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1. 发明申请

US20110135695A1 ORAL DOSAGE FORM FOR CONTROLLED DRUG RELEASE 有权
标题翻译：用于控制药物释放的口服剂型
公开(公告)号：US20110135695A1
公开(公告)日：2011-06-09
申请号：US12966323
申请日：2010-12-13
申请人： Chi Leung Li , Luigi Martini , Vincenzo Re , Helen Anne Willy
发明人： Chi Leung Li , Luigi Martini , Vincenzo Re , Helen Anne Willy
IPC分类号： A61K9/00 , A61K31/4439 , A61K31/522 , A61K31/4525 , A61K31/4178 , A61K31/137 , A61P3/10 , A61P31/22 , A61K9/28
CPC分类号： A61K9/2072
摘要： An oral dosage form comprising, (i) an erodable core, which core comprises a pharmaceutically active weak base or a pharmaceutically acceptable salt or solvate thereof; and (ii) an erodable coating surrounding said core, which coating comprises one or more openings extending substantially completely through said coating but not penetrating said core and communicating from the environment of use to said core; characterised in that release of the pharmaceutically active weak base or a pharmaceutically acceptable salt or solvate thereof from the dosage form occurs through the said opening(s) by the erosion of said erodable core and through erosion of said erodable coating under pre-determined pH conditions; a process for preparing such a dosage form and the use of such a dosage form in medicine.
摘要翻译：口服剂型，其包含（i）可侵蚀的核心，所述核心包含药学活性的弱碱或其药学上可接受的盐或溶剂合物; 和（ii）围绕所述芯的可侵蚀涂层，所述涂层包括基本上完全延伸穿过所述涂层但不穿透所述芯并且从使用环境与所述芯连通的一个或多个开口; 其特征在于药物活性弱碱或其药学上可接受的盐或溶剂合物从剂型的释放通过所述开口通过所述可侵蚀的核心的侵蚀和通过在预定pH条件下侵蚀所述可侵蚀的涂层而发生 ; 制备这种剂型的方法以及在药物中使用这种剂型。

2. 发明授权

US07146479B2 Method and apparatus of storage allocation/de-allocation in object-oriented programming environment 有权
公开(公告)号：US07146479B2
公开(公告)日：2006-12-05
申请号：US10198947
申请日：2002-07-18
申请人： Richard Chi Leung Li , Anthony Shi Sheung Fong
发明人： Richard Chi Leung Li , Anthony Shi Sheung Fong
IPC分类号： G06F12/00
CPC分类号： G06F9/5016 , G06F12/023 , Y10S707/99953 , Y10S707/99956
摘要： Methods and/or systems and/or apparatus for improved memory management include different allocation and deallocation strategies for various sizes of objects needing memory allocation during runtime.

3. 发明授权

US08765065B2 Process 失效
标题翻译：处理
公开(公告)号：US08765065B2
公开(公告)日：2014-07-01
申请号：US13029198
申请日：2011-02-17
申请人： Luigi Martini , Philip Smith , Chi Leung Li , Ronald Raby
发明人： Luigi Martini , Philip Smith , Chi Leung Li , Ronald Raby
IPC分类号： B06B1/00
CPC分类号： A61K9/2866 , A61K9/0004 , A61K9/2846 , A61K9/2886 , B23B37/00
摘要： The present invention relates to a process using ultrasonic cutting for the preparation of an oral delivery device comprising a core which includes a pharmaceutically active agent covered by an outer coating which includes one or more openings communicating from the exterior of the device toward the core.
摘要翻译：本发明涉及一种使用超声波切割来制备口服递送装置的方法，所述口腔递送装置包括芯，所述芯包括由外部涂层覆盖的药物活性剂，所述外部涂层包括从所述装置的外部朝向芯部连通的一个或多个开口。

