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1. 发明授权

US07759461B2 Expression system for enhancing solubility and immunogeneicity of recombinant proteins 有权
标题翻译：用于增强重组蛋白质的溶解度和免疫原性的表达系统
公开(公告)号：US07759461B2
公开(公告)日：2010-07-20
申请号：US12406789
申请日：2009-03-18
申请人： Ming-Yu Chen , Chin-Kai Chuang , Yu-Hsyu Su , Chiu-Ting Fan , Jung-Chuan Yu , Wen-Chuan Lee
发明人： Ming-Yu Chen , Chin-Kai Chuang , Yu-Hsyu Su , Chiu-Ting Fan , Jung-Chuan Yu , Wen-Chuan Lee
IPC分类号： C07K1/00
CPC分类号： C12N15/62 , C07K14/005 , C07K14/47 , C07K2319/01 , C07K2319/35 , C07K2319/70 , C12N2710/22022 , C12N2740/16322 , C12P21/02
摘要： Expression system for enhancing solubility and immunogenicity of recombinant proteins. The expression system includes a protein expression vector that contains a chimeric gene encoding a chimeric protein comprising: (a) a first polypeptidyl fragment at the N-terminal end of the chimeric protein, containing a protein transduction domain (PTD), or a fragment thereof, having HIV Tat PTD activity; (b) a second polypeptidyl fragment at the C-terminal end of the first polypeptidyl fragment, containing a J-domain, or a fragment thereof, having heat shock protein 70 (Hsp70)-interacting activity; and (c) a third polypeptidyl fragment at the C-terminal end of the second polypeptidyl fragment, containing a target protein or polypeptide.
摘要翻译：用于增强重组蛋白质的溶解度和免疫原性的表达系统。表达系统包括含有编码嵌合蛋白的嵌合基因的蛋白质表达载体，其包含：（a）嵌合蛋白的N-末端的第一多肽基片段，其含有蛋白质转导结构域（PTD）或其片段具有HIV Tat PTD活性; （b）含有具有热休克蛋白70（Hsp70） - 相互作用活性的J结构域或其片段的第一多肽片段C末端的第二多肽基片段; 和（c）含有靶蛋白或多肽的第二多肽片段的C末端的第三多肽基片段。

2. 发明授权

US07524648B2 Expression system for enhancing solubility and immunogeneicity of recombinant proteins 有权
标题翻译：用于增强重组蛋白质的溶解度和免疫原性的表达系统
公开(公告)号：US07524648B2
公开(公告)日：2009-04-28
申请号：US12149606
申请日：2008-05-05
申请人： Ming-Yu Chen , Chin-Kai Chuang , Yu-Hsyu Su , Chiu-Ting Fan , Jung-Chuan Yu , Wen-Chuan Lee
发明人： Ming-Yu Chen , Chin-Kai Chuang , Yu-Hsyu Su , Chiu-Ting Fan , Jung-Chuan Yu , Wen-Chuan Lee
IPC分类号： C12P21/06 , C12N15/00 , C12N1/20 , C07H21/04
CPC分类号： C12N15/62 , C07K14/005 , C07K14/47 , C07K2319/01 , C07K2319/35 , C07K2319/70 , C12N2710/22022 , C12N2740/16322 , C12P21/02
摘要： Expression system for enhancing solubility and immunogenicity of recombinant proteins. The expression system includes a protein expression vector that contains a chimeric gene encoding a chimeric protein. The chimeric protein contains three polypeptidyl fragments: (a) a first polypeptidyl fragment at the N-terminal end of the chimeric protein that contains a protein transduction domain (PTD) or a fragment thereof having HIV Tat PTD activity; (b) a second polypeptidyl fragment at the C-terminal end of the first polypeptidyl fragment that contains a J-domain or a fragment thereof having heat shock protein 70 (Hsp70)-interacting activity; and (c) a third polypeptidyl fragment at the C-terminal end of the second polypeptidyl fragment that contains a target protein or polypeptide.
摘要翻译：用于增强重组蛋白质的溶解度和免疫原性的表达系统。表达系统包括含有编码嵌合蛋白的嵌合基因的蛋白质表达载体。嵌合蛋白含有三个多肽基片段：（a）嵌合蛋白N末端的第一个多肽基片段，其含有具有HIV Tat PTD活性的蛋白质转导结构域（PTD）或其片段; （b）含有具有热休克蛋白70（Hsp70） - 相互作用活性的J结构域或其片段的第一多肽基片段的C-末端的第二多肽基片段; 和（c）含有靶蛋白或多肽的第二多肽基片段的C末端的第三多肽基片段。

