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1. 发明授权

US08228499B2 Method for positioning biological samples in a microscopic arrangement 有权
标题翻译：将微生物样品定位的方法
公开(公告)号：US08228499B2
公开(公告)日：2012-07-24
申请号：US12682234
申请日：2008-09-18
申请人： Helmut Lippert , Benno Radt , Christian Dietrich , Christopher Power
发明人： Helmut Lippert , Benno Radt , Christian Dietrich , Christopher Power
IPC分类号： G01N21/01 , G06K9/00 , G01N1/00
CPC分类号： G02B21/34
摘要： The invention relates to methods for positioning at least one preferably biological specimen in the specimen space of a microscope arrangement, and to devices for carrying out these methods. Methods and devices are proposed, wherein the specimen's orientation relative to a detection objective's optical axis can be repeatedly changed and, in doing so, the specimen is held so that a substantially unobstructed view of the specimen is ensured from every detection direction. In different constructional variants, the specimen is held at a supporting device by adhesive forces or by a flowing medium, the specimen is held at a capillary opening by capillary action, or at least one specimen is embedded in a body of transparent gel, and the gel body is fixed in the specimen space by means of a rotatable holding device, and the detection direction is changed by rotating the holding device by a given angle of rotation.
摘要翻译：本发明涉及将显影装置的样本空间中至少一个优选生物样本定位的方法以及用于实施这些方法的装置。提出了相对于检测对象的光轴的试样的取向可以反复改变的方法和装置，并且在这样做的同时，保持试样，使得从每个检测方向确保了样本的基本无阻碍的视图。在不同的结构变型中，试样通过粘合力或流动介质保持在支撑装置上，通过毛细管作用将样品保持在毛细管开口处，或者至少一个样品嵌入透明凝胶体中，凝胶体通过可旋转保持装置固定在样本空间中，并且通过使保持装置旋转给定的旋转角度来改变检测方向。

2. 发明授权

US08921809B2 Device for microscopy having selective illumination of a plane 有权
标题翻译：具有选择性照射平面的显微镜装置
公开(公告)号：US08921809B2
公开(公告)日：2014-12-30
申请号：US12937103
申请日：2009-04-04
申请人： Helmut Lippert , Christopher Power , Christian Dietrich , Benno Radt
发明人： Helmut Lippert , Christopher Power , Christian Dietrich , Benno Radt
IPC分类号： G01J1/58 , G02B21/00 , G02B21/16 , G02B21/06 , G02B21/10
CPC分类号： G02B21/16 , G02B21/002 , G02B21/06 , G02B21/10
摘要： A microscopy device, particularly for use in an imaging fluorescence lifetime microscopy method is provided. The microscopy device comprises an illumination means for generating an illumination beam, an imaging detector for spatially resolved acquisition of an emission radiation emitted by an object to be examined, an illumination beam path between the illumination means and the object to be examined, and a detection beam path between the object to be examined and the detector. The illumination beam path comprises illumination optics which are designed to generate a light sheet of illumination radiation extending transverse to the axis of the illumination beam path, wherein the axis of the detection beam path is oriented substantially perpendicular to a section plane of the light sheet and of the object to be examined. The illumination means comprise a pulsed laser.
摘要翻译：提供了特别用于成像荧光寿命显微术方法的显微镜装置。显微镜装置包括用于产生照明光束的照明装置，用于空间分辨地获取由待检查对象发射的发射辐射的成像检测器，照明装置和待检查对象之间的照明光束路径，以及检测要检查的物体与检测器之间的光束路径。照明光束路径包括照明光学器件，其设计成产生横向于照明光束路径的轴线延伸的照明辐射的光片，其中检测光束路径的轴线基本上垂直于光片的截面定向，的被检查对象。照明装置包括脉冲激光器。

3. 发明授权

US08547634B2 Optical arrangement for photomanipulation 有权
标题翻译：光调制的光学布置
公开(公告)号：US08547634B2
公开(公告)日：2013-10-01
申请号：US12680165
申请日：2008-09-16
申请人： Christopher Power , Helmut Lippert , Benno Radt , Christian Dietrich
发明人： Christopher Power , Helmut Lippert , Benno Radt , Christian Dietrich
IPC分类号： G02B21/06
CPC分类号： G02B21/32 , G02B21/0032
摘要： The invention is directed to an optical arrangement for photomanipulation of a sample comprising a sample holder for receiving the sample, an illumination device comprising an illumination light source and an illumination beam path for illuminating the sample with a light sheet. It further comprises a detection device for detecting light that is radiated from the sample and imaging optics which image the sample on the detection device by means of an imaging objective in an imaging beam path, wherein the light sheet is substantially planar in the focus of the imaging objective, and wherein the imaging objective has an optical axis which intersects the plane of the light sheet at an angle different from zero. Further, the arrangement also has means for photomanipulation of the sample.
摘要翻译：本发明涉及用于光调制样品的光学装置，其包括用于接收样品的样品保持器，包括照明光源的照明装置和用于用光照射样品的照明光束路径。它还包括检测装置，用于检测从样本辐射的光和成像光学元件，其通过成像光束路径中的成像目标将检测装置上的样品成像在检测装置上，其中光片在成像目标，并且其中所述成像物镜具有与所述光片的平面以不同于零的角度相交的光轴。此外，该装置还具有用于对样品进行光电处理的装置。

