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1. 发明申请

US20100179098A1 FUROST-5-ENE-3, 22, 26-TRIOL GLYCOSIDE COMPOUND FOR PREVENTING AND TREATMENT CANCER 审中-公开
标题翻译：用于预防和治疗癌症的FUROST-5-ENE-3,22,26-三聚氰尿酸化合物
公开(公告)号：US20100179098A1
公开(公告)日：2010-07-15
申请号：US12440273
申请日：2006-09-07
申请人： Shoei-Sheng Lee , Ming-Yang Lai , Chien-Kuang Chen , Chih-Chiang Wang
发明人： Shoei-Sheng Lee , Ming-Yang Lai , Chien-Kuang Chen , Chih-Chiang Wang
IPC分类号： A61K31/7048 , A61P35/00
CPC分类号： A61K31/7048
摘要： A pharmaceutical composition for preventing and treating cancer comprising furost-5-ene-3,22,26-triol glycoside, which can be used to prevent and treat cancer by promoting apoptosis.
摘要翻译：一种用于预防和治疗癌症的药物组合物，其包含呋喃葡萄糖-5-烯-3,22,26-三醇糖苷，其可用于通过促进细胞凋亡来预防和治疗癌症。

2. 发明授权

US06949642B2 Production of tertiary amines by reductive amination 失效
标题翻译：通过还原胺化生产叔胺
公开(公告)号：US06949642B2
公开(公告)日：2005-09-27
申请号：US10121014
申请日：2002-04-11
申请人： Zhinong Gao , Chien-Kuang Chen
发明人： Zhinong Gao , Chien-Kuang Chen
IPC分类号： C07C209/24 , C07D403/04 , C07D409/14 , C07D243/14
CPC分类号： C07D403/04 , C07C209/24 , C07D409/14
摘要： A process for the production of tertiary amines by reductive amination of carbonyl compounds with secondary amines in the presence of a water scavenger, preferably trifluoroacetic acid anhydride, is disclosed. This process has applications in the preparation of imidazole-containing benzodiazepines, which are inhibitors of farnesyl protein transferase.
摘要翻译：公开了通过在除水剂，优选三氟乙酸酐的存在下用羰基化合物还原胺化叔胺来制备叔胺的方法。该方法在制备含咪唑的苯并二氮杂的应用中，其为法呢基蛋白转移酶的抑制剂。

3. 发明授权

US6162913A Preparation of [4S-(4.alpha.,7.alpha.,10a.beta.)]-4-amino-octahydro-5-oxo-7H-pyrido[2,1 -b] [1,3]thiazepine-7-carboxylic acid, methyl ester and salts thereof via novel disulfides 有权
标题翻译： [4S-（4α，7α，10aβ）] -4-氨基 - 八氢-5-氧代-7H-吡啶并[2,1-b] [1,3]硫氮杂-7-甲酸甲酯酯及其盐通过新的二硫化物
公开(公告)号：US6162913A
公开(公告)日：2000-12-19
申请号：US349861
申请日：1999-07-08
申请人： Jerome L. Moniot , Sushil K. Srivastava , William J. Winter , John J. Venit , Shankar Swaminathan , Keith Ramig , Paul A. Jass , Mark D. Schwinden , John L. Dillon, Jr. , Saibaba Racha , James Simpson , Chien-Kuang Chen , Shawn K. Pack
发明人： Jerome L. Moniot , Sushil K. Srivastava , William J. Winter , John J. Venit , Shankar Swaminathan , Keith Ramig , Paul A. Jass , Mark D. Schwinden , John L. Dillon, Jr. , Saibaba Racha , James Simpson , Chien-Kuang Chen , Shawn K. Pack
IPC分类号： C07D513/04 , C07B53/00 , C07B61/00 , C07C229/04 , C07C229/22 , C07C261/00 , C07C319/22 , C07C323/59 , C07C323/60 , C07D281/02
CPC分类号： C07D513/04 , C07C323/60 , Y02P20/55
摘要： N-protected-L-homocysteine disulfide of the formula ##STR1## or an activated form thereof is reacted with (S)-2-amino-6,6-dimethoxyhexanoic acid, methyl ester to give the disulfide intermediate of the formula ##STR2## Cleavage of the disulfide bond followed by acid catalyzed cyclization produces the N-protected lactam of formula III which is useful for preparing the pharmaceutically active compound omapatrilat.
摘要翻译：将下式的N-保护的L-高半胱氨酸二硫化物或其活化形式与（S）-2-氨基-6,6-二甲氧基己酸甲酯反应，得到式的二硫化物中间体通过酸催化环化产生式III的N-保护的内酰胺，其可用于制备药物活性化合物omapatrilat。