3. 发明申请

US20090187004A1 EXPRESSION SYSTEM FOR ENHANCING SOLUBILITY AND IMMUNOGENEICITY OF RECOMBINANT PROTEINS 有权
标题翻译：用于增强重组蛋白的溶解性和免疫原性的表达系统
公开(公告)号：US20090187004A1
公开(公告)日：2009-07-23
申请号：US12406789
申请日：2009-03-18
申请人： MING-YU CHEN , Chin-Kai Chuang , Yu-Hsyu Su , Chiu-Ting Fan , Jung-Chuan Yu , Wen-Chuan Lee
发明人： MING-YU CHEN , Chin-Kai Chuang , Yu-Hsyu Su , Chiu-Ting Fan , Jung-Chuan Yu , Wen-Chuan Lee
IPC分类号： C07K14/00 , C12P21/02
CPC分类号： C12N15/62 , C07K14/005 , C07K14/47 , C07K2319/01 , C07K2319/35 , C07K2319/70 , C12N2710/22022 , C12N2740/16322 , C12P21/02
摘要： Expression system for enhancing solubility and immunogenicity of recombinant proteins. The expression system includes a protein expression vector that contains a chimeric gene encoding a chimeric protein comprising: (a) a first polypeptidyl fragment at the N-terminal end of the chimeric protein, containing a protein transduction domain (PTD), or a fragment thereof, having HIV Tat PTD activity; (b) a second polypeptidyl fragment at the C-terminal end of the first polypeptidyl fragment, containing a J-domain, or a fragment thereof, having heat shock protein 70 (Hsp70)-interacting activity; and (c) a third polypeptidyl fragment at the C-terminal end of the second polypeptidyl fragment, containing a target protein or polypeptide.
摘要翻译：用于增强重组蛋白质的溶解度和免疫原性的表达系统。表达系统包括含有编码嵌合蛋白的嵌合基因的蛋白质表达载体，其包含：（a）嵌合蛋白的N-末端的第一多肽基片段，其含有蛋白质转导结构域（PTD）或其片段具有HIV Tat PTD活性; （b）含有具有热休克蛋白70（Hsp70） - 相互作用活性的J结构域或其片段的第一多肽片段C末端的第二多肽基片段; 和（c）含有靶蛋白或多肽的第二多肽片段的C末端的第三多肽基片段。

4. 发明授权

US07806079B2 Poultry selection method to improve the egg production rate 有权
标题翻译：家禽选择方法提高产蛋率
公开(公告)号：US07806079B2
公开(公告)日：2010-10-05
申请号：US12214527
申请日：2008-06-19
申请人： Ming-Li Liou , Chuan-Yi Tang , Yen-Jen Lin , Jyh-Hung Lin , Chin-Kai Chuang , Wen-Chuan Lee
发明人： Ming-Li Liou , Chuan-Yi Tang , Yen-Jen Lin , Jyh-Hung Lin , Chin-Kai Chuang , Wen-Chuan Lee
IPC分类号： A01K45/00
CPC分类号： A01K67/02 , A01K2227/30
摘要： The present invention discloses a poultry selection method to improve the egg production rate, the method comprises steps of collecting protein samples and egg productivity information of multiple poultry groups, transforming these information into multiple scores, ranks, and their corresponding codes; the next step is to combine the corresponding codes to form regional codes, and compare the matching rate; and select the poultry with the required egg production. The present invention further discloses another method, comprising: the collecting and ranking of protein samples and egg productivity information of known and unknown poultry groups to sort out the ratings; select a poultry group having the required egg production from the known group; define the regional codes based on the ratings of the known group; compare the ratings between the known and unknown groups, select the poultry (from the unknown group) with the same regional codes to the previously selected poultry group with required egg production; and select the poultry with required egg production according to the matching rate after the comparison.
摘要翻译：本发明公开了一种提高产蛋率的家禽选择方法，该方法包括收集多个家禽群体的蛋白质样品和蛋生产力信息的步骤，将这些信息转化为多个分数，等级及其相应的代码; 下一步是结合相应的代码形成区域代码，并比较匹配率; 并选择所需鸡蛋生产的家禽。本发明还公开了另一种方法，其包括：收集和排列已知和未知家禽群体的蛋白质样品和蛋生产力信息，以整理评分; 从已知组中选择具有所需蛋产量的家禽组; 根据已知组的评级定义区域代码; 比较已知和未知群体之间的等级，从具有相同区域代码的禽类（来自未知群体）中选择需要产蛋的先前选择的家禽群; 并根据比较后的匹配率选择需要生产蛋的家禽。

