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1. 发明授权

US08030304B2 Thiazole pyrazolopyrimidines CRF1 receptor antagonists 有权
标题翻译：噻唑吡唑并嘧啶CRF1受体拮抗剂
公开(公告)号：US08030304B2
公开(公告)日：2011-10-04
申请号：US12377733
申请日：2007-09-17
申请人： Zhaogen Chen , Chafiq Hamdouchi Hamdouchi , Erik James Hembre , Philip Arthur Hipskind , Jason Kenneth Myers , Takako Takakuwa , James Lee Toth
发明人： Zhaogen Chen , Chafiq Hamdouchi Hamdouchi , Erik James Hembre , Philip Arthur Hipskind , Jason Kenneth Myers , Takako Takakuwa , James Lee Toth
IPC分类号： A01N43/58 , A01N43/54 , A01N43/64 , A01N43/78 , A01N43/56 , A61K31/50 , A61K31/505 , A61K31/41 , A61K31/425 , A61K31/415 , C07D239/42 , C07D401/04 , C07D471/04 , C07D471/22 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention relates to compounds of Formula (I), pharmaceutical compositions thereof, and use thereof as corticotropin releasing factor 1 (CRF1) receptor antagonists in the treatment of psychiatric and neuroendocrine disorders, neurological diseases, and metabolic syndrome.
摘要翻译：本发明涉及式（I）的化合物，其药物组合物及其作为促肾上腺皮质激素释放因子1（CRF1）受体拮抗剂在治疗精神和神经内分泌障碍，神经系统疾病和代谢综合征中的用途。

2. 发明授权

US06358971B1 Anti-viral compounds 失效
标题翻译：抗病毒化合物
公开(公告)号：US06358971B1
公开(公告)日：2002-03-19
申请号：US09674037
申请日：2000-12-04
申请人： Jesus Ezquerra-Carrera , Joseph Michael Gruber , Chafiq Hamdouchi Hamdouchi , Richard Elmer Holmes , Wayne Alfred Spitzer
发明人： Jesus Ezquerra-Carrera , Joseph Michael Gruber , Chafiq Hamdouchi Hamdouchi , Richard Elmer Holmes , Wayne Alfred Spitzer
IPC分类号： A61K31437
CPC分类号： C07D471/04
摘要： The present invention relates to compounds of Formula (I) below, which inhibit the growth of picornaviruses, Hepatitus viruses, enteroviruses, cardioviruses, polioviruses, coxsackieviruses of the A and B groups, echo virus and Mengo virus. wherein: A is phenyl, pyridyl, substituted phenyl, substituted pyridyl, or benzyl; R is hydrogen, COR4, or COCF3; X is N—OH, O, or CHR1; R1 is hydrogen, halo, CN, C1-C4 alkyl, —C≡CH, CO(C1-C4 alkyl), CO2(C1-C4 alkyl), or CONR2R3; R2 and R3 are independently hydrogen or C1-C4 alkyl; A′ is hydrogen, halo, C1-C6 alkyl, benzyl, naphthyl, thienyl, furyl, pyridyl, pyrollyl, COR4, S(O)nR4, or a group of the formula R4 is C1-C6 alkyl, phenyl, or substituted phenyl; n is 0, 1, or 2; R5 is independently at each occurrence hydrogen or halo; m is 1, 2, 3, or 4; and R6 is hydrogen, halo, CF3, OH, CO2H, NH2, NO2, CONHOCH3, C1-C4 alkyl, or CO2(C1-C4 alkyl), C1-C4 alkoxy; or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明涉及抑制小核糖核酸病毒，肝病毒，肠病毒，心脏病毒，脊髓灰质炎病毒，A组和B组柯萨克病毒，回波病毒和孟戈病毒的生长的下列式（I）的化合物。其中A是苯基，吡啶基取代的苯基，取代的吡啶基或苄基; R是氢，COR4或COCF3; X是N-OH，O或CHR1; R1是氢，卤素，CN，C1-C4烷基，-C = CH， C1-C4烷基），CO2（C1-C4烷基）或CONR2R3; R2和R3独立地是氢或C1-C4烷基; A'是氢，卤素，C1-C6烷基，苄基，萘基，噻吩基，呋喃基，吡啶基，吡咯烷基，COR4，S（O）nR4或式R4的基团是C1-C6烷基，苯基或取代的苯基; n是0,1或2; R5各自独立地为氢或卤素; m为 1，2，3或4; 或者其药学上可接受的盐，R 6是氢，卤素，CF 3，OH，CO 2 H，NH 2，NO 2，CONHOCH 3，C 1 -C 4烷基或CO 2（C 1 -C 4烷基），C 1 -C 4烷氧基。

3. 发明申请

US20100022560A1 THIOPHENE PYRAZOLOPYRIMIDINE COMPOUNDS 有权
标题翻译：噻吩类吡唑并嘧啶化合物
公开(公告)号：US20100022560A1
公开(公告)日：2010-01-28
申请号：US12438953
申请日：2007-09-13
申请人： Zhaogen Chen , Chafiq Hamdouchi Hamdouchi , Erik James Hembre , Philip Arthur Hipskind , Shaojuan Jia , James Lee Toth
发明人： Zhaogen Chen , Chafiq Hamdouchi Hamdouchi , Erik James Hembre , Philip Arthur Hipskind , Shaojuan Jia , James Lee Toth
IPC分类号： A61K31/519 , C07D487/04 , A61P25/24 , A61P25/22
CPC分类号： C07D487/04
摘要： The present invention relates to compounds of Formula (I), pharmaceutical compositions thereof, and the use of such compounds as corticotropin releasing factor 1 (CRF1) receptor antagonists in the treatment of psychiatric and neuroendocrine disorders, neurological diseases, and metabolic syndrome.
摘要翻译：本发明涉及式（I）的化合物，其药物组合物，以及这些化合物作为促肾上腺皮质激素释放因子1（CRF1）受体拮抗剂在治疗精神和神经内分泌障碍，神经系统疾病和代谢综合征中的用途。

