compounds to the brain and other tissues 有权
标题翻译：基于Megalin的治疗化合物向大脑和其他组织递送
公开(公告)号：US08609103B2
公开(公告)日：2013-12-17
申请号：US12941619
申请日：2010-11-08
申请人： Todd C. Zankel , Christopher M. Starr
发明人： Todd C. Zankel , Christopher M. Starr
IPC分类号： A61K39/00
CPC分类号： C07K14/705 , A61K38/00 , A61K47/64 , C07K2319/00 , C07K2319/22 , C07K2319/23
摘要： The present invention is directed to a methods and compositions for receptor mediated drug delivery, particularly across the blood-brain barrier.
摘要翻译：本发明涉及受体介导的药物递送的方法和组合物，特别是跨血脑屏障。

2. 发明申请

US20090191178A1 Manufacture of Highly Phosphorylated Lysosomal Enzymes and Uses Thereof 审中-公开
标题翻译：高度磷酸化溶酶体酶的制备及其用途
公开(公告)号：US20090191178A1
公开(公告)日：2009-07-30
申请号：US12182818
申请日：2008-07-30
申请人： Todd C. Zankel , Christopher M. Starr
发明人： Todd C. Zankel , Christopher M. Starr
IPC分类号： A61K38/47 , C12N9/24 , C12P21/04 , C12N5/06
CPC分类号： C12P21/005 , A61K38/00 , C12N9/2408 , C12N9/2434 , C12Y302/01003 , C12Y302/0102
摘要： This invention provides compositions of highly phosphorylated lysosomal enzymes, their pharmaceutical compositions, methods of producing and purifying such lysosomal enzymes and compositions and their use in the diagnosis, prophylaxis, or treatment of diseases and conditions, including particularly lysosomal storage diseases.
摘要翻译：本发明提供高度磷酸化溶酶体酶的组合物，其药物组合物，生产和纯化这些溶酶体酶及其组合物的方法及其在疾病和病症的诊断，预防或治疗中的用途，特别是溶酶体贮积病。

3. 发明授权

US5591839A Polynucleotides encoding .alpha.2-3 neuraminidase 失效
标题翻译：编码α2-3神经氨酸酶的多核苷酸
公开(公告)号：US5591839A
公开(公告)日：1997-01-07
申请号：US294477
申请日：1994-08-18
申请人： Harvey I. Miller , John C. Klock , Christopher M. Starr
发明人： Harvey I. Miller , John C. Klock , Christopher M. Starr
IPC分类号： C12N9/24 , C07H21/02 , C07H21/04
CPC分类号： C12Y302/01018 , C12N9/2402
摘要： Polynucleotide sequences encoding enzymes that possess .alpha.2-3 neuraminidase activity are provided. Of particular interest are polynucleotide sequences encoding an enzyme having .alpha.2-3 neuraminidase activity and naturally produced by the bacteria Streptococcus pneumoniae. Recombinant DNA expression of enzymes possessing .alpha.2-3 specific neuraminidase activity is also described, including methods, recombinant host cells and a genetic construction. The invention also provides a purified enzyme having .alpha.2-3 neuraminidase activity from Streptococcus pneumoniae, wherein the enzyme is isolated from S. pneumoniea cultures. Another aspect of this invention is to provide methods of isolating genes encoding enzymes having neuraminidase activity, particularly .alpha.2-3 neuraminidase activity. The gene isolation methods of the invention comprise the step of labeling a hybridization probe derived from the neuraminidase coding portion of plasmid pND-1. The hybridization probe may then be used to isolate homologous genes encoding enzymes having the desired enzymatic activity.
摘要翻译：提供了编码具有α2-3神经氨酸酶活性的酶的多核苷酸序列。特别感兴趣的是编码具有α2-3神经氨酸酶活性并由细菌肺炎链球菌天然产生的酶的多核苷酸序列。还描述了具有α2-3特异性神经氨酸酶活性的酶的重组DNA表达，包括方法，重组宿主细胞和遗传构建。本发明还提供了具有来自肺炎链球菌的α2-3神经氨酸酶活性的纯化酶，其中所述酶从肺炎链球菌培养物中分离。本发明的另一方面是提供分离编码具有神经氨酸酶活性的酶的基因，特别是α2-3神经氨酸酶活性的方法。本发明的基因分离方法包括标记衍生自质粒pND-1的神经氨酸酶编码部分的杂交探针的步骤。然后可以使用杂交探针来分离编码具有所需酶活性的酶的同源基因。

