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1. 发明授权

US08580865B2 Phase-and sedimentation-stable, plastically deformable preparation with intrinsic pore forming, intended for example for filling bone defects or for use as bone substitute material, and method of producing it 有权
标题翻译：具有内在孔隙形成的相和沉降稳定的，可塑性变形的制剂，例如用于填充骨缺损或用作骨替代材料，以及生产它的方法
公开(公告)号：US08580865B2
公开(公告)日：2013-11-12
申请号：US12310770
申请日：2007-08-30
申请人： Fabian Peters , Christiane Hoffmann , Kathleen Hasanovic
发明人： Fabian Peters , Christiane Hoffmann , Kathleen Hasanovic
IPC分类号： A61F2/28 , C08K3/32
CPC分类号： A61L27/56 , A61L27/46 , A61L27/50 , A61L2430/02
摘要： The invention relates to a phase and sedimentation-stable, plastically deformable preparation with intrinsic pore formation that can be used for instance for filling bone defects and for augmentation, and also relates to a method for producing same. The object of the invention, to provide a phase and sedimentation-stable, plastically deformable implant material with intrinsic pore formation, that is not complex to create, and that can be inserted into a bone defect by injection or alternatively can be applied to/fitted in a bone defect as a kneadable mass, is attained in that a plastically deformable preparation for bone construction/replacement based on ceramic suspension includes a particulate, porous component that is not easily soluble in water and at least one liquid, wax-like, or gel component that is dissolved in water or alcohol, the component that is not easily soluble in water being 60-98% by weight and the composition dissolved in water or alcohol being 1-30% by weight, the particles of the particulate component having a diameter in a size range that is essentially greater than a phagocytabler particle and smaller than the passage diameter of standard injection cannulas and the portion of the dissolved component in the water or alcohol being 0.1-3% by weight.
摘要翻译：本发明涉及具有内在孔形成的相和沉降稳定的可塑性变形的制剂，其可用于例如用于填充骨缺损和增加，并且还涉及其制备方法。本发明的目的是提供具有内在孔形成的相和沉降稳定的塑性变形的植入材料，其不是复杂的，并且可以通过注射插入到骨缺损中，或者可以施加到/适配在作为可捏合物质的骨缺损中的实现是，基于陶瓷悬浮液的用于骨骼构造/置换的可塑性变形的制剂包括不容易溶于水的颗粒状多孔成分和至少一种液体，蜡状或溶解在水或醇中的凝胶成分，不易溶于水的成分为60〜98重量％，溶解在水或醇中的组合物为1-30重量％，颗粒成分的粒子为直径大小基本上大于吞噬细胞颗粒，并且小于标准注射插管的通道直径和溶解组分的部分水或醇为0.1-3重量％。

2. 发明授权

US09907884B2 Biodegradable composite material 有权
公开(公告)号：US09907884B2
公开(公告)日：2018-03-06
申请号：US14122724
申请日：2012-05-31
申请人： Fabian Peters , Wolf-Dietrich Huebner , Christiane Hoffmann , Nikica Andic , Kathleen Hasanovic , Tilo Hniopek
发明人： Fabian Peters , Wolf-Dietrich Huebner , Christiane Hoffmann , Nikica Andic , Kathleen Hasanovic , Tilo Hniopek
IPC分类号： A61L27/58 , A61L27/56 , A61L27/10 , A61L27/24 , A61L27/12 , A61L27/02 , A61L31/12 , A61L27/42 , B29C44/02
CPC分类号： A61L27/56 , A61L27/42 , A61L27/425 , A61L2430/02 , B29C44/02 , C08L89/06
摘要： The invention relates to a biologically degradable composite material and to a process for the preparation thereof. The biologically degradable composite material according to the invention is preferably a bone reconstruction material which can be used in the field of regenerative medicine, especially as a temporary bone defect filler for bone regeneration.