4. 发明申请

US20120282667A1 METHOD FOR POSITIONING BIOLOGICAL SAMPLES IN A MICROSCOPIC ARRANGEMENT 审中-公开
标题翻译：在微观结构中定位生物样本的方法
公开(公告)号：US20120282667A1
公开(公告)日：2012-11-08
申请号：US13554232
申请日：2012-07-20
申请人： Helmut Lippert , Benno Radt , Christian Dietrich , Christopher Power
发明人： Helmut Lippert , Benno Radt , Christian Dietrich , Christopher Power
IPC分类号： C12N11/00 , B05C11/00 , B05C5/00
CPC分类号： G02B21/34
摘要： The invention relates to methods for positioning at least one preferably biological specimen in the specimen space of a microscope arrangement, and to devices for carrying out these methods. Methods and devices arc proposed, wherein the specimen's orientation relative to a detection objective's optical axis can be repeatedly changed and, in doing so, the specimen is held so that a substantially unobstructed view of the specimen is ensured from every detection direction. In different constructional variants, the specimen is held at a supporting device by adhesive forces or by a flowing medium, the specimen is held at a capillary opening by capillary action, or at least one specimen is embedded in a body of transparent gel, and the gel body is fixed in the specimen space by means of a rotatable holding device, and the detection direction is changed by rotating the holding device by a given angle of rotation.
摘要翻译：本发明涉及将显影装置的样本空间中至少一个优选生物样本定位的方法以及用于实施这些方法的装置。提出了一种方法和装置，其中相对于检测对象的光轴的样本的取向可以重复地改变，并且在这样做时，保持样本，使得从每个检测方向确保样本的基本上无障碍的视图。在不同的结构变型中，试样通过粘合力或流动介质保持在支撑装置上，通过毛细管作用将样品保持在毛细管开口处，或者至少一个样品嵌入透明凝胶体中，凝胶体通过可旋转保持装置固定在样本空间中，并且通过使保持装置旋转给定的旋转角度来改变检测方向。

5. 发明申请

US20120105235A1 METHOD FOR IDENTIFYING DIRT AND/OR DEW ON COMPONENTS OF A VOLTAGE INTERMEDIATE CIRCUIT CONVERTER 失效
标题翻译：用于识别电压中间电路转换器的组件的方法和/或DEW
公开(公告)号：US20120105235A1
公开(公告)日：2012-05-03
申请号：US13320326
申请日：2010-01-29
申请人： Christian Dietrich , Werner Fischer , Jörg Hassel , Marc Hiller , Carsten Probol , Rainer Sommer
发明人： Christian Dietrich , Werner Fischer , Jörg Hassel , Marc Hiller , Carsten Probol , Rainer Sommer
IPC分类号： G08B21/00
CPC分类号： H02M1/32
摘要： The invention relates to a method for identifying dirt and/or dew on components of a voltage intermediate circuit converter. According to the invention, the temporal curve of a partial discharge pulsed current is detected at least during a precharging process of an intermediate circuit capacitor of the voltage intermediate circuit converter comprising at least one capacitor, wherein a frequency spectrum is calculated from said current pulse, and wherein depending of the result, a dirt warning and/or a dew warning is activated. Thus, the degree of dirt and/or dew of said voltage intermediate circuit converter can be determined at least during a charging process of an intermediate circuit capacitor of a voltage intermediate circuit converter, thereby preventing a breakdown including the consequences thereof.
摘要翻译：本发明涉及一种用于识别电压中间电路转换器的部件上的污垢和/或露点的方法。根据本发明，至少在包括至少一个电容器的电压中间电路转换器的中间电路电容器的预充电过程期间至少检测局部放电脉冲电流的时间曲线，其中从所述电流脉冲计算频谱，并且其中依赖于结果，激活了污物警告和/或露水警告。因此，可以至少在电压中间电路转换器的中间电路电容器的充电过程期间确定所述电压中间电路转换器的污垢和/或露点的程度，从而防止包括其后果的故障。

