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1. 发明授权

US08793078B2 Method for predicting activation energy using atomic fingerprint descriptor or atomic descriptor 有权
标题翻译：使用原子指纹描述符或原子描述符预测活化能的方法
公开(公告)号：US08793078B2
公开(公告)日：2014-07-29
申请号：US13277929
申请日：2011-10-20
申请人： Ky Youb Nam , Kyoung Tai No , Doo Nam Kim , Won Seok Oh , Sung Kwang Lee , Ji Hoon Jung , Kwang Hwi Cho , Chang Joon Lee
发明人： Ky Youb Nam , Kyoung Tai No , Doo Nam Kim , Won Seok Oh , Sung Kwang Lee , Ji Hoon Jung , Kwang Hwi Cho , Chang Joon Lee
IPC分类号： G01N33/00 , G01N33/50 , G06G7/58 , G06F19/00
CPC分类号： G06F19/704 , G06F19/702 , G06F19/706 , G06F19/709
摘要： The present invention provides a method for constructing a database of atomic fingerprint descriptors. The invention provides a method for predicting activation energy using an atomic fingerprint descriptor and an atomic descriptor, the method comprising the steps of: (i) calculating the atomic fingerprint descriptor of a substrate; (ii) comparing the calculated atomic fingerprint descriptor with the constructed atomic fingerprint descriptor database to select an atomic position where cytochrome P450-mediated metabolism occurs; and (iii) predicting activation energy for the selected atomic position using an atomic descriptor. Also, the invention provides a method of predicting the activation energy of CYP450-mediated phase I metabolism using effective atomic descriptors. Specifically, the invention provides a method of predicting the activation energy either for cytochrome P450-mediated hydrogen abstraction or for tetrahedral intermediate formation in cytochrome P450-aromatic hydroxylation using equations including effective atomic descriptors.
摘要翻译：本发明提供了一种构建原子指纹描述符数据库的方法。本发明提供一种使用原子指纹描述符和原子描述符来预测激活能的方法，该方法包括以下步骤：（i）计算衬底的原子指纹描述符; （ii）将计算的原子指纹描述符与构建的原子指纹描述符数据库进行比较，以选择细胞色素P450介导代谢发生的原子位置; 和（iii）使用原子描述符预测所选原子位置的活化能。此外，本发明提供了使用有效原子描述符预测CYP450介导的I期代谢的活化能的方法。具体地，本发明提供了一种使用包括有效原子描述符的方程式来预测细胞色素P450介导的氢提取或细胞色素P450-芳族羟基化中的四面体中间体形成的活化能的方法。

2. 发明申请

US20110213558A1 METHOD FOR PREDICTING ACTIVATION ENERGY USING AN ATOMIC FINGERPRINT DESCRIPTOR OR AN ATOMIC DESCRIPTOR 审中-公开
公开(公告)号：US20110213558A1
公开(公告)日：2011-09-01
申请号：US13001579
申请日：2009-11-12
申请人： Ky Youb Nam , Kyoung Tai No , Doo Nam Kim , Won Seok Oh , Sung Kwang Lee , Ji Hoon Jung , Kwang Hwi Cho , Chang Joon Lee
发明人： Ky Youb Nam , Kyoung Tai No , Doo Nam Kim , Won Seok Oh , Sung Kwang Lee , Ji Hoon Jung , Kwang Hwi Cho , Chang Joon Lee
IPC分类号： G06F19/00
CPC分类号： G16C20/30 , G16C20/10 , G16C20/50 , G16C20/90
摘要： The present invention provides a method for constructing a database of atomic fingerprint descriptors. The invention provides a method for predicting activation energy using an atomic fingerprint descriptor and an atomic descriptor, the method comprising the steps of: (i) calculating the atomic fingerprint descriptor of a substrate; (ii) comparing the calculated atomic fingerprint descriptor with the constructed atomic fingerprint descriptor database to select an atomic position where cytochrome P450-mediated metabolism occurs; and (iii) predicting activation energy for the selected atomic position using an atomic descriptor. Also, the invention provides a method of predicting the activation energy of CYP450-mediated phase I metabolism using effective atomic descriptors. Specifically, the invention provides a method of predicting the activation energy either for cytochrome P450-mediated hydrogen abstraction or for tetrahedral intermediate formation in cytochrome P450-aromatic hydroxylation using equations including effective atomic descriptors. The method of the invention can rapidly predict activation energy for phase I metabolites at a practical level without having to perform a docking experiment between any additional CYP450 and the substrate, or a quantum mechanical calculation, thereby making it easier to develop new drugs using a computer. Also, the present invention may propose a strategy for increasing the bioavailability of drugs through the avoidance of metabolites based on the possibility of drug metabolism. Furthermore, the method of the present invention proposes new empirical approaches which can also be easily applied to activation energies for various chemical reactions, and makes it possible to explain physical and chemical factors that determine activation energy. In addition, through the prediction of activation energy according to the present invention, it is possible to predict i) metabolic products, ii) the relative rate of metabolism, iii) metabolic regioselectivity, iv) metabolic inhibition, v) drug-drug interactions, and vi) the toxicity of a metabolite.

