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1. 发明授权

US09463242B2 Methods for treating prostate cancer 有权
标题翻译：治疗前列腺癌的方法
公开(公告)号：US09463242B2
公开(公告)日：2016-10-11
申请号：US14115217
申请日：2012-05-03
申请人： Chawnshang Chang
发明人： Chawnshang Chang
IPC分类号： A61K31/353 , A61K31/355 , A61K31/706 , A61K39/395 , A61K45/06 , A61K31/121 , A61K31/167 , A61K31/277 , A61K31/4166 , A61K31/44 , A61K31/09
CPC分类号： A61K39/3955 , A61K31/09 , A61K31/121 , A61K31/167 , A61K31/277 , A61K31/353 , A61K31/355 , A61K31/4166 , A61K31/44 , A61K31/706 , A61K45/06 , A61K2300/00
摘要： Disclosed herein are methods and compositions for reducing the recurrence of prostate cancer and for treating prostate cancer.
摘要翻译：本文公开了用于减少前列腺癌复发和治疗前列腺癌的方法和组合物。

2. 发明授权

US06699714B1 Androgen receptor coactivators 失效
标题翻译：雄激素受体共激活因子
公开(公告)号：US06699714B1
公开(公告)日：2004-03-02
申请号：US09354221
申请日：1999-07-15
申请人： Chawnshang Chang
发明人： Chawnshang Chang
IPC分类号： C12N1500
CPC分类号： C07K14/721 , C07K14/4705 , G01N2333/723
摘要： Disclosed are androgen receptor-associated proteins, designated ARA24, ARA54, ARA55, and Rb, that have been demonstrated to interact with the androgen receptor to alter levels of androgen receptor-mediated transcriptional activation. Certain of these proteins interact with the androgen receptor in an androgen-dependent manner, whereas certain proteins may induce transcriptional activation in the presence of other ligands, such as E2 or HF. Also disclosed is a method of detecting androgenic or antiandrogenic activity using these proteins in a mammalian two-hybrid transient transfection assay.
摘要翻译：公开了已被证明与雄激素受体相互作用以改变雄激素受体介导的转录激活水平的雄激素受体相关蛋白，命名为ARA24，ARA54，ARA55和Rb。某些这些蛋白质以雄激素依赖的方式与雄激素受体相互作用，而某些蛋白质可能在其它配体如E2或HF的存在下诱导转录激活。还公开了在哺乳动物双杂交瞬时转染测定中使用这些蛋白质检测雄激素或抗雄激素活性的方法。

3. 发明申请

US20100017900A1 Prostate Epithelial Androgen Receptor Suppresses Prostate Growth and Tumor Invasion 审中-公开
标题翻译：前列腺上皮雄激素受体抑制前列腺生长和肿瘤侵袭
公开(公告)号：US20100017900A1
公开(公告)日：2010-01-21
申请号：US12301559
申请日：2007-05-21
申请人： Chawnshang Chang
发明人： Chawnshang Chang
IPC分类号： A01K67/027 , A61K31/7088 , A61K39/395 , A61K31/7105 , C12N15/00 , C12Q1/02 , C12N5/06
CPC分类号： C07K14/721 , A01K67/0275 , A01K67/0276 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/0331 , C12N15/1138 , C12N15/8509 , C12N2310/111 , C12N2310/14 , C12N2800/30 , C12N2830/008
摘要： Described herein is the generation of the first conditional knockout AR (pes-ARKO) mice that lack AR only in prostate epithelia. Additionally demonstrated herein, through AR gain- and loss-of-function experiments, are the novel growth and differentiation roles of epithelial AR within the normal and cancerous prostate cells.
摘要翻译：本文描述的是仅在前列腺上皮细胞中缺乏AR的第一个条件敲除AR（pes-ARKO）小鼠的产生。此外，通过AR增益和功能丧失实验，本文还显示了正常和癌前列腺细胞内上皮AR的新生长和分化作用。