4. 发明授权

US08123509B2 Injection molding process for the preparation of an oral delivery device for the pharmaceutically active agent 有权
标题翻译：用于制备用于药物活性剂的口服递送装置的注射成型方法
公开(公告)号：US08123509B2
公开(公告)日：2012-02-28
申请号：US12627330
申请日：2009-11-30
申请人： Allan J. Clarke , Robert Glinecke , Ronald Raby , Chi Leung Li , Luigi Martini
发明人： Allan J. Clarke , Robert Glinecke , Ronald Raby , Chi Leung Li , Luigi Martini
IPC分类号： B29C45/14
CPC分类号： A61K9/2072 , A61K9/0004 , A61K9/284 , A61K9/2893 , B29C45/14065 , B29C45/14073 , B29C2045/14122 , B29C2045/14155 , B29K2105/0035
摘要： An injection molding process for the preparation of an oral delivery device comprising a core which contains a pharmaceutically active agent, having a coating with one or more openings leading to such a core. The invention also relates to devices produced by the process, and to injection molds suitable for performing the process.
摘要翻译：一种用于制备口服递送装置的注射模制方法，所述口腔递送装置包含含有药物活性剂的核心，所述药物活性剂具有具有通向所述核心的一个或多个开口的涂层。本发明还涉及通过该方法生产的装置，以及适用于执行该方法的注射模具。

5. 发明授权

US07638081B2 Injection molding process for the preparation of an oral delivery device for a pharmaceutically active agent 有权
标题翻译：用于制备用于药物活性剂的口服递送装置的注射成型方法
公开(公告)号：US07638081B2
公开(公告)日：2009-12-29
申请号：US10487853
申请日：2002-08-20
申请人： Allan J. Clarke , Robert Glinecke , Ronald Raby , Chi Leung Li , Luigi Martini
发明人： Allan J. Clarke , Robert Glinecke , Ronald Raby , Chi Leung Li , Luigi Martini
IPC分类号： B29C45/14 , A61K9/20
CPC分类号： A61K9/2072 , A61K9/0004 , A61K9/284 , A61K9/2893 , B29C45/14065 , B29C45/14073 , B29C2045/14122 , B29C2045/14155 , B29K2105/0035
摘要： An injection moulding process for the preparation of an oral delivery device comprising a core which contains a pharmaceutically active agent, having a coating with one or more openings leading to such a core. The invention also relates to devices produced by the process, and to injection moulds suitable for performing the process.
摘要翻译：一种用于制备口服递送装置的注射模制方法，所述口腔递送装置包含含有药物活性剂的核心，所述药物活性剂具有具有通向所述核心的一个或多个开口的涂层。本发明还涉及通过该方法生产的装置，以及适用于执行该方法的注射模具。

6. 发明授权

US09144547B2 Oral dosage form for controlled drug release 有权
标题翻译：用于控制药物释放的口服剂型
公开(公告)号：US09144547B2
公开(公告)日：2015-09-29
申请号：US12966323
申请日：2010-12-13
申请人： Chi Leung Li , Luigi Martini , Vincenzo Re , Helen Anne Willy
发明人： Chi Leung Li , Luigi Martini , Vincenzo Re , Helen Anne Willy
IPC分类号： A61K9/20 , A61K9/24 , A61K9/28
CPC分类号： A61K9/2072
摘要： An oral dosage form comprising, (i) an erodable core, which core comprises a pharmaceutically active weak base or a pharmaceutically acceptable salt or solvate thereof; and (ii) an erodable coating surrounding said core, which coating comprises one or more openings extending substantially completely through said coating but not penetrating said core and communicating from the environment of use to said core; characterized in that release of the pharmaceutically active weak base or a pharmaceutically acceptable salt or solvate thereof from the dosage form occurs through the said opening(s) by the erosion of said erodable core and through erosion of said erodable coating under pre-determined pH conditions; a process for preparing such a dosage form and the use of such a dosage form in medicine.
摘要翻译：口服剂型，其包含（i）可侵蚀的核心，所述核心包含药学活性的弱碱或其药学上可接受的盐或溶剂合物; 和（ii）围绕所述芯的可侵蚀涂层，所述涂层包括基本上完全延伸穿过所述涂层但不穿透所述芯并且从使用环境与所述芯连通的一个或多个开口; 其特征在于药物活性弱碱或其药学上可接受的盐或溶剂合物从剂型的释放通过所述开口通过所述可侵蚀的核心的侵蚀和通过在预定pH条件下侵蚀所述可侵蚀的涂层而发生 ; 制备这种剂型的方法以及在药物中使用这种剂型。