4. 发明授权

US08461894B1 Low-power configurable delay element 有权
标题翻译：低功耗可配置延迟元件
公开(公告)号：US08461894B1
公开(公告)日：2013-06-11
申请号：US13585142
申请日：2012-08-14
申请人： Fulong Zhang , Zheng Chen , Chien Kuang Chen , John Schadt
发明人： Fulong Zhang , Zheng Chen , Chien Kuang Chen , John Schadt
IPC分类号： H03H11/26
CPC分类号： H03K5/131
摘要： In one embodiment, a configurable delay element has three stages. The first stage has an 8-buffer first delay chain and an (8×1) first mux that selects one of the eight first-delay-chain outputs. The second stage has a 24-buffer second delay chain connected to receive the first-mux output and organized into three 8-buffer sub-chains and a (4×1) second mux that selects one of the four second-delay-chain outputs. The third stage has a 96-buffer third delay chain connected to receive the second-mux output and organized into three 32-buffer sub-chains and a (4×1) third mux that selects one of the four third-delay-chain outputs as the delay-element output signal. A delay-element controller provides glitch-less updates to the signal used to control the delay-element muxes by timing those updates to occur when all delay-element buffers have the same state. The controller bases the update timing on the delay-element output signal.
摘要翻译：在一个实施例中，可配置延迟元件具有三个阶段。第一级具有8缓冲器第一延迟链和（8×1）第一多路复用器，其选择八个第一延迟链输出之一。第二级具有连接的24缓冲器第二延迟链，用于接收第一多路复用器输出并被组织成三个8缓冲子链和选择四个第二延迟链输出之一的（4×1）第二复用器。第三级具有96缓冲器第三延迟链，用于接收第二多路复用器输出，并组织成三个32缓冲子链和（4×1）第三复用器，选择四个第三延迟链输出中的一个作为延迟元件输出信号。延迟元件控制器通过定时在所有延迟元件缓冲器具有相同状态时进行定时的这些更新来为用于控制延迟元件多路复用器的信号提供无故障更新。控制器基于延迟元件输出信号的更新时序。

5. 发明授权

US08248136B1 Low-power, glitch-less, configurable delay element 有权
标题翻译：低功耗，无毛刺，可配置延迟元件
公开(公告)号：US08248136B1
公开(公告)日：2012-08-21
申请号：US13007804
申请日：2011-01-17
申请人： Fulong Zhang , Zheng Chen , Chien Kuang Chen , John Schadt
发明人： Fulong Zhang , Zheng Chen , Chien Kuang Chen , John Schadt
IPC分类号： H03H11/26
CPC分类号： H03K5/131
摘要： In one embodiment, a configurable delay element has three stages. The first stage has an 8-buffer first delay chain and an (8×1) first mux that selects one of the eight first-delay-chain outputs. The second stage has a 24-buffer second delay chain connected to receive the first-mux output and organized into three 8-buffer sub-chains and a (4×1) second mux that selects one of the four second-delay-chain outputs. The third stage has a 96-buffer third delay chain connected to receive the second-mux output and organized into three 32-buffer sub-chains and a (4×1) third mux that selects one of the four third-delay-chain outputs as the delay-element output signal. A delay-element controller provides glitch-less updates to the signal used to control the delay-element muxes by timing those updates to occur when all delay-element buffers have the same state. The controller bases the update timing on the delay-element output signal.
摘要翻译：在一个实施例中，可配置延迟元件具有三个阶段。第一级具有8缓冲器第一延迟链和（8×1）第一多路复用器，其选择八个第一延迟链输出之一。第二级具有连接的24缓冲器第二延迟链，用于接收第一多路复用器输出并被组织成三个8缓冲子链和选择四个第二延迟链输出之一的（4×1）第二复用器。第三级具有96缓冲器第三延迟链，用于接收第二多路复用器输出，并组织成三个32缓冲子链和（4×1）第三复用器，选择四个第三延迟链输出中的一个作为延迟元件输出信号。延迟元件控制器通过定时在所有延迟元件缓冲器具有相同状态时进行定时的这些更新来为用于控制延迟元件多路复用器的信号提供无故障更新。控制器基于延迟元件输出信号的更新时序。