3. 发明申请

US20140170202A1 BIODEGRADABLE COMPOSITE MATERIAL 有权
标题翻译：生物可降解复合材料
公开(公告)号：US20140170202A1
公开(公告)日：2014-06-19
申请号：US14122724
申请日：2012-05-31
申请人： Fabian Peters , Wolf-Dietrich Huebner , Christiane Hoffmann , Nikica Andic , Kathleen Hasanovic , Tilo Hniopek
发明人： Fabian Peters , Wolf-Dietrich Huebner , Christiane Hoffmann , Nikica Andic , Kathleen Hasanovic , Tilo Hniopek
IPC分类号： A61L27/56 , B29C44/02 , A61L27/42
CPC分类号： A61L27/56 , A61L27/42 , A61L27/425 , A61L2430/02 , B29C44/02 , C08L89/06
摘要： The invention relates to a biologically degradable composite material and to a process for the preparation thereof. The biologically degradable composite material according to the invention is preferably a bone reconstruction material which can be used in the field of regenerative medicine, especially as a temporary bone defect filler for bone regeneration.
摘要翻译：本发明涉及生物降解性复合材料及其制备方法。根据本发明的生物可降解复合材料优选是可用于再生医学领域的骨重建材料，特别是作为用于骨再生的临时骨缺损填料。

4. 发明申请

US20090254194A1 Phase-and sedimentation-stable, plastically deformable preparation with intrinsic pore forming, intended for example for filling bone defects or for use as bone substitute material, and method of producing it 有权
标题翻译：具有内在孔隙形成的相和沉降稳定的，可塑性变形的制剂，例如用于填充骨缺损或用作骨替代材料，以及生产它的方法
公开(公告)号：US20090254194A1
公开(公告)日：2009-10-08
申请号：US12310770
申请日：2007-08-30
申请人： Fabian Peters , Christiane Hoffmann , Kathleen Hasanovic
发明人： Fabian Peters , Christiane Hoffmann , Kathleen Hasanovic
IPC分类号： A61F2/28
CPC分类号： A61L27/56 , A61L27/46 , A61L27/50 , A61L2430/02
摘要： The invention relates to a phase and sedimentation-stable, plastically deformable preparation with intrinsic pore formation that can be used for instance for filling bone defects and for augmentation, and also relates to a method for producing and using same.The object of the invention, to provide a phase and sedimentation-stable, plastically deformable implant material with intrinsic pore formation, that is not complex to create, and that can be inserted into a bone defect by injection or alternatively can be applied to/fitted in a bone defect as a kneadable mass, is attained in that a plastically deformable preparation for bone construction/replacement based on ceramic suspensions includes a particulate, porous component that is not easily soluble in water and at least one liquid, wax-like, or gel component that is dissolved in water or alcohol, the component that is not easily soluble in water being 60-98% by weight and the component dissolved in water or alcohol being 1-30% by weight, the particles of the particulate component having a diameter in a size range that is essentially greater than a phagocytabler particle and smaller than the passage diameter of standard injection cannulas and the portion of the component soluble in water or alcohol being 0.1-3% by weight.
摘要翻译：本发明涉及具有内在孔形成的相和沉降稳定的可塑变形的制剂，其可用于例如用于填充骨缺损和增加，并且还涉及其制备和使用方法。本发明的目的是提供具有内在孔形成的相和沉降稳定的塑性变形的植入材料，其不是复杂的，并且可以通过注射插入到骨缺损中，或者可以施加到/适配在作为可捏合块的骨缺损中，实现了基于陶瓷悬浮液的用于骨构建/替换的可塑性变形的制剂包括不容易溶于水的至少一种液体，蜡状或溶解在水或醇中的凝胶成分，不易溶于水的成分为60-98重量％，溶于水或醇的成分为1-30重量％，颗粒成分的颗粒具有直径大小基本上大于吞噬细胞颗粒，并且小于标准注射插管的通道直径和部分可溶于水的部分o 醇为0.1-3重量％。

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