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1. 发明申请

US20110118850A1 Bioactive Grafts and Composites 审中-公开
标题翻译：生物活性接枝和复合材料
公开(公告)号：US20110118850A1
公开(公告)日：2011-05-19
申请号：US12959777
申请日：2010-12-03
申请人： Amit Prakash Govil , Christian Gamboa
发明人： Amit Prakash Govil , Christian Gamboa
IPC分类号： A61F2/28
CPC分类号： A61L27/20 , A61F2/4644 , A61F2002/4646 , A61K35/32 , A61L27/12 , A61L27/3608 , A61L27/365 , A61L27/50 , A61L27/54 , A61L2300/232 , A61L2300/404 , A61L2300/412 , A61L2300/45 , A61L2300/60 , A61L2300/62 , A61L2400/16 , A61L2430/02 , C08L5/08
摘要： Disclosed are various bioactive grafts and/or biocompatible materials and methods of making the same. In one embodiment, bone material is harvested from a donor. The harvested bone material is exposed to a lysing agent, the lysing agent configured to release growth factors and bioactive materials from cellular material of the harvested bone material. The harvested bone material is then rinsed with a rinsing agent. The pH of the harvested bone material is substantially neutralized. In another embodiment, an orthopaedic implant includes an antibacterial polysaccharide. The implant may also include an osteostimulative agent.
摘要翻译：公开了各种生物活性移植物和/或生物相容性材料及其制备方法。在一个实施方案中，从供体收获骨材料。收获的骨材料暴露于裂解剂，裂解剂配置为从收获的骨材料的细胞材料中释放生长因子和生物活性物质。然后用收集的骨材料用漂洗剂漂洗。收获的骨材料的pH被基本上中和。在另一个实施方案中，矫形植入物包括抗菌多糖。植入物还可以包括骨质疏松剂。

2. 发明申请

US20090137042A1 PROCESSES AND SYSTEMS FOR HYDRATING AND SEEDING MEDICAL IMPLANTS WITH BIOLOGICAL COMPONENTS 有权
标题翻译：用于生物组分的植入和植入医疗植入物的方法和系统
公开(公告)号：US20090137042A1
公开(公告)日：2009-05-28
申请号：US12130920
申请日：2008-05-30
申请人： AMIT GOVIL , Christian Gamboa
发明人： AMIT GOVIL , Christian Gamboa
IPC分类号： C12N5/02 , A61B19/02 , C12M3/00
CPC分类号： A61F2/4644 , A61F2/0095 , A61F2/28 , A61F2310/00359
摘要： Methods and systems for providing an improved apparatus and packaging system to more expeditiously hydrate or reconstitute medical grafts and to effectively and uniformly seed the medical grafts with biological components and cultured cells. The systems generally comprise a container comprising entry port, at least one substrate cavity, and top, side and bottom walls defining an inner surface. The entry port is configured to receive the biological solution. The cavity is in communication with the entry port and includes the porous substrate maintained under negative pressure. The container volume is substantially the same as a volume of the porous substrate. The side and bottom walls are configured to promote a laminar flow of the biological solution received through the entry port.
摘要翻译：用于提供改进的装置和包装系统的方法和系统，以更快速地水合或重建医学移植物，并且用生物组分和培养细胞有效地和均匀地种植医用移植物。系统通常包括容器，其包括进入端口，至少一个基板空腔，以及限定内表面的顶部，侧壁和底壁。进入端口被配置为接收生物解决方案。空腔与入口端口连通并且包括保持在负压下的多孔基底。容器体积与多孔基材的体积基本相同。侧壁和底壁构造成促进通过入口接收的生物溶液的层流。

3. 发明申请

US20200237955A1 Bioactive Grafts and Composites 审中-公开
公开(公告)号：US20200237955A1
公开(公告)日：2020-07-30
申请号：US16590467
申请日：2019-10-02
申请人： Amit Prakash GOVIL , Christian GAMBOA
发明人： Amit Prakash GOVIL , Christian GAMBOA
IPC分类号： A61L27/20 , A61L27/54 , A61F2/46 , A61L27/50 , A61L27/12 , A61L27/36 , A61K35/32
摘要： Disclosed are various bioactive grafts and/or biocompatible materials and methods of making the same. In one embodiment, bone material is harvested from a donor. The harvested bone material is exposed to a lysing agent, the lysing agent configured to release growth factors and bioactive materials from cellular material of the harvested bone material. The harvested bone material is then rinsed with a rinsing agent. The pH of the harvested bone material is substantially neutralized. In another embodiment, an orthopaedic implant includes an antibacterial polysaccharide. The implant may also include an osteostimulative agent.

4. 发明授权

US08070740B2 Processes and systems for hydrating and seeding medical implants with biological components 有权
标题翻译：用生物成分保湿和种植医用植入物的方法和系统
公开(公告)号：US08070740B2
公开(公告)日：2011-12-06
申请号：US12130920
申请日：2008-05-30
申请人： Amit Govil , Christian Gamboa
发明人： Amit Govil , Christian Gamboa
IPC分类号： A61M5/00 , A61K31/74 , A61F2/28
CPC分类号： A61F2/4644 , A61F2/0095 , A61F2/28 , A61F2310/00359
摘要： Methods and systems for providing an improved apparatus and packaging system to more expeditiously hydrate or reconstitute medical grafts and to effectively and uniformly seed the medical grafts with biological components and cultured cells. The systems generally comprise a container comprising entry port, at least one substrate cavity, and top, side and bottom walls defining an inner surface. The entry port is configured to receive the biological solution. The cavity is in communication with the entry port and includes the porous substrate maintained under negative pressure. The container volume is substantially the same as a volume of the porous substrate. The side and bottom walls are configured to promote a laminar flow of the biological solution received through the entry port.
摘要翻译：用于提供改进的装置和包装系统的方法和系统，以更快速地水合或重建医学移植物，并且用生物组分和培养细胞有效地和均匀地种植医用移植物。系统通常包括容器，其包括进入端口，至少一个基板空腔，以及限定内表面的顶部，侧壁和底壁。进入端口被配置为接收生物解决方案。空腔与入口端口连通并且包括保持在负压下的多孔基底。容器体积与多孔基材的体积基本相同。侧壁和底壁构造成促进通过入口接收的生物溶液的层流。