4. 发明授权

US08877714B2 Compositions comprising receptor-associated protein (RAP) variants specific for LRP2 and uses thereof 有权
标题翻译：包含对LRP2特异的受体相关蛋白（RAP）变体的组合物及其用途
公开(公告)号：US08877714B2
公开(公告)日：2014-11-04
申请号：US11576506
申请日：2006-06-14
申请人： Christopher M. Starr , Todd C. Zankel
发明人： Christopher M. Starr , Todd C. Zankel
IPC分类号： C07K14/705 , A61K38/17 , A61K38/00
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention relates generally to receptor-selective variants of the low-density lipoprotein receptor-associated protein (RAP) and compositions thereof, methods of generating such variants and methods of using such receptor-selective RAP variant compositions for therapeutic purposes. The invention also relates to antibodies that bind to one or a small subset of CR-containing proteins.
摘要翻译：本发明一般涉及低密度脂蛋白受体相关蛋白（RAP）的受体选择性变体及其组合物，产生这些变体的方法和使用这种受体选择性RAP变体组合物用于治疗目的的方法。本发明还涉及结合至含有CR的蛋白质的一个或一小组的抗体。

5. 发明授权

US07829537B2 Receptor associated protein (RAP) conjugates 有权
标题翻译：受体相关蛋白（RAP）偶联物
公开(公告)号：US07829537B2
公开(公告)日：2010-11-09
申请号：US12508956
申请日：2009-07-24
申请人： Todd C. Zankel , Christopher M. Starr
发明人： Todd C. Zankel , Christopher M. Starr
IPC分类号： A61K38/18 , A61K38/30 , A61K33/24
CPC分类号： C07K14/705 , A61K38/00 , A61K47/64 , C07K2319/00 , C07K2319/22 , C07K2319/23
摘要： The present invention is directed to a methods and compositions for receptor mediated drug delivery, particularly across the blood-brain barrier.
摘要翻译：本发明涉及受体介导的药物递送的方法和组合物，特别是跨血脑屏障。

6. 发明授权

US07569544B2 Methods of increasing delivery of active agents to brain comprising administering receptor associated protein (RAP) fragments conjugated to active agents 有权
标题翻译：增加活性剂向脑的递送的方法，包括施用与活性剂缀合的受体相关蛋白（RAP）片段
公开(公告)号：US07569544B2
公开(公告)日：2009-08-04
申请号：US10812849
申请日：2004-03-30
申请人： Todd Zankel , Christopher M. Starr
发明人： Todd Zankel , Christopher M. Starr
IPC分类号： A61K38/18 , C07K19/00 , C07K14/435 , C07K14/48 , C07K14/485 , C07K14/50
CPC分类号： C07K14/705 , A61K38/00 , A61K47/64 , C07K2319/00 , C07K2319/22 , C07K2319/23
摘要： The present invention is directed to a methods and compositions for receptor mediated drug delivery, particularly across the blood-brain barrier.
摘要翻译：本发明涉及受体介导的药物递送的方法和组合物，特别是跨血脑屏障。

7. 发明申请

US20080260715A1 Precursor N-acetylgalactosamine-4 sulfatase, methods of treatment using said enzyme and methods for producing and purifying said enzyme 审中-公开
标题翻译：前体N-乙酰半乳糖胺-4-硫酸酯酶，使用所述酶的处理方法和生产和纯化所述酶的方法
公开(公告)号：US20080260715A1
公开(公告)日：2008-10-23
申请号：US11804369
申请日：2007-05-18
申请人： Minmin Qin , Gary N. Zecherle , Wai-Pan Chan , Paul A. Fitzpatrick , Stuart Swiedler , John M. Henstrand , Dan J. Wendt , Lin Chen , Christopher M. Starr
发明人： Minmin Qin , Gary N. Zecherle , Wai-Pan Chan , Paul A. Fitzpatrick , Stuart Swiedler , John M. Henstrand , Dan J. Wendt , Lin Chen , Christopher M. Starr
IPC分类号： A61K38/46
CPC分类号： B01D15/327 , A61K38/00 , A61K48/00 , B01D15/3804 , B01D15/3828 , C12N9/16 , C12Y301/06012
摘要： The present invention provides a highly purified recombinant human precursor N-acetylgalactosamine-4-sulfatase and biologically active mutants, fragments and analogs thereof as well as pharmaceutical formulations comprising highly purified recombinant human precursor N-acetylgalactosamine-4-sulfatase. The invention also provides methods for treating diseases caused all or in part by deficiencies in human N-acetylgalactosamine-4-sulfatase including MPS VI and methods for producing and purifying the recombinant precursor enzyme to a highly purified form.
摘要翻译：本发明提供高度纯化的重组人前体N-乙酰半乳糖胺-4-硫酸酯酶及其生物活性突变体，其片段和类似物以及包含高度纯化的重组人前体N-乙酰半乳糖胺-4-硫酸酯酶的药物制剂。本发明还提供了用于治疗全部或部分由包括MPS VI在内的人N-乙酰半乳糖胺-4-硫酸酯酶缺陷引起的疾病的方法，以及用于将重组前体酶生产和纯化成高度纯化形式的方法。

