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1. 发明授权

US09428727B2 Cell culture medium 有权
标题翻译：细胞培养基
公开(公告)号：US09428727B2
公开(公告)日：2016-08-30
申请号：US13643998
申请日：2011-04-25
申请人： Christian Leist , Petra Meissner , Jörg Schmidt
发明人： Christian Leist , Petra Meissner , Jörg Schmidt
IPC分类号： C12N5/02 , C12N5/00 , C12N5/07 , C12N5/071 , C12N5/10 , C12P21/04 , C12P21/06
CPC分类号： C12N5/005 , C12N5/0018 , C12N2500/05 , C12N2500/12
摘要： The present application describes an optimized medium for growth of mammalian cells as well as polypeptide production. The cell culture medium is characterized by a Sow ratio of sodium to potassium ions, it further relates to the method of producing polypeptides using such cell culture media. Sn another aspect, the method of polypeptide production can also comprise a temperature shift and/or a pH-shift to further optimize growth and product yield.
摘要翻译：本申请描述了用于哺乳动物细胞生长和多肽生产的优化培养基。细胞培养基的特征在于钠离子与钾离子的母体比例，其还涉及使用这种细胞培养基产生多肽的方法。另一方面，多肽生产的方法还可以包括温度变化和/或pH转换，以进一步优化生长和产物产率。

2. 发明申请

US20120204999A1 Method and device for contamination-free transport of pourable bulk product 有权
标题翻译：用于无污染运输可倾倒散装产品的方法和装置
公开(公告)号：US20120204999A1
公开(公告)日：2012-08-16
申请号：US13455231
申请日：2012-04-25
申请人： Helmuth Bauer , Christian Leist
发明人： Helmuth Bauer , Christian Leist
IPC分类号： B65B1/06 , B65B39/00 , B65B57/06 , B65B1/32
CPC分类号： B65G69/183
摘要： A method for substantially contamination-free transport of pourable bulk product from a dosing unit into a container is proposed, wherein the dosing outlet of the dosing unit is connected in a detachable manner with the receiving inlet of the container, the dosing outlet and the receiving inlet are opened, and the bulk product is transported into the container from the dosing unit via its dosing outlet and via the receiving inlet of the container. The receiving inlet of the container is disposed at the dosing unit by means of an elastic joining element to prevent transfer of forces between the dosing unit and the container during the dosing process. A device for carrying out such a method is also proposed.
摘要翻译：提出了一种用于将可倾倒散装产品从计量单元基本上无污染地输送到容器中的方法，其中计量单元的计量出口以可拆卸的方式连接到容器的接收入口，计量出口和接收器入口被打开，并且散装产品从配量单元经由其计量出口和容器的接收入口运送到容器中。容器的接收入口通过弹性连接元件设置在计量单元处，以防止在给料过程期间在计量单元和容器之间传递力。还提出了一种用于执行这种方法的装置。

3. 发明申请

US20130122543A1 IMPROVED CELL CULTURE MEDIUM 有权
标题翻译：改进细胞培养液
公开(公告)号：US20130122543A1
公开(公告)日：2013-05-16
申请号：US13643998
申请日：2011-04-25
申请人： Christian Leist , Petra Meissner , Jörg Schmidt
发明人： Christian Leist , Petra Meissner , Jörg Schmidt
IPC分类号： C12N5/00
CPC分类号： C12N5/005 , C12N5/0018 , C12N2500/05 , C12N2500/12
摘要： The present application describes an optimized medium for growth of mammalian cells as well as polypeptide production. The cell culture medium is characterized by a Sow ratio of sodium to potassium ions, it further relates to the method of producing polypeptides using such cell culture media. Sn another aspect, the method of polypeptide production can also comprise a temperature shift and/or a pH-shift to further optimize growth and product yield.
摘要翻译：本申请描述了用于哺乳动物细胞生长和多肽生产的优化培养基。细胞培养基的特征在于钠离子与钾离子的母体比例，其还涉及使用这种细胞培养基产生多肽的方法。另一方面，多肽生产的方法还可以包括温度变化和/或pH转换，以进一步优化生长和产物产率。

