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1. 发明申请

US20060014271A1 Fabrication of a completely polymeric microfluidic reactor for chemical synthesis 审中-公开
标题翻译：用于化学合成的完全聚合微流控反应器的制造
公开(公告)号：US20060014271A1
公开(公告)日：2006-01-19
申请号：US10893688
申请日：2004-07-16
申请人： Yujun Song , Challa Kumar , Josef Hormes
发明人： Yujun Song , Challa Kumar , Josef Hormes
IPC分类号： C12M1/34 , H01L21/00
CPC分类号： B01J19/0093 , B01J2219/00783 , B01J2219/00833 , B01L3/5027
摘要： An inexpensive apparatus and method of fabricating completely polymeric (e.g., SU-8, PMMA, and PEEK) microfluidic reactors suitable for the synthesis of chemicals, particularly nanoparticles (e.g., mono, bi, tri, alloy, core-shell, polymeric, and metal-polymer nano-particles), is disclosed. A high precision process uses polymeric microfluidic patterning techniques and a new microfluidic sealing technique, referred to as “flexible semi-solid transfer,” to fabricate high aspect ratio polymeric micro-reactors. In one embodiment, high quality microfluidic channels are patterned onto a support substrate. The microfluidic structure is then sealed by transferring a polymeric material from a sacrificial substrate to the microfluidic structure, and cured. Then, the structure is bonded to a second support structure to form a micro-reactor.
摘要翻译：一种廉价的装置和方法，其制造完全聚合物（例如，SU-8，PMMA和PEEK）微流控反应器，其适用于合成化学品，特别是纳米颗粒（例如单，双，三，合金，核 - 壳，聚合物和金属 - 聚合物纳米颗粒）。高精度工艺使用聚合物微流体图案化技术和新的微流体密封技术，称为“柔性半固体转移”，以制造高纵横比聚合物微反应器。在一个实施例中，将高质量微流体通道图案化到支撑衬底上。然后通过将聚合物材料从牺牲衬底转移到微流体结构并固化来密封微流体结构。然后，结构被结合到第二支撑结构以形成微反应器。

2. 发明申请

US20210235690A1 BLOOD PRESERVATION COMPOSITIONS, DEVICES, AND USES THEREOF 有权
公开(公告)号：US20210235690A1
公开(公告)日：2021-08-05
申请号：US17263526
申请日：2019-07-26
申请人： Challa KUMAR , EDWARD VIA COLLEGE OF OSTEOPATHIC MEDICINE
发明人： Beverly A. RZIGALINSKI , Siva Sai Ramana Kumar Challa
IPC分类号： A01N1/02 , A61L27/30 , A61L27/58
摘要： Described herein are blood storage containers that can contain a CeONP composition and/or coating on an object surface. In some aspects, the blood storage container can include an insert. In some aspects the inserts can contain a CeONP compositions and/or coating on an object surface. In aspects, the CeONP composition and/or coating on an object surface can be effective to increase the useful storage lifespan of blood, blood product, and/or component thereof stored in the blood storage container. Also described herein are methods of making and using the CeONP compositions, coatings, and devices containing the CeONP compositions and/or coatings described herein.

3. 发明申请

US20060177660A1 Core-shell nanostructures and microstructures 审中-公开
标题翻译：核壳纳米结构和微观结构
公开(公告)号：US20060177660A1
公开(公告)日：2006-08-10
申请号：US11054513
申请日：2005-02-09
申请人： Challa Kumar , Elizabeth Podlaha , Zhanhu Guo , Josef Hormes
发明人： Challa Kumar , Elizabeth Podlaha , Zhanhu Guo , Josef Hormes
IPC分类号： B32B5/16
CPC分类号： B01J13/02 , B22F1/025 , B22F2001/0037 , B22F2998/00 , B82Y25/00 , B82Y30/00 , C23C18/1658 , C23C18/31 , C23C18/54 , H01F1/0009 , H01F1/0054 , H01F1/0072 , Y10T428/12181 , Y10T428/2991 , B22F1/0018 , B22F1/0025
摘要： A method is disclosed for synthesizing core-shell nanoparticles or microparticles in an aqueous solution. A displacement reaction produces a protective, noble metal shell around nanoparticles or microparticles, for example a copper shell around cobalt nanoparticles. In an electroless displacement reaction in an aqueous solution, a less noble metal core is oxidized by cations of a more noble metal in solution, and the noble metal ions are reduced by the less noble atoms of the metal core, forming a thin layer of the reduced noble metal on the surface of the core metal. The formation of the nanoscale shell is self-terminating once the core is fully covered, because the core metal is then inaccessible for further redox reaction with ions in solution. The magnetic core is preferably a ferromagnetic metal, e.g., Co, Fe, Ni. The shell is a more noble metal, e.g., Cu, Ag, Au, Pt, or Pd.
摘要翻译：公开了一种在水溶液中合成核 - 壳纳米颗粒或微粒的方法。位移反应在纳米颗粒或微粒周围产生保护性的贵金属壳，例如围绕钴纳米颗粒的铜壳。在水溶液中的无电位移反应中，较低贵重的金属芯被溶液中较贵贵金属的阳离子氧化，并且贵金属离子被金属芯的较低原子还原，从而形成薄层在金属芯的表面上还原贵金属。一旦核心被完全覆盖，纳米级壳体的形成就是自我终止的，因为核心金属然后不能与溶液中的离子进行进一步的氧化还原反应。磁芯优选为铁磁性金属，例如Co，Fe，Ni。壳是更贵族的金属，例如Cu，Ag，Au，Pt或Pd。

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