4. 发明申请

US20090305980A1 Methods and Compositions Related to TR4 审中-公开
标题翻译：与TR4相关的方法和组成
公开(公告)号：US20090305980A1
公开(公告)日：2009-12-10
申请号：US12300077
申请日：2007-05-09
申请人： Yi-Fen Lee , Chawnshang Chang
发明人： Yi-Fen Lee , Chawnshang Chang
IPC分类号： A61K38/17 , C12Q1/68 , C12N15/63 , C12N5/10 , A61P43/00
CPC分类号： G01N33/57434 , A61K31/355 , A61K31/713 , A61K38/1783 , A61K45/06 , G01N33/5011 , G01N33/57496 , G01N2333/723 , G01N2500/10 , G01N2800/105 , A61K2300/00
摘要： Disclosed are compositions and methods related to TR4 and cancer.
摘要翻译：公开了与TR4和癌相关的组合物和方法。

5. 发明申请

US20090282496A1 Androgen Receptor Related Methods for Treating Bladder Cancer 审中-公开
标题翻译：雄激素受体相关方法治疗膀胱癌
公开(公告)号：US20090282496A1
公开(公告)日：2009-11-12
申请号：US12418369
申请日：2009-04-03
申请人： Chawnshang Chang
发明人： Chawnshang Chang
IPC分类号： A01K67/00 , A61K31/7088 , A61K39/395 , A61K31/12 , A61K31/16 , A61K31/165 , C12N15/63 , C12Q1/68 , C12N5/10
CPC分类号： C12Q1/6886 , A61K31/12 , A61K31/16 , A61K31/165 , A61K31/7088 , C07K14/72 , C12N15/1138 , C12N2310/14 , C12Q2600/136 , C12Q2600/158
摘要： Disclosed are compositions and methods for treating bladder cancer.
摘要翻译：公开了治疗膀胱癌的组合物和方法。

6. 发明申请

US20090012019A1 Methods and Compositions Related to TR4 审中-公开
标题翻译：与TR4相关的方法和组成
公开(公告)号：US20090012019A1
公开(公告)日：2009-01-08
申请号：US11795788
申请日：2006-01-20
申请人： Chawnshang Chang , Yifen Lee
发明人： Chawnshang Chang , Yifen Lee
IPC分类号： A61K31/7105 , G01N33/53 , A61P43/00
CPC分类号： C07K14/705 , A61K38/00
摘要： Disclosed are compositions and methods related to TR4 and aging.
摘要翻译：公开了与TR4和老化有关的组合物和方法。

7. 发明申请

US20060270591A1 Androgen receptor coregulators 审中-公开
标题翻译：雄激素受体配体
公开(公告)号：US20060270591A1
公开(公告)日：2006-11-30
申请号：US10517155
申请日：2003-06-06
申请人： Chawnshang Chang
发明人： Chawnshang Chang
IPC分类号： A61K38/17 , C07H21/04 , C12P21/06 , A01K67/00 , C07K14/705 , C07K14/72
CPC分类号： C07K14/4702 , A61K38/00
摘要： Disclosed are compositions and methods related to androgen receptor coregulators.
摘要翻译：公开了与雄激素受体共调节剂相关的组合物和方法。

8. 发明授权

US5614620A DNA binding proteins including androgen receptor 失效
标题翻译： DNA结合蛋白包括雄激素受体
公开(公告)号：US5614620A
公开(公告)日：1997-03-25
申请号：US149691
申请日：1993-11-08
申请人： Shutsung Liao , Chawnshang Chang
发明人： Shutsung Liao , Chawnshang Chang
IPC分类号： C07K14/47 , C07K14/72 , C07K16/18 , C07K16/28 , C12N15/85 , C12Q1/68 , C07H21/04 , C12N1/20 , C12N15/00
CPC分类号： C12N15/8509 , C07K14/47 , C07K14/721 , C07K16/18 , C07K16/2869 , C12Q1/6876 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/03 , C07K2317/34 , C12Q2600/158
摘要： Disclosed are DNA sequences encoding DNA binding polypeptides including androgen receptor (AR) and TR2 polypeptides. Illustratively, human and rat AR-cDNA have 79 kD and 98 kD polypeptide expression products which are immunoprecipitable by human auto-immune anti-androgen receptor antibodies and are capable of binding androgens specifically and with high affinity. Also disclosed are antibodies and immunological methods and materials for detection of androgen receptor and TR2 polypeptides and hybridization methods and materials for detection of AR-and TR2-related nucleic acids.
摘要翻译：公开了编码包括雄激素受体（AR）和TR2多肽的DNA结合多肽的DNA序列。说明性地，人和大鼠AR-cDNA具有79kD和98kD的多肽表达产物，其可被人自身免疫抗雄激素受体抗体免疫沉淀，并能够以高亲和力特异性结合雄激素。还公开了用于检测雄激素受体和TR2多肽的抗体和免疫学方法和材料以及用于检测AR和TR2相关核酸的杂交方法和材料。