4. 发明申请

US20100222339A1 Thiazole pyrazolopyrimidines CRF1 receptor antagonists 有权
标题翻译：噻唑吡唑并嘧啶CRF1受体拮抗剂
公开(公告)号：US20100222339A1
公开(公告)日：2010-09-02
申请号：US12377733
申请日：2007-09-17
申请人： Zhaogen Chen , Chafiq Hamdouchi Hamdouchi , Erik James Hembre , Philip Arthur Hipskind , Jason Kenneth Myers , Takako Takakuwa , James Lee Toth
发明人： Zhaogen Chen , Chafiq Hamdouchi Hamdouchi , Erik James Hembre , Philip Arthur Hipskind , Jason Kenneth Myers , Takako Takakuwa , James Lee Toth
IPC分类号： A61K31/5377 , C07D471/04 , A61K31/437 , C07D417/14 , A61P25/30 , A61P25/32
CPC分类号： C07D487/04
摘要： The present invention relates to compounds of Formula (I), pharmaceutical compositions thereof, and use thereof as corticotropin releasing factor 1 (CRF1) receptor antagonists in the treatment of psychiatric and neuroendocrine disorders, neurological diseases, and metabolic syndrome.
摘要翻译：本发明涉及式（I）的化合物，其药物组合物及其作为促肾上腺皮质激素释放因子1（CRF1）受体拮抗剂在治疗精神和神经内分泌障碍，神经系统疾病和代谢综合征中的用途。

5. 发明申请

US20090318443A1 KINASE INHIBITORS 审中-公开
公开(公告)号：US20090318443A1
公开(公告)日：2009-12-24
申请号：US12509886
申请日：2009-07-27
申请人： Rosanne Bonjouklian , Chafiq Hamdouchi Hamdouchi , Chuan Shih , Alfonso De Dios , Miriam Filadelfa Del Prado , Carlos Jaramillo Aguado , Pramila Kotiyan , Mary Margaret Mader , Sheila Pleite Selgas , Concepcion Sanchez-Martinez
发明人： Rosanne Bonjouklian , Chafiq Hamdouchi Hamdouchi , Chuan Shih , Alfonso De Dios , Miriam Filadelfa Del Prado , Carlos Jaramillo Aguado , Pramila Kotiyan , Mary Margaret Mader , Sheila Pleite Selgas , Concepcion Sanchez-Martinez
IPC分类号： A61K31/5377 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04
摘要： The present invention provides kinase inhibitors of Formula I.

6. 发明授权

US07320995B2 Benzimidazoles and benzothiazoles as inhibitors of map kinase 失效
标题翻译：苯并咪唑和苯并噻唑作为地图激酶的抑制剂
公开(公告)号：US07320995B2
公开(公告)日：2008-01-22
申请号：US10522227
申请日：2003-07-31
申请人： Rosanne Bonjouklian , Jose Eugenio De Diego Gomez , Alfonso De Dios , Chafiq Hamdouchi Hamdouchi , Tiecho Li , Beatriz Lopez De Uralde Garmendia , Michal Vieth , Jeremy Schulenberg York , Robert Dean Dally , Miriam Filadelfa Del Prado Catalina , Carlos Jaramillo Aguado , Luisa Maria Martin-Cabrejas , Carlos Montero Salgado , Sheila Pleite Selgas , Concepcion Sanchez-Martinez , Timothy Alan Shepherd , James Howard Wikel
发明人： Rosanne Bonjouklian , Jose Eugenio De Diego Gomez , Alfonso De Dios , Chafiq Hamdouchi Hamdouchi , Tiecho Li , Beatriz Lopez De Uralde Garmendia , Michal Vieth , Jeremy Schulenberg York , Robert Dean Dally , Miriam Filadelfa Del Prado Catalina , Carlos Jaramillo Aguado , Luisa Maria Martin-Cabrejas , Carlos Montero Salgado , Sheila Pleite Selgas , Concepcion Sanchez-Martinez , Timothy Alan Shepherd , James Howard Wikel
IPC分类号： A61K31/4184 , A61K31/428 , C07D277/68 , C07D235/10
CPC分类号： C07D403/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D513/04
摘要： The present invention provides kinase inhibitors of Formula I: wherein W represents inter alia imidazol, oxazol, pyrazol, thiazol as triazol, which are substituted by phenyl or thienyl. The disclosed compounds inhibit p-38 kinase and are useful in the treatment of metastasis or rheumatoid arthritis
摘要翻译：本发明提供式I的激酶抑制剂：其中W代表由苯基或噻吩取代的咪唑，恶唑，吡唑，噻唑三唑。所公开的化合物抑制p-38激酶，并且可用于治疗转移或类风湿性关节炎

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