4. 发明申请

US20110214780A1 SYSTEM FOR GRAVIMETRICALLY DOSING VARIOUS BULK GOODS COMPONENTS 有权
标题翻译：用于精确计量各种各样的商品组件的系统
公开(公告)号：US20110214780A1
公开(公告)日：2011-09-08
申请号：US12737997
申请日：2009-08-25
申请人： Frank Pahl , Helmut Bauer , Christian Leist
发明人： Frank Pahl , Helmut Bauer , Christian Leist
IPC分类号： B65B1/04
CPC分类号： G01G19/32 , G01G19/22
摘要： The invention proposes a system for gravimetrically combining individual bulk material components in one or a plurality of transport container(s). The system comprises a plurality of storage containers for storing the bulk material components equipped with one dosing unit each in order to transfer a respective bulk material component into the transport container. Each of the storage containers is associated with a weighing means disposed below each storage container. The transport containers can be moved between the dosing units of the supply containers along a guidance and cooperate with the weighing means. In accordance with the invention, the guidance has several guiding segments that are disposed behind one another in the guiding direction and on which the transport container is guided, and at least the guiding segments disposed below the dosing units of the supply containers are formed by weighing/guiding segments which are mechanically decoupled from the other guiding segments or weighing/guiding segments such that the transport container is in its respective dosing position on the weighing/guiding segments for detecting its weight.
摘要翻译：本发明提出了一种用于在一个或多个运输容器中重量分配组合各个散装材料部件的系统。该系统包括多个存储容器，用于存储装配有一个计量单元的散装材料部件，以便将相应的散装材料部件转移到运输容器中。每个存储容器与设置在每个存储容器下方的称重装置相关联。运输容器可以沿着引导件在供给容器的计量单元之间移动并与称重装置配合。根据本发明，引导具有在引导方向上彼此相对设置并且运输容器被引导的多个引导段，并且至少设置在供给容器的计量单元下方的引导段通过称重 /导向段，其与其他引导段或称重/引导段机械地分离，使得运输容器处于其在称重/引导段上的相应配量位置，用于检测其重量。

5. 发明授权

US08765413B2 Cell cultivation process 有权
标题翻译：细胞培养过程
公开(公告)号：US08765413B2
公开(公告)日：2014-07-01
申请号：US13643996
申请日：2011-04-25
申请人： Christoph E. Joosten , Christian Leist , Jörg Schmidt
发明人： Christoph E. Joosten , Christian Leist , Jörg Schmidt
IPC分类号： A61K38/00 , C07K16/00 , C07K14/005 , C12N15/81
CPC分类号： C07K16/00 , C07K2317/14 , C12N5/00 , C12N2500/60 , C12N2510/02 , C12N2523/00 , C12P21/005
摘要： This invention relates to a cell culture process for the production of polypeptides in mammalian CHO cells characterized by one or more temperature and pH shifts which are adjusted in respect to their timing and step size to reduce cell death, increase product yield and improve product quality.
摘要翻译：本发明涉及用于在哺乳动物CHO细胞中产生多肽的细胞培养方法，其特征在于一个或多个温度和pH值偏移，其相对于其时间和步骤大小进行调整，以减少细胞死亡，提高产物产量并提高产品质量。

6. 发明申请

US20130130316A1 CELL CULTIVATION PROCESS 有权
标题翻译：细胞培养方法
公开(公告)号：US20130130316A1
公开(公告)日：2013-05-23
申请号：US13643996
申请日：2011-04-25
申请人： Christoph E. Joosten , Christian Leist , Jörg Schmidt
发明人： Christoph E. Joosten , Christian Leist , Jörg Schmidt
IPC分类号： C07K16/00
CPC分类号： C07K16/00 , C07K2317/14 , C12N5/00 , C12N2500/60 , C12N2510/02 , C12N2523/00 , C12P21/005
摘要： This invention relates to a cell culture process for the production of polypeptides in mammalian CHO cells characterized by one or more temperature and pH shifts which are adjusted in respect to their timing and step size to reduce cell death, increase product yield and improve product quality.
摘要翻译：本发明涉及用于在哺乳动物CHO细胞中产生多肽的细胞培养方法，其特征在于一个或多个温度和pH漂移，其相对于其时间和步骤大小进行调整，以减少细胞死亡，提高产物产量并提高产品质量。