3. 发明申请

US20130034232A1 METHOD AND APPARATUS FOR DOWN-MIXING MULTI-CHANNEL AUDIO SIGNAL 审中-公开
标题翻译：用于下混频多声道音频信号的方法和装置
公开(公告)号：US20130034232A1
公开(公告)日：2013-02-07
申请号：US13554505
申请日：2012-07-20
申请人： Chang-Joon LEE
发明人： Chang-Joon LEE
IPC分类号： H04R5/00
CPC分类号： G10L19/008 , G10L19/0204
摘要： A method of down-mixing a multi-channel audio signal is provided. The method including restoring sub-band Pulse Coded Modulation (PCM) samples for each channel of the multi-channel audio signal by decoding the multi-channel audio-signal and then dequantizing a sub-band coded multi-channel audio signal, scaling the restored sub-band PCM samples for each channel with a coefficient corresponding to a down-mixing configuration, generating sub-band PCM samples corresponding to predetermined channels by down-mixing the scaled sub-band PCM samples for each channel into the predetermined channels, and performing inverse sub-band filtering on the generated sub-band PCM samples corresponding to the predetermined channels.
摘要翻译：提供了一种降低混合多声道音频信号的方法。该方法包括通过对多声道音频信号进行解码，然后对子频带编码的多声道音频信号进行去量化，对多声道音频信号的每个通道恢复子带脉冲编码调制（PCM）采样，缩放恢复的每个信道的子带PCM样本具有对应于下混合配置的系数，通过将每个信道的缩放子带PCM样本下混合到预定信道中，生成对应于预定信道的子带PCM样本，并执行对与预定信道相对应的所生成的子带PCM样本进行逆子带滤波。

4. 发明申请

US20120093322A1 METHOD AND APPARATUS FOR DOWNMIXING MULTI-CHANNEL AUDIO SIGNALS 有权
标题翻译：用于下行多通道音频信号的方法和装置
公开(公告)号：US20120093322A1
公开(公告)日：2012-04-19
申请号：US13272632
申请日：2011-10-13
申请人： Chang-joon LEE
发明人： Chang-joon LEE
IPC分类号： H04R5/00
CPC分类号： G10L19/008 , G10L19/0212 , G10L19/022 , G10L25/18 , H04S2400/03
摘要： Downmixing multi-channel audio signals to target channels by pre-downmixing frequency coefficients that are encoded using a most frequently used block type in stereo channels in the frequency domain, thereby reducing an amount of calculations and an amount of power required to downmix the multi-channel audio signals.
摘要翻译：通过使用在频域中的立体声通道中使用最频繁使用的块类型进行编码的频率系数，将多声道音频信号下混混入目标频道，从而减少了多频道音频信号的下降，频道音频信号。

5. 发明申请

US20120084012A1 METHOD FOR PREDICTING ACTIVATION ENERGY USING ATOMIC FINGERPRINT DESCRIPTOR OR ATOMIC DESCRIPTOR 有权
标题翻译：使用原子指纹描述符或原子描述符预测激活能量的方法
公开(公告)号：US20120084012A1
公开(公告)日：2012-04-05
申请号：US13277929
申请日：2011-10-20
申请人： Ky Youb Nam , Kyoung Tai No , Doo Nam Kim , Won Seok Oh , Sung Kwang Lee , Ji Hoon Jung , Kwang Hwi Cho , Chang Joon Lee
发明人： Ky Youb Nam , Kyoung Tai No , Doo Nam Kim , Won Seok Oh , Sung Kwang Lee , Ji Hoon Jung , Kwang Hwi Cho , Chang Joon Lee
IPC分类号： G06F19/10
CPC分类号： G06F19/704 , G06F19/702 , G06F19/706 , G06F19/709
摘要： The present invention provides a method for constructing a database of atomic fingerprint descriptors. The invention provides a method for predicting activation energy using an atomic fingerprint descriptor and an atomic descriptor, the method comprising the steps of: (i) calculating the atomic fingerprint descriptor of a substrate; (ii) comparing the calculated atomic fingerprint descriptor with the constructed atomic fingerprint descriptor database to select an atomic position where cytochrome P450-mediated metabolism occurs; and (iii) predicting activation energy for the selected atomic position using an atomic descriptor. Also, the invention provides a method of predicting the activation energy of CYP450-mediated phase I metabolism using effective atomic descriptors. Specifically, the invention provides a method of predicting the activation energy either for cytochrome P450-mediated hydrogen abstraction or for tetrahedral intermediate formation in cytochrome P450-aromatic hydroxylation using equations including effective atomic descriptors.
摘要翻译：本发明提供了一种构建原子指纹描述符数据库的方法。本发明提供一种使用原子指纹描述符和原子描述符来预测激活能的方法，该方法包括以下步骤：（i）计算衬底的原子指纹描述符; （ii）将计算的原子指纹描述符与构建的原子指纹描述符数据库进行比较，以选择细胞色素P450介导代谢发生的原子位置; 和（iii）使用原子描述符预测所选原子位置的活化能。此外，本发明提供了使用有效原子描述符预测CYP450介导的I期代谢的活化能的方法。具体地，本发明提供了一种使用包括有效原子描述符的方程式来预测细胞色素P450介导的氢提取或细胞色素P450-芳族羟基化中的四面体中间体形成的活化能的方法。

6. 发明授权

US08874449B2 Method and apparatus for downmixing multi-channel audio signals 有权
标题翻译：用于降低多声道音频信号的方法和装置
公开(公告)号：US08874449B2
公开(公告)日：2014-10-28
申请号：US13272632
申请日：2011-10-13
申请人： Chang-joon Lee
发明人： Chang-joon Lee
IPC分类号： G10L19/00 , G10L19/008 , G10L19/02 , G10L25/18 , G10L19/022
CPC分类号： G10L19/008 , G10L19/0212 , G10L19/022 , G10L25/18 , H04S2400/03
摘要： Downmixing multi-channel audio signals to target channels by pre-downmixing frequency coefficients that are encoded using a most frequently used block type in stereo channels in the frequency domain, thereby reducing an amount of calculations and an amount of power required to downmix the multi-channel audio signals.
摘要翻译：通过使用在频域中的立体声通道中使用最频繁使用的块类型进行编码的频率系数，将多声道音频信号下混混入目标频道，从而减少了多频道音频信号的下降，频道音频信号。

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