9. 发明申请

US20100197784A1 NOVEL CURCUMIN ANALOGUES AND USES THEREOF 有权
标题翻译：新型CURCUMIN类似物及其用途
公开(公告)号：US20100197784A1
公开(公告)日：2010-08-05
申请号：US12758462
申请日：2010-04-12
申请人： Kuo-Hsiung Lee , Li Lin , Charles C-Y Shih , Ching-Yuan Su , Junko Ishida , Hironori Ohtsu , Hui-Kang Wang , Hideji Itokawa , Chawnshang Chang
发明人： Kuo-Hsiung Lee , Li Lin , Charles C-Y Shih , Ching-Yuan Su , Junko Ishida , Hironori Ohtsu , Hui-Kang Wang , Hideji Itokawa , Chawnshang Chang
IPC分类号： A61K31/12 , C12N5/00 , A61K31/215 , A61P17/10 , A61P35/02 , A61P35/00
CPC分类号： C07D307/58 , C07C49/248 , C07C49/255 , C07C49/755 , C07C49/84 , C07C59/84 , C07C69/738 , C07C205/45
摘要： The present invention relates to compounds capable of acting as androgen receptor antagonists, pharmaceutical formulations containing the same, and methods of use thereof. Such uses include, but are not limited to, use as antitumor agents, particularly for the treatment of cancers such as colon, skin and prostate cancer and to induce androgen receptor antagonist activity in a subject afflicted with an androgen-related affliction. Examples of androgen-related afflictions include, but are not limited to, baldness, hirsutism, behavioral disorders, acne, and uninhibited spermatogenesis wherein inhibition of spermatogenesis is so desired.
摘要翻译：本发明涉及能够作为雄激素受体拮抗剂的药物，含有它们的药物制剂及其使用方法。这些用途包括但不限于用作抗肿瘤剂，特别是用于治疗诸如结肠癌，皮肤癌和前列腺癌的癌症，并且在受雄激素相关疾病影响的受试者中诱导雄激素受体拮抗剂活性。雄激素相关疾病的实例包括但不限于秃发，多毛症，行为障碍，痤疮和未抑制的精子发生，其中精子发生的抑制是如此期望的。

10. 发明申请

US20100048676A1 Non-androgen dependent roles for androgen receptor in liver cancer 审中-公开
标题翻译：雄激素受体在肝癌中的非雄激素依赖性作用
公开(公告)号：US20100048676A1
公开(公告)日：2010-02-25
申请号：US12535487
申请日：2009-08-04
申请人： Chawnshang Chang
发明人： Chawnshang Chang
IPC分类号： A61K31/105 , G01N33/53 , A61K31/7088 , A61P35/00
CPC分类号： A61K31/105 , A61K31/7088 , C07K14/721 , C12N15/1138 , C12N2310/14 , C12Q1/6886 , C12Q2600/158 , G01N33/57438 , G01N33/743
摘要： Disclosed are compositions and methods for modulating AR activity, such as non-androgen dependent AR activity. Also disclosed are compositions and methods for diagnosing beast cancer and for inhibiting liver cancer growth. In addition, disclosed are methods for identifying molecules that inhibit AR in non-androgen dependent ways.
摘要翻译：公开了用于调节AR活性的组合物和方法，例如非雄激素依赖性AR活性。还公开了用于诊断野兽癌和抑制肝癌生长的组合物和方法。此外，公开了用于鉴定以非雄激素依赖性方式抑制AR的分子的方法。

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