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1. 发明授权

US06737063B2 FimH adhesin proteins and methods of use 有权
标题翻译： FimH粘附素蛋白及其使用方法
公开(公告)号：US06737063B2
公开(公告)日：2004-05-18
申请号：US09900575
申请日：2001-07-06
申请人： Solomon Langermann , Andrew Revel , Christine Auguste , Jeanne Burlein
发明人： Solomon Langermann , Andrew Revel , Christine Auguste , Jeanne Burlein
IPC分类号： A61K3902
CPC分类号： C07K14/245 , A61K39/00
摘要： The present invention provides bacterial immunogenic agents for administration to humans and non-human animals to stimulate an immune response. Also provided are methods for vaccination of mammalian species, especially human patients, with variants of the E. coli FimH protein, said variants being derived from different strains of E. coli, and to production of antibodies that protect the vaccine recipient against infection by pathogenic bacterial species. In another aspect the invention provides antibodies against such proteins and protein complexes that may be used as diagnostics and/or as protective/treatment agents for pathogenic bacterial species. A plasmid-based method of producing polypeptides, especially fused polypeptides, such as the complex of a bacterial chaperone and a bacterial adhesin, is also disclosed.
摘要翻译：本发明提供用于给予人和非人动物以刺激免疫应答的细菌免疫原性试剂。还提供了用大肠杆菌FimH蛋白的变体对哺乳动物物种，特别是人类患者进行疫苗接种的方法，所述变体来自不同的大肠杆菌菌株，并且产生保护疫苗接受者免受致病性感染的抗体细菌种类。在另一方面，本发明提供了抗这种蛋白质和蛋白质复合物的抗体，其可以用作诊断和/或作为病原菌种的保护/治疗剂。还公开了一种基于质粒的产生多肽，特别是融合多肽的方法，例如细菌分子伴侣和细菌粘附素的复合物。

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