7. 发明申请

US20110131754A1 PROCESS 失效
标题翻译：处理
公开(公告)号：US20110131754A1
公开(公告)日：2011-06-09
申请号：US13029198
申请日：2011-02-17
申请人： Luigi MARTINI , Philip Smith , Chi Leung Li , Ronald Raby
发明人： Luigi MARTINI , Philip Smith , Chi Leung Li , Ronald Raby
IPC分类号： A47L9/00
CPC分类号： A61K9/2866 , A61K9/0004 , A61K9/2846 , A61K9/2886 , B23B37/00
摘要： The present invention relates to a process using ultrasonic cutting for the preparation of an oral delivery device comprising a core which includes a pharmaceutically active agent covered by an outer coating which includes one or more openings communicating from the exterior of the device toward the core.
摘要翻译：本发明涉及一种使用超声波切割来制备口服递送装置的方法，所述口腔递送装置包括芯，所述芯包括由外部涂层覆盖的药物活性剂，所述外部涂层包括从所述装置的外部朝向芯部连通的一个或多个开口。

8. 发明授权

US07923027B2 Process 有权
标题翻译：处理
公开(公告)号：US07923027B2
公开(公告)日：2011-04-12
申请号：US10416116
申请日：2001-11-02
申请人： Luigi Martini , Philip Smith , Chi Leung Li , Ronald Raby
发明人： Luigi Martini , Philip Smith , Chi Leung Li , Ronald Raby
IPC分类号： A61K9/24
CPC分类号： A61K9/2866 , A61K9/0004 , A61K9/2846 , A61K9/2886 , B23B37/00
摘要： The present invention relates to a process using ultrasonic cutting for the preparation of an oral delivery device comprising a core which includes a pharmaceutically active agent covered by an outer coating which includes one or more openings communicating from the exterior of the device toward the core.
摘要翻译：本发明涉及一种使用超声波切割来制备口服递送装置的方法，所述口腔递送装置包括芯，所述芯包括由外部涂层覆盖的药物活性剂，所述外部涂层包括从所述装置的外部朝向芯部连通的一个或多个开口。

9. 发明申请

US20100221292A1 INJECTION MOLDING PROCESS FOR THE PREPARATION OF AN ORAL DELIVERY DEVICE FOR THE PHARMACEUTICALLY ACTIVE AGENT 有权
标题翻译：用于制备药物活性剂的口服递送装置的注射成型方法
公开(公告)号：US20100221292A1
公开(公告)日：2010-09-02
申请号：US12627330
申请日：2009-11-30
申请人： Allan J. Clarke , Robert Glinecke , Ronald Raby , Chi Leung Li , Luigi Martini
发明人： Allan J. Clarke , Robert Glinecke , Ronald Raby , Chi Leung Li , Luigi Martini
IPC分类号： A61K9/00 , B29C45/00
CPC分类号： A61K9/2072 , A61K9/0004 , A61K9/284 , A61K9/2893 , B29C45/14065 , B29C45/14073 , B29C2045/14122 , B29C2045/14155 , B29K2105/0035
摘要： An injection moulding process for the preparation of an oral delivery device comprising a core which contains a pharmaceutically active agent, having a coating with one or more openings leading to such a core. The invention also relates to devices produced by the process, and to injection moulds suitable for performing the process.
摘要翻译：一种用于制备口服递送装置的注射模制方法，所述口腔递送装置包含含有药物活性剂的核心，所述药物活性剂具有具有通向所述核心的一个或多个开口的涂层。本发明还涉及通过该方法生产的装置，以及适用于执行该方法的注射模具。

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