8. 发明授权

US5672881A Charge-coupled device imaging apparatus 失效
标题翻译：电荷耦合器件成像装置
公开(公告)号：US5672881A
公开(公告)日：1997-09-30
申请号：US612195
申请日：1996-03-06
申请人： Steven K. Striepeke , Peter Edridge , Christopher M. Starr , John C. Klock
发明人： Steven K. Striepeke , Peter Edridge , Christopher M. Starr , John C. Klock
IPC分类号： G01N21/64
CPC分类号： G01N21/6456
摘要： An apparatus for fluorescence of a biological sample includes a light illumination source, an ambient light-excluding optical chamber, a sample holder, a two-dimensional array charge coupled device ("CCD") sensor providing for on-chip signal integration of each pixel of the array, and an analog/digital converter for digitizing the CCD signal. Signal acquisition time from the array is varied so that the integrated signal from each pixel is below its saturation level. A darkfield value for each pixel is acquired and subtracted from the illuminated signal from that pixel so as to yield a darkfield corrected signal. The fluorescence value for each pixel can be compensated for variations in excitation energy reaching different sample areas. Image readout is through a single channel output.
摘要翻译：用于生物样品的荧光的装置包括光照射源，环境光排除光学室，样品架，二维阵列电荷耦合器件（“CCD”）传感器，用于提供每个像素的片上信号积分的阵列，以及用于数字化CCD信号的模拟/数字转换器。来自阵列的信号采集时间是变化的，使得来自每个像素的积分信号低于其饱和水平。获取每个像素的暗场值，并从该像素的照明信号中减去暗场值，以产生暗场校正信号。每个像素的荧光值可以补偿到不同样品区域的激发能量的变化。图像读出是通过单通道输出。

9. 发明授权

US08795627B2 Treatment of liver disorders by administration of RAP conjugates 有权
标题翻译：通过施用RAP偶联物治疗肝脏疾病
公开(公告)号：US08795627B2
公开(公告)日：2014-08-05
申请号：US12441618
申请日：2007-09-18
申请人： Christopher M. Starr , Todd C. Zankel
发明人： Christopher M. Starr , Todd C. Zankel
IPC分类号： C07K14/705 , A61K38/17 , A61K47/48
CPC分类号： A61K38/17 , A61K31/704 , A61K31/715 , A61K33/24 , A61K38/168 , A61K38/177 , A61K39/395 , A61K45/06 , A61K47/64 , A61N5/1001 , C07K14/705 , Y02A50/403 , A61K2300/00
摘要： The present invention relates to the use of receptor-associate protein (RAP) and fragments and variants thereof to improve delivery of therapeutic compounds to the liver and provides methods to treat liver disorders and conditions, such as hepatic carcinoma, by administering RAP or RAP variants conjugated to active agents.
摘要翻译：本发明涉及受体相关蛋白（RAP）及其片段和变体的用途，以改善治疗化合物向肝脏的递送，并提供通过施用RAP或RAP变体来治疗肝脏疾病和病症如肝癌的方法与活性剂缀合。

10. 发明授权

US08546319B2 Use of p97 as an enzyme delivery system for the delivery of therapeutic lysosomal enzymes 有权
标题翻译：使用p97作为递送治疗性溶酶体酶的酶递送系统
公开(公告)号：US08546319B2
公开(公告)日：2013-10-01
申请号：US12729792
申请日：2010-03-23
申请人： Christopher M. Starr , Todd Zankel
发明人： Christopher M. Starr , Todd Zankel
IPC分类号： C07K14/00 , C12N9/00
CPC分类号： A61K47/64 , A61K38/465 , A61K38/47 , C12Y302/01076 , G01N33/5008 , G01N33/5035 , G01N33/5058 , G01N33/566 , A61K2300/00
摘要： The present invention provides for compositions and methods for treating, ameliorating or preventing a lysosomal storage disease by administering to a patient suffering from a lysosomal storage disease a P97 conjugated with an enzyme which is capable of transportation into the lysosomes of cells on either sides of the blood brain barrier.
摘要翻译：本发明提供了通过向患有溶酶体储存疾病的患者施用与能够转运到细胞的溶酶体中的P97缀合的P97来治疗，改善或预防溶酶体贮积病的组合物和方法血脑屏障。

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