5. 发明申请

US20090151640A1 Poultry selection method to improve the egg production rate 有权
标题翻译：家禽选择方法提高产蛋率
公开(公告)号：US20090151640A1
公开(公告)日：2009-06-18
申请号：US12214527
申请日：2008-06-19
申请人： Ming-Li Liou , Chuan-Yi Tang , Yen-Jen Lin , Jyh-Hung Lin , Chin-Kai Chuang , Wen-Chuan Lee
发明人： Ming-Li Liou , Chuan-Yi Tang , Yen-Jen Lin , Jyh-Hung Lin , Chin-Kai Chuang , Wen-Chuan Lee
IPC分类号： A01K45/00
CPC分类号： A01K67/02 , A01K2227/30
摘要： The present invention discloses a poultry selection method to improve the egg production rate, the method comprises steps of collecting protein samples and egg productivity information of multiple poultry groups, transforming these information into multiple scores, ranks, and their corresponding codes; the next step is to combine the corresponding codes to form regional codes, and compare the matching rate; and select the poultry with the required egg production. The present invention further discloses another method, comprising: the collecting and ranking of protein samples and egg productivity information of known and unknown poultry groups to sort out the ratings; select a poultry group having the required egg production from the known group; define the regional codes based on the ratings of the known group; compare the ratings between the known and unknown groups, select the poultry (from the unknown group) with the same regional codes to the previously selected poultry group with required egg production; and select the poultry with required egg production according to the matching rate after the comparison.
摘要翻译：本发明公开了一种提高产蛋率的家禽选择方法，该方法包括收集多个家禽群体的蛋白质样品和蛋生产力信息的步骤，将这些信息转化为多个分数，等级及其相应的代码; 下一步是结合相应的代码形成区域代码，并比较匹配率; 并选择所需鸡蛋生产的家禽。本发明还公开了另一种方法，其包括：收集和排列已知和未知家禽群体的蛋白质样品和蛋生产力信息，以整理评分; 从已知组中选择具有所需蛋产量的家禽组; 根据已知组的评级定义区域代码; 比较已知和未知群体之间的等级，从具有相同区域代码的禽类（来自未知群体）中选择需要产蛋的先前选择的家禽群; 并根据比较后的匹配率选择需要生产蛋的家禽。

6. 发明申请

US20080274508A1 Expression system for enhancing solubility and immunogeneicity of recombinant proteins 有权
标题翻译：用于增强重组蛋白质的溶解度和免疫原性的表达系统
公开(公告)号：US20080274508A1
公开(公告)日：2008-11-06
申请号：US12149606
申请日：2008-05-05
申请人： Ming-Yu Chen , Chin-Kai Chuang , Yu-Hsyu Su , Chiu-Ting Fan , Jung-Chuan Yu , Wen-Chuan Lee
发明人： Ming-Yu Chen , Chin-Kai Chuang , Yu-Hsyu Su , Chiu-Ting Fan , Jung-Chuan Yu , Wen-Chuan Lee
IPC分类号： C12P21/04 , C07K7/00 , C07K14/00 , C12N15/11 , C12N15/00 , C12N1/20
CPC分类号： C12N15/62 , C07K14/005 , C07K14/47 , C07K2319/01 , C07K2319/35 , C07K2319/70 , C12N2710/22022 , C12N2740/16322 , C12P21/02
摘要： Expression system for enhancing solubility and immunogenicity of recombinant proteins. The expression system includes a protein expression vector that contains a chimeric gene encoding a chimeric protein. The chimeric protein contains three polypeptidyl fragments: (a) a first polypeptidyl fragment at the N-terminal end of the chimeric protein that contains a protein transduction domain (PTD) or a fragment thereof having HIV Tat PTD activity; (b) a second polypeptidyl fragment at the C-terminal end of the first polypeptidyl fragment that contains a J-domain or a fragment thereof having heat shock protein 70 (Hsp70)-interacting activity; and (c) a third polypeptidyl fragment at the C-terminal end of the second polypeptidyl fragment that contains a target protein or polypeptide.
摘要翻译：用于增强重组蛋白质的溶解度和免疫原性的表达系统。表达系统包括含有编码嵌合蛋白的嵌合基因的蛋白质表达载体。嵌合蛋白含有三个多肽基片段：（a）嵌合蛋白N末端的第一个多肽基片段，其含有具有HIV Tat PTD活性的蛋白质转导结构域（PTD）或其片段; （b）含有具有热休克蛋白70（Hsp70） - 相互作用活性的J结构域或其片段的第一多肽基片段的C-末端的第二多肽基片段; 和（c）含有靶蛋白或多肽的第二多肽基片段的C-末端的第三多肽基片段。

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