7. 发明授权

US08814420B2 System for gravimetrically dosing bulk goods components having a transport container which can be coupled to and decoupled from a drive carriage 有权
标题翻译：用于重量分配散装货物部件的系统，其具有可以与驱动托架耦合并与驱动托架分离的运输容器
公开(公告)号：US08814420B2
公开(公告)日：2014-08-26
申请号：US12737997
申请日：2009-08-25
申请人： Frank Pahl , Helmut Bauer , Christian Leist
发明人： Frank Pahl , Helmut Bauer , Christian Leist
IPC分类号： G01G19/22 , G01G19/32
CPC分类号： G01G19/32 , G01G19/22
摘要： The invention proposes a system for gravimetrically combining individual bulk material components in one or a plurality of transport container(s). The system comprises a plurality of storage containers for storing the bulk material components equipped with one dosing unit each in order to transfer a respective bulk material component into the transport container. Each of the storage containers is associated with a weighing means disposed below each storage container. The transport containers can be moved between the dosing units of the supply containers along a guidance and cooperate with the weighing means. In accordance with the invention, the guidance has several guiding segments that are disposed behind one another in the guiding direction and on which the transport container is guided, and at least the guiding segments disposed below the dosing units of the supply containers are formed by weighing/guiding segments which are mechanically decoupled from the other guiding segments or weighing/guiding segments such that the transport container is in its respective dosing position on the weighing/guiding segments for detecting its weight.
摘要翻译：本发明提出了一种用于在一个或多个运输容器中重量分配组合各个散装材料部件的系统。该系统包括多个存储容器，用于存储装配有一个计量单元的散装材料部件，以便将相应的散装材料部件转移到运输容器中。每个存储容器与设置在每个存储容器下方的称重装置相关联。运输容器可以沿着引导件在供给容器的计量单元之间移动并与称重装置配合。根据本发明，引导具有在引导方向上彼此相对设置并且运输容器被引导的多个引导段，并且至少设置在供给容器的计量单元下方的引导段通过称重 /导向段，其与其他引导段或称重/引导段机械地分离，使得运输容器处于其在称重/引导段上的相应配量位置，用于检测其重量。

8. 发明授权

US08573267B2 Method and device for contamination-free transport of pourable bulk product 有权
标题翻译：用于无污染运输可倾倒散装产品的方法和装置
公开(公告)号：US08573267B2
公开(公告)日：2013-11-05
申请号：US13455231
申请日：2012-04-25
申请人： Helmuth Bauer , Christian Leist
发明人： Helmuth Bauer , Christian Leist
IPC分类号： B65B1/04
CPC分类号： B65G69/183
摘要： A method for substantially contamination-free transport of pourable bulk product from a dosing unit into a container is proposed, wherein the dosing outlet of the dosing unit is connected in a detachable manner with the receiving inlet of the container, the dosing outlet and the receiving inlet are opened, and the bulk product is transported into the container from the dosing unit via its dosing outlet and via the receiving inlet of the container. The receiving inlet of the container is disposed at the dosing unit by means of an elastic joining element to prevent transfer of forces between the dosing unit and the container during the dosing process. A device for carrying out such a method is also proposed.
摘要翻译：提出了一种用于将可倾倒散装产品从计量单元基本上无污染地输送到容器中的方法，其中计量单元的计量出口以可拆卸的方式连接到容器的接收入口，计量出口和接收器入口被打开，并且散装产品从配量单元经由其计量出口和容器的接收入口运送到容器中。容器的接收入口通过弹性连接元件设置在计量单元处，以防止在给料过程期间在计量单元和容器之间传递力。还提出了一种用于执行这种方法的装置。

9. 发明申请

US20090260715A1 Method and device for contamination-free transport of pourable bulk product 审中-公开
标题翻译：用于无污染运输可倾倒散装产品的方法和装置
公开(公告)号：US20090260715A1
公开(公告)日：2009-10-22
申请号：US12385564
申请日：2009-04-13
申请人： Helmuth Bauer , Christian Leist
发明人： Helmuth Bauer , Christian Leist
IPC分类号： B65B1/04
CPC分类号： B65G69/183
摘要： A method for substantially contamination-free transport of pourable bulk product from a dosing unit having a lidded dosing outlet into a container having a lidded receiving inlet is proposed, wherein the dosing outlet of the dosing unit is connected in a detachable manner with the receiving inlet of the container, the dosing outlet and the receiving inlet are opened, and the bulk product is transported into the container from the dosing unit via its dosing outlet and via the receiving inlet of the container. The invention envisions that the dosing outlet of the dosing unit and/or the receiving inlet of the container is/are disposed at the dosing unit and/or the container by means of an elastic joining element to prevent transfer of forces between the dosing outlet and the dosing unit and/or between the receiving inlet and the container, wherein the dosing outlet/receiving inlet, which are connected with each other, are disposed relative to the dosing unit and/or the container at least during the dosing process in such a way that a transfer of forces between the dosing unit and the container is prevented by the elastic joining element. The invention further concerns a device for carrying out such a method.
摘要翻译：提出了一种用于将可倾倒的散装产品从具有带盖的计量出口的计量单元基本上无污染地输送到具有带盖的接收入口的容器中的方法，其中计量单元的计量出口以可接收的方式连接到接收入口的容器，定量出口和接收入口打开，并且散装产品通过其计量出口和容器的接收入口从配量单元输送到容器中。本发明设想，计量单元的剂量出口和/或容器的接收入口通过弹性接合元件设置在计量单元和/或容器处，以防止在计量出口和计量单元和/或接收入口和容器之间，其中彼此连接的计量出口/接收入口至少在给药过程期间相对于计量单元和/或容器设置在这样的通过弹性接合元件防止计量单元和容器之间的力传递的方式。本发明还涉及一种用于执行这种方法的装置。

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