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1. 发明授权

US07220829B2 Cytokine binding domain of cytokine receptors 失效
标题翻译：细胞因子受体的细胞因子结合结构域
公开(公告)号：US07220829B2
公开(公告)日：2007-05-22
申请号：US09913419
申请日：2001-08-08
申请人： Jamie Rossjohn , William John McKinstry , Joanna May Woodcock , Michael William Parker , Angel Francisco Lopez , Christopher James Bagley
发明人： Jamie Rossjohn , William John McKinstry , Joanna May Woodcock , Michael William Parker , Angel Francisco Lopez , Christopher James Bagley
IPC分类号： C07K14/715
CPC分类号： C07K14/715 , A61K38/00 , C07K16/2866 , C07K2317/565
摘要： The present invention provides a cytokine-binding domain or portion thereof which binds to at least one cytokine and is capable of transducing a cytokine signal through a single cytokine receptor, said domain comprising a portion of the B′-C′ loop of domain 4 of a βc chain or analogous structure of a cytokine receptor. In another aspect of the invention there is provided a method of identifying a compound having cytokine agonist or antagonist activity, said method including subjecting a potential cytokine agonist and/or cytokine antagonist compound to a cytokine binding domain or portion thereof wherein said domain binds to at least one cytokine and is capable of transducing a cytokine signal through a single cytokine receptor, said domain comprising a portion of the B′-C′ loop of domain 4 of a βc chain or analogous structure of the cytokine receptor; and determining the presence of an agonist or antagonist response of the compound on the activity of a cytokine. In a preferred aspect there is provided a method fo identifying a GM-CSF, IL-3 and IL-5 agonist or antagonist, said method including: subjecting a potential agonist or antagonist to a GM-CSF, IL-3 and IL-5 binding domain or portion thereof wherein said domain binds to at least one of the cytokines and is capable of transducing a cytokine signal through a single cytokine receptor, said domain comprising a portion of the B′-C′ loop of domain 4 of a βc chain or analogous structure of the cytokine receptor; and determining the presence of a agonist or antagonist response from the compound on the activity of GM-CSF, IL-3 and IL-5.
摘要翻译：本发明提供了结合至少一种细胞因子并且能够通过单个细胞因子受体转导细胞因子信号的细胞因子结合结构域或其部分，所述结构域包含一部分结构域4的B'-C'环的部分细胞因子受体的β链或类似结构。在本发明的另一方面，提供了鉴定具有细胞因子激动剂或拮抗剂活性的化合物的方法，所述方法包括将潜在的细胞因子激动剂和/或细胞因子拮抗剂化合物经受细胞因子结合结构域或其部分，其中所述结构域结合于至少一种细胞因子，并且能够通过单个细胞因子受体转导细胞因子信号，所述结构域包含β3 C链的结构域4的部分B'-C'环或类似结构细胞因子受体; 并确定化合物的激动剂或拮抗剂应答对细胞因子活性的存在。在优选的方面，提供了鉴定GM-CSF，IL-3和IL-5激动剂或拮抗剂的方法，所述方法包括：使潜在的激动剂或拮抗剂对GM-CSF，IL-3和IL-5 结合结构域或其部分，其中所述结构域与至少一种细胞因子结合并且能够通过单个细胞因子受体转导细胞因子信号，所述结构域包含β4区域4的B'-C'环的一部分，细胞因子受体的链或类似结构; 并确定来自该化合物的激动剂或拮抗剂应答对GM-CSF，IL-3和IL-5的活性的存在。

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