6. 发明申请

US20110170182A1 DEVICE FOR HOLDING AND POSITIONING A SAMPLE RELATIVE TO A MICROSCOPE LENS 审中-公开
标题翻译：用于保存和定位相对于微镜镜头的样品的装置
公开(公告)号：US20110170182A1
公开(公告)日：2011-07-14
申请号：US13056417
申请日：2009-07-28
申请人： Helmut Lippert , Christopher Power , Christian Dietrich , Benno Radt
发明人： Helmut Lippert , Christopher Power , Christian Dietrich , Benno Radt
IPC分类号： G02B21/26
CPC分类号： G02B21/26 , G02B21/0088 , G02B21/33 , G02B21/34
摘要： An arrangement for holding and positioning a sample in the detection area of the objective of a microscope, the detection area being located in a chamber which is filled with an immersion liquid. This arrangement includes (1) a sample holder to which the sample is affixed so as to lie upon a point P in a coordinate system X, Y, Z, coordinate Z being defined by the optical axis of the microscope objective and the coordinate origin laying within the detection area, (2) a device by which the position of point P can be varied within the coordinate system X, Y, Z, wherein the range of variation comprehends the detection area, and (3) a device for rotating the sample affixed to the sample holder around point P, wherein a straight line G which encloses with coordinate Z an angle α whose size can be changed is the axis of rotation.
摘要翻译：用于将样品保持和定位在显微镜的目标的检测区域中的装置，检测区域位于填充有浸没液体的室中。这种布置包括（1）样品固定器，样品被固定在其上，以便位于坐标系X，Y，Z中的点P上，坐标Z由显微镜物镜的光轴和坐标原点铺设在检测区域内，（2）能够在坐标系X，Y，Z内改变点P的位置的装置，其中变化范围包括检测区域，以及（3）旋转样品的装置固定在点P附近的样品架上，其中以坐标Z包围尺寸可以改变的角度α的直线G是旋转轴。

7. 发明申请

US20100201784A1 METHOD FOR THE MICROSCOPIC THREE-DIMENSIONAL REPRODUCTION OF A SAMPLE 审中-公开
标题翻译：一种样品的微观三维再现方法
公开(公告)号：US20100201784A1
公开(公告)日：2010-08-12
申请号：US12680056
申请日：2008-09-16
申请人： Helmut Lippert , Benno Radt , Michael Kempe , Christian Dietrich
发明人： Helmut Lippert , Benno Radt , Michael Kempe , Christian Dietrich
IPC分类号： H04N13/02
CPC分类号： G06T7/97 , G02B21/002 , G02B21/244 , G02B21/367
摘要： A method for the three-dimensional imaging of a sample in which image information from different depth planes of the sample is stored in a spatially resolved manner, and the three-dimensional image of the sample is subsequently reconstructed from this stored image information is provided. A reference structure is applied to the illumination light, at least one fluorescing reference object is positioned next to or in the sample, images of the reference structure of the illumination light, of the reference object are recorded from at least one detection direction and evaluated. The light sheet is brought into an optimal position based on the results and image information of the reference object and of the sample from a plurality of detection directions is stored. Transformation operators are obtained on the basis of the stored image information and the reconstruction of the three-dimensional image of the is based on these transformation operators.
摘要翻译：提供了一种用于样本的三维成像的方法，其中以空间分辨的方式存储来自样本的不同深度平面的图像信息，并且随后从该存储的图像信息重建样本的三维图像。参考结构被应用于照明光，至少一个发荧光参考对象被放置在样本旁边或样本中，从至少一个检测方向记录参考物体的照明光的参考结构的图像并进行评估。基于结果使光照片进入最佳位置，存储参考对象的图像信息和来自多个检测方向的样本的图像信息。基于存储的图像信息和基于这些变换算子的三维图像的重建获得转换算子。

