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1. 发明公开

US20240043944A1 NOVEL ENTEROVIRUS 71 MUTATIONS ASSOCIATED WITH DISEASE SEVERITY 审中-公开
公开(公告)号：US20240043944A1
公开(公告)日：2024-02-08
申请号：US18268842
申请日：2021-12-20
申请人： Chiaho SHIH , Chun-Che LIAO , Chih-Shin CHANG , ACADEMIA SINICA
发明人： Chiaho SHIH , Chun-Che LIAO , Chih-Shin CHANG
IPC分类号： C12Q1/70
CPC分类号： C12Q1/701 , C12Q2600/156
摘要： A method of detecting severe disease-associated mutations in an enterovirus 71 (EV-A71), comprising: performing an assay on a test sample containing an EV-A71 genomic RNA, a fragment thereof or an amplicon thereof, or an EV-A71 VP1 protein or fragment thereof to detect one or more severe disease-associated mutations in the EV-A71 genomic RNA, the fragment thereof or the amplicon thereof, or the EV-A71 protein or fragment thereof, wherein the one or more mutations are selected from mutations at positions corresponding to 5′ UTR nucleotide positions C580, A707, and C709 in an EV-A71 5′ UTR nucleic acid sequence and at residues corresponding to A280 and E145 in an EV-A71 VP1 protein sequence.

2. 发明申请

US20050153280A1 Viral propagation system and uses thereof 审中-公开
标题翻译：病毒传播系统及其用途
公开(公告)号：US20050153280A1
公开(公告)日：2005-07-14
申请号：US10988348
申请日：2004-11-12
申请人： Chiaho Shih
发明人： Chiaho Shih
IPC分类号： A61K20060101 , C12N5/06 , C12N5/10 , C12N5/16 , C12N15/85 , C12N15/86 , C12Q1/18 , C12Q1/70 , G01N33/50 , G01N33/53 , G01N33/569
CPC分类号： G01N33/507 , C12N2506/22 , C12N2730/10151 , C12N2770/32451 , G01N33/5044 , G01N33/56983
摘要： Trans-differentiation induced by dexamethasone with or without oncostatin M results in cells that are capable of propagating and replicating hepatitis virus. Such trans-differentiated cells are useful for screening drugs that may affect the propagation and replication of hepatitis virus such as hepatitis B virus or hepatitis C virus.
摘要翻译：由含有或不含制瘤素M的地塞米松引起的转分化导致能够繁殖和复制肝炎病毒的细胞。这种转分化细胞可用于筛选可能影响肝炎病毒如乙型肝炎病毒或丙型肝炎病毒的繁殖和复制的药物。

3. 发明授权

US5156970A Methods of viral propagation and gene expression 失效
标题翻译：病毒繁殖和基因表达方法
公开(公告)号：US5156970A
公开(公告)日：1992-10-20
申请号：US228600
申请日：1988-08-04
申请人： Chiaho Shih
发明人： Chiaho Shih
IPC分类号： A61K39/29
CPC分类号： A61K39/292 , A61K39/12 , C12N2730/10134
摘要： Novel methods for stable in vitro propagation of human hepatitis virus using non-human hepatocytes are disclosed. Also discussed are novel systems for efficient expression and secretion of foreign genes employing particular rat hepatoma cells.
摘要翻译：公开了使用非人肝细胞稳定体外增殖人肝炎病毒的新方法。还讨论了使用特定的大鼠肝癌细胞有效表达和分泌外源基因的新系统。

4. 发明申请

US20190144510A1 MODIFIED ANTIMICROBIAL PEPTIDE DERIVED FROM AN ARGININE-RICH DOMAIN 审中-公开
公开(公告)号：US20190144510A1
公开(公告)日：2019-05-16
申请号：US16303464
申请日：2017-05-25
申请人： Chiaho Shih , Academia Sinica Office Of Public Affairs (Technology Transfer)(05)
发明人： Chiaho Shih , Heng-Li Chen , Pei-Yi Su
IPC分类号： C07K14/005 , A61P31/04
摘要： An antimicrobial peptide, the peptide comprising 2 to 20 variable domains, each variable domain is a sequence of 2 to 20 consecutive basic amino acids, wherein (a) the variable domains are separated from each other by a variable linker, (b) the variable linker can have 1 to 20 any amino acids other than two or more consecutive basic amino acids, and (c) the peptide has no more than 100 amino acids.