6. 发明授权

US06313308B1 Methods for the preparation of biphenyl isoxazole sulfonamides 失效
标题翻译：联苯异恶唑磺酰胺的制备方法
公开(公告)号：US06313308B1
公开(公告)日：2001-11-06
申请号：US09528819
申请日：2000-03-20
申请人： Ambarish Singh , Chien-Kuang Chen , John A. Grosso , Edward J. Delaney , Xuebao Wang , Richard P. Polniaszek , John K. Thottathil
发明人： Ambarish Singh , Chien-Kuang Chen , John A. Grosso , Edward J. Delaney , Xuebao Wang , Richard P. Polniaszek , John K. Thottathil
IPC分类号： C07D26116
CPC分类号： C07D413/12 , C07C303/22 , C07D261/16 , C07D263/32 , C07D263/50 , C07C309/32
摘要： Methods for the preparation of biphenyl isoxazole sulfonamides and intermediates therof. The present invention also relates to the novel intermediates prepared by these methods. The biphenyl isoxazole sulfonamides prepared by the present methods are endothelin antagonists useful, inter alia, for the treatment of hypertension, congestive heart failure and male erectile dysfunction.
摘要翻译：联苯异恶唑磺酰胺和中间体的制备方法。本发明还涉及通过这些方法制备的新型中间体。通过本方法制备的联苯异恶唑磺酰胺是内皮素拮抗剂，尤其用于治疗高血压，充血性心力衰竭和男性勃起功能障碍。

7. 发明申请

US20100298549A1 Extraction method for target bio-molecule from a sample solution and fabrication of extraction module 审中-公开
标题翻译：从样品溶液中提取目标生物分子的方法和提取模块的制备
公开(公告)号：US20100298549A1
公开(公告)日：2010-11-25
申请号：US12454686
申请日：2009-05-20
申请人： Chien-Kuang Chen
发明人： Chien-Kuang Chen
IPC分类号： C07K1/34 , C07H1/06 , B01D15/00 , B05D3/00 , C08F2/46
CPC分类号： C07K1/34 , B01D15/00 , B01J20/3204 , B01J20/327 , B01J20/3278 , C07K1/145
摘要： An extraction method for a target bio-molecule of a sample solution is described. First, a substrate having a thermally responsive polymer brush immobilized thereon is provided. The thermally responsive polymer brush has a lower critical solution temperature (LCST). Thereafter, while the sample solution flows over the substrate, the temperature of the sample solution or the substrate or both is decreased to less than the LCST, so that the target bio-molecule of the sample solution is captured inside the thermally responsive polymer brush. Afterwards, while the extraction solution flows over the substrate, the temperature of the extraction solution or the substrate or both is increased to more than the LCST, so that the captured target bio-molecule of the sample solution is released out of the thermally responsive polymer brush.
摘要翻译：描述了样品溶液的目标生物分子的提取方法。首先，提供固定有热敏聚合物刷的基板。热响应聚合物刷具有较低的临界溶解温度（LCST）。此后，当样品溶液流过衬底时，样品溶液或衬底或两者的温度降低到小于LCST，使得样品溶液的目标生物分子被捕获在热响应聚合物刷内。之后，当提取溶液流过衬底时，提取溶液或衬底或两者的温度升高到超过LCST，使得捕获的样品溶液的目标生物分子从热响应聚合物中释出刷。

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