8. 发明申请

US20100177381A1 Sample Holding System for a Microscope 有权
标题翻译：显微镜样品保持系统
公开(公告)号：US20100177381A1
公开(公告)日：2010-07-15
申请号：US12597144
申请日：2008-04-04
申请人： Helmut Lippert , Christopher Power , Christian Dietrich , Benno Radt
发明人： Helmut Lippert , Christopher Power , Christian Dietrich , Benno Radt
IPC分类号： G02B21/34
CPC分类号： G02B21/26
摘要： The invention relates to a sample holding system for a microscope, comprising a sample chamber which has an upper opening and is filled with an immersion liquid, and in which a sample embedded in a transparent embedding compound is placed in a holder. The sample holding system also comprises means for the translatory movement of the sample in relation to a detection objective of the microscope, and means for rotating the sample about an essentially vertical rotational axis in a plane forming an angle different from zero with the optical axis of the detection objective. The means for rotating the sample in such a sample holding system comprise a rotational drive provided with a magnetic coupling or a belt drive and/or toothed wheel rotational drive arranged above the sample chamber, said drives transmitting the rotational movement to the holder, or the rotational movement is generated directly by the movement of the entire sample chamber.
摘要翻译：本发明涉及一种用于显微镜的样品保持系统，其包括具有上部开口并填充有浸没液体的样品室，并且将嵌入在透明嵌入物中的样品放置在保持器中。样品保持系统还包括用于相对于显微镜的检测目标的样品的平移运动的装置，以及用于使样品围绕基本上垂直的旋转轴旋转的装置，该平面形成与零的光轴不同的角度检测目标。在这种样品保持系统中旋转样品的装置包括旋转驱动器，其设置有设置在样品室上方的磁耦合或带驱动和/或齿轮旋转驱动器，所述驱动器将旋转运动传递到保持器，或通过整个样品室的运动直接产生旋转运动。

9. 发明授权

US08786450B2 Method for identifying dirt and/or dew on components of a voltage intermediate circuit converter 失效
标题翻译：用于识别电压中间电路转换器的部件上的污垢和/或露点的方法
公开(公告)号：US08786450B2
公开(公告)日：2014-07-22
申请号：US13320326
申请日：2010-01-29
申请人： Christian Dietrich , Werner Fischer , Jörg Hassel , Marc Hiller , Carsten Probol , Rainer Sommer
发明人： Christian Dietrich , Werner Fischer , Jörg Hassel , Marc Hiller , Carsten Probol , Rainer Sommer
IPC分类号： G08B21/00
CPC分类号： H02M1/32
摘要： The invention relates to a method for identifying dirt and/or dew on components of a voltage intermediate circuit converter. According to the invention, the temporal curve of a partial discharge pulsed current is detected at least during a precharging process of an intermediate circuit capacitor of the voltage intermediate circuit converter comprising at least one capacitor, wherein a frequency spectrum is calculated from said current pulse, and wherein depending of the result, a dirt warning and/or a dew warning is activated. Thus, the degree of dirt and/or dew of said voltage intermediate circuit converter can be determined at least during a charging process of an intermediate circuit capacitor of a voltage intermediate circuit converter, thereby preventing a breakdown including the consequences thereof.
摘要翻译：本发明涉及一种用于识别电压中间电路转换器的部件上的污垢和/或露点的方法。根据本发明，至少在包括至少一个电容器的电压中间电路转换器的中间电路电容器的预充电过程期间至少检测局部放电脉冲电流的时间曲线，其中从所述电流脉冲计算频谱，并且其中依赖于结果，激活了污物警告和/或露水警告。因此，可以至少在电压中间电路转换器的中间电路电容器的充电过程期间确定所述电压中间电路转换器的污垢和/或露点的程度，从而防止包括其后果的故障。

10. 发明授权

US08699133B2 Sample holding system for a microscope with magnetic coupling 有权
标题翻译：带磁耦合显微镜的样品保持系统
公开(公告)号：US08699133B2
公开(公告)日：2014-04-15
申请号：US12597144
申请日：2008-04-04
申请人： Helmut Lippert , Christopher Power , Christian Dietrich , Benno Radt
发明人： Helmut Lippert , Christopher Power , Christian Dietrich , Benno Radt
IPC分类号： G02B21/26
CPC分类号： G02B21/26
摘要： A sample holding system for a microscope, including a sample chamber which has an upper opening and is filled with an immersion liquid, and in which a sample embedded in a transparent embedding compound is placed in a holder. Translatory movement of the sample in relation to a detection objective of the microscope, and rotating the sample about an essentially vertical rotational axis in a plane forming an angle different from zero with the optical axis of the detection objective is included. Rotating the sample includes a rotational drive provided with a magnetic coupling or a belt drive and/or toothed wheel rotational drive arranged above the sample chamber.
摘要翻译：一种用于显微镜的样品保持系统，包括具有上部开口并填充有浸没液体的样品室，并且将嵌入在透明嵌入物中的样品放置在保持器中。样品相对于显微镜的检测目标的平移运动，并且包括在与检测对象的光轴形成不同于零的角度的平面中基本上垂直的旋转轴线旋转样品。旋转样品包括旋转驱动器，其设置有设置在样品室上方的磁耦合或带驱动和/或齿轮旋转驱动。

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