5. 发明申请

US20160244755A1 TREATING DISEASES ASSOCIATED WITH PGC1-ALPHA BY MODULATING MICRORNAS MIR-130A AND MIR-130B 审中-公开
标题翻译：通过调节MICRORNAS MIR-130A和MIR-130B与PGC1-ALPHA相关的治疗疾病
公开(公告)号：US20160244755A1
公开(公告)日：2016-08-25
申请号：US15023300
申请日：2014-09-19
申请人： Chiaho SHIH , Jyun-Yuan HUANG , ACADEMIA SINICA;
发明人： Chiaho Shih , Jyun-Yuan Huang
IPC分类号： C12N15/113
CPC分类号： C12N15/1131 , A61K31/7088 , A61K45/06 , C12N7/00 , C12N15/113 , C12N2310/113 , C12N2310/141 , C12N2310/531 , C12N2320/30 , C12N2730/10111
摘要： Methods of regulating PGC1α and/or PGC1β, or treating diseases associated with PGC1α and/or PGC1β using a miR-130a RNA, miR-130b RNA, or a combination thereof, or using an antagomiR of miR-130a, an antagomiR of miR-130b, or both, which can be in the form of microRNA sponge or a locked nucleic acid (LNA).
摘要翻译：调节PGC1α和/或PGC1β的方法，或使用miR-130a RNA，miR-130b RNA或其组合治疗与PGC1α和/或PGC1β相关的疾病，或使用miR-130a的antagomiR，miR- 130b或两者，其可以是微RNA海绵或锁定核酸（LNA）的形式。

6. 发明授权

US5980901A Viral defective interfering particles and uses thereof 失效
标题翻译：病毒性干扰颗粒及其用途
公开(公告)号：US5980901A
公开(公告)日：1999-11-09
申请号：US933480
申请日：1997-09-18
申请人： Chiaho Shih , Ta-Tung Yuan
发明人： Chiaho Shih , Ta-Tung Yuan
IPC分类号： A61K35/76 , A61K39/00 , A61K39/29 , A61P31/12 , C07K14/02 , C12N7/00 , A61K39/12 , C12N7/04
CPC分类号： C07K14/005 , A61K39/12 , A61K39/292 , C12N7/00 , A61K39/00 , C12N2730/10122 , C12N2730/10132 , C12N2730/10134 , Y10S977/802 , Y10S977/805 , Y10S977/915 , Y10S977/918
摘要： The present invention provides a composition of matter comprising a defective interfering virus particle, wherein said particle naturally occurs in a human infection and wherein said particles has a naturally occurring core antigen internal deletion. Provided is a pharmaceutical composition, comprising defective interfering virus particle and a pharmaceutically acceptable carrier. Provided is a method for preparing defective interfering virus, comprising the steps of: (1) introduce a defective interfering virus and a complementing plasmid expressing a wild type virus core antigen and optionally containing a drug resistance gene, into a recipient cell; (2) selecting for stably transfected colonies; (3) growing the drug resistant cells and screening for the production of virus DNA replication; and (4) collecting defective interfering virus particles from the medium. Further provided is a vaccine, comprising a defective interfering virus particle.
摘要翻译：本发明提供了包含有缺陷的干扰性病毒颗粒的物质组合物，其中所述颗粒天然存在于人感染中，并且其中所述颗粒具有天然存在的核心抗原内部缺失。提供了一种药物组合物，其包含有缺陷的干扰性病毒颗粒和药学上可接受的载体。本发明提供一种制备有缺陷的干扰性病毒的方法，其特征在于包括以下步骤：（1）将受损细胞引入缺陷干扰病毒和表达野生型病毒核心抗原的互补质粒，并任选地含有耐药性基因; （2）选择稳定转染的菌落; （3）生长耐药细胞并筛选生产病毒DNA复制; 和（4）从介质中收集有缺陷的干扰性病毒颗粒。还提供了包含有缺陷的干扰性病毒颗粒的疫苗。

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