5. 发明申请

US20170312386A1 Bioactive Grafts and Composites 审中-公开
公开(公告)号：US20170312386A1
公开(公告)日：2017-11-02
申请号：US15654830
申请日：2017-07-20
申请人： Amit Prakash GOVIL , Christian GAMBOA
发明人： Amit Prakash GOVIL , Christian GAMBOA
IPC分类号： A61L27/20 , A61K35/32 , A61L27/12 , A61L27/36 , A61L27/50 , A61L27/54 , C08L5/08 , A61F2/46
CPC分类号： A61L27/20 , A61F2/4644 , A61F2002/4646 , A61K35/28 , A61K35/32 , A61L27/12 , A61L27/3608 , A61L27/365 , A61L27/3821 , A61L27/3834 , A61L27/50 , A61L27/54 , A61L2300/232 , A61L2300/404 , A61L2300/406 , A61L2300/412 , A61L2300/45 , A61L2300/60 , A61L2300/62 , A61L2400/16 , A61L2430/02 , C08L5/08
摘要： Disclosed are various bioactive and/or biocompatible materials and methods of making the same.

6. 发明申请

US20160367723A1 Bioactive Grafts and Composites 审中-公开
标题翻译：生物活性接枝和复合材料
公开(公告)号：US20160367723A1
公开(公告)日：2016-12-22
申请号：US15252737
申请日：2016-08-31
申请人： Amit Prakash GOVIL , Christian GAMBOA
发明人： Amit Prakash GOVIL , Christian GAMBOA
IPC分类号： A61L27/20 , A61L27/12 , A61L27/36 , A61L27/54
CPC分类号： A61L27/20 , A61F2/4644 , A61F2002/4646 , A61K35/32 , A61L27/12 , A61L27/3608 , A61L27/365 , A61L27/50 , A61L27/54 , A61L2300/232 , A61L2300/404 , A61L2300/412 , A61L2300/45 , A61L2300/60 , A61L2300/62 , A61L2400/16 , A61L2430/02 , C08L5/08
摘要： Disclosed are various bioactive grafts and/or biocompatible materials and methods of making the same. In one embodiment, bone material is harvested from a donor. The harvested bone material is exposed to a lysing agent, the lysing agent configured to release growth factors and bioactive materials from cellular material of the harvested bone material. The harvested bone material is then rinsed with a rinsing agent. The pH of the harvested bone material is substantially neutralized. In another embodiment, an orthopaedic implant includes an antibacterial polysaccharide. The implant may also include an osteostimulative agent.
摘要翻译：公开了各种生物活性移植物和/或生物相容性材料及其制备方法。在一个实施方案中，从供体收获骨材料。收获的骨材料暴露于裂解剂，裂解剂配置为从收获的骨材料的细胞材料中释放生长因子和生物活性物质。然后用收集的骨材料用漂洗剂漂洗。收获的骨材料的pH被基本上中和。在另一个实施方案中，矫形植入物包括抗菌多糖。植入物还可以包括骨质疏松剂。

7. 发明申请

US20150125508A1 Bioactive Grafts and Composites 审中-公开
标题翻译：生物活性接枝和复合材料
公开(公告)号：US20150125508A1
公开(公告)日：2015-05-07
申请号：US14598681
申请日：2015-01-16
申请人： Amit Prakash GOVIL , Christian GAMBOA
发明人： Amit Prakash GOVIL , Christian GAMBOA
IPC分类号： A61L27/20 , A61L27/36 , A61L27/12 , A61L27/54
CPC分类号： A61L27/20 , A61F2/4644 , A61F2002/4646 , A61K35/32 , A61L27/12 , A61L27/3608 , A61L27/365 , A61L27/50 , A61L27/54 , A61L2300/232 , A61L2300/404 , A61L2300/412 , A61L2300/45 , A61L2300/60 , A61L2300/62 , A61L2400/16 , A61L2430/02 , C08L5/08
摘要： Disclosed are various bioactive grafts and/or biocompatible materials and methods of making the same. In one embodiment, bone material is harvested from a donor. The harvested bone material is exposed to a lysing agent, the lysing agent configured to release growth factors and bioactive materials from cellular material of the harvested bone material. The harvested bone material is then rinsed with a rinsing agent. The pH of the harvested bone material is substantially neutralized. In another embodiment, an orthopedic implant includes an antibacterial polysaccharide. The implant may also include an osteostimulative agent.
摘要翻译：公开了各种生物活性移植物和/或生物相容性材料及其制备方法。在一个实施方案中，从供体收获骨材料。收获的骨材料暴露于裂解剂，裂解剂配置为从收获的骨材料的细胞材料中释放生长因子和生物活性物质。然后用收集的骨材料用漂洗剂漂洗。收获的骨材料的pH被基本上中和。在另一个实施方案中，矫形植入物包括抗菌多糖。植入物还可以包括